138results about How to "Strong drug resistance" patented technology

The present invention provides a pegylated lapatinib, an injection and a preparation method thereof, wherein the general formula of the pegylated lapatinib is defined in the specification, A is selected from a single-arm or multi-arm polyethylene glycol or poly ethylene glycol derivative, X is selected from the formula defined in the specification, Y and M are independently and respectively selected from double carboxylic acids having amino or corresponding acyl substituents, N is selected from an amino acid or peptide, LPT is lapatinib, a is 0 or 1, b is 0 or 1, c is 1 or 2, d is 1 or 2, and e is equal to the arm number of X. According to the present invention, the pegylated drug of lapatinib is synthesized, such that the lapatinib toxicity is reduced, the water solubility and the biological stability are improved, the drug resistance of cancer cells and cancer stem cells are avoided, the targeting property is enhanced, and the anticancer treatment effect is significantly improved.

The invention relates to a solid preparation of a novel sterilant herbicide composition employing saflufenacil and glyphosate and containing a herbicide auxiliary agent. The solid preparation comprises the two effective compositions saflufenacil and glyphosate, the auxiliary agent and a carrier. The two effective compositions saflufenacil and glyphosate account for 10%-70% by weight of the composition, and the weight ratio of saflufenacil to glyphosate is 1:5-1:40. The solid preparation of the herbicide composition containing saflufenacil and glyphosate employs a particulate agent, a wettable powder and a water-dispersable granule as a product form. The herbicide auxiliary agent is a combination of at least two or more of a plant-resource spray auxiliary agent, a plant-source SD auxiliary agent, an alkyl glycoside surfactant, a trisiloxane surfactant, a tallow amine surfactant, betain, amino oligosaccharin and a penetrating agent JFC. The herbicide composition containing the herbicide auxiliary agent has excellent control efficacy on common gramineae and broad leaf weeds, and especially on weeds generating drug resistance on herbicides such as glyphosate, sulfonylureas, triazines and the like.

The invention provides a human colorectal adenocarcinoma tumor cell line as well as a preparation method and an application thereof. The cell line P6C of human colorectal adenocarcinoma tumor stem cell line has the preservation number of CGMCC No.5558. The preparation method comprises the following steps of: 1) separating original colon cancer stem cells; 2) culturing the primary colon cancer stem cells in vitro; 3) culturing and identifying the colon cancer stem cells; and 4) separating and culturing the obtained colon cancer stem cells according to the same method in the steps 1), 2) and 3) to screen and express the tumor stem cell of CD44 membrane protein. The cell line can be applied in the preparation of the medicine for inducing tumour formation, a medicine for tumor metastasis and medicines for screening antituvmorigenesis, anti-tumor growth and anti-tumor metastasis.

The invention provides chroman and chromene derivatives as tumor multidrug resistance inhibitors as well as a preparation method of the chroman and chromene derivatives. The chroman and chromene derivatives are represented by the following general formulae I and II respectively, wherein R is one or more of hydrogen, hydroxy, alkoxy, alkyl amino, alkyl acylamino, halogen, fluorine-containing alkyl or benzoyl; the benzoyl contains one or more of substituent groups of hydroxy, alkoxy, alkyl amino, alkyl acylamino, halogen or fluorine-containing alkyl; the alkyls in the alkoxy, the alkyl amino, the fluorine-containing alkyl and the alkyl acylamino are linear-chain or branch-chain alkyls with 1-10 carbon atoms; X is hydrogen or oxygen; and Y is oxygen or nitrogen. The chroman and chromene derivatives have low toxicity and good tumor multidrug resistance inhibiting activities, and can be used for preparing drugs for treating breast cancer, colon cancer, prostate cancer, leukemia, myeloma, pancreatic cancer and the like.

