83results about How to "Increased radiation sensitivity" patented technology

It has now been determined that antisense therapy which reduces the expression of TRPM-2 provides therapeutic benefits in the treatment of cancer. In particular, such antisense therapy can be applied in treatment of prostate cancer and renal cell cancer. Addition of antisense TRPM-2 ODN to prostatic tumor cells in vivo is effective for delaying the onset of androgen independence. Thus, prostate cancer can be treated in an individual suffering from prostate cancer by initiating androgen-withdrawal to induce apoptotic cell death of prostatic tumor cells in the individual, and administering to the individual a composition effective to inhibit expression of TRPM-2 by the tumor cells, thereby delaying the progression of prostatic tumor cells to an androgen-independent state in an individual Combined use of antisense TRPM-2 and taxanes synergistically enhances cytotoxic chemosensitivity of androgen-independent prostate cancer. In addition, it has also been found that antisense TRPM-2 has beneficial effect for other cancer types. Specifically, antisense TRPM-2 ODN enhances chemosensitivity in human Renal cell cancer, a normally chemoresistant disease with no active chemotherapeutic agent having an objective response rate higher than 10%. Radiation sensitivity is also enhanced when cells expressing TRPM-2 are treated with antisense TRPM-2 ODN. Thus, the antisense TRPM-2 ODNs can be used to enhance hormone sensitivity, chemosensitivity and radiation sensitivity of a variety of cancer types in which expression of TRPM-2 has been observed.

The invention provides modified gold nanoparticles that enable a non-invasive, real time, targeted cancer imaging-therapeutic in one step. After reaching the cancer targets, the designed targeted gold nanoparticles significantly enhance conventional treatment modalities at the cellular level. In this aspect the gold nanoparticles of the invention are modified to be bound to a Positron Emission Tomography (PET) tracer.

A classifier to predict cellular radiation sensitivity based on gene expression profiles in thirty-five cell lines from the NCI panel of 60 cancer cell lines (NCI-60), using a novel approach to predictive gene analysis. Three novel genes are provided, retinoblastoma binding protein 4 (RbAp48), G-protein signaling regulator 19 (RGS19) and ribose-5-phosphate isomerase A (R5PIA) whose expression values were correlated with radiation sensitivity.

The present invention provides a positive-type radiation-sensitive composition containing (A) a siloxane polymer, and (B) a quinone diazide compound, in which the content of aryl groups relative to Si atoms in the siloxane polymer (A) is greater than 60% by mole and no greater than 95% by mole.

A photonic crystal interferometric optical gyroscope system including a light source for providing a primary beam of light, a photonic crystal sensing coil having a rotational axis, and a beam controlling device configured to split the primary beam into first and second counter-propagating beams in the photonic crystal sensing coil and configured to direct return of the counter-propagating beams wherein the power of the returning counter-propagating beams represents the phase shift between the counter-propagating beams and is indicative of the rate of rotation of the coil about the rotational axis.

There is disclosed a radiation sensitive composition containing a silane compound represented by the following formula (1):wherein R<1 >is an unhydrolyzable organic group having 1 to 12 carbon atoms, X is a hydrolyzable group, and p is an integer of 0 to 3,a hydrolyzate thereof and a condensate of the hydrolyzate;and a compound which generates an acid or base upon exposure to radiation. The composition is used to form an insulating film for an organic EL display device, and an interlayer insulating film for a liquid crystal display device.

The invention discloses a fluorescent material for X-ray memory imaging, which comprises zinc sulfide serving as a substrate material, wherein an activator which is an acidic compound of one or more of copper, silver, gold, manganese and lead is added into the substrate material; the added amount of the activator is 1*10<-5> to1*10<-3> of the weight of each gram of the substrate material; the fluorescent material is prepared by heating at high temperature, the prepared fluorescent material can generate memory longtime afterglowing after being activated by X-rays; the fluorescent material is coated on the surface of a film and glass; the film and glass are placed before a charge coupled device (CCD) or complementary metal-oxide-semiconductor (CMOS) light sensitive camera for shielding and sealing the light sensitive camera; the camera is connected with a computer; and thus, an X-ray instant quick imaging system is formed.

