82 results about "Toxicity reduction" patented technology

The invention discloses a preparation method of a nanometer Fe(0)-porous sludge carbon material. The method includes: taking iron salt as an iron source of nanometer Fe(0), taking sludge as a precursor for thermal reduction of porous carbon and iron salt, taking an organic matter capable of generating a great quantity of gas by thermal decomposition at 300-500 DEG C as a pore forming agent, taking waste organics as a carbon regulating agent (in order to solve the problem of difference of organic carbon composition of sludge different in source), taking water as a harmonizing agent, and performing pyrolysis carbonization and thermal reduction at 500-900 DEG C to obtain the nanometer Fe(0)-porous sludge carbon material being 0.01-100micron in pore diameter, wherein Fe(0) average particle size is 30-80mm. The nanometer Fe(0)-porous sludge carbon material is effective in dechlorination and toxicity reduction and has a promising application prospect in various environmental pollution control fields including dehalogenation reduction, soil remediation, heavy metal wastewater treatment, printing and dyeing wastewater treatment and / or anaerobic wastewater treatment and the like, and sludge recycling and 'using waste to treat waste' are realized.

Disclosed is an apparatus and an operating method for deep denitrification and toxicity reduction of wastewater. The apparatus comprises a regulation tank, an aeration biofilter, an ozone reaction tank, an ozone generation and diffusion device, and a denitrification biofilter. By the coupling reaction treatment of microorganisms, ozone, electrolysis and denitrification, an effect of refractory organic contaminants and nitrate nitrogen removal, deep denitrification and toxicity reduction can be achieved.

The invention belongs to the technical field of soil restoration and discloses a device and method for removing polychlorinated biphenyl in bottom mud through a microorganism electrolytic tank. The microorganism electrolytic tank is established, hybrid electrochemical activity bacteria and perchlorate domesticated bacteria are inoculated to an anode chamber, soil polluted by polychlorinated biphenyl is added, a nutrient solution is supplemented to the rest part, the water phase-bottom mud anode chamber is formed, anode potential is controlled to be kept constant through an electrochemical work station, growth and propagation of the hybrid electrochemical activity bacteria and the perchlorate domesticated bacteria can be promoted, dechloridation efficiency can be greatly improved, and constant bioelectric currents can be generated. By the adoption of the device and method, natural restoration and toxicity reduction can be conducted on the polluted soil, and good environmental protection benefits are achieved.

The invention discloses an injectable preparation of an anti-cancer drug, belonging to the technical field of medicines. The anti-cancer active ingredient in the preparation is paclitaxel or Docetaxol, and the dosage thereof is 0.01-10 percent (w / v); a solubilizer in the preparation is novel auxiliary polyethylene glycol-12-hydroxystearic acid (Solutol HS 15) with the characteristics of low hemolysis and low histamine release, and the dosage thereof is 5-50 percent (w / v). The preparation does not contain other surface active agent except Solutol HS 15. The preparation can eliminate or reduce anaphylactic reaction or haemocylolysis caused by Cremophor EL and Tween-80, has the characteristics of toxicity reduction, higher safety, certain slow release and targeting action, simple prescription constitution, simple and convenient process and low cost and has wide application prospect in the practice of preparing the anti-cancer drug.

The invention discloses a moringa leaf extract and an application of the moringa leaf extract in the aspects of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers. Dry moringa leaves are extracted through 20%-80% ethanol aqueous solution the amount of which is 3-10 times of the weight of the dry moringa leaves, concentrated and dried so as to obtain the moringa leaf extract. The moringa leaf extract which is extracted through the method has the functions of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers, and can be used for producing various auxiliary anti-cancer medicaments, functional food and food.