The invention discloses a cheb used on filtering material and the production method. When the measured pressure of the product is 125Pa according to JIS L 1096 8.27.1A standard, the venting quality value of the cheb is 300cc / cm2 / s to 600cc / cm2 / s; according to JIS L 1096 8. 12. 1A standard, the warp direction of the tensile strength of the cheb is 500N / 5cm to 1000N / 5cm, and the direction of weft is 300N / 5cm to 800N / 5cm. The production method comprises the procedures of choosing warp and weft yarn fiber, weaving and so on; During the process of weaving, the yarn before weaving and the cheb after weaving is processed by heat setting and controls the indexes of warp and weft density, tilter and twist. The invention has good tension strength and venting quality, which improves the filtering performance of the filtering material and prolongs the service life of the filtering material.

The invention relates to an Edwardsiella tarda strain and an application method thereof. The Edwardsiella tarda strain is separated from a turbot adult fish body and is a wild strain with strong virulence, and the preservation number of the Edwardsiella tarda strain is CGMCC No.7197. Preparation modes of an antigen of the Edwardsiella tarda strain comprise any one or more than one of an inactivated thallus, a bacteruak ghost ingredient, an attenuated strain, a protective antigen, an antigen subunit and an expression product of an antigen determinant or an antigen gene expression carrier; the produced vaccine can be a single ingredient of the antigen prepared by utilizing the Edwardsiella tarda strain and can also be a combined vaccine produced by mixing the antigen prepared by utilizing the Edwardsiella tarda strain with antigens of other bacteria, and the prepared single or combined vaccine antigen is added with an adjuvant to produce the vaccine; and an inoculation mode of the vaccine in immunization application can adopt injection immunization, wound immunization, immersion bath immunization or oral administration immunization.

The invention discloses a microbial environment protectant, which is characterized by comprising mixed bacteria and a traditional Chinese medicine extract, wherein the mixed bacteria are formed by Rhodopseudomonas palustris, Bacillus Subtilis and Lactobacillus delbruckii. The weight ratio of the Rhodopseudomonas palustris to the Bacillus Subtilis to the Lactobacillus delbruckii is 3:4:7; the volume ratio of the traditional Chinese medicine extract to the mixed bacteria is 1-2 percent. The microbial environment protectant disclosed by the invention has the positive effects that through performing mixed fermentation on the compound bacterial liquid and the traditional Chinese medicine extract, the traditional Chinese medicine ingredients are further activated, and the traditional Chinese medicine ingredients and thallus exoenzyme interact to restrain the incubation of ova, and the generation of adult flies is reduced. As a traditional Chinese medicine and bacterial liquid fermentation medium is special in smell, a trapping and killing effect is performed on the adult flies, and the bad smell of a smelly source can also be effectively prevented from being emitted. The microbial environment protectant disclosed by the invention is harmless to people, is low in cost, simple in preparation process, simple and convenient in operation and remarkable in deodorization and fly killing effect. The problems that mosquitoes and the flies and foul smell exist in refuse landfills, waste transfer stations and digestion tanks are well solved, and a good effect is achieved.

Cepharanthine is used as effective component in preparing medicine for resisting SARS virus. Within the safe dosage range, the present invention has high inhibition rate to SARS virus and powerful effect of preventing SARS virus infection. The medicine can alleviate the syndromes of SARS patient and has fast after cure, less toxicity, high stability and other advantages.

The invention relates to a method of reducing amount of plutella xylostella by using cotesia plutellae. The method of reducing the amount of the plutella xylostella by using the cotesia plutellae plays a part in extinction of the plutella xylostella through eclosion, parasitism and field release of the cotesia plutellae. The method of reducing the amount of the plutella xylostella by using the cotesia plutellae has the advantages of being ecologically environment-friendly, avoiding damage of agriculture to the environment, being efficient and economical in extinction effect to the plutella xylostella, and being applicable to large-scale utilization in the agriculture.

