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137results about How to "Strong drug resistance" patented technology

Human colorectal adenocarcinoma tumor cell line as well as preparation method and application thereof

The invention provides a human colorectal adenocarcinoma tumor cell line as well as a preparation method and an application thereof. The cell line P6C of human colorectal adenocarcinoma tumor stem cell line has the preservation number of CGMCC No.5558. The preparation method comprises the following steps of: 1) separating original colon cancer stem cells; 2) culturing the primary colon cancer stem cells in vitro; 3) culturing and identifying the colon cancer stem cells; and 4) separating and culturing the obtained colon cancer stem cells according to the same method in the steps 1), 2) and 3) to screen and express the tumor stem cell of CD44 membrane protein. The cell line can be applied in the preparation of the medicine for inducing tumour formation, a medicine for tumor metastasis and medicines for screening antituvmorigenesis, anti-tumor growth and anti-tumor metastasis.
Owner:INST OF ZOOLOGY CHINESE ACAD OF SCI

Microbial environment protectant

ActiveCN102813949AReduce contentStrong degradation conversion abilityBiocideBacteriaChinese herbsBlastomycetes
The invention discloses a microbial environment protectant, which is characterized by comprising mixed bacteria and a traditional Chinese medicine extract, wherein the mixed bacteria are formed by Rhodopseudomonas palustris, Bacillus Subtilis and Lactobacillus delbruckii. The weight ratio of the Rhodopseudomonas palustris to the Bacillus Subtilis to the Lactobacillus delbruckii is 3:4:7; the volume ratio of the traditional Chinese medicine extract to the mixed bacteria is 1-2 percent. The microbial environment protectant disclosed by the invention has the positive effects that through performing mixed fermentation on the compound bacterial liquid and the traditional Chinese medicine extract, the traditional Chinese medicine ingredients are further activated, and the traditional Chinese medicine ingredients and thallus exoenzyme interact to restrain the incubation of ova, and the generation of adult flies is reduced. As a traditional Chinese medicine and bacterial liquid fermentation medium is special in smell, a trapping and killing effect is performed on the adult flies, and the bad smell of a smelly source can also be effectively prevented from being emitted. The microbial environment protectant disclosed by the invention is harmless to people, is low in cost, simple in preparation process, simple and convenient in operation and remarkable in deodorization and fly killing effect. The problems that mosquitoes and the flies and foul smell exist in refuse landfills, waste transfer stations and digestion tanks are well solved, and a good effect is achieved.
Owner:YIBIN WANHUA BIOLOGICAL ENVIRONMENT CO LTD

Method of reducing amount of plutella xylostella through propagation and field release of cotesia plutellae

The invention relates to a method of reducing amount of plutella xylostella by using cotesia plutellae. The method of reducing the amount of the plutella xylostella by using the cotesia plutellae plays a part in extinction of the plutella xylostella through eclosion, parasitism and field release of the cotesia plutellae. The method of reducing the amount of the plutella xylostella by using the cotesia plutellae has the advantages of being ecologically environment-friendly, avoiding damage of agriculture to the environment, being efficient and economical in extinction effect to the plutella xylostella, and being applicable to large-scale utilization in the agriculture.
Owner:INST OF AGRI ENVIRONMENT & RESOURCES YUNNAN ACAD OF AGRI SCI

Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof

The invention relates to a copper-doped zinc oxide quantum dot nano antibacterial agent and a preparation method thereof. A chemical formula of the copper-doped zinc oxide quantum dot nano antibacterial agent is Zn<1-x>OCu<x> (x = 0.003-0.01). The preparation method comprises the following steps: weighing a zinc source and a copper source and performing dispersing in an organic solvent, performingstirring and heating in a water bath until a solution is clear and transparent, and performing stirring again to obtain a zinc and copper mixed precursor solution; adding an alkali source into an organic solvent, and performing stirring to obtain an alkali solution; dropwise adding the alkali solution into the zinc and copper mixed precursor solution, and performing stirring to obtain a mixed solution; and adding a precipitant into the mixed solution, performing stirring and then performing standing, washing and centrifuging to obtain the copper-doped zinc oxide quantum dot nano antibacterialagent. A size of the Cu-doped ZnO quantum dot is mainly distributed in 4-8 nm. A minimum bacteriostatic concentration of the nano antibacterial agent against Escherichia coli can reach 2.7 mg / mL, anda bacteriostatic rate against Escherichia coli can reach 81.79%.
Owner:GMY LIGHTING TECH CO LTD

