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Preparation method of alginate and silk fibroin composite sponge

A technology of silk fibroin and composite sponge, which is applied in the field of materials, can solve the problems that the mechanical strength of alginate-based sponges cannot meet the application requirements, reduce the biocompatibility and degradation of sponges, etc., achieve excellent moisture absorption and moisturizing properties, and improve product quality. Effect of adding value and expanding development and utilization

Inactive Publication Date: 2017-01-04
DALIAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] Medical dressings are materials that cover wounds and assist wound healing. In recent years, new materials such as calcium alginate fibers and alginate-based gels have received widespread attention in the application of functional medical dressings. Among them, alginate-based sponge dressings are more absorbent. and use advantages, but the mechanical strength of alginic acid-based sponges produced under conventional methods cannot meet the requirements of medical and biological applications. Adding some inorganic and organic substances usually reduces the biocompatibility and degradability of sponges

Method used

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  • Preparation method of alginate and silk fibroin composite sponge
  • Preparation method of alginate and silk fibroin composite sponge

Examples

Experimental program
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Effect test

preparation example Construction

[0028] Preparation of silk fibroin solution:

[0029] (1) Cut silkworm cocoons into pieces of 0.5cm 2 The pieces were dried in an oven for later use. Prepare 5g / L of Na 2 CO 3 solution, take a certain amount of silkworm cocoon fragments and put them in it, degumming for 30min under heating in a water bath at 100°C. Take it out, wring it dry, and wash it 2 to 3 times. The obtained product was dried in an oven.

[0030] (2) Prepare a mixed solution of calcium chloride, ethanol and water, put it in a flask, and add the above dried silk fibroin into it. Dissolve and stand at a certain temperature, cool in the air, and then pour the solution into a dialysis bag, and immerse the dialysis bag in deionized water for dialysis. After the dialysis, pour out the solution, put it into a centrifuge for centrifugation, and take the supernatant after centrifugation.

Embodiment 1

[0032] This example discloses a method for preparing a sponge blended with alginate and silk fibroin, which is prepared by the following method:

[0033] 0.2g (solid weight) silk fibroin and 2g sodium alginate were prepared into 100mL blending solution. When preparing, first add water to dissolve sodium alginate, then add silk fibroin solution, and mechanically stir to make the solution evenly mixed. Put the prepared mixed solution into a freeze dryer to dry and remove water, and the freeze dryer to dry and remove water for 6 to 8 hours to form a pore structure.

[0034] Immerse the product into the prepared solution, the solution is calcium chloride, glycerol and ethanol solution with a mass ratio of 7:3:90, and the soaking time is 15 minutes. After a period of time, it is taken out and dried to obtain a composite sponge product. Composite sponge products have a water absorption rate of 170%, a moisture absorption rate of 79%, and a moisture retention rate of 76%.

[0035]...

Embodiment 2

[0037] This example discloses a method for preparing a sponge by blending alginate and silk fibroin, which is prepared by the following method:

[0038] 0.6g (solid weight) silk fibroin and 2g sodium alginate were prepared into 100mL blending solution. When preparing, first add water to dissolve sodium alginate, then add silk fibroin solution, and mechanically stir to make the solution evenly mixed. Put the prepared mixed solution into a freeze dryer to dry and remove water, and the freeze dryer to dry and remove water for 6 to 8 hours to form a pore structure.

[0039] Immerse the product into the prepared solution, the solution is calcium chloride, glycerol and ethanol solution with a mass ratio of 7:3:90, and the soaking time is 15 minutes. After a period of time, it is taken out and dried to obtain a composite sponge product. Composite sponge products have a water absorption rate of 180%, a moisture absorption rate of 88%, and a moisture retention rate of 82%.

[0040] ...

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Abstract

The invention discloses a preparation method of alginate and silk fibroin composite sponge. Dried and sheared silkworm cocoons are degummed, fibroin fibers obtained after degumming is dissolved in a mixed solution including calcium chloride, ethanol and water, and a yellowish-brown solution is obtained. A pure silk fibroin solution is obtained with a dialysis and centrifugation method and mixed with a sodium alginate solution, the mixture is stirred, blended and freeze-dried, the dried product is immersed into a prepared solution (the mass ratio of calcium chloride to glycerin to ethanol being 7:3:90) and is taken out to be dried, and the composite sponge is obtained. The composite sponge is prepared from alginate and silk fibroin, and the application of the sponge material in actual production is expanded; compared with other sponge materials, the alginate and silk fibroin composite sponge has the excellent and outstanding characteristics of being economical, environment-friendly, good in biocompatibility and degradability and the like and can be applied to the fields such as medical dressing, cosmetic articles, architectural ornament and the like.

Description

technical field [0001] The invention belongs to the field of materials, in particular to a preparation method and application of a composite sponge of alginate and silk fibroin. Background technique [0002] With the increasing consumption of resources, the gradual deterioration of the environment, and the improvement of people's living standards, there is an urgent need for new green and environmentally friendly materials. Therefore, the discovery and in-depth research of biomass materials have brought dawn to it. [0003] Existing foaming materials such as polyurethane and polystyrene have performance defects such as slow degradation, easy to cause white pollution, and flammability, and usually have poor hygroscopicity and moisture retention, and the body does not have antibacterial properties and flame retardancy. sex. Natural biomass-based foaming materials can make up for the above deficiencies, but current research and products are very limited. [0004] Medical dres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/40C08J9/28C08L5/04C08L89/00
CPCC08J9/28C08J9/40C08J2201/0484C08J2305/04C08J2489/00C08L5/04C08L2201/02C08L2201/06C08L89/00
Inventor 张鸿丁伟杰祝国富邹新全王廷亦谭倩王智汉
Owner DALIAN POLYTECHNIC UNIVERSITY
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