The invention discloses a preparation method of 4-chloro-3-(4-ethoxybenzyl)
benzaldehyde. The preparation method comprises the following steps that 2-chloro-5-bromobenzoic acid is dissolved in an
organic solvent, an acylating chlorination
reagent is added into the solution, the
mixed solution undergoes a reaction to produce 5-bromo-2-chlorobenzoyl
chloride, 5-bromo-2-chlorobenzoyl
chloride is dissolved in an
organic solvent, the solution is cooled, the cooled solution is added with phenetole and acid catalysts, the
mixed solution undergoes a reaction to produce (5-bromo-2-chlorphenyl)(4-ethoxyphenyl)
ketone, (5-bromo-2-chlorphenyl)(4-ethoxyphenyl)
ketone is dissolved in an
organic solvent, the solution is added with a reduction
reagent system, the solution undergoes a reaction to produce 4-bromo-1-chloro-2-(4-ethoxybenzyl)
benzene, 4-bromo-1-chloro-2-(4-ethoxybenzyl)
benzene is dissolved in an organic
solvent, a
formylation reagent is added into the solution and the
mixed solution undergoes a reaction to produce 4-chloro-3-(4-ethoxybenzyl)
benzaldehyde. The preparation method utilizes cheap and easily available raw materials and reagents and has a simple synthesis
route, simple processes and a high yield.