The invention discloses an X-ray detector based on a perovskite material and a preparation method of the X-ray detector. The method comprises the steps: 1, weighing AI and BI3 raw materials accordingto a molar ratio of 3: 2, and dissolving the AI and BI3 raw materials in an organic solvent to obtain a mixed precursor solution, wherein AI is CsI, CH3NH3I or RbI, and BI3 is BiI3 or SbI3; 2, sealingthe mixed precursor solution, heating the solution to 60-100 DEG C and maintaining the temperature for 2-48 hours to achieve full dissolution equilibrium, and then, taking supernate to obtain a completely saturated solution of the precursor; 3, placing the completely saturated solution of the precursor at an environment temperature lower than the heating termination temperature in the step 2, then, gradually carrying out heating at a speed of less than 5 DEG C / day until crystallization, and stopping heating until the temperature is continuously increased by at most 10 DEG C to obtain an A3B2I9 perovskite single crystal; 4, taking out the single crystal and carrying out drying; and 5, evaporating an interdigital metal electrode on the surface of the single crystal.

An object of the invention is to provide a liquid crystal alignment agent which has excellent radiosensitivity and shows good liquid crystal alignment properties in the low-irradiation photo alignment method. A liquid crystal alignment film forming method using the liquid crystal alignment agent and a liquid crystal alignment film are provided. A liquid crystal display element which contains the liquid crystal alignment film and has excellent performances, such as electrical properties, in addition to the liquid crystal alignment properties, is provided. Further, a compound which serves as material of the liquid crystal alignment agent is provided. The liquid crystal alignment agent provided by the invention comprises an [A] polymer which has a structural unit (I) containing a radical represented by the following formula (1) or a radical represented by the following formula (2). Besides, the [A] polymer is preferably polyester or polythioester.

The radiation-sensitive resin composition contains (A) a polymer obtained by living radical polymerization in the presence of a specific thiocarbonyl thio compound and having carboxyl groups or polymer of epoxy radical or oxetane group, wherein the ratio (Mw / Mn) between weight average molecular weight (Mw) and number average molecular weight (Mn) in terms of polystyrene measured by gel permeation chromatography is <=1.7.

The invention belongs to the field of microbial fungi, and relates to a Cordyceps militaris strain capable of producing heat-resistant proteinase and cordycepin at high yield and application thereof. The strain is prepared by the following steps: selecting a Cordyceps militaris wild-type strain newly separated from the natural world as the initial strain, carrying out composite mutagenization under the actions of Cordyceps militaris protoplast nitrosoguanidine and ultraviolet light, separating and screening to obtain the strain. The strain was collected by China General Microbiological Culture Collection Center on November 11th, 2016; the collection number is CGMCC No.13179; the strain is named HYCM12; and the classification designation is Cordyceps militaris. After the strain is subjected to deep liquid ventilation fermentation, the cordycepin content reaches 2.89 g / L, and the heat-resistant proteinase activity reaches 5326U / ml. Meanwhile, the method is simple to operate and easy to implement, has the advantages of short period, abundant and accessible raw material sources, low cost, no environmental pollution, low equipment and reagent price and the like, and is convenient for large-scale production.

The invention relates to a radiation sensitive linear resin composition, a layer insulation film and a manufacture method thereof. The radiation sensitive linear resin composition also displays the excellent film thickness uniformity and has high ray sensibility even thought a slot mold coating method as the coating method. In a developing step, the development tolerance of a good pattern shape is still formed even though exceeding the best developing time. The layer insulation film has various excellent performances such as high heat endurance, high solvent resistance, high transmittance andlow dielectric constant. The radiation sensitive linear resin composition comprises (A)alkali soluble resin, (B) 1,2-quinone-bi-azide compound and (C) special polymer with siloxane chain. The layer insulation film is formed by the radiation sensitive linear resin composition.

