81 results about "Colposcopes" patented technology

Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.

The invention discloses a colposcopy image-based cervical cancer detection method, device and terminal equipment and a computer readable storage medium. The method comprises the following steps of: ina bidirectional convolutional neural network-based cervical cancer detection model, positioning and extracting a cervical opening position of an obtained colposcopy image so as to generate an ROI image comprising a cervical cancer disease area; extracting a cutting edge of the ROI image through a bidirectional convolutional neural network so as to generate a cut image; and carrying out cancer grade classification on the cut image through a classification convolutional neural network so as to output a cervical cancer lesion grade and then rapidly and correctly obtain a cervical cancer detection result. According to the method, doctors that are lack of experiences can be helped to rapidly judge diseased regions, discover atypical diseased regions and judge the disease degrees and sampling regions, so that help and auxo-action are provided for discovering cervical cancer and precancerous lesions.

The invention relates to a method and device intelligently identifying characteristics of images collected by a colposcope. Automatic extraction and identification are conducted on a normal saline test colposcope original image red characteristic, an original image green light image blood vessel distribution characteristic and an acetic acid test image white epithelium distribution characteristic; the central position of a cervical opening is positioned through an identifier shape easy to identify, the identifier shape and the position can be automatically identified, and therefore the characteristic images are distributed in four quadrants , the identifiability of the images is improved, the extracted characteristics are presented in a direct and visible mode on this basis. According to the method and device intelligently identifying characteristics of the images collected by the colposcope, a method of the combination of automatic image characteristic identification and automatic image characteristic display is adopted, the complexity of judging and reading of the images is simplified, the amount of information of judging and reading of the images is enriched, the image characteristics which are direct, visible and easy to identify are provided for a doctor, the precision, the uniformity and the repeatability of an image judgment, reading and assessing method are improved, and the dependence on subjective experience is reduced.

The invention belongs to the field of medical appliances, and particularly relates to an intelligent electronic endoscope system passing through natural orifices. The intelligent electronic endoscope system is suitable for a colposcope system, an anorectal endoscope system and a hysteroscope system, and comprises an electronic endoscope, an endoscope clamping mechanical arm for fixing the electronic endoscope, a movable adjustment operating platform, an intelligent robot-arm, a control desk and a central processing system, wherein the tail end of the main body of the endoscope is provided with a linear type robot-arm passage running through a hard working end part. By using the intelligent electronic endoscope system, a patient needs no operation, only the electronic endoscope is put inside through the natural orifices, and the intelligent robot-arm is put into an operation area by taking the intelligent robot-arm passage of the electronic endoscope as a platform; and the intelligent robot-arm is miniaturized, deformable and direction-changeable and simultaneously is provided with functions of a plurality of operative instruments (such as operative snap-on tongs, electric cutting equipment, electric coagulation equipment and the like), and thus, various operation treatments can be performed without introducing other instruments, and the difficulty of operations and the paint of patients are reduced.

A method and apparatus for personal screening for early signs of cervical cancer is claimed, whereby the user performs daily or almost daily a diagnostic self-check for some other aspect of reproductive health, and the electronic testing for cervical cancer type of tissue aberration is performed automatically in the background. The screening is invisible to the user, causing no anxiety and no discomfort. The user only becomes alerted to the need to see a physician if a preset condition of reproducibility is reached in the background evaluation of the measurement data if the aberrant pattern has been detected consecutively in a preset number of menstrual cycles, the device prompts the woman to see a physician with a view to undergoing a more demanding definitive diagnostic examination such as colposcopy with biopsy. The invention provides the diagnostic screen in a manner that does not cause the discomfort, anguish and anxiety associated with the Pap smear screen of the prior art.

Disclosed is an integrated electric vagina expander, relating to a combined structure of a vagina expander and a colposcope and comprising a detector, a detector permanent seat and a spring regulating mechanism. The spring regulating mechanism is composed of a duck mouth and a duck-mouth open-close device. The duck-mouth open-close device is composed of an open-close shaft and a shell sleeved outside the open-close shaft. A spring is arranged on the open-close shaft, regulating the open and close of the duck mouth. The integrated electric vagina expander which integrates the functions of the vagina expander and the colposcope can achieve continuous operations of examination, sampling and medicine application by a doctor, greatly improving the work efficiency of the doctor; the duck mouth is opened and closed in parallel so that the pain that a patient feels is reduced. In addition the invention is simply structured and produce with low cost.

