84 results about "Phosphamide" patented technology

The invention belongs to the field of medical chemical antiviral effects, and relates to an acyclic nucleoside phosphamide D-amino-acid ester derivative, a preparation method of derivative salt and an application of the derivative to the antiviral effects. The invention further provides a compound comprising the derivative, a stereoisomer of the derivative, pharmaceutically acceptable salt, a hydrate, a solvate or crystal and drug combination and an application of the compound or combination to treatment and / or prevention of Aids and hepatitis B virus infection. The in vivo activity of the compound is remarkably superior to that of a pro-drug of acyclic nucleoside phosphamide L-amino-acid ester, and the compound has obvious clinical application values.

The invention relates to a catalyst which uses the phosphor-phosphamide as ligand, which is the phosphor-phosphamide ligand metallic complex of chiral ferrocenyl bone, wherein, the metal is rhodium, ruthenium, iridium, platinum or palladium; and the mol rate between the ligand and the metal precursor is 1.1:1-2.2:1. The ligand is compounded from chiral ferrocenyl to intermediate compound via several reaction steps, to be processed condensation with phosphite ester chloridate to attain the phosphor-phosphamide ligand with different chiral centers. Said ligand has new structure, stable property, simple compounding method, and wider application to the catalyst, which has higher catalysis activity (TON reaches 10000) and higher spatial selectivity (ee reaches more than 99%) in catalyzing asymmetry hydrogenization of itaconic acid, etc.

The invention discloses a phosphorus-containing and nitrogen-containing expansion type flame-retardant polymer and a preparation method thereof. The preparation method is characterized in that: the phosphorus-containing and nitrogen-containing expansion type flame-retardant polymer is prepared by solution polycondensation reaction or melt polycondensation reaction of diphosphorus acylchloride or diphosphorus acylbromide and a diamine functional group-containing compound. The expansion type flame-retardant polymer comprises phosphorus-containing and nitrogen-containing phosphamide with a structure unit formula shown in the specifications, wherein n is an integer of from 1 to 200; R1 is oxygen or sulphur; and R is alkoxy, alkylthio, aryloxy or arylthio. The product of the invention has high compatibility with a high molecular material matrix, difficult transfer and excellent durability. The preparation method has the advantages of simpleness, easy control, high yield, wide sources of the required raw materials and easy industrialized production. A high polymer with a flame-retardant function can be directly prepared, or the high polymer serving as a flame-retardant additive can be added into various polyesters, polyamide, polyolefin, epoxy resin, polystyrene, high impact polystyrene or acrylonitrile butadiene styrene (ABS) polymer.

The invention discloses a flame-retardant lithium ion battery electrolyte and a method for preparing the same and relates to a battery electrolyte. The electrolyte has the characteristic of flame retardance and complete non-combustion and is well compatible with an electrode material, and the wettability of a diaphragm can be improved. The flame-retardant lithium ion battery electrolyte comprises 5 to 20 percent of lithium salt, 60 to 90 percent of solvent and 1 to 20 percent of alkenyl phosphamide. The method comprises the following steps of: reacting dialkoxyl phosphoryl chloride and alkenyl-containing secondary amine, or hydro-diphosphite, the alkenyl-containing secondary amine, carbon tetrachloride and alkali, which are taken as raw materials, in an organic solvent to obtain an alkenyl phosphamide compound; and preparing the alkenyl phosphamide compound, the lithium salt and the solvent to obtain the flame-retardant lithium ion battery electrolyte.

The invention discloses a hot-rolled composition with organic silicon anti-friction antilubricant, which comprises the following parts: (I) lubricant basic oil with viscosity at 5-300mm2 / s at 40 deg.c, (II) 0.1-20wt% sulphur extreme pressure agent with one or more material from alkyl polysulfide, sulfur ore oil and sulfur polyol ester, (III) 0.05-15wt% phosphorus antiwear agent with one or more material from phosphate, phosphonate, phosphite ester, acid phosphate ester, phosphite ester amine salt, phosphamide ester, dialkyl dithiophosphate, dimercaptothiodiazole dithiophosphate ester and acid phosphate imidazoline salt, (IV) 0.001-25% organosilicon abrasion resistance antilubricant with silicon chloride, C2-16 aliphatic amine, disperser and non-ionic surface activator.

