191results about How to "Low biocompatibility" patented technology

The present invention relate to a poly(vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. The hydrogel construct may include a tissue scaffolding, a low bearing surface within a joint, or any other structure which is suitable for supporting the growth of tissue.

The present invention provides porous material of calcium phosphate of high strength whose open pores penetrate the porous body and have a size of 70 μm or more, preferably 100 μm or more, and are arranged in a three-dimensional network, whose porosity is sufficiently high for blood vessels to invade and perforate itself or for cells to infiltrate itself, whose chemical composition, in particular, Ca/P molar ratio can be freely changed within the range of 0.75 to 2.1, to which elements important for facilitating osteogenesis and producing resorbable effect can be added, and whose phase composition can be relatively easily changed. The invention is porous sintered compact of calcium phosphate which has artificially formed, penetrated open pores 70 μm to 4 mm in diameter, whose porosity is from 20% to 80%, and whose chief ingredient is calcium phosphate having a Ca/P molar ratio of from 0.75 to 2.1.

The invention discloses a macromolecular microcarrier and a preparation method thereof, belonging to the technical field of biomedicine. The preparation method comprises the following steps of: splitting a silk solution and a drug solution into micrometer grade liquid drops with core-shell structures under the action of a high-voltage electric field by adopting a coaxial high-voltage electrostatic technology and a freeze drying method; concreting through liquid nitrogen, and then preparing the microcarrier which is difficult to dissolve in water through freeze drying. The microcarrier is in the shape of a microsphere with the core-shell structure, and the diameter of the microsphere is 100-500 micrometers; the shell of the microcarrier comprises the components of silk fibroin; the random-coil conformation of silk fibroin molecules is 80-90 percent; the shell is in a porous structure, and an aperture is 5-20 micrometers; and a core of the microcarrier comprises the components of water-soluble drugs. The silk microcarrier has extensive application prospect in the fields of cell culture, drug release, and the like.

The invention relates to a porous material and a preparation method thereof, in particular to a technology in which silk fibroin is taken as a raw material to prepare porous three-dimensional materials. In the method, silk fibroin solution is injected into a metal mould, 1-24 hours of quick freezing is carried out on the solution at the low temperature of minus 10-minus 80 DEG C, thus obtaining afrozen body; the frozen body is preserved at the temperature of minus 5-minus 25 DEG C for 2-60 days, thus obtaining frozen crystalline solid; then the frozen crystalline solid is thawed and dried, thus obtaining the silk fibroin porous three-dimensional material. The silk fibroin of the porous material is fibroin I type crystal structure, therefore, the silk fibroin is insoluble in water and canbe completely degraded in a while and is finally degraded into nonpoisonous amino acid; the material of the invention has mutual run-through pores with aperture of 10-500 microns; the pores and pore diameter are relatively large, thus being suitable for growth of cells; meanwhile, in the process of preparation, no chemical cross linking agent, foaming agent or denaturing agent are needed, thus retaining fine biocompatibility of the silk fibroin.

Disclosed herein is an injectable composition for the treatment of cancers comprising a poorly water-soluble anti-cancer drug, and glycofurol and Solutol HS15 as solubilizer, of the anticancer drug.

The invention provides a preparation method of porous three-dimensional silk fibroin material, comprising the following steps of concentrating a silk fibroin solution, and manufacturing a bracket by the processed silk fibroin solution through a salting out method. By utilizing the self-assembling behaviors of silk fibroin, a secondary structure of the silk fibroin is improved. Compared with other methods of obtaining porous brackets, not only can the pore-forming property be good but also the inner walls of pores are in a very obvious fine structure.

The invention relates to a preparation method of a porous scaffold material and discloses a preparation method of a nano-fibrous silk fibroin-based porous scaffold. The preparation method comprises the following steps: blending a silk fibroin solution and a collagen solution under the temperature of 0-20 DEG C, standing to ensure the complete reaction of collagen and silk fibroin and generate nano-fiber; freezing the mixed solution to obtain a freezing body; performing freeze drying treatment on the freezing body to obtain a nano-fibrous porous scaffold material; and placing the nano-fibrous porous scaffold material in a vacuum drier with water and methanol, or an ethanol aqueous solution at the bottom, vacuumizing, and then standing to obtain the water-insoluble nano-fibrous porous scaffold. The obtained porous scaffold has 10-1000 microns of communicated pores. The pore walls consist of 10-100nm of nano-fibers; and the porous scaffold has similar nanoscale structures and micronscalestructures to extracellular matrix, is suitable for the adhesion and growth of cells and has good biocompatibility.

