The invention discloses a preparation method of an oxidoreduction responsiveness tumor-targeted cis-
platinum nanometer
drug delivery system, and application thereof, relates to the building and the preparing of a high-load cis-
platinum macromolecule pro-
drug and a
hyaluronic acid-coated high-load cis-
platinum nanometer
drug delivery system, and can be applied to active targeting treatment of tumors. Polyethyleneimine is adopted as a framework, and
cystamine containing a
disulfide bond with oxidoreduction responsiveness is selected to be reacted with butanedioic anhydride so as to be complexedwith cis-platinum, so that a cis-
platinum complex is obtained. The obtained cis-
platinum complex and the polyethyleneimine are covalently bonded to obtain the high-load cis-platinum
macromolecule pro-drug, and a
hyaluronic acid targeted group is coated on an outer layer, so that the oxidoreduction responsiveness tumor-targeted cis-platinum nanometer
drug delivery system with a tumor active targeting function is obtained. Compared with traditional
chemotherapy drug cis-platinum, the oxidoreduction responsiveness tumor-targeted cis-platinum nanometer
drug delivery system provided by the invention can realize tumor active targeting
drug delivery and oxidoreduction responsiveness
drug release, plays a role in anti-tumor treatment, is capable of effectively reducing the toxic and side effects caused by the cis-platinum on other visceral organs of a body, and has a favorable clinic application prospect.