The invention relates to instant functional food, compound polygonatum sibiricum chewable tablets, and a preparation method thereof. The composition of the compound polygonatum sibiricum chewable tablets comprises the following components in parts by weight: 35-45 parts of polygonatum sibiricum, 5-10 parts of medlar, 0-5 parts of black bean, 5-10 parts of yellow wine and 35-50 parts of water. The preparation method of the compound polygonatum sibiricum chewable tablets comprises the following steps: decocting the medlar, the black bean and the water according to the weight ratio until the volume is 1 / 2 of the original volume and filtering; adding the polygonatum sibiricum and the yellow wine into the filtrate according to the weight ratio; soaking for 8-12 hours; taking out and steaming with a pressure cooker for 2-5 hours; slicing; drying at 70-90 DEG C for 0.5-2 hours until the polygonatum sibiricum is not sticky. According to the method, various conventional polygonatum sibiricum processing technologies such as processing with wine and processing with black bean are combined, the irritating ingredients in the polygonatum sibiricum are removed, and toxicity reduction and efficacy enhancement are realized. The method excellently solves the problems such as rough taste and difficulty in chewing of a processed product existing in the conventional polygonatum sibiricum processing and the compound polygonatum sibiricum chewable tablets can be conveniently eaten as the functional food to achieve a better nourishing effect.

The invention discloses a monitoring and identifying evaluation method for group biotoxicity in printing and dyeing wastewater and belongs to the field of biotoxicity identification. The method comprises the following steps: screening photogenic bacteria, zebrafish larvae, zebrafish embryos and chlorella as test organisms; and performing risk and toxicity reduction evaluation on the printing and dyeing wastewater by adopting group biotoxicity tests and combining with a toxicity evaluation method, and constructing a toxicity identification evaluation system by combining with a TIE technology according to the wastewater contamination characteristics and results. According to the method disclosed by the invention, the group biotoxicity tests comprising three trophic levels such as decomposer,producer and consumer are performed for characterizing toxicities of the printing and dyeing wastewater, and the problem that a single biotoxicity test does not have representativeness is solved. Themethod has the advantages of being comprehensive, simple, high-efficiency, capable of controlling from the source, high in safety and the like, can be widely applied to researching and evaluating influences of toxic pollutants on the ecological environment, and provides a certain basis for ecological risk assessment.

Pharmaceutical compositions and methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise and other toxic insults are provided. These methods comprise administering an effective amount of a protectant combination or composition comprising two or more protectants selected from the group of methionine protectant agents, N-acetylcysteine, carnitine, magnesium ions, lipoic acid, ebselen, glutathione, and glutathione ester. These protectant combinations can be administered prior to, simultaneously with, or subsequently to exposure to noise other toxic insults.

According to the invention, a series of reduction-sensitive disulfide bond bridged docetaxel fatty acid prodrugs are designed and synthesized. The series of prodrugs can be self-assembled into a nano drug delivery system through a one-step nano precipitation method. The nano drug delivery system has the following advantages that: docetaxel is prepared into a disulfide bond connected prodrug, so that the system toxicity of a docetaxel parent drug is reduced, the parent drug can be specifically released in a high reduction environment in tumor cells, and the effects of synergy and toxicity reduction are achieved; the drug loading capacity is high, the use of a solubilizer with higher toxicity is avoided, and the tolerance and the compliance of a patient are expected to be improved; through the one-step nano precipitation method, the preparation process is simple, and large-scale production is easy; the nanoparticles are small and uniform in particle size and are easily enriched at a tumor part through an EPR effect; and surface modification is easy, and removal of a reticuloendothelial system can be slowed down through modification of PEG modification.

The invention provides a method which is applicable to process alangium platanifolium, as for the alangium platanifolium, alkaloid is not only the active ingredient but also the toxic ingredient of the alangium platanifolium. Consequently, the research on the method for safely and reasonably processing the drug is very important to improve the clinic medication safety of the drug. The method for processing the alangium platanifolium is scientific and reasonable, has stable technological parameters, can effectively improve the safety of the alangium platanifolium to realize the purposes of toxicity reduction and efficacy enhancement, and benefits industrial production.

The invention discloses a method for controlling quality of red medicinal gel. In the method, the contents of pseudo-ginseng and diphenhydramine hydrochloride in the red medicinal gel are detected by adopting a high performance liquid chromatography method, and effective substances are identified. Requirement to the method is improved based on National Formulary and national standard, and the method represents the advantages of simple operation, detection conservation, reagent toxicity reduction, specificity improvement and the like.

The invention provides a chitosan-aliphatic polyester-phosphatidylethanolamine graft polymer, and a preparation method and a use thereof. The structural formula of the graft polymer is represented by formula (I) shown in the specification. The chitosan-aliphatic polyester-phosphatidylethanolamine graft polymer provided by the invention simultaneously comprises a hydrophilic part and a hydrophobic part. Chitosan has a biological degradability and hydrophilicity, and aliphatic polyester and phosphatidylethanolamine have the hydrophobicity, so the nanometer micelle of the amphiphilic chitosan-aliphatic polyester-phosphatidylethanolamine graft polymer has the advantages of effective prolongation of the drug effect, toxicity reduction, and improvement of the biological availability and the biological activity as a drug carrier. The formula (I) is shown in the description.

