The invention relates to an industrial production method applicable to citric acid tofacitinib. The invention relates to a novel industrial production method of a high-purity orally taken JAK inhibitor and a medicine for treating rheumatoid arthritis. Raw materials are subjected to substitution, protecting group removal, reduction debenzylation, condensation and salifying to obtain a compound shown in a formula I, and the defects of a synthetic route reported in existing literatures that the impurity content in the prepared finished product is high, cost is high and yield is low are overcome. The novel industrial production method provided by the invention has the advantages that cost of a used reagent is low, environmental pollution is hardly caused, operation is easy, and short time is consumed, so that the novel industrial production method is applicable to industrial production; meanwhile, product quality is good, total impurity content is low, content of each individual impurity is controlled to be 0.1% or below, the finished product is controlled to be in a single stable crystal form, and medicinal-grade raw material requirements can be met.