The invention provides a phosphamide nucleosides compound as shown in a formula (I). Compared with the prior art, the phosphamide nucleosides compound has the advantages that the phosphamide nucleosides compound has antiviral activity which is remarkably higher than that of TAF on aspects of HIV resisting and hepatitis B resisting; the HIV resisting activity of some compounds is about 10 times higher than that of the TAF, and the hepatitis B resisting activity of the same compounds is also 2-5 times higher than that of the TAF; moreover, the phosphamide nucleosides compound has stable chemical properties and is difficult to hydrolyze by hydrolytic enzymes; compared with the TAF, the phosphamide nucleosides compound has superiority on aspect of toxicity and especially renal toxicity, and patients suffering from HIV and / or HBV can be effectively treated by the compound or isomer thereof at a low clinic dosage.

The invention discloses a phosphamide compound with flame retardance and a preparation method and application thereof to epoxy resin. The phosphamide compound is the O, O'-diphenyl phosphamide ester derivative which has the general formula I, contains two flame retardant elements which are phosphorus and nitrogen and can generate the intramolecular synergistic flame retardance effect. The phosphamide compound can be used as the active ingredients of the flame retardant, can be added into epoxy resin as the flame retardant to produce the flame-retardant epoxy resin material and can be also compounded with melamine (MA) so as to be applied to the epoxy resin material. The phosphamide compound can significantly improve the flame retarding function of the epoxy resin material.

The invention provides a stripping liquid for removing residual photoresist in the semiconductor technology. The stripping liquid comprises the following components in percentage by weight: 20-70% of multimethyl phosphamide, 5-30% of alkanol amine, 0.01-10% of organosilicon polyether type compounds, 0.01-10% of alkynol, 1-30% (including mass) of hydroxylamine and 5-50% of deinoized water. With the stripping liquid, residual cured photoresist layer in the dry etching technology can be easily and quickly removed. The stripping liquid has good protection action on metallic membrane materials, especially aluminum and aluminiferous wiring materials, so the application prospect is good.

The invention discloses monophosphine ligand based on a tetramethyl spirobiindane skeleton, as well as an intermediate, a preparation method and application thereof. The monophosphine ligand adopts acompound with a structure as shown in a general formula I or I' or an enantiomer, a racemate or a diastereoisomer of the compound, and comprises phosphorous ester ligand, phosphorous ester ligand, phosphoramidite ester ligand, phosphoric acid and phosphamide. The monophosphine ligand takes a known 3, 3, 3', 3'-tetramethyl-1, 1'-spirobiindane-7, 7'-dimethyl aldehyde as a raw material, and is formedthrough a formula II which is taken as a preparation route of a key intermediate. The novel monophosphine ligand can serve as ligand to be used for organic reaction of metal catalysis or be directlyused for catalyzing the organic reaction, can particularly serve as chiral monophosphine ligand to be widely applied to multichiral catalytic reaction including asymmetric addition, asymmetric hydrogenation, asymmetric coupling and asymmetric allylic alkylation, and has economical practicability and an industrial application prospect.

The invention discloses heteroaryl phosphamide compounds, which are used for curing or preventing hepatitis C virus infection or other virus infections. These compounds can be used as hepatitis C virus replication inhibitors, and can be used together with other therapeutic agents, especially other anti-virus drugs or preparations. The invention especially provides compounds, which are used as the hepatitis C virus replication inhibitors, drug components, which contain these compounds, and a usage method of these compounds to cure virus infection such as hepatitis C virus infection.

A process for preparing thiophosphamide from O, O-dimethyl thiophosphamide and trichloroacetaldehyde through preparing the intermediate C, exchanging the sites of O and S in the intermediate by use of dimethyl sulfate (or carbonate), and preparing O, S-dimethyl (2, 2, 2-trichloro-1-hydroxy-ethyl) thio phosphamide. Its advantages are low cost and high purity.

The invention provides a extreme pressure antiwear agent with structure of right general formula, wherein R, R' is same or different alkyl group with C1-C20 linear chain or branched chain, asphalt base, aromatic group or aralkyl, R'' is amino (-NH2) or alkyl group with C1-C18 linear chain or branched chain, aromatic group, aralkyl or asphalt base. The antiwear agent is reacted by phosphorus trichloride and C1-C20 alcohol, hydrazine hydrate or C4-C18 orgnic amine. The antiwear agent of the invention can be used in lubrication oil and lubricant grease with 0.1-3.0 w% of recommeding amount.

The invention provides a nucleoside phosphamide compound shown as a formula (I), and an application of the compound as an antiviral drug. The compound can inhibit replication of RNA virus, and can be used as an inhibitor for hepatitis c virus (HCV)NS5B polymerase. The compound has inhibiting effect for NS5B polymerase and has little toxicity on hepatic cells.