The invention belongs to the field of a medicinal preparation, and relates to an EGFR (epidermal growth factor receptor) modified platinum drug albumin nano preparation with a target tumor cell identification function. According to the invention, albumin is used for supporting platinum drugs, medical PEG (polyethylene glycol) is taken as a dispersing and cross-linking agent, and amination EGFR aptamer is taken as a target modifying molecule, so that the soluble albumin nano (Apt-PtNPs) preparation is prepared. The nanoparticle can be specifically combined with the EGFR on the surface of the tumor cell and has a cell endocytosis function, so that the toxic and side effects of the platinum drugs can be reduced, the purposes of toxicity reduction and efficacy enhancement are achieved, EGFR expression can be inhibited by prompting EGFR protein phosphorylation, and the anti-tumor effect of the nanoparticle in combination of the platinum drugs is achieved; the nanoparticle can be used for preparing the anti-tumor drugs, and particularly, the treatment research of the nanoparticle in the aspects of cervical cancer and ovarian cancer proves that the nanoparticle is good in targeting and good in killing effect and has good application prospect in gene therapy of tumors and combined treatment by chemotherapeutic drugs.

This invention is a preparation with comprehensive and multi-functions—for reducing the toxicity in cigarette smoke, strengthening smokers' health and eliminating their addiction to smoking. More specifically, the liquid additive is designed to lower the toxin level in tobacco smoke on a broader scale and by a larger margin; the health pills, with their unfailing nutritious effect guaranteed, can fundamentally prevent smokers from getting various smoking related diseases; both the liquid additive and the health pills can also resolve and inactivate the addiction-causing substances in the human brain so as to help smokers quit smoking.

The invention discloses a toxicity reduction and recycling system and a treatment method for biotreated effluent in the printing and dyeing industry, and belongs to the technical field of deep treatment of printing and dyeing wastewater. The system comprises a V-shaped filtering pond, a middle water pond, a magnetic resin reactor, an anaerobic pond, a surface flow wetland and an ecological pond, wherein the magnetic resin reactor is reasonably combined with ecosystems such as the ecological pond and a constructed wetland; the filtering pond is used for removing suspended organic matters in the biotreated effluent by filtering in order to lower turbidity; magnetic resin is used for adsorbing soluble organic pollutants in the biotreated effluent in order to lower chromaticity and biological toxicity. An alternative anaerobic-aerobic process is formed by a pond-wetland-pond combination to further lower the concentration of organic matters, nitrogen, phosphorus and toxic pollutants in a water body in order to form a set of biotreated effluent recycling method which runs stably, makes effluent be up to surface water IV and US EPA (Environmental Protection Agency) wastewater biological toxicity standards, has a landscape function and is suitable for printing and dyeing textile zones.

The invention relates to a compound granule or microgranule of trichlorphon and phoxim and a preparation method thereof. The granule or the microgranule comprises the following components in percentage by weight: 1-10 percent of trichlorphon, 1-8 percent of phoxim, 1-8 percent of white carbon black, 1-5 percent of calcium chloride or ammonium sulfate, 2-5 percent of starch or paraffin and 68-86 percent of china clay or kaolin or kieselguhr or coal gangue or slag. For some crops, particularly for the planting of tobaccos, the granule or the microgranule has good settleability, small drift, light environmental pollution, short residual period, convenient application and time and labor saving. The new preparation form has strong complementarity, greatly improves the stability of solid preparations and avoids adverse factors that the trichlorphon is easy to absorb moisture, acidize and decompose, and the phoxim is easy to decompose under light during spraying. The invention has the advantages of cost reduction, toxicity reduction, convenient application and enlargement of prevent and cure spectrum.

The invention discloses a quality control method for asiaticoside gel. In the method, the content of asiaticoside in the asiaticoside gel is determined by titration, and active substances are identified. The method has the advantages of simple operation, detection saving, reagent toxicity reduction, specificity improvement and the like according to the national pharmacopoeia commission national standard improvement requirement.

