The present invention discloses a
drug sustained and
controlled release microparticle preparation for treating intestinal diseases. The preparation comprises: a
pill core containing the
drug, wherein the
pill core contains 5-
aminosalicylic acid and an assistant material; an
isolation layer for providing a smooth and flat surface for the
microparticle and preventing the
drug from penetrating into a sustained release
coating layer, wherein the penetration of the drug into the sustained release
coating layer can affect the release effect, the used material of the
isolation layer comprises one or a plurality of materials selected from a water-
soluble polymer and an anti-adhesion agent; the sustained release
coating layer for slowly releasing the drug, wherein different
drug release levels can be achieved through adjusting the thickness of the sustained release coating layer, the used material of the sustained release coating layer mainly adopts a sustained-release material; an enteric-coating layer, the enteric-coating layer is provided for avoiding the
early release of the drug in gastric juice, reducing stimulation of the main drug to
stomach, increasing the local concentration of the drug in the
lesion location, the used material of the enteric-coating layer mainly adopts a
polymer enteric material. The invention further discloses a preparation method for the
microparticle preparation. According to the present invention, the drug and the sustained release coating material are uniformly dispersed on the surface of the pellet, such that the problem of mixing uniformity of the assistant material and the main drug can be effectively solved.