Nucleoside phosphamide compound and preparation method and application of nucleoside phosphamide in medicine

The invention provides a nucleoside phosphamide compound shown as a formula (I), and an application of the compound as an antiviral drug. The compound can inhibit replication of RNA virus, and can be used as an inhibitor for hepatitis c virus (HCV)NS5B polymerase. The compound has inhibiting effect for NS5B polymerase and has little toxicity on hepatic cells.
Owner:SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD

Preparation method of modified MMT (montmorillonite)/ZnO/GQDs (graphene quantum dots) nano-composite antibacterial agent

The invention relates to a preparation method of a modified MMT/ZnO/GQDs nano-composite antibacterial agent. The preparation method of the modified MMT/ZnO/GQDs nano-composite antibacterial agent comprises dispersing Na-montmorillonite into deionized water, and then stirring the mixture at high speed; dispersing modifier into deionized water, after the modifier is fully dissolved, adding the mixture into the Na-montmorillonite dispersion mixture, and then performing high-speed stirring, standing, cooling, suction filtration, drying and grinding treatment to obtain modified montmorillonite (modified MMT); heating citric acid to obtain an orange solution; regulating the pH of the orange solution through sodium hydroxide solution, and performing dialysis and rotary evaporation to obtain GQDssolution; adding an alkali source into ethyl alcohol, and performing magnetic stirring to obtain a solution A: adding a zinc source into ethyl alcohol, performing magnetic stirring, then adding in theGQDs solution and performing ultrasonic treatment; adding in the modified MMT, and then performing water bath reaction; adding in the solution A for reaction for 20 min, then performing heating reaction, and cooling, washing and centrifuging reaction products to obtain the modified MMT/ZnO/GQDs nano-composite antibacterial agent. The prepared modified MMT/ZnO/GQDs nano-composite antibacterial agent has the advantages of being safe, environmentally friendly, high in tolerance and the like.
Owner:上海鹏图抗菌新材料有限公司 +1

Preparation method of ZnO/GQD-PEI composite quantum dot antibacterial agent

The invention relates to a preparation method of a ZnO / GQD-PEI composite quantum dot antibacterial agent. The preparation method comprises the following steps: heating citric acid to obtain an orangesolution; dropwise adding a NaOH solution to adjust pH, and performing dialysis and rotary evaporation, thus obtaining a graphene quantum dot (GQDs) solution; firstly diluting the obtained GQDs solution, then adding modifier to adjust the concentration, performing the ultrasonic treatment, adding EDC-HCl in two times, ultrasonically stirring, and obtaining GQD-PEI; separately adding an alkaline source and a zinc source into an ethanol solution, stirring, and obtaining a solution A and a solution B; adding the obtained GQD-PEI into the solution B, ultrasonically dispersing, then adding the solution A into the solution B, heating in a water bath, reacting, then washing, and centrifuging, thus obtaining the composite quantum dot antibacterial agent. Compared with the traditional antibacterialagent, the nano composite antibacterial agent prepared in the invention has the advantages of safety, environmental protection, high drug resistance and the like, and the minimum antibacterial concentration for escherichia coli can reach 1.8 mg / ml.
Owner:四川华运天晨新材料技术有限公司

Endless belt for image-forming apparatuses, and image-forming apparatus

InactiveCN1826561AExcellent external environment stabilityLow voltage dependenceElectrographic process apparatusSurface resistivityEngineering
An endless belt for image forming devices is disclosed. The endless belt is produced by molding a compound comprising a thermoplastic elastomer, a thermoplastic resin, and a conductive material, and satisfies formulae (1), (2), (3) shown below. An image forming device using this endless belt is also disclosed. [FORMULAE 1] SR(100V) / SR(500V) G03G 15 / 16 G03G 15 / 08 G03G 15 / 20 G03G 21 / 00 G03G 5 / 10 6 53 4 2004 / 7 / 23 1826561 2006 / 8 / 30 100444042 2008 / 12 / 17 2008 / 12 / 17 2008 / 12 / 17 Mitsubishi Chem Corp. Japan Morikoshi Makoto Otsu Toshihiro Yamaoka Katsushi Mizumoto Kazuya zhang bengyuan zhao renlin 11105 Japan 2003 / 7 / 25 201844 / 2003 Japan 2003 / 9 / 5 314291 / 2003 Japan 2004 / 4 / 12 116996 / 2004 Japan 2004 / 4 / 23 128485 / 2004 2006 / 1 / 23 PCT / JP2004 / 010458 2004 / 7 / 23 WO2005 / 010621 2005 / 2 / 3 Japanese
Owner:MITSUBISHI RAYON CO LTD +1

