Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof

A technology of nano antibacterial agent and zinc oxide, applied in the field of copper doped zinc oxide quantum dot nano antibacterial agent and its preparation, can solve the problem of no antibacterial effect found, and achieve the effect of good biocompatibility

Active Publication Date: 2020-01-14
GMY LIGHTING TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, studies have also shown that the antibacterial activity of quantum dots is related to their morphology. ZnO quantum dots in aqueous solution and ZnO quantum dots suspended in polyvinylpyrrolidone gel are effective against Listeria monocytogenes, Salmonella enteritidis and Escherichia coli 0157:H7 It has obvious antibacterial effect, but the ZnO quantum dots attached to the polystyrene film have not been found to have antibacterial effects on the above three bacteria

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  • Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof
  • Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof
  • Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof

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preparation example Construction

[0049] A preparation method of Cu-doped ZnO quantum dot nano antibacterial agent, comprising the following steps:

[0050] Weigh 0.5-2.0g zinc source and the copper source according to the molar ratio of the zinc in the zinc source to the copper in the copper source is 1:0.003-0.01 and disperse in 80-120mL organic solvent, after stirring evenly , poured into a three-necked flask, heated in a water bath at 60-90°C, and kept warm for 0.5-2h until the solution was clear and transparent, then continued to stir at 20-30°C and stood by to obtain a mixed precursor solution of zinc and copper; 0.15-1g Add the alkali source into 80-120mL organic solvent, stir magnetically at 20-30°C for 20-40min, then add the obtained alkali solution dropwise to the mixed precursor solution of zinc and copper prepared in the previous stage, after mixing evenly, magnetically stir at 20-30°C Stir for 20-40min, add 50-100mL precipitant after the reaction until the solution turns milky white, stir magnetic...

Embodiment 1

[0056] A preparation method of copper-doped zinc oxide quantum dot nano antibacterial agent, comprising the following steps:

[0057] Weigh 0.768g of zinc acetate dihydrate and 4.89mg of copper acetate monohydrate and disperse them in 100mL of absolute ethanol. After stirring evenly, pour them into a three-necked flask and heat the reaction in a water bath at 80°C for 0.5h until the solution is clear and transparent. Continue to stir and wait for use to obtain the zinc and copper mixed precursor solution; add 0.15g lithium hydroxide to 100mL ethanol solution, stir magnetically at 20°C for 30 minutes, then add the obtained alkali solution dropwise to the zinc and copper mixed precursor solution prepared earlier. In the precursor solution, after mixing evenly, stir magnetically at 20°C for 30min, add 80mL deionized water until the solution turns milky white after the reaction, stir magnetically at 20°C for 10min, let stand, wash, and centrifuge at 6000rpm for 30min to obtain copp...

Embodiment 2

[0059] A preparation method of copper-doped zinc oxide quantum dot nano antibacterial agent, comprising the following steps:

[0060] Weigh 1.1g of zinc nitrate hexahydrate and 6.98mg of copper nitrate trihydrate and disperse them in 100mL of absolute ethanol. After stirring evenly, pour them into a three-necked flask, heat and react in a water bath at 80°C for 1h until the solution is clear and transparent, and then continue at 23°C. Stir and set aside to obtain the zinc and copper mixed precursor solution; add 0.3g lithium hydroxide to 100mL ethanol solution, stir magnetically at 23°C for 30min, then add the obtained alkali solution dropwise to the zinc and copper mixed precursor prepared earlier After mixing evenly, stir magnetically at 23°C for 30min. After the reaction, add 100mL of deionized water until the solution turns milky white, stir magnetically at 23°C for 10min, let stand, wash, and centrifuge at 8000rpm for 18min to obtain copper (Cu). Doped with zinc oxide qua...

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Abstract

The invention relates to a copper-doped zinc oxide quantum dot nano antibacterial agent and a preparation method thereof. A chemical formula of the copper-doped zinc oxide quantum dot nano antibacterial agent is Zn<1-x>OCu<x> (x = 0.003-0.01). The preparation method comprises the following steps: weighing a zinc source and a copper source and performing dispersing in an organic solvent, performingstirring and heating in a water bath until a solution is clear and transparent, and performing stirring again to obtain a zinc and copper mixed precursor solution; adding an alkali source into an organic solvent, and performing stirring to obtain an alkali solution; dropwise adding the alkali solution into the zinc and copper mixed precursor solution, and performing stirring to obtain a mixed solution; and adding a precipitant into the mixed solution, performing stirring and then performing standing, washing and centrifuging to obtain the copper-doped zinc oxide quantum dot nano antibacterialagent. A size of the Cu-doped ZnO quantum dot is mainly distributed in 4-8 nm. A minimum bacteriostatic concentration of the nano antibacterial agent against Escherichia coli can reach 2.7 mg / mL, anda bacteriostatic rate against Escherichia coli can reach 81.79%.

Description

technical field [0001] The invention belongs to the technical field of novel antibacterial agents, and relates to a copper (Cu) doped zinc oxide quantum dot (ZnO QDs) nano antibacterial agent and a preparation method thereof. Background technique [0002] With the development of society and the improvement of material living standards, people have higher and higher requirements for living environment, but the increase of microbial resistance to drug treatment, control and eliminate the growth and reproduction of harmful bacteria to ensure human health and safety issues It is getting more and more attention from all walks of life. In the decades of human use of antibiotics to treat infectious diseases, a large number of multidrug-resistant strains have emerged. In order to improve the efficacy of antibiotics, powerful new antibiotics or compound antibacterial agents have been developed on the one hand, but the functions of new drugs are inevitably affected by pathogenic bacte...

Claims

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Application Information

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IPC IPC(8): A01N59/20A01N59/16A01P1/00B82Y30/00B82Y40/00
CPCA01N59/16A01N59/20B82Y30/00B82Y40/00
Inventor 刘俊莉王宇涵刘辉洪燕南李军奇蔡永华廖辉
Owner GMY LIGHTING TECH CO LTD
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