The invention relates to a copper-doped zinc oxide quantum dot nano antibacterial agent and a preparation method thereof. A chemical formula of the copper-doped zinc oxide quantum dot nano antibacterial agent is Zn<1-x>OCu<x> (x = 0.003-0.01). The preparation method comprises the following steps: weighing a zinc source and a copper source and performing dispersing in an organic solvent, performingstirring and heating in a water bath until a solution is clear and transparent, and performing stirring again to obtain a zinc and copper mixed precursor solution; adding an alkali source into an organic solvent, and performing stirring to obtain an alkali solution; dropwise adding the alkali solution into the zinc and copper mixed precursor solution, and performing stirring to obtain a mixed solution; and adding a precipitant into the mixed solution, performing stirring and then performing standing, washing and centrifuging to obtain the copper-doped zinc oxide quantum dot nano antibacterialagent. A size of the Cu-doped ZnO quantum dot is mainly distributed in 4-8 nm. A minimum bacteriostatic concentration of the nano antibacterial agent against Escherichia coli can reach 2.7 mg / mL, anda bacteriostatic rate against Escherichia coli can reach 81.79%.

The invention provides a nucleoside phosphamide compound shown as a formula (I), and an application of the compound as an antiviral drug. The compound can inhibit replication of RNA virus, and can be used as an inhibitor for hepatitis c virus (HCV)NS5B polymerase. The compound has inhibiting effect for NS5B polymerase and has little toxicity on hepatic cells.

The invention relates to a preparation method of a modified MMT / ZnO / GQDs nano-composite antibacterial agent. The preparation method of the modified MMT / ZnO / GQDs nano-composite antibacterial agent comprises dispersing Na-montmorillonite into deionized water, and then stirring the mixture at high speed; dispersing modifier into deionized water, after the modifier is fully dissolved, adding the mixture into the Na-montmorillonite dispersion mixture, and then performing high-speed stirring, standing, cooling, suction filtration, drying and grinding treatment to obtain modified montmorillonite (modified MMT); heating citric acid to obtain an orange solution; regulating the pH of the orange solution through sodium hydroxide solution, and performing dialysis and rotary evaporation to obtain GQDssolution; adding an alkali source into ethyl alcohol, and performing magnetic stirring to obtain a solution A: adding a zinc source into ethyl alcohol, performing magnetic stirring, then adding in theGQDs solution and performing ultrasonic treatment; adding in the modified MMT, and then performing water bath reaction; adding in the solution A for reaction for 20 min, then performing heating reaction, and cooling, washing and centrifuging reaction products to obtain the modified MMT / ZnO / GQDs nano-composite antibacterial agent. The prepared modified MMT / ZnO / GQDs nano-composite antibacterial agent has the advantages of being safe, environmentally friendly, high in tolerance and the like.

The invention discloses a high-performance medical liquid adhesive bandage. The liquid adhesive bandage contains the following raw materials (by weight): 80-120 parts of cellulose acetate, 20-50 parts of castor oil, 30-70 parts of glyceryl triacetate, 200-500 parts of benzyl alcohol, 80-1200 parts of ethyl acetate, 1-10 parts of dopamine, 40-400 parts of a silver nitrate aqueous solution and 100-500 parts of an ethanol solution. The adhesive bandage of the invention has a good antibacterial property and also has properties such as high adhesion to skin, waterproofness, air permeability, concealing performance and the like.

The invention relates to a preparation method of a ZnO / GQD-PEI composite quantum dot antibacterial agent. The preparation method comprises the following steps: heating citric acid to obtain an orangesolution; dropwise adding a NaOH solution to adjust pH, and performing dialysis and rotary evaporation, thus obtaining a graphene quantum dot (GQDs) solution; firstly diluting the obtained GQDs solution, then adding modifier to adjust the concentration, performing the ultrasonic treatment, adding EDC-HCl in two times, ultrasonically stirring, and obtaining GQD-PEI; separately adding an alkaline source and a zinc source into an ethanol solution, stirring, and obtaining a solution A and a solution B; adding the obtained GQD-PEI into the solution B, ultrasonically dispersing, then adding the solution A into the solution B, heating in a water bath, reacting, then washing, and centrifuging, thus obtaining the composite quantum dot antibacterial agent. Compared with the traditional antibacterialagent, the nano composite antibacterial agent prepared in the invention has the advantages of safety, environmental protection, high drug resistance and the like, and the minimum antibacterial concentration for escherichia coli can reach 1.8 mg / ml.