The invention relates to applications of cyclic phosphorus-nitrogen synergic halogen-free flame retardant, and particularly relates to applications of 2,7-bis(N,N-dimethylamine)-1,6,3,8,2,7-octahydrodioxadiazole diphosphinic acid, belonging to the field of synthesizing a novel halogen-free high polymer material. As a hard segment chain extender, 2,7-bis(N,N-dimethylamine)-1,6,3,8,2,7-octahydrodioxadiazole diphosphinic acid is applied to halogen-free flame-retardant modification of water-based polyurethane emulsion. Cyclic phosphamide flame retardant 2,7-bis(N,N-dimethylamine)-1,6,3,8,2,7-octahydrodioxadiazole diphosphinic acid as the hard segment chain extender is embedded into a water-based polyurethane macromolecular chain; the research shows that due to the addition of the flame retardant, the limit oxygen index of a polyurethane membrane can be improved to a greater extent, the thermal stability of the polyurethane membrane is enhanced, the carbon residue rate of the material after which is decomposed at high temperature is increased, and the usage amount of the flame retardant is reduced.

The invention discloses a hot-rolled composition with organic silicon anti-friction antilubricant, which comprises the following parts: (I) lubricant basic oil with viscosity at 5-300mm2 / s at 40 deg.c, (II) 0.1-20wt% sulphur extreme pressure agent with one or more material from alkyl polysulfide, sulfur ore oil and sulfur polyol ester, (III) 0.05-15wt% phosphorus antiwear agent with one or more material from phosphate, phosphonate, phosphite ester, acid phosphate ester, phosphite ester amine salt, phosphamide ester, dialkyl dithiophosphate, dimercaptothiodiazole dithiophosphate ester and acid phosphate imidazoline salt, (IV) 0.1-25% organosilicon abrasion resistance antilubricant with organic modified clay, plastic and alkyl benzene, insaturated ester oil, animal and plant oil.

The invention discloses a synthesizing method of ifosfamide, which comprises the following steps: adopting propanolamine as raw material to ring with phosphorus oxytrichloride to obtain phosphorus oxychloride; adding chlorethamin hydrochlorate to substitute to obtain phosphamide; adding chloracetyl chloride to substitute to obtain 3-(2-chloracetyl )-2-[(2-chloroethyl ) amino]-tetrahydrochysene -2H-1,3,2-phosphor-2-oxide as intermediate; reducing the intermediate and alkaline hydroxide to obtain the product.

At first, to proceed culturing activition to galotinous sporobacillus by one to three stages fermenting culture on substratum, bacterial liquid is adsorbed by danty powder when stirring to be galotinous sporobacillus bacterial agent. Then to proceed culturing activition to streptomycete strain by one to three stages fermenting culture on substratum, fermented liquid is adsorbed by danty powder when stirring to be streptomycete bacterial agent. Finally, danty, bone meal, phosphamide, urea, potassium sulfate, zinc sulfate, borax, magnesium sulfate, manganese sulfate, copper sulfate, ferrous sulfate, molybdate, galotinous sporobacillus bacterial agent and streptomycete bacterial agent are compounded to obtain the product in proper ratio. In the invention, biological engineering technology is used to produce double-effect composed microbial fertilizer, microbial bacterins with functions of depotassium, dephosphorus, nitrogen fixation and multipathogene fungus controlling are prepared to baterial agent by biological fermenting, high grade organic matter is used as carrier.

The invention discloses a phosphamide-(di) secondary amine dual-functional catalyst and a synthesis method thereof. The structure of the catalyst is represented as follows, and the synthesis method comprises the steps of performing reaction on simple and readily available chiral 1,2-diamine and various phosphoryl chloride, and performing reaction with an aldehyde compound to prepare the phosphamide-(di) secondary amine dual-functional catalyst with chirality and efficient catalysis activity. The prepared catalyst is novel in structure and stable in property; the synthesis method is simple, and the catalysis activity is high; the synthesis method is simple and has the outstanding characteristics of wide application range, mild reaction condition, simplicity and convenience in operation and the like. The structural formula of the catalyst is shown in the description.

The invention discloses a chiral phosphamide synthesizing method, relating to a chiral phosphamide, in particular to a method for synthesizing chiral phosphamide in which phosphorus has single chiral center configuration. The invention provides the chiral phosphamide synthesizing method which has the advantages of low-price and easily obtained raw materials, high productivity, no easy racemization, simple operation and is suitable for large-scale production. Under the existence of halogenating agents and organic base, the chiral phosphamide, in which phosphorus has single chiral center configuration, or phosphinate and unhindered amina, primary amine or secondary amine reacts in a solvent to generate corresponding chiral phosphamide in which phosphorus has single chiral center configuration.

