The invention discloses a preparation method and application of
eclipta extract. The preparation method comprises the following steps of: 1) selecting
eclipta, soaking for 0.5 hour with
ethanol water solution with the
volume percent concentration of 5-95%, extracting for 1 hour when the weight of the
ethanol water solution is 20 times of the weight of
eclipta and extracting for 0.5 hour when the weight of the
ethanol water solution is 16 times of the weight of the eclipta, mixing extracts together, concentrating the extract into 0.25-1.0g
crude drug / ml, standing for 6 hours, and filtering to obtain the eclipta extract; and 2) adsorbing the eclipta extract by adopting pretreated
macroporous resin, wherein the weight ratio of the eclipta extract to the
macroporous resin is 1:1-1:5, feeding flow rate is 1-3BV / h and the
diameter height ratio of the resin is 1:4- 1:7, washing for 3-6BV with water after adsorbing, wherein eluting flow rate is 2-4BV / h, throwing away eluent; eluting for 3-6BV with the ethanol water solution with the
volume percent concentration of 20-90%, wherein the flow rate is 2-4BV / h, collecting the ethanol / water eluent, concentrating, and
drying to obtain the eclipta extract. By adopting the preparation method disclosed by the invention, purification cost is reduced, industrial production is easy to realize, and no environment
pollution is caused.