The invention relates to a light-driven nano-antibacterial agent and a preparation method thereof. The preparation method comprises the steps of heating citric acid and reacting so as to obtain orange solid; adding an NaOH water solution and performing ultrasonic treatment till the solid is dissolved completely, and then regulating pH of the solution to be 7; dialyzing the obtained solution in ultra-pure water so as to obtain a graphene quantum dot solution; drying and then adding the solution into diglycol and performing ultrasonic treatment; adding zinc stearate and reacting so as to obtain dark brown liquid; and centrifugally washing a product with methylbenzene, dialyzing in ultra-pure water, and filtering to remove suspended matters so as to obtain the nano-antibacterial agent. Compared with a traditional antibacterial agent, the nano-antibacterial agent prepared by the method has the advantages of being safe and environment-friendly, and having a good antibacterial effect and high drug resistance. The nano-antibacterial agent prepared through the method can kill 99.78% of colibacillus after being exposed in 100w of ultraviolet light for 1min.

An endless belt for image forming devices is disclosed. The endless belt is produced by molding a compound comprising a thermoplastic elastomer, a thermoplastic resin, and a conductive material, and satisfies formulae (1), (2), (3) shown below. An image forming device using this endless belt is also disclosed. [FORMULAE 1] SR(100V) / SR(500V) G03G 15 / 16 G03G 15 / 08 G03G 15 / 20 G03G 21 / 00 G03G 5 / 10 6 53 4 2004 / 7 / 23 1826561 2006 / 8 / 30 100444042 2008 / 12 / 17 2008 / 12 / 17 2008 / 12 / 17 Mitsubishi Chem Corp. Japan Morikoshi Makoto Otsu Toshihiro Yamaoka Katsushi Mizumoto Kazuya zhang bengyuan zhao renlin 11105 Japan 2003 / 7 / 25 201844 / 2003 Japan 2003 / 9 / 5 314291 / 2003 Japan 2004 / 4 / 12 116996 / 2004 Japan 2004 / 4 / 23 128485 / 2004 2006 / 1 / 23 PCT / JP2004 / 010458 2004 / 7 / 23 WO2005 / 010621 2005 / 2 / 3 Japanese

The invention provides a benzopyranyl-3-alcohol esterified derivative and a preparation method of the benzopyranyl-3-alcohol esterified derivative. The benzopyranyl-3-alcohol esterified derivative is shown as the following formula I, wherein in the formula I, R represents one or more of hydrogen, hydroxy, alkoxy, alkyl amino, alkyl acylamino, fluorine or benzoyl; the benzoyl contains one or more of hydroxy, alkoxy, alkyl amino, alkyl acylamino or fluorinated substituents, wherein alkyl in alkoxy, alkyl amino and alkyl acylamino is C1 to C10 straight chain or branched chain alkyl; X in the formula represents hydrogen or oxygen; and Y in the formula represents oxygen or nitrogen and hydrogen. The benzopyranyl-3-alcohol esterified derivative is low-toxic, has excellent antineoplastic multidrug resistance activity and can be used for preparing a medicament for treating breast cancer, colon cancer, prostatic cancer, leukemia, myeloma, pancreatic cancer and the like.

The invention discloses a trastuzumab drug-resistant human breast cancer cell line BT-474 / HR. The human breast cancer cell line has the collection number of CCTCC NO:C2014245 in China Center for Type Culture Collection, and the collection date of the human breast cancer cell line is 14, January in 2015. The invention also discloses a method for constructing the trastuzumab drug-resistant human breast cancer cell line BT-474 / HR. The method comprises the following step of preparing a human breast cancer cell line BT-474 / HR with excellent in-vitro and in-vivo trastuzumab drug resistance by utilizing a human breast cancer cell line BT-474 and combining two means of in-vitro induction and in-vivo induction of trastuzumab. According to the cell line, the HER2 overexpression characteristics of a parental cell line are remained, and the cell line has excellent in-vitro and in-vivo drug resistance on an HER2 targeted antibody drug. Therefore, the human breast cancer cell line can be directly applied to development and research of novel anti-tumor treatment drugs.