The invention belongs to the field of radiation sensitizing agents, in particular to an application of BTG2 (B cell translocation gene 2) in preparing a tumor radiation sensitizing agent for ionizing radiation including X-rays. The invention discloses an application of liposome mediated eukaryotic expression plasmid pcDNA3-BTG2 in preparing the radiation sensitizing agent, wherein the liposome mediated eukaryotic expression plasmid pcDNA3-BTG2 is transfected to MCF-7 (macrophage chemotactic factor-7) breast cancer cells and MDA-MB-231 breast cancer cells and expressed successfully, and the BTG2 protein can up-regulate the proapoptosis Bax protein and down-regulate the cell cycle regulatory protein Cyclin D1, and by promoting the cell apoptosis, G0 / G1 phase arrest of the cells is promoted, thereby increasing the sensitivity of the breast cancer cells to ionizing radiation including the X-rays.

The invention relates to active radiation hardenable resin composition, and a spacer and / or a color filter protective layer for a display element using the same. The objective of the invention lies in providing the spacer and the color filter protective layer for the display element, wherein the spacer or the protective layer is good in heat resistant transparency, flatness, flexibility, and tenacity. The active radiation hardenable resin composition for spacer or the protective layer contains a reactive polybasic carboxylic acid compound (A), a reactive compound (B) different from the reactive polybasic carboxylic acid compound (A), a photopolymerization initiator (C), and an organic solvent (D). The reactive polybasic carboxylic acid compound (A) enables the reaction products of epoxy resin with a compound (B) and a compound (C) to further react with polybasic anhydride (D) to obtain the reactive polybasic carboxylic acid compound (A), wherein one molecule of the reactive polybasic carboxylic acid compound (A) at least contains two or more epoxy groups, one molecule of the compound (B) contains one or more polymerizable olefinic unsaturated groups and one or more carboxy groups, and one molecule of the compound (C) at least contains two or more hydroxide radicals and one or more carboxy groups.

There is disclosed a radiation sensitive composition containing a silane compound represented by the following formula (1): (R<1>)pSi(X)4-p (1) wherein R<1 >is an unhydrolyzable organic group having 1 to 12 carbon atoms, X is a hydrolyzable group, and p is an integer of 0 to 3, a hydrolyzate thereof and a condensate of the hydrolyzate; and a compound which generates an acid or base upon exposure to radiation. The composition is used to form an insulating film for an organic EL display device, and an interlayer insulating film for a liquid crystal display device.

The invention relates to a radiation-sensitive resin composition, an interlayer dielectric, and a method for producing thereof. More particular, the invention provides a positively radiation-sensitive resin composition which can form an interlayer dielectric, an interlayer dielectric formed by composition and the method of forming the interlayer dielectric. In addition to excellent coating performance, radiation sensitiveness and easy obtainablility of beautiful patterns, the interlayer dielectric also has excellent heat-resistant, anti-solvent and dry-corrosion-proof properties and high light transmitting rate. The radiation-sensitive resin composition is a positively radiation-sensitive resin composition containing (A) a soluble resin, (B) 1, 2-quinone diazide compound and (C) a compound represented by the formula (1).

The invention provides a capacitance Si-based radiation detecting device, and a preparation method thereof. The detecting device comprises an Si substrate layer, wherein a buried oxide layer is set above the Si substrate layer; a metal fill area, a gate dielectric area, a Si thin layer, an ohmic contact injection area and an oxide isolation layer are set on the buried oxide layer from the center to the periphery; an ohmic contact area is set above the ohmic contact injection area; a gate metal electrode is set above the metal fill area. The detector has the advantages of high radiation sensitivity and induced charge capacity, low work gate voltage and high reliability. The method comprises the steps of growing the oxide isolation layer on a substrate; forming the ohmic contact injection area by doping light and heavy ions; forming the ohmic contact area via sputter deposition; forming a groove area via etching; forming the gate dielectric area via an atomic layer deposition process; forming a metal fill groove area via secondary etching; forming the metal fill area and the gate metal electrode via the Cu interconnection process. The method has the advantages of simpleness in process, good repeatability, low cost and easiness in integration with the fabrication process of the existing large-scale integrated circuit.