Cockroach prevention and control agent

The invention discloses a cockroach prevention and control agent which consists of the following components in parts by weight: 0.5-2 parts of dinotefuran, 10-30 parts of fish meal, 5-10 parts of peanut oil, 30-50 parts of bagasse, 10-20 parts of maltose and 1-5 parts of rosin. The cockroach prevention and control agent is simple in formula, low in cost and easy to popularize, and can be produced without using complex equipment; moreover, the added spinosad and azadirachtin have synergistic effects, so that the cockroach prevention and control agent has the advantages of quick response and good prevention and control effects.
Owner:马瑞

Easy-to-tear type drug packaging composite film for automatic drug dispensing machine

InactiveCN103963409AAvoid breakingTo achieve the effect of easy tearingFlexible coversWrappersPolyesterPolymer science
The invention relates to an easy-to-tear type drug packaging composite film for an automatic drug dispensing machine. The preparation method of the easy-to-tear type drug packaging composite film comprises the following steps: coating the surface of a polyester film to change the molecular structure of the polyester film; then, gluing the treated polyester film through a gluing device and drying; adding a lot of low-temperature heat-sealing materials in the film blowing process of the polyester film to obtain a low-temperature heat-sealing film; printing and compositing the polyester film (PET) and a polyethylene film (LDPE) to obtain a composite film, and finally performing curing, slitting, bag making, edge folding and packaging, so that the low-temperature heat-sealing easy-to-tear type composite film is obtained. The composite film overcomes the defects that in the prior art, the composite film is not easy to tear, used glass paper is high in cost, and the hot-sealing temperature is high. The composite film is good in application performance, convenient for packaging, good in moisture resistance performance, light in materials and good in drug resistance, thereby effectively protecting the quality of drugs, and being particularly suitable for being used in hospitals.
Owner:HANGZHOU ZHONGDA MEDICAL PACKAGING

Anti-tumor medicament structure

The invention provides a novel anti-tumor medicament structure which is shown by a structural general formula (I). In the formula, R1 to R5 are independently selected from H, NO2, OH, halogen and OCH3. The medicament has a simple and convenient synthesis method, and molecules comprise nitroxide free radical structure units, so the anti-tumor medicament structure can effectively suppress proliferation of liver cancer, stomach cancer, breast cancer and ovarian cancer cells.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Diacetone amine copper oxalate containing bactericidal composition

The invention discloses a diacetone amine copper oxalate containing bactericidal composition. The diacetone amine copper oxalate containing bactericidal composition comprises a first active ingredient and a second active ingredient with a weight ratio of (1:15)-(10:1), wherein the first active ingredient is diacetone amine copper oxalate, and the second active ingredient is selected from one of self-protective fungicides such as zineb, mancozeb, trioneb, dithane stainless, propineb, thiram, ziram, chlorothalonil, sulfur and dimethachlon. The bactericidal composition can be prepared into water dispersible granules, wettable powder, suspending agents or dispersible oil suspending agents which are allowed to be used agriculturally, and has the relatively good prevention effect on apple altermaria leaf spot, apple brown spot, cucumber downy mildew, powdery mildew of cucumbers, and potato late blight. The diacetone amine copper oxalate containing bactericidal composition effectively solves the problem that a bactericidal composition adopting the diacetone amine copper oxalate or one of the protective fungicides singly has the poor prevention effect, and has the remarkable synergism due to compounding of the diacetone amine copper oxalate and one of the protective fungicides, and besides, the resistance generation can be delayed.
Owner:SHAANXI SUNGER ROAD BIO SCI
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