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Gold-silver alloy nano material as well as preparation method and application thereof

A technology of gold-silver alloy and nano-materials, which is applied in radiation-sensitizing materials, wave energy or particle radiation treatment materials, drug combinations, etc., can solve problems such as deficiencies, and achieve reduced side effects of radiotherapy, good CT imaging effects, and good biophase capacitive effect

Active Publication Date: 2020-07-24
SHANGHAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Although the method of tumor radiation therapy has developed rapidly and is widely used, there are still obvious deficiencies

Method used

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  • Gold-silver alloy nano material as well as preparation method and application thereof
  • Gold-silver alloy nano material as well as preparation method and application thereof
  • Gold-silver alloy nano material as well as preparation method and application thereof

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preparation example Construction

[0043] The embodiment of the present invention also provides the preparation method of the aforementioned gold-silver alloy nanomaterial, including:

[0044] Provide gold-silver alloy nanoparticles and sulfhydryl-modified hyaluronic acid;

[0045] The sulfhydryl-modified hyaluronic acid is coated on the surface of the gold-silver alloy nano-particles to obtain the gold-silver alloy nano-material.

[0046] In some embodiments, the thiol-modified hyaluronic acid is bound to the surface of the gold-silver alloy nanoparticles through gold-sulfur bonds and silver-sulfur bonds.

[0047] In some embodiments, the surface of the gold-silver alloy nanoparticles is further coated with sodium citrate.

[0048] In some preferred embodiments, specifically include:

[0049] Sodium citrate solution, chloroauric acid solution and silver nitrate solution were used as raw materials to synthesize gold-silver alloy nanoparticles coated with sodium citrate through redox reaction.

[0050] Furthe...

Embodiment 1

[0079] 1. Synthesis of gold-silver alloy nanoparticles (Au-Ag NPs):

[0080] Put 100 mL of three times water in a 200 mL round bottom flask, then add 5 mL of sodium citrate solution with a mass fraction of 1%, set the magnetic stirring speed to 800 rpm, and set the temperature to 120 °C. After the solution boiled, add 1mL silver nitrate aqueous solution with a concentration of 24mM immediately, and 3 seconds later, add 1mL aqueous solution of chloroauric acid with a concentration of 24mM, continue to stir for 10min, take out the round-bottomed flask from the constant temperature magnetic stirrer, and store it under cooling at room temperature.

[0081] 2. Synthesis of mercaptoethylamine-modified hyaluronic acid:

[0082] Weigh HA 10mg, weigh 50mg SH-CH 2 -CH 2 -NH 2 , dissolve it in 100mL of water three times with the assistance of ultrasound, then add 50mg EDC and 50mg NHS, stir at room temperature for 48h, then dialyze for 3 days, change the water every 3h on the first da...

Embodiment 2

[0086] 1. Synthesis of gold-silver alloy nanoparticles (Au-Ag NPs):

[0087] Put 100 mL of three times water in a 200 mL round bottom flask, then add 3 mL of sodium citrate solution with a mass fraction of 1%, set the magnetic stirring speed to 800 rpm, and set the temperature to 120 °C. After the solution boiled, add 1mL silver nitrate aqueous solution with a concentration of 24mM immediately, and 3 seconds later, add 1mL aqueous solution of chloroauric acid with a concentration of 24mM, continue to stir for 10min, take out the round-bottomed flask from the constant temperature magnetic stirrer, and store it under cooling at room temperature.

[0088] 2. Synthesis of mercaptoethylamine-modified hyaluronic acid:

[0089] Weigh 20mg of HA, weigh 40mg of SH-CH 2 -CH 2 -NH 2 , dissolve it in 100mL of water three times with the assistance of ultrasound, then add 50mg EDC and 50mg NHS, stir at room temperature for 48h, then dialyze for 3 days, change the water every 3h on the fi...

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Abstract

The invention discloses a gold-silver alloy nano material. The material comprises gold-silver alloy nano particles and sulfydryl-modified hyaluronic acid, and the sulfydryl-modified hyaluronic acid coats the surfaces of the gold-silver alloy nano particles. The invention also discloses a preparation method of the gold-silver alloy nano material. The preparation method comprises the following steps: providing the gold-silver alloy nano particles and the sulfydryl-modified hyaluronic acid; and coating the surfaces of the gold-silver alloy nano particles with the sulfydryl-modified hyaluronic acid so as to obtain the gold-silver alloy nano material. The gold-silver alloy nano material disclosed by the invention has the characteristics of low toxicity and high tumor targeting, and has the effects of improving intracellular active oxygen and reducing glutathione after X-ray radiation, so that the purpose of radiotherapy sensitization is achieved. The gold-silver alloy nano material has goodCT capability, so that the material can also be applied to synchronous clinical diagnosis and treatment of tumors, and helps to realize and promote the construction of a diagnosis and treatment integrated platform.

Description

technical field [0001] The invention relates to the technical field of biological nanomaterial preparation, in particular to a gold-silver alloy nanomaterial, its preparation method and application. Background technique [0002] Radiation therapy is one of the most important therapeutic strategies for tumor diseases in clinic. In the process of radiotherapy, high-energy rays (such as X-ray or γ-ray) can directly cause different degrees of damage to DNA molecules; at the same time, these high-energy rays can also act on intracellular organic molecules and water molecules to generate a variety of free radicals , so as to induce apoptosis, and then achieve the purpose of effectively killing the target tissue. [0003] Although the method of tumor radiation therapy has developed rapidly and is widely used, there are still obvious deficiencies. For example, when conventional radiation doses are used for clinical treatment, the average cure rate of tumors is only nearly 40%. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/36A61P35/00A61K49/04
CPCA61K41/0038A61P35/00A61K49/04
Inventor 宁欣宇张智军崇羽徐小雨黄洁
Owner SHANGHAI UNIV
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