Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oxidized-graphene nano-drug carrier with targeting function and preparing method thereof

A nano-drug carrier, graphene technology, applied in the field of medicine, can solve the problems of low drug loading, large toxic and side effects, etc.

Inactive Publication Date: 2017-05-24
CHANGZHOU IND TECH RES INST OF ZHEJIANG UNIV
View PDF8 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The first purpose of the present invention is to solve the defects of low drug loading and high toxic and side effects of anti-tumor targeted drugs in the prior art, and provide a drug with low toxic and side effects, long circulation time in the blood, and the ability to target Nanoscale drug carriers for action and responsive drug release

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oxidized-graphene nano-drug carrier with targeting function and preparing method thereof
  • Oxidized-graphene nano-drug carrier with targeting function and preparing method thereof
  • Oxidized-graphene nano-drug carrier with targeting function and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Polyethylene glycol NH with a molecular weight of 3000 2 -PEG-NH 2 Add 1-pyrenebutyric acid to the organic solvent DMF in a molar ratio of 1:0.5, the amount of DMF is 30 times the mass of the reactant, and react at 100°C for 6 hours. After the reaction, the mixed solution is dialyzed and freeze-dried You can get PyBA-PEG-NH 2 ; then PyBA-PEG-NH 2 Add folic acid to DMSO at a molar ratio of 1:2, react at 100°C for a period of 8 hours, dialyze the mixed solution after the reaction and freeze-dry to obtain PyBA-PEG-FA;

[0028] Then cystamine and 1-pyrenebutyric acid were added to the organic solvent DMSO at a molar ratio of 1:0.3, and reacted for a period of 12 hours at room temperature. After the reaction was completed, the mixed solution was dialyzed and freeze-dried to obtain PyBA-S-S-NH 2 ; then PyBA-S-S-NH 2 Treat it with succinic anhydride to form PyBA-S-S-COOH and add the antitumor drug DOX into the organic solvent dioxane at a molar ratio of 1:4, react at room ...

Embodiment 2

[0034] Polyethylene glycol NH with a molecular weight of 4000 2 -PEG-NH 2 Add 1-pyrenebutyric acid to the organic solvent DMSO at a molar ratio of 1:1, the amount of DMSO is 10 times the mass of the reactant, and react at 100°C for 8 hours. After the reaction is completed, the mixed solution is dialyzed and freeze-dried You can get PyBA-PEG-NH 2 ; then PyBA-PEG-NH 2 Add folic acid to DMF at a molar ratio of 1:3, react at 100°C for a period of 12 hours, dialyze the mixed solution after the reaction and freeze-dry to obtain PyBA-PEG-FA;

[0035] Then cystamine and 1-pyrenebutyric acid were added to the organic solvent DMSO at a molar ratio of 1:0.6, and reacted for a period of 18 hours at room temperature. After the reaction was completed, the mixed solution was dialyzed and freeze-dried to obtain PyBA-S-S-NH 2 ; then PyBA-S-S-NH 2 Treat it with succinic anhydride to form PyBA-S-S-COOH and add the antineoplastic drug DOX to the organic solvent dioxane at a molar ratio of 1:3...

Embodiment 3

[0041] Polyethylene glycol NH2-PEG-NH with a molecular weight of 5000 2 Add 1-pyrenebutyric acid to the organic solvent DMF at a molar ratio of 1:0.5, and react at 80°C for 12 hours. After the reaction is completed, dialyze the mixed solution and freeze-dry to obtain PyBA-PEG-NH 2 ; then PyBA-PEG-NH 2 Add folic acid to DMF at a molar ratio of 1:5, react at 100°C for 6 hours, dialyze the mixed solution after the reaction and freeze-dry to obtain PyBA-PEG-FA;

[0042] Then cystamine and 1-pyrenebutyric acid were added to the organic solvent DMSO at a molar ratio of 1:1, and reacted at room temperature for 24 hours. After the reaction was completed, the mixed solution was dialyzed and freeze-dried to obtain PyBA-S-S-NH 2 ; then PyBA-S-S-NH 2 Treat it with succinic anhydride to form PyBA-S-S-COOH and add the antineoplastic drug DOX into the organic solvent dioxane at a molar ratio of 1:5, react at room temperature for 12 hours, dialyze the mixed solution after the reaction, and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to an oxidized-graphene nano-drug carrier with a targeting function. The oxidized-graphene nano-drug carrier comprises oxidized-graphene, PyBA PEG FA and PyBA S S Drug. The invention further provides a preparing method of the oxidized-graphene nano-drug carrier, and the preparing method comprises the steps of firstly using polyethylene glycol with dual-amidogens be subjected to coupled reactions with folic acid and pyrene-1-butyric acid respectively to prepare PyBA PEG FA, conducting a reaction among pyrene-1-butyric acid and cystine and adriamycin amycin to prepare PyBA S S Drug, then mixing oxidized-graphene, PyBA PEG FA and PyBA S S Drug according to a certain proportion, conducting stirring and time treatment to some degree to obtain a nano-drug carrier solution with a certain concentration. The preparing method of the oxidized-graphene nano-drug carrier is simple in technology, and the obtained nano-drug carrier has high drug-carrying efficiency, and has a redox-responsive property and targeting property; meanwhile, various kinds of materials used for preparing the carrier have good biocompatibility.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a graphene oxide-based nano drug carrier with targeting effect and a preparation method thereof. Background technique [0002] With the increasing development of nanotechnology and biopharmaceuticals, nano drug carriers have become a hot research field. Nano-drug carriers can efficiently load drugs, deliver targeted drugs and release drugs in a controlled manner. And it can prolong the action time of the medicine, and has the advantages of biocompatibility, small toxic and side effects, and the like. Nano-drug carriers can be divided into nanoparticles, nano-liposomes, polymer gels and nano-magnetic particles. Common nano-drug carriers include carbon nanotubes, microspheres, liposomes, or ferrite magnetic particles, which load drugs through surface adsorption, hydrogen bonding, intercalation, or other reactions. [0003] Graphene is a new type of nanomaterial with two-dimensional honey...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/54A61K47/22A61K45/00A61P35/00
CPCA61K47/02A61K45/00A61K47/22
Inventor 魏伟潘祥华
Owner CHANGZHOU IND TECH RES INST OF ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com