The invention discloses a graphene oxide / phosphamide composite material and a preparation method thereof. The invention aims to solve the problems that the adsorption capacity of graphene oxide for uranium is insufficient and the graphene oxide is difficult to be separated from an aqueous phase due to excellent hydrophilia of graphene oxide. The graphene oxide / phosphamide composite material contains the following components by weight percent: 85%-95% of graphene oxide and 5%-15% of phosphamide. The graphene oxide / phosphamide composite material can be used for effectively solving the problems that the adsorption capacity of graphene oxide for uranium is insufficient and the graphene oxide is difficult to be separated from the aqueous phase due to excellent hydrophilia of graphene oxide. The graphene oxide / phosphamide composite material has high practical value in purifying metal or organic wastewater. Meanwhile, the preparation method provided by the invention is simple in operation, low in production cost and high in yield, can meet the requirements of industrial large-scale production and application, has wider application prospect and higher market value and is worthy of large-scale popularization and application.

The invention discloses a flame-retardant organic phase-change material and a preparation method thereof. The preparation method of the flame-retardant organic phase-change material comprises the following steps: triethoxysilyl phosphamide is well mixed with lower alcohol; the mixture is added into a mixture of carbon nano-tubes, an organic phase-change material and an organic solvent drop by drop; ammonia water is added; the mixture is well mixed by stirring; and cooling, rotary evaporation, washing, and vacuum drying are carried out, such that the flame-retardant organic phase-change material is obtained. With the method, the obtained flame-retardant organic phase-change material has the advantages of good compatibility, high flame retardant performance, high thermal conductivity coefficient and relatively long service life.

The invention discloses a self-lubricating rubber lifting lug with a function of improving NVH (noise, vibration and harshness) performance of an automobile and a preparation method of the self-lubricating rubber lifting lug. The rubber lifting lug is prepared from raw materials as follows: EPDM (ethylene propylene diene monomer) rubber, chlorinated butyl rubber, nitrile rubber, EVA (ethylene vinyl acetate copolymer) resin, a lubricant, a vulcanizing agent, an anti-aging agent, glass fiber, calcined pottery clay, white carbon black, hydroxyethyl cellulose, tetramethyl thiuram disulfide, microencapsulated red phosphorus, epoxidized soybean oil, tributyl citrate and phosphamide. According to the self-lubricating rubber lifting lug with the function of improving NVH performance of the automobile and the preparation method of the self-lubricating rubber lifting lug, the product can effectively improve the NVH performance of the automobile, has good mechanical properties such as hardness, tensile strength, elasticity, toughness and the like, and has good wear resistance, heat resistance, aging resistance, corrosion resistance, flame retardance and self-lubrication property, performance is stable and lasting, the assembly efficiency is high, and the service life is long.

The invention discloses an alpha-benzyl-modified diaryl phosphonic compound and a preparation method thereof. The method is a novel method for preparing a mono-substituted benzyl phosphamide compound from a copper salt as a catalyst, P,P-diaryl-N-(8-aminoquinoline) phosphamide as a raw material, methylbenzene and a derivative thereof as a solvent and a benzyl source and peroxide as an oxidizing agent under a nitrogen condition at high yield and high selectivity. Corresponding alpha-benzylated arylphosphonic acid and alpha-benzylated aryl hydrogen phosphonate can be prepared from alpha-benzylated aryl phsophonamidate through adding alkali and a reducing agent. The method is simple in reaction condition, easy to operate, low in cost, green and environmentally friendly in preparation process, high in conversion rate and yield of a target product; the target product can be prepared at high yield after the reaction scale is amplified by 50 times; and the alpha-benzyl-modified diaryl phosphonic compound has a good industrial application prospect.

A method for preparing a vanadium electrolyte comprises the following steps that (1) a vanadium-containing acidic solution is prepared; (2) vanadium in the vanadium-containing acidic solution is reduced to be tetravalence, and a stabilizer is added to obtain a vanadium-containing water phase, wherein the stabilizer is alkyl phosphamide, aryl phosphate, alkyl phosphate or amine alkyl phosphate; (3)the vanadium-containing water phase is extracted through an organic phase, and the extracted organic phase is washed through washing liquid; (4) the washed organic phase is subjected to reverse extraction to obtain reverse extraction liquid; and (5) organic matter carried in the reverse extraction liquid is removed, and thus the vanadium electrolyte is obtained. According to the method, the middle step for preparing a high-purity vanadium oxide is omitted, the one-step solvent extraction method is adopted, the vanadium electrolyte is prepared from the alkaline vanadium-containing solution, inthe preparing process, the steps are few, simple and easy to control, the cost is low, and the prepared vanadium electrolyte is high in composition controllability.