The invention relates to the medical field, particularly to a system and a method for performing real-time remote control on a colposcopy period. According to the system and the method for performing real-time remote control on the colposcopy period, an examining side issues a consultation request to a consultation side; after determining consultation, a consultation side analyzes received currently-collected colposcopic images and collected colposcopic images to generate analysis results and to feed the analysis results to the examining side; the examining side receives the analysis results to perform next operations and to perform collection for a colposcopic collection period with problems. Therefore, real-time control on the colposcopy process can be achieved, and examining time of doctors as well as treatment cost of patients can be reduced.

The invention relates to the technical field of medical instruments, and discloses an intelligent assistant judgment system for a cervical image and a processing method thereof. The intelligent assistant judgment system for a cervical image comprises a colposcope detection device and an assistant judgment device. Through combining the colposcope detection device and the assistant judgment device, a to-be-detected cervical image is acquired by using the colposcope detection device, the assistant judgment device is matched to carry out comparison and analysis on the to-be-detected cervical image and feature data thereof, whether the current to-be-detected cervical is a normal cervical can be judged, the feature data of the to-be-detected cervical image can also be used to obtain which lesion type the current to-be-detected cervical possibly belongs and feature parameters of the lesion, a doctor can be assisted to make a right diagnosis and judgment, the diagnosis level of the doctor is improved, and the error diagnosis possibility and the missed diagnosis possibility are reduced.

The present invention involves an apparatus and method to detect lesions in the lower female genital tract produced by the Human Papilloma Virus using an actinic light colposcope. The apparatus of the present invention comprises mechanical, electrical and optical (also referred to herein as the actinic light) components. The method of the present invention comprises the general steps of: (1) illumination, (2) excitement, and (3) suppression. The method disclosed and claimed herein in the clinical context takes between 15 and 20 minutes and reliable results are obtained during the patient's office visit.

The invention provides an intelligent colposcope image collection and evaluation method, which is characterized by comprising the following steps of selecting a suspected lesion region from a colposcope image; automatically regulating the magnification times of a colposcope according to the position of the suspected lesion region in the colposcope image; and collecting the colposcope image. The invention also provides an intelligent colposcope image collection and evaluation device, which is characterized by comprising an image display unit, a suspected lesion region selecting unit, a magnification time control unit and an image collecting unit. The intelligent colposcope image collection and evaluation method provided by the invention has the advantages that the magnification times can be automatically regulated; the optimum magnification times can be elected in an automatic zooming and focal length changing mode on the precise of not moving a lens; the definition of the cervix uteri focus position is improved to the maximum degree; the manual focal length regulating operation of a doctor is reduced; and convenience and high speed are realized.

The invention discloses a built-in colposcope realizing multiple imaging modes. For the built-in colposcope, the amplification factor is continuously adjustable, meanwhile, various imaging modes (such as the white-light imaging mode, multi-spectrum imaging mode, fluorescent staining imaging mode and green-light imaging mode) are realized, the tested tissue is imaged through the different imaging modes, the multi-spectrum imaging mode and the fluorescent staining imaging mode provide the superfine-blood-vessel-level image with high contrast ratio distribution, the white-light imaging mode is used for common occasions, the use is convenient, for example, the white vinegar reaction and the iodine test technology can be adapted; a built-in amplification imaging unit is placed in the vagina, the work distance is adjusted according to the demands, and thus the amplification factor is adjusted; in order to not influence the sampling of biopsy forceps, a camera unit is arranged on the bottom of the built-in amplification imaging unit for matching with the built-in amplification imaging unit with small diameter, and the operation is not influenced. The built-in colposcope provides the first-hand blood vessel distribution information for the clinic, the biopsy accuracy rate is improved, and the misdiagnosis rate is reduced.

The invention discloses a cervical lesion prediction system based on multi-modal feature level fusion. The system comprises a computer memory, a computer processor and a computer program which is stored in the computer memory and can be executed on the computer processor, a cervical lesion prediction model is stored in the computer memory and comprises an acetic acid image feature extraction network, an iodine image feature extraction network and an auxiliary module used for fusing extracted features. When the computer processor executes a computer program, the following steps are realized: receiving an acetic acid image and an iodine image in colposcopy, and cutting out an area containing cervix uteri; respectively inputting the acetic acid image and the iodine image into an acetic acid image feature extraction network and an iodine image feature extraction network in the cervical lesion prediction model, respectively inputting the acetic acid image and the iodine image into respective auxiliary modules after feature extraction, carrying out feature fusion, and outputting a prediction result through calculation. According to the system, the prediction result can be more accurate so as to assist a doctor in making correct diagnosis and judgment.