The invention provides a traditional Chinese medicine nigrum fruit product, wherein coramsine accounts for 1.3-1.55% of the nigrum fruit product by weight. The invention also provides a preparation method and an application of the traditional Chinese medicine nigrum fruit product. The traditional Chinese medicine nigrum fruit product provided by the invention reduces the toxicity of nigrum fruit and is sweet and easy to take. The preparation method of the traditional Chinese medicine nigrum fruit product provided by the invention is simple in technology, and reduces the content of toxic substances while ensuring that the active ingredients are not damaged; a high-temperature treatment process is saved; and meanwhile, an ideal sterilization effect can be realized on medicinal slices, and a positive effect is realized in promoting the effect enhancement and toxicity reduction and the improvement of quality standard of the nigrum fruit slices and related products thereof.

The invention discloses an acidity and lipase double-sensitive nano-container and a preparation method thereof. The double-sensitive nano-container is prepared by connecting a mesoporous silica microsphere to a benzimidazole-modified cyclodextrin molecule through an ester chain, and storing rhodamine or gemcitabine in the mesoporous silica microsphere through adsorption. The method comprises the following steps: executing the modification of an organic functional group on the surface of the mesoporous silica microsphere and the cyclodextrin, and finally connecting the modified macrocyclic molecular cyclodextrin to the silica microsphere through a carbon chain containing an ester bond. The ester bond of the nano-container is broken by the hydrolysis under the environment of over-expression of the lipase, the cyclodextrin is stripped, and drug molecules are released. Under the acidic condition, the inclusion and release of a guest by a host can be realized by the pH regulation of an imidazole group, and the molecule adsorbing-releasing of the nano-container is realized. The nano-container can be applied for the targeted therapy in the chemotherapy, and the purposes of specific killing effect, curative effect improvement and toxicity reduction can be realized.

The invention discloses a rubber anti-aging agent which is particularly prepared through the following steps: drying terephthalic acid metal salt at the mass percent of 20%-50% at 100-120 DEG C for 0.5-1 hour; adding a silane coupling agent at the mass percent of 15%-35% to the terephthalic acid metal salt in a nitrogen environment, sufficiently and uniformly mixing, standing, and activating for 0.5-1 hour; heating an anti-aging agent A at the mass percent of 30%-60% into a melting state, adding an completely activated mixture, and sufficiently and uniformly mixing. Compared with the prior art, the rubber anti-aging agent disclosed by the invention has the advantages of toxicity reduction, low impurity content and low mobility; a preparation process of the rubber anti-aging agent is simple and low in price, the cost can be reduced and the product quality and the economic benefit can be improved.

The invention relates to a natural pharmaceutical composition, a preparation method and a use thereof in preparation of a toxicity-reducing efficacy-enhancing drug in cancer chemotherapy. The natural pharmaceutical composition is formed from a pistacia chinensis bunge water decoction concentrated extract and a lance asiabell root water decoction concentrated extract according to a ratio of 1:1-20. The composition has a quite good curative effect on emesis and other toxic and side effects caused by the cancer chemotherapy, and can simultaneously play a role in inhibiting tumor.

The invention relates to a processing method of aconitine hydroxyl reduction structure converted aconitine traditional Chinese medicine decoction pieces. According to a novel hydroxyl reduction reaction method in an aconitine structure, the reduction reaction of aconitine in processing is that 1-methoxyl hydrolysis and 3, 13, 15-hydroxyl reduction are carried out while ester bond alkali hydrolysis is carried out; under the condition, benzyl aconitine, aconitine and other aconitine compounds without ester bonds are not reduced. According to the invention, the toxic component aconitine in aconite, kusnezoff monkshood root and aconitum brachypodum can be converted, and the effective components such as sonchin in the kusnezoff monkshood root and aconitum brachypodum A in the aconitum brachypodum can be retained, so that the purposes of toxicity reduction and synergism can be achieved. The invention accidentally finds that the reaction occurs in decoction piece processing, the conditions are easy to control, the selectivity is strong, the product yield is high, the method is simple, the cost is low, the method is suitable for large-scale production, the reaction product is single, and the method can be used for preparing the aconitum traditional Chinese medicine low-toxicity decoction pieces.