The invention discloses a polyolefin resin composition with a lusterless characteristic. The composition comprises, by weight, 20 to 80% of a polypropylene random copolymer resin of homo-polypropylene or ethylene / 1-butylene and 80 to 20% of a high density polyethylene resin. The polyolefin resin composition has the advantages of a low price and excellent performance; a film prepared from the polyolefin resin composition has excellent mechanical properties, heat resistance, resistance to chemical reagents and superior formability, can be used for food packaging and commodity packaging and as coating materials for other materials and is a lusterless biaxial drawing polypropylene film with the advantages of the lusterless characteristic, simple manufacturing and excellent processability.

The invention discloses a cockroach prevention and control agent which consists of the following components in parts by weight: 0.5-2 parts of dinotefuran, 10-30 parts of fish meal, 5-10 parts of peanut oil, 30-50 parts of bagasse, 10-20 parts of maltose and 1-5 parts of rosin. The cockroach prevention and control agent is simple in formula, low in cost and easy to popularize, and can be produced without using complex equipment; moreover, the added spinosad and azadirachtin have synergistic effects, so that the cockroach prevention and control agent has the advantages of quick response and good prevention and control effects.

The invention relates to an easy-to-tear type drug packaging composite film for an automatic drug dispensing machine. The preparation method of the easy-to-tear type drug packaging composite film comprises the following steps: coating the surface of a polyester film to change the molecular structure of the polyester film; then, gluing the treated polyester film through a gluing device and drying; adding a lot of low-temperature heat-sealing materials in the film blowing process of the polyester film to obtain a low-temperature heat-sealing film; printing and compositing the polyester film (PET) and a polyethylene film (LDPE) to obtain a composite film, and finally performing curing, slitting, bag making, edge folding and packaging, so that the low-temperature heat-sealing easy-to-tear type composite film is obtained. The composite film overcomes the defects that in the prior art, the composite film is not easy to tear, used glass paper is high in cost, and the hot-sealing temperature is high. The composite film is good in application performance, convenient for packaging, good in moisture resistance performance, light in materials and good in drug resistance, thereby effectively protecting the quality of drugs, and being particularly suitable for being used in hospitals.

The invention provides a novel anti-tumor medicament structure which is shown by a structural general formula (I). In the formula, R1 to R5 are independently selected from H, NO2, OH, halogen and OCH3. The medicament has a simple and convenient synthesis method, and molecules comprise nitroxide free radical structure units, so the anti-tumor medicament structure can effectively suppress proliferation of liver cancer, stomach cancer, breast cancer and ovarian cancer cells.

The invention relates to the field of crop herbicides, and in particular relates to a compound synergistic herbicide and a preparation technology thereof. The compound synergistic herbicide comprises active components and auxiliary materials in a pesticide preparation, wherein the active components comprise a glyphosate type compound and diquat; the weight ratio of the glyphosate type compound to diquat ranges from 1.5:1 to 25:1. The herbicide is water aqua which comprises the following components in percentage by weight: 25-50 percent of ammonium glyphosate, 1-20 percent of diquat, 3-15 percent of a surfactant, 0-0.1 percent of a vomitive, 0.1-1 percent of alert pigment, 3-10 percent of a synergist and the balance being a solvent. By compounding of the herbicide, the prevention and treatment spectrum can be expanded, the weeding speed is increased, and the prevention effect is enhanced; furthermore, the drug resistance is delayed, and the existing drug resistance is treated.

The invention relates to a method for disinfecting and sterilizing an aquaculture pond water body with sterilizing electrochemical water, and belongs to the technical field of disinfecting and sterilizing water bodies in aquaculture ponds. A NaCl solution with the concentration of 5-7%o is treated in a sterilizing electrochemical water generator to generate the sterilizing electrochemical water, a specific treatment method is used in cooperation, microorganisms such as germs, algae and worms in the aquaculture water body and live fish body surfaces can be effectively killed, the harmful microorganisms are prevented from breeding in quantity, fish disease prevention and control can be achieved effectively, water quality is improved to a certain degree, and aquaculture benefits are increased. In addition, the adverse effects on fish are avoided due to the specific sterilizing electrochemical water and the specific water body treatment method.