Colposcopic viewing tubes for use with external colposcopes, otoscopes, velscopes. The colposcopic viewing tube is configured to be placed in front of the viewing lens of the colposcope, is typically opaque for a desired portion, and can create a light-tight connection between the patent and the external colposcope and enhance the accuracy or ease of examination of the cervix and other structures in the vagina. The tubes can, if desired, be flexed, extended, retracted, articulated, etc., while in use and can also be removed from the colposcope and be either sterilizable or disposable. The colposcopic viewing tube can be used with a disposable or sterilizable sleeve. The colposcopic viewing tube can comprise a one or more channels for illumination light, detection, spectroscopy, and imaging. In addition, colposcopic viewing tube can comprise extendable members that can be extended through one or more ports in the colposcopic viewing tube, which extension numbers can be sized and configured to fit within the os or other desired target.

The invention belongs to the field of medical devices, and in particular relates to a diagnosis and treatment integration confocal colposcopic system. The diagnosis and treatment integration confocal colposcopic system comprises a hard colposcope, wherein a treatment device is arranged on the hard endoscopic end part of the hard colposcope, and a treatment system host which is correspondingly matched with the treatment device is connected to the hard colposcope. Specifically, the diagnosis and treatment integration confocal colposcopic system organically combines the hard colposcope and a confocal laser scanning microscope system with a laser scalpel system or a microwave scalpel system. Through the clinical application of the diagnosis and treatment integration confocal colposcopic system, an effect of diagnosing and treating at the same time can be realized, one colposcopic can realize two problems of diagnosis and treatment simultaneously, endoscopes are prevented from being frequently changed, and the corresponding treatment can be immediately carried out, so that surgical time is greatly saved, and the pain of a patient is relieved; and furthermore, the surgical accuracy and safety are improved, and an unexpected effect is realized.

The invention discloses an integrated optical coherence tomography (OCT) hard colposcope system, comprising an integrated OCT hard colposcope, an OCT processing system, an optical photographic system, a cold light source host and a keyboard, wherein the integrated OCT hard colposcope is respectively connected and matched with the OCT processing system, the optical photographic system and the cold light source host, a flexible movable OCT probe module is embedded in a tip part of the OCT hard colposcope, and an OCT imaging component which does circular movement along the axial direction of the OCT probe module is arranged in the OCT probe module. The OCT hard colposcope system has the beneficial effects that the OCT probe module is designed in the tip part of the integrated OCT hard colposcope, and can be linearly pushed out to operate through a first micro motor therein, so that the operation simplicity of the OCT probe module is improved, and the OCT probe module is more durable, is not easily damaged and has a prolonged service life; and moreover, the OCT imaging component is utilized to carry out 360-degree all-dimensional OCT scanning imaging, so real-time images with high resolution are obtained, and effective basis is provided for the accurate diagnosis of doctors.

The invention discloses a suspicious early-stage cancer lesion examination device suitable for an endoscopy. A medical endoscope (a gastroscope, an enteroscope, a bronchoscope, a cystoscope, a colposcope, a laparoscope and the like) used in medical clinical examinations becomes an important tool for disease diagnosis. Many cancers can be found through observing the morphological characteristic of a pathological changed region, however, the pathological changes of early-stage cancers without remarkable morphological characteristics are difficultly detected, a great number of medical researches show that the early-stage pathological changes of the cancers are not remarkably changed in shape, but fluorescent substances in the cancer tissue are changed along with the formation of the canceration, then, the fluorescence of a cancer tissue is caused to be greatly different from that of a normal tissue, and thus, the suspicious lesions of the early-stage cancers are identified easily through fluorescence detection and expression of a difference by using a false color image way, the pathological biopsy can also be precisely indicated, and the suspicious early-stage cancer lesion examination device plays an important role in increasing the detection rate and the accuracy rate of early-stage cancer diagnosis.

The invention provides a monoclonal antibody for recognizing HPV16 positive cervical epithelial cancer cells, and applications thereof, wherein the antibody can specifically detect the cervical cancer biomarker HPV16E7 protein in tumor cells so as to distinguish the cancerous cervical epithelial cells and the cervical abnormality or non-cancerous cervical epithelial cells, such that the basis can be provided for doctors so as to accurately diagnose the cancer caused by HPV infection, the missed diagnosis rate of the high-grade cervical lesion can be effectively reduced, the sufficient time and the basis can be provided for the clinical doctor to diagnose and treat the patients, and the early cervical disease detection and the early intervention can be improved; and with the monoclonal antibody, the unnecessary colposcopy can be reduced and avoided.

