The invention provides a total nutrient organic-inorganic compound fertilizer, which comprises the following components in percentage by weight: 10-15 percent of bean cake, 10-15 percent of cotton cake, 20-25 percent of poultry excrement, 5-10 percent of humic acid, 0.1-0.2 percent of sporotrichum thermophile, 15-33 percent of urea, 8-25 percent of monoammonium phosphate, 8-25 percent of potassium sulfate or potassium chloride, 0.6-1 percent of calcium powder, 0.5-1.5 percent of magnesium oxide, 0.1-0.3 percent of copper sulfate, 0.3-0.5 percent of ferrous sulfate, 0.2-0.5 percent of zinc sulfate, 0.2-0.5 percent of manganese sulfate, 0.2-0.3 percent of boric acid and 0.000006-0.00002 percent of ammonium molybdate. The total nutrient organic-inorganic compound fertilizer contains macroelements, secondary elements, microelements, organic matters and microorganisms, the utilization rate of the fertilizer can be increased, the soil organisms can be activated, and soil hardening is relieved or eliminated.