The invention provides high-strength pipeline steel for petroleum and a manufacturing method of the pipeline steel, and the high-strength pipeline steel for the petroleum and the manufacturing methodof the pipeline steel is characterized by comprising the following components of, by weight, 0.045-0.05% of C, 0.05%-0.15% of Si, 1.2-1.5% of Mn, less than or equal to 0.015% of P, less than or equalto 0.005% of S, 0.01-0.015% of V, 0.07-0.08% of Nb, 0.010-012% of Ti, less than or equal to 0.050% of Al, 0.65-0.75% of Cr, 0.55-0.65% of Mo, 0.1-0.15% of Ni, 0.05 -0.06% of Cu, 0.005-0.008% of W, 0.0001-0.0005% of rare earth (Hf+La), 0.0001-0.005% of B, 0.001-0.005% of N, 3.42-5.5 Ti / N, and the balance Fe and inevitable impurity elements; a final tissue of the acicular ferrite with the area rateis counted as 92-94% and the final tissue of the martensite with the area rate is counted as 6-8%, electron microscope detection is carried out, wherein the average range of the formed TiN grain sizeis 20-30 nanometers, the area rate is 0.5-1%; and meanwhile, the cold cracking sensitivity index Pcm is also required to be in the range of 18-0.28%; the process route comprises the following steps ofproportioning material preparation, molten iron pretreatment, molten steel smelting, secondary refining, continuous casting, rolling and reeling.