An image analysis system for a colposcope and a hysteroscope comprises image processing software, affected light spot shadow subtraction segmentation software, image light and shade color difference analysis software and virtual three-dimensional imaging software, wherein the image processing software, the affected light spot shadow subtraction segmentation software, the image light and shade color difference analysis software and the virtual three-dimensional imaging software are connected with a host machine of the colposcope or a host machine of the hysteroscope. The image processing software is used for carrying out denoising or restoration on noisy images or degraded images, enhancing the images to obtain higher definition, extracting characteristics, analyzing shapes and textures of the images and matching the two images. The affected light spot shadow subtraction segmentation software can display the morpha of subcutaneous blood vessels, and is used for carrying out image comparison analysis on the images after uterine neck iodine dying. The image light and shade color difference analysis software is used for carrying out the light and shade color difference analysis on the images of a uterine cavity before and after a surgery. The virtual three-dimensional imaging software achieves virtual three-dimensional imaging of the vagina and the uterine cavity. The image analysis system can well assist a doctor to carry out cure and diagnosis on diseases.

The invention discloses a multimodal colposcope system and a method for acquiring multimodal images. According to the multimodal colposcope system and the method for acquiring multimodal images, opening and closing of all channels of a light source and the intensity of the light source are controlled independently through the ultra-bright LED light source and an imaging module which are selected through the special arrangement design and the wavelength, and several sorts of different medical imaging modalities are fused organically. Substance compositions can be effectively classified by multispectral imaging, normal tissue and lesion tissue can be distinguished according to fluorescence intensity by cervix uteri autofluorescence imaging, a doctor can be guided to judge the development degree of a nidus from the aspect of forms, colors and the like by conventional RGB color imaging, and therefore a more comprehensive, accurate and quantitative diagnosis basis can be provided for the doctor.

The invention discloses a laser-induced fluorescence spectrum colposcope. The invention uses laser light as the light source for inducing fluorescence, controls the laser scanning component to scan the cervical tissue site point by point, detects the excited fluorescence spectrum synchronously, and analyzes the correlation between the point-by-point acquired spectrum and the characteristic spectrum of the lesion to calculate the point-by-point lesion index , and then generate a lesion index distribution map. The invention can assist medical personnel to complete the detection process by adding an illumination source, an image sensor and the like. The laser scanning component, the spectrum acquisition component, the illumination source, and the image sensor realize light beam combining through the optical path beam combining component, and communicate the light with the lesion site through the positioning intubation tube. The invention utilizes the characteristics of high brightness, monochromaticity, and good directionality of laser light to irradiate the lesion with small spot area, high brightness, and high detection sensitivity. At the same time, it can excite laser-induced fluorescence specific spectra, greatly improving detection sensitivity and accuracy. .

A stereo colposcope having variable linearity filter systems for both the excitation step and the suppression step, and can be used universally with any fluorescent compound or drug, as is the case of photodynamic diagnosis (PDD). The colposcope is a two-way colposcope because the treatment can be administered by an optical system or by a light-producing radio-frequency electrical current with a diathermic effect which facilitates photodynamic treatment. The colposcope produces ozone, which has an antiseptic effect when applied to the genital tract. A monitor provides for three-dimensional viewing through the use of two video cameras with the DLP (Digital Light Processing) and HDTV (High Definition Television) systems with the use of active lenses.

The invention belongs to the field of medical apparatus, in particular relates to an integrated hard amplifying colposcope system for diagnosis and treatment. The integrated hard amplifying colposcope system for diagnosis and treatment comprises a hard amplifying colposcope. A treating device for treatment is arranged a hard endoscope end part of the hard amplifying colposcope. A treatment system host machine matched with the treating device for use is connected with the hard amplifying colposcope. According to the integrated hard amplifying colposcope system for diagnosis and treatment provided by the invention, organic combination of an amplifying colposcope with a laser knife system or that of the amplifying colposcope with a microwave knife system is realized. The integrated hard amplifying colposcope system for diagnosis and treatment is applied clinically to realize the effects of diagnosis and treatment simultaneously. The hard amplifying colposcope can be used for observing the macro condition in the vaginal cavity, vagina mucosa and the amplified microstructure of pathological changes while the laser knife system or the microwave knife system can be used for carrying out laser treatment or microwave treatment on pathological changes under direct view of a monitor. The problems of diagnosis and treatment for patients can be solved by using one endoscope by utilizing the integrated hard amplifying colposcope system for colposcope surgery, so that frequent change of endoscopes is avoided, a plenty of operative time is saved, the pain of patients is alleviated, and the operative accuracy and safety are further improved.