The invention belongs to the technical field of oral cavity nursing liquid, and relates to natural active bacterium restraining mouthwash by using marine oligosaccharides as a core component. The mouthwash comprises the components of the marine oligosaccharides, composite vitamins, semen sterculiae lychnophorae, a sweetening agent, a flavoring agent, potassium sorbate and water, wherein the marineoligosaccharides are small-molecular-weight carbohydrate substances extracted from marine animals and plants, and the sweetening agent is stevioside, licorice roots, disodium glycyrrhizinate or tripotassium glycyrrhizinate. The mouthwash disclosed by the invention is wide in application range and convenient to use, has the effects of cleaning teeth, restraining bacteria, resisting viruses, preventing tooth decay and promoting repairing of oral mucosa and does not have any toxic or side effects.

The invention discloses a quaternary phosphonium salt modified montmorillonite (MMT) loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent and a preparation method thereof. Thehuge specific surface area and high absorption rate of quaternary phosphonium salt modified MMT are utilized to adsorb bacteria to the surface, and then the quaternary phosphonium salt modified MMT cooperates with the cobalt (CO) doped zinc oxide quantum dots (ZnO QDs) loaded on the surface and between the layers of montmorillonite to play an efficient antibacterial role so as to kill bacteria, and finally the novel nano-composite antibacterial agent with good biocompatibility and high antibacterial activity can be prepared. The quaternary phosphonium salt modified montmorillonite loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent prepared according to the invention has the advantages of safety, environmental protection, strong drug resistance, etc., and the minimum inhibitory concentration to escherichia coli can reach 1.8mg / mL.

The invention provides a traditional Chinese medicine prepared from callicarpa nudiflora. The traditional Chinese medicine has an effect of resisting mycobacterium trberculosis. At the same time, a preparation method of the traditional Chinese medicine is also disclosed.

The invention particularly relates to a cement brick with embedded metal balls and a manufacture method of the cement brick with the embedded metal balls and belongs to the manufacture technology field of building decorative materials. The cement brick with the embedded metal balls comprises a face layer, a transition layer and a base layer. The thickness ratio of the face layer, the transition layer and the base layer is 1.8-2.2: 2.8-3.2: 3-4. Multiple metal balls which are provided with specific patterns and protrude out of the face layer are embedded in the face layer. Water soluble resin and cement are mixed in a specific ratio to form the transition layer so that the transition layer is arranged between the base layer and the face layer. The problem that when the face layer is directly pasted with the base layer, cracks are prone to occur due to a large drying shrinkage value difference is solved. Thus, the face layer and the base layer can be pasted well. Meanwhile, materials of the face layer, the transition layer and the base layer are specifically limited so that surface tension among the three layers can match with each other and good pasting effect is achieved.

The invention discloses a diacetone amine copper oxalate containing bactericidal composition. The diacetone amine copper oxalate containing bactericidal composition comprises a first active ingredient and a second active ingredient with a weight ratio of (1:15)-(10:1), wherein the first active ingredient is diacetone amine copper oxalate, and the second active ingredient is selected from one of self-protective fungicides such as zineb, mancozeb, trioneb, dithane stainless, propineb, thiram, ziram, chlorothalonil, sulfur and dimethachlon. The bactericidal composition can be prepared into water dispersible granules, wettable powder, suspending agents or dispersible oil suspending agents which are allowed to be used agriculturally, and has the relatively good prevention effect on apple altermaria leaf spot, apple brown spot, cucumber downy mildew, powdery mildew of cucumbers, and potato late blight. The diacetone amine copper oxalate containing bactericidal composition effectively solves the problem that a bactericidal composition adopting the diacetone amine copper oxalate or one of the protective fungicides singly has the poor prevention effect, and has the remarkable synergism due to compounding of the diacetone amine copper oxalate and one of the protective fungicides, and besides, the resistance generation can be delayed.