The invention relates to a device and a method for dynamically preparing heterocavity bacterium cellulose materials. The device comprises a thermometer hole, an acid liquor and alkali liquor adding hole, a handle, a venting hole, a pH meter hole, a nutrition supplement hole, a rotating shaft, a fermentation tank, a motor, a water bath device and a mould. The preparation method comprises the following steps of: inoculating bacterium cellulose strains into a fluid nutrient medium to be propagated and then transferring to a fermentation device provided with specific shape moulds for later dynamic disturbance cultivation, and then obtaining the heterocavity cellulose materials after the cultivation step. The size and the shape of the heterocavity BC (Bacterium Cellulose) materials prepared by utilizing the invention are controllable, and the moulds of the fermentation device can be detached to be reused. The preparation method has the advantages of simple and convenient implementation, low cost and high production efficiency, and is suitable for industrialization production. The heterocavity BC materials can be widely applied to cavity organ succedaneums of artificial vessels, nerve fiber conduits and the like, and can be used as food packing materials, such as meat sausage wrappers, jelly wrappers and the like.

The invention relates to application of an immobilized quinone compound in accelerating the denitrification process of a microorganism, belonging to the technical field of chemical engineering, biological engineering and environmental engineering. The immobilized quinone compound is 1,8-dichloroanthraquinone and 1,5-dichloroanthraquinone or 1,4,5,8-tetrachloroanthraquinone. The immobilized quinone compound can intensify, regulate and control the denitrification process of an organism, accelerate the velocity and the capacity of the microorganism on the denitrification process of nitrogenous substances, effectively reduce the cost of water treatment and has the advantages of good stability, loss difficulty and reduced secondary pollution, low price of immobilized raw material sodium alginate, good biocompatibility, simple fixing process and low production cost and is easy to realize redox mediator recovery, regeneration and recycling.

The invention belongs to the technical field of biology and relates to a nucleic acid self-assembled composite nanoflower particle material as well as a preparation method and application thereof. The self-assembled composite material refers to nanoflower particles formed by cocrystallizing contracted nucleic acid and Mg2P2O7, wherein the particle size of the particles is less than 500nm. The self-assembled composite material disclosed by the invention is of a nanoflower structure with high specific surface area, the DNA nanoflower self-assembled composite material has the yield close to 100% and the particle size of 500nm or less, and later utilization is facilitated; moreover, the DNA or RNA in the self-assembled composite material disclosed by the invention is an endogenous macromolecule in animal cells and has low toxicity and excellent biocompatibility, the DNA serves as a carrier of genetic information and can also achieve effects of targeting identification, enzyme catalysis and the like, multifunctional integration of the DNA nanoflower composite material can be realized by introducing functional nucleic acids, natural bio-molecules are totally adopted, and the self-assembled composite material is high in biocompatibility, low in cytotoxicity, low in production cost and favorable or large-scale production and development.

The invention relates to a blood pump auxiliary device, in particular to an artificial heart auxiliary device which uses external magnetic field for driving a magnetic bearing to support an embeddable conical spiral impeller rotor, belonging to the field of biomedical engineering technique; the blood pump is arranged in an alternating magnetic field and comprises a small end shell (1) which is connected with a blood vessel, a large end shell (4) and a middle shell (3); the large end and the small end of the middle shell (3) are respectively connected with the small end shell (1) and the large end shell (4) hermetically; the small end shell (1) and the large end shell (4) are internally and fixedly provided with a small end guide wheel (2) and a large end guide wheel (6) with impellers on the external surface thereof respectively; the impeller rotor (5) is arranged in a space which is formed by the middle shell (3), the small end guide wheel (2) and the large end guide wheel (6); the impeller rotor (5) is internally provided with a shaft (11); a permanent magnetic strip (12) is fixedly arranged between the impeller rotor (5) and the shaft (11); and clearances are arranged between the impeller rotor (5) and the small end guide wheel (2) and the large end guide wheel (6). The blood pump auxiliary device effectively solves a series of technical problems such as sealing infection and biocompatibility and the like, which are caused by leads passing through skins and can not be overcome by traditional blood pumps.

Provided is an organic/inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.