The invention relates to a construction method of a nano drug with small-intestine adhesiveness. The method includes: activating basic amino acid by a micromolecular catalyst, and adding into polysaccharide solution to obtain an amphiphilic macromolecular polymer through reaction; adding drug solution, and well mixing to obtain drug-loading nanoparticles, wherein each nanoparticle comprises a hydrophilic portion and a hydrophobic portion, each hydrophilic portion refers to basic amino acid, and each hydrophobic portion consists of polysaccharide and a drug with a radiation protection performance or an inhibiting effect on ionizing radiation induced apoptosis; adding the drug-loading nanoparticles into dopamine solution, and performing complete reaction to obtain the nano drug with basic amino acid and polydopamine on the surface. The oral nano drug with intestinal adhesiveness is high in biocompatibility and tolerant to gastrointestinal acid-base environments and has small-intestine adhesiveness and intestinal mucus barrier penetrating power.

A method for forming a semiconductor device includes forming an implant mask on a substrate, such that a first portion of the substrate is located under the implant mask, and a second portion of the substrate is exposed; performing oxygen ion implantation of the substrate; removing the implant mask; and forming a first field effect transistor (FET) on the first portion of the substrate, and forming a second FET on the second portion of the substrate, wherein the second FET has a higher radiation sensitivity than the first FET.

The invention relates to the technical field of biomedicine engineering and provides application of a reagent for inhibiting or down-regulating expression of a GTSE1 gene in preparation of a tumor radiotherapy sensitization drug, particularly application in preparation of a lung cancer radiotherapy sensitization drug. Experiments prove that GTSE1 knockdown promotes DNA damage of exposure to lung cancer cells, increases the radiosensitivity of three lung censer cells significantly and increases the apoptosis rate of the three lung cancer cells after exposure significantly with the increase of an exposure dose, and the cell survival rate of the three lung cancer cells is obviously lower than that of a normal lung cancer cell group. Therefore, the application provides a new exploration for improving the sensitivity of radiotherapy, contributes to radiotherapy sensitivity of malignant tumor and has certain clinical application prospects.

The invention relates to the technical fields of microbial genetic breeding and biological active substance production, and discloses a method for enhancing worm grass fermentation biomass. The method comprises the following steps: (1) preparing a worm grass protoplast; (2) carrying out mutagenesis on the worm grass protoplast, and regenerating the protoplast; (3) selecting the bacterial colony, and inoculating a PDA (potato dextrose agar) culture medium; (4) inoculating a liquid fermentation culture medium; and (5) obtaining the active product containing worm grass biomass, polysaccharide, cordycepin and the like. The worm grass strain with high hypha growth speed and high biomass is obtained by mutagenesis for the first time; by using white jade snail viscera and shells as the main raw material and adding proper glucose, K2HPO4, MgSO4 and other nutrient substances, the mutagenesis worm grass strain is inoculated and subjected to submerged fermentation to produce the worm grass mycelia. The method is simple to operate, sufficiently utilizes the waste resources and enhances the worm grass fermentation biomass. The fermentation product can be used in an animal feed additive to become a green food, thereby avoiding adding antibiotics in the animal feed.

The invention relates to an active energy ray curable resin composition, and a spacer and / or a color filter protective layer for a display device using the same and is aimed to provide a spacer and a color filter protective layer for a display device and with excellent heat resistance, heat resistant transparency, flatness, flexibility and toughness. The active energy ray curable resin composition for a spacer and / or a color filter protective layer for a display device comprises reactive polycarboxylic compounds (A), reactive compounds (B) except the reactive polycarboxylic compounds (A), photopolymerization initiators (C) and organic solvents (D). The reactive polycarboxylic compounds (A) is obtained through further reaction of epoxy resins (a) wherein one molecule comprises at least more than two epoxy groups, compounds (b) wherein one molecule comprises more than one polymerizable olefinic unsaturated group and more than one carboxyl and compounds (c) wherein one molecule comprises at least more than two hydroxys and more than one carboxyl according to requirements, and itaconic anhydrides as polybasic anhydrides (d).

The invention relates to a solidified resin composite, a method for forming a solidified membrane and a solidified membrane. The invention comprises a polymer which is polymerized through an actively free radical polymerization in the effect of a particular thiocarbonyl sulphur compound. The ratio (Mw / Mn) of the weight average molecular weight (Mw) of the polymer (expressed in terms of polystyrene) to the number average molecular weight (Mn) measured by gel permeation chromatography is1.7 or less than 1.7, the polystyrene also includes carboxyl, epoxy ethyl or oxygen heterocycle butyl.