The invention provides a extreme pressure antiwear agent with structure of right general formula, wherein R, R' is same or different alkyl group with C1-C20 linear chain or branched chain, asphalt base, aromatic group or aralkyl, R'' is amino or alkyl group with C1-C18 linear chain or branched chain, aromatic group, aralkyl or asphalt base. The antiwear agent is reacted by phosphorus trichloride and C1-C20 alcohol, hydrazine hydrate or C4-C18 orgnic amine. The antiwear agent of the invention can be used in lubrication oil and lubricant grease with 0.1-3.0 w% of recommeding amount.

The invention discloses an aluminum and aluminum alloy water-based cutting fluid, belonging to the metal processing coolant. The cutting fluid has good rust resistance and extreme pressure lubrication performance, and does not contain any NO<2-> ions and any reaction for formation of NO<2-> ions, and is a multi-purpose, efficient and environmentally friendly aluminum and alloy cutting fluid. The aluminum and aluminum alloy water-based cutting fluid formula comprises 3-9% of triethanolamine borate, 2-3% of triethanolamine, 10-14% of imidazole phosphamide, 2-3% of NSH, 12-18% of fatty alcohol polyoxyethylene ether, 2% of borax, 10% of dimethyl silicone, 2% of sodium benzoate, and balance of water.

The invention relates to a chiral phosphamide compound and a preparation method thereof. Expensive agents used in the prior art are replaced by a nucleophilic catalyst, and rigor reaction conditions of the prior art are also replaced. The chiral phosphamide compound is produced by the following steps: a racemate of phosphorus oxychloride and a primary amine or a secondary amine are subjected to asymmetric phosphorylation reaction in the protection of inert gas, and a chiral biimidazole compound is used as the nucleophilic catalyst; and then the chiral phosphamide compound is obtained with high production rate and medium enantioselectivity.

The invention provides a soil remediation agent used for anaerobic microorganisms. The soil remediation agent used for the anaerobic microorganisms is characterized by being produced by mixing the following raw materials in parts by mass: 20-50 parts of an ammonium salt, 15-45 parts of a carbonate, 10-30 parts of humus soil, 10-20 parts of crushed straw, 20-30 parts of a phosphamide-containing matter, 10 parts of hydrogen production stone and 10-20 parts of emulsified plant oil. The soil remediation agent used for the anaerobic microorganisms can be suitable for remediation of deep soil with low or medium concentration pollution, and remediation effects which are more effective, more economic, more convenient and free from pollution are achieved.

The invention discloses an environment-friendly soundproof material. The environment-friendly soundproof material is prepared from, by weight, 60-70 parts of polyethylene, 20-25 parts of natural fiber, 18-25 parts of allyl phenyl isopentene ether, 10-15 parts of calcium carbonate, 5-8 parts of starch phosphate monoester, 2-6 parts of polyoxyethylene stearate, 3-5 parts of polyglycerol fatty acid ester, 2-5 parts of sodium silicate, 1-3 parts of sodium hydrogen carbonate, 1-2 parts of di(2-chloroethyl) dichloride phosphamide, 1-2 parts of cetanethiol and 0.2-0.8 part of diamyl succinic acid sodium sulfonate. The invention further provides a preparation method of the environment-friendly soundproof material.

The invention discloses a pyridyl phosphamide compound as well as a preparation method thereof and application thereof as nickel-cobalt extracting agent. The method comprises the following steps: performing ammonia-aldehyde condensation reaction between pyridine-4-formaldehyde and alkyl primary amine to generate a Schiff base intermediate; performing addition reaction between the Schiff base compound and dialkyl phosphite to obtain the pyridyl phosphamide compound. The preparation method has the advantages of being green and environmentally-friendly, mild in condition, simple in process and short in flow; the synthesized pyridyl phosphamide compound is cooperated with P204 to serve as the nickel-cobalt extracting agent for extraction and separation of cations containing nickel, cobalt, magnesium and manganese, and has the characteristics of being high in extraction capacity, short in phase-split time, and excellent in extraction and anti-extraction performance, thereby having excellentindustrial application prospects.