The invention discloses a papermaking waste water deep processing and safe ecological utilization integrated technology based on toxicity reduction. The technology comprises the following steps: 1) processing by an internal circulation anaerobic reactor; 2) processing by a Fenton fluidized bed; and 3) purifying by constructed wetland: papermaking tail water flows the surface-flow constructed wetland and then is processed, then is introduced into a next vertical-flow constructed wetland , then is introduced into a water plant pool for purification, and finally, the water can be taken as a landscape reclaimed water for reuse to obtain the receiving water. According to the different technical advantages and characteristics of the internal circulation anaerobic reactor, the Fenton fluidized bed and the constructed wetland, scientific combination and design can be carried out, and a papermaking waste water deep processing and safe ecological utilization integrated technology capable of effectively reducing toxicity is formed. The method solves the problem of difficult realization of papermaking waste water up-to-standard discharge and safe ecological utilization in a conventional or single water treatment technology.

The invention relates to a natural medicinal composition, its preparation method and its use in the preparation of medicines for the toxicity reduction and efficacy enhancement in the cancer chemotherapy. The natural medicinal composition is composed of a concentrate of an extract obtained through decocting Radix Sanguisorbae and Pomegranate Rind in water, Radix Sanguisorbae total saponins, an ethanol extract of Pomegranate Rind, and Pomegranate Rind tannins according to a ratio of 2-8:1-2:3-7:5-8. The composition has a very good curative effect on cancer chemotherapy related diarrhea, and simultaneously has a synergistic effect on the cancer chemotherapy.

The invention discloses a folic acid mediated dual-drug-loading targeting polymeric micelle and a preparation method and application thereof. The polymeric micelle is a nanoparticle formed by that polyglutamic acid grafted with paclitaxel, gemcitabine and folic acid is subjected to electrostatic self-assembly with polylysine. Compared with the prior art, the dual-drug-loading targeting polymeric micelle has advantages that by joint use of paclitaxel and gemcitabine, great antitumor effects can be achieved, the problem of poor water solubility of paclitaxel is solved, efficacy improvement and toxicity reduction are realized by targeting, and probability is provided for cancer targeted low-toxicity treatment.

The invention discloses a fertility improvement-growth promotion-toxicity reduction treatment and detection method for organically-contaminated farmland soil, and belongs to the technical field of soil remediation. The fertility improvement-growth promotion-toxicity reduction treatment and detection method for the organically-contaminated farmland soil comprises the steps that after being air-dried, the to-be-detected farmland soil is screened through a sieve and mixed with reagent bags, crushed organic materials and fertilizer, and then the humidity of the oil is maintained for a period of time; and after treatment, polycyclic aromatic hydrocarbon and organo-chlorine pesticide in the soil can be removed, the content of organic matter, nitrogen, phosphorus and potassium in the soil can beincreased, and growth of crops planted in the later stage can be promoted. The removal rate of total polycyclic aromatic hydrocarbon, the removal rate of total hexachlorocyclohexane and the removal rate of total DDT respectively reach 45.07%, 71.00% and 71.16%, the content of total nitrogen and the content of total potassium are increased to 0.43 g / kg and 16.97 g / kg, and the content of organic matter is increased to 11.98% to the maximum extent. In conclusion, the fertility improvement-growth promotion-toxicity reduction treatment and detection method for the organically-contaminated farmlandsoil has a good soil remediation effect and can also promote the growth of plants.

The invention discloses FA (ferulic acid) and VCR (vincristine) composition and an application in preparation of a drug for preventing and treating human tumor. The FA and VCR composition comprises FAand VCR. Cell biological function experiments prove that FA and VCR can better synergistically inhibit activity of human tumor cells when combined and used in a range of the mass ratio being (6.28-30.57):1, reduce dosage of VCR and play a toxicity reduction role, thereby showing good treatment effects on occurrence of tumor. Therefore, the FA and VCR can be combined into composition to be used asan effective component to prepare the drug for preventing and treating human tumor.

A medicinal composition comprises 0.1-90wt% of curcumin, 0.1-90wt% of ginsenoside Rg3 and 0.1-90wt% of Rhizoma Polygoni Cuspidati saponin. The medicinal composition has the advantages of wide pharmacological activity, small side effects, tumor prevention and treatment effects, and synergy and toxicity reduction effects on chemotherapy medicines, and also has blood fat reducing and liver protecting effects.