The present invention discloses an intelligent assistant judgment system for images of cervix uteri and a processing method thereof. This system comprises a colposcope device and an assistant judgment device. By combining the colposcope device and the assistant judgment device together to obtain the images of the cervix uteri to be detected by the colposcope device and to compare and analyze the images of the cervix uteri to be detected and its characteristic data by the assistant judgment device, the present invention can judge whether the current cervix uteri to be detected are normal cervix uteri, and can obtain, from the characteristic data of the images of the cervix uteri to be detected, the type of a lesion occurring in the current cervix uteri to be detected and characteristic parameters of the lesion. The doctors are assisted in making correct diagnosis and judgment.

The present invention provides a monoclonal antibody capable of recognizing high-risk HPV E7 positive cervical epithelial cancer cells, and applications thereof. According to the present invention, the monoclonal antibody can highly specifically detect cervical cancer biomarkers HPV E7 protein in tumor cells, wherein the cervical cancer biomarker HPV E7 protein covers HPV16, HPV31, HPV35, HPV52 and HPV58 and other high-risk subtypes, such that cancerous cervical epithelial cells and abnormal cervix or non-cancerous cervical epithelial cells can be distinguishes so as to provide basis for the accurate diagnosis of HPV infection-induced cancers, effectively reduce the missed diagnosis of high-grade cervical lesions, provide complete time and complete basis for the diagnosis and the treatmentof patients by clinicians, improve the detection of early-stage cervical diseases and the early intervention, and reduce and avoid unnecessary colposcopy.

The invention discloses a primer combination, a probe combination and a human papilloma virus nucleic acid detection kit. The invention relates to the field of biological detection, in particular to aPCR fluorescent probe detection method for diagnosing high-risk human papilloma virus infection, which comprises the following steps: extracting human papilloma virus nucleic acid in cervical exfoliated cells by using a paramagnetic particle method, and carrying out real-time fluorescence polymerase chain reaction to obtain the high-risk human papilloma virus detection kit to detect 14 HPV DNA types in the sample and typing the HPV 16 / 18; and meanwhile, carrying out female cervical cancer screening in combination with cytological examination. The kit can be used for qualitative detection of high-risk human papilloma viruses in cervical cell samples of patients, and typing identification of HPV16 and HPV18 types is realized while HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68 are detected. The kit is used for qualitatively detecting high-risk HPV DNA in cervical cells of a patient and determining whether the patient needs colposcope examination or not.

The invention discloses a disinfectant for cleaning a colposcope. The disinfectant consists of the following components in percentage by weight: 0.5-1.0 percent of peroxyacetic acid, 2.0-5.0 percent of hydrogen peroxide, 0.1-0.5 percent of chlorhexidine hydrochloride, 0.01-0.05 percent of phenol, 1.0-5.0 percent of salicylic acid, 2.0-6.0 percent of trichloroisocyanuric acid and the rest of water. The colposcope cleaning disinfectant prepared by the preparation method disclosed by the invention is colorless and transparent in appearance; the physical and chemical index performance is stable; during use, crystals, turbidity and precipitates are not generated; all physical and chemical indexes are stable. Compared with the prior art, the disinfectant has the advantages that the production cost is low, the preparation technology is simple, the technical conditions are easy to implement, and the product stability is high.

The present invention discloses an endoscopic vagina examination device. The endoscopic vagina examination device comprises a hard tube endoscope, a control host, a monitor and a limiting vagina expander matched with the hard tube endoscope, the control host comprises an image processing system and a light source system, the image processing system and the light source system are both connected with the hard tube endoscope, and an upper end of the control host is provided with an operation panel. The endoscopic vagina examination device solves a problem that the prior colposcopes have more observation blind spots, realizes omnibearing observation, realizes essential breakthrough compared with the colposcopy examination products in the prior art, facilitates operation of medical staff, cangreatly improve examination efficiency, improves an examination effect, helps the medical staff quickly and safely obtain fully prepared examination data, effectively shortens examination time and promotes comfort levels of examinees, built-in parts are all passive products, and the endoscopic vagina examination device avoids cross infection that probably produces, strengthens examination safety simultaneously and promotes diagnostic quality comprehensively.

The invention discloses a fluorescence detection device for an electronic colposcope. The fluorescence detection device comprises a light source unit, a fluorescence filtering unit, an image enhancement unit and a fluorescence detection control unit. The light source unit serves as a fluorescence excitation light source to produce fluorescence. The fluorescence filtering unit is placed at the front end of an imaging sensor in the electronic colposcope and used for filtering non-fluorescent images. The image enhancement unit is used for changing gray level of fluorescence and enhancing characteristics of fluorescent images. The fluorescence detection control unit is used for control and coordination of all parts for fluorescence detection and provides a fluorescence detection control interface of a user program. The fluorescence detection device for the electronic colposcope is advantaged by being simple in structure and easy in operation and is capable of improving image acquisition and processing accuracy.