An imaging device (1) for electromagnetic radiation, especially for x-ray and / or gamma radiation, is disclosed. In an embodiment, the imaging device includes a layering including a number of detection elements (4), a number of read-out boards (6) and a base board (8). Each of the detection elements (4) is electrically contacted with a respective read-out board (6) via a plurality of first solder contacts (16). The or each read-out board (6) includes a plurality of through-contacts (20) and is electrically contacted with the base board (8) via a plurality of second solder contacts (24).

The invention provides an SOI CMOS technology-based radiation detector and a preparation method thereof. A Si film area, a source electrode or drain electrode injection area and a medium isolation area are arranged on an oxygen-buried oxidation layer in sequence from inside to outside, a body area injection area is embedded in the Si film area, and ohmic contact electrodes are arranged on the source electrode or drain electrode injection area and the body area injection area; and a Si substrate is arranged under the oxygen-buried oxidation layer, a groove with the bottom facing upwards is arranged on the Si substrate, a back gate electrode is arranged on the surface of the groove, and a back through hole metal filling area connected with the back gate electrode is arranged inside the oxygen-buried oxidation layer. The device has high radiation sensitivity, high induced charge capacity, low working gate voltage, and high reliability. The medium isolation area grows on a front side of a substrate; the source electrode or drain electrode injection area and the body area injection area are obtained by injecting ions; the ohmic contact electrodes are obtained by sputter deposition; and a detection window area and the back through hole area are etched on the reverse side of the substrate and are filled with metal. The method is simple in technology, good in repeatability, and low in cost, and is easy to be integrated with the manufacturing technology of an existing large scale integrated circuit.

The invention discloses a gold-silver alloy nano material. The material comprises gold-silver alloy nano particles and sulfydryl-modified hyaluronic acid, and the sulfydryl-modified hyaluronic acid coats the surfaces of the gold-silver alloy nano particles. The invention also discloses a preparation method of the gold-silver alloy nano material. The preparation method comprises the following steps: providing the gold-silver alloy nano particles and the sulfydryl-modified hyaluronic acid; and coating the surfaces of the gold-silver alloy nano particles with the sulfydryl-modified hyaluronic acid so as to obtain the gold-silver alloy nano material. The gold-silver alloy nano material disclosed by the invention has the characteristics of low toxicity and high tumor targeting, and has the effects of improving intracellular active oxygen and reducing glutathione after X-ray radiation, so that the purpose of radiotherapy sensitization is achieved. The gold-silver alloy nano material has goodCT capability, so that the material can also be applied to synchronous clinical diagnosis and treatment of tumors, and helps to realize and promote the construction of a diagnosis and treatment integrated platform.

The invention pertains to biological engineering field and relates to antisense ribonucleotide technology, in particular to antisense STAT3 oligonucleotide and the application thereof in antitumor drugs. The STAT3 becomes one of the hot study and application issues in the world because the STAT3 is a promising molecular target in the phyma treatment field. The invention discloses three series of high-effective antisense STAT3 oligonucleotide series which has proliferation inhibition effect to phyma cells, and compared with the known series, proliferation inhibition effect to phyma cells is improved and apoptosis of phyma cells can be effectively induced; therefore, the invention can be applied to the preparation of antitumor drugs. Combined with radiation factors, the invention is observed to evidently reduce radiation sensitivity of phyma cell and the invention can be used as radiation sensitizing agent.

A radiation-sensitive resin composition that exhibits high radiation sensitivity, having such a development margin that desirable pattern configuration can be formed even when the optimum development time is exceeded in the development step, that is capable of easily forming a patterned thin film excelling in adherence and reduces the amount of sublimed matter occurring at firing, and that is appropriately usable in production of an interlayer insulation film or microlens. There is provided a radiation-sensitive resin composition comprising carboxylated epoxidized polymer (A) exhibiting a ratio of, as measured by gel permeation chromatography, weight average molecular weight (Mw) in terms of polystyrene to number average molecular weight (Mn) in terms of polystyrene, Mw / Mn, of 1.7 or below, and 1,2-quinonediazide compound (B).