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54results about How to "Avoid early release" patented technology
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Drug sustained and controlled release microparticle preparation for treating intestinal diseases, and preparation method thereof
ActiveCN102319218AEvenly distributedGuaranteed uniformityPowder deliveryOrganic active ingredientsDiseaseAnti-Adhesion Agent
The present invention discloses a drug sustained and controlled release microparticle preparation for treating intestinal diseases. The preparation comprises: a pill core containing the drug, wherein the pill core contains 5-aminosalicylic acid and an assistant material; an isolation layer for providing a smooth and flat surface for the microparticle and preventing the drug from penetrating into a sustained release coating layer, wherein the penetration of the drug into the sustained release coating layer can affect the release effect, the used material of the isolation layer comprises one or a plurality of materials selected from a water-soluble polymer and an anti-adhesion agent; the sustained release coating layer for slowly releasing the drug, wherein different drug release levels can be achieved through adjusting the thickness of the sustained release coating layer, the used material of the sustained release coating layer mainly adopts a sustained-release material; an enteric-coating layer, the enteric-coating layer is provided for avoiding the early release of the drug in gastric juice, reducing stimulation of the main drug to stomach, increasing the local concentration of the drug in the lesion location, the used material of the enteric-coating layer mainly adopts a polymer enteric material. The invention further discloses a preparation method for the microparticle preparation. According to the present invention, the drug and the sustained release coating material are uniformly dispersed on the surface of the pellet, such that the problem of mixing uniformity of the assistant material and the main drug can be effectively solved.
Owner:PIVOT PHARMA TECH SHANGHAI
Method for preparing three-dimensional porous stent composite layer
The invention discloses a method for preparing a three-dimensional porous stent composite layer, and belongs to the technical field of biomaterials. In order to prevent inflammatory reaction caused by drop of scraps of a stent due to a dynamic action, a coating film is required on the surface of a porous ceramic stent, and addition of hydroxyapatite powder fills up a voidness defect of the surface layer of the stent so as to improve the strength of the stent; a porous calcium phosphate ceramic stent is compounded by a polylactic acid solution added with hydroxyapatite and a growth factor-loaded hydrogel solution; growth factors loaded in the hydrogel can be slowly released to a human part needing the growth factors under the joint action of own diffusion and slow degradation of polymeric hydrogel so as to promote vascular endothelial growth of a tissue and proliferation and differentiation of an osteoblast; and the stent is gradually degraded and eventually transformed into a bone; and the method is mainly used for preparing the three-dimensional porous stent composite layer.
Owner:SOUTHWEST JIAOTONG UNIV
ROS-responsive nanoparticle and application thereof in precise tumor treatment mediated by acoustic dynamic
ActiveCN110354273AImprove the effect of treatmentPrecision therapyPowder deliveryOrganic active ingredientsAntineoplastic drugRos responsive
The invention discloses an ROS-responsive nanoparticle and application thereof in precise tumor treatment mediated by acoustic dynamic. An ROS sensitive molecule TL is utilized to be connected with anantitumor drug PTX and a hydrophilic fragment NH2-PEG1K-NH2 to obtain an amphipathic ROS sensitive fragment PTX-TL-PEG1K-NH2, and then an ultrasonic emulsification method is utilized to obtain the ROS-responsive nanoparticle loaded with a sensitizer IR780; the prepared nanoparticle can generate ROS under the action of external ultrasound to not only kill tumor cells, but also make the nanoparticle release the PTX to kill the tumor cells, thereby forming a cascading amplification synergistic effect during tumor treatment by the acoustic dynamic to achieve precise tumor treatment.
Owner:XI AN JIAOTONG UNIV
Oxidative stress drug system with charge reversal capability and preparation method of oxidative stress drug system
ActiveCN110575545AHigh drug loadingSmart Release of Drug EffectsHeavy metal active ingredientsOrganic active ingredientsTherapeutic effectTumor cells
The invention discloses a drug carrier system, which is obtained by the following steps: taking hollow manganese dioxide (HMDN) as a matrix, loading a coordination polymer (GA-Fe) of gallic acid and iron, encapsulating by branched polyethyleneimine (PEI), and encapsulating by polyaspartic acid (PASP-API) grafted with imidazole. According to the drug carrier system provided by the invention, through ionization of imidazolyl, charge reversal of the drug carrier can be realized to overcome an EPR effect to reach a tumor site. Meanwhile, the drug carrier system is decomposed in a tumor cell subacid environment, GA-Fe is released to serve as a catalyst of a Fenton reaction, hydrogen peroxide in tumor cells can continuously generate hydroxyl radicals (.OH), and the tumor cells are killed; and HMDN can react with glutathione (GSH) in tumor cells, .OH consumed by GSH is effectively inhibited, oxidative stress in the cells is enhanced, and the treatment effect is greatly improved.
Owner:HUBEI UNIV
Preparation of cross-linked nano-micelle with redox sensitive performance
The invention discloses a cross-linked nano-micelle with redox sensitive performance and a preparation method of the cross-linked nano-micelle. The preparation method comprises the following steps: a reversible addition-fragmentation chain transfer polymerization method is adopted, a macromolecular chain transfer agent is synthesized firstly and polymerized with poly(ethylene glycol) methacrylate to synthesize a block polymer which can be further modified, on the basis of self-assembly, a cross-linking agent having chemical linking capacity and containing a disulfide bond is introduced, and one stably cross-linked nano-micelle with the redox response performance is constructed in a mode of assembly and later cross-linking. The method is easy to control, the reaction conditions are mild, a metal catalyst is avoided, a product is easy to purify, and the obtained nano-micelle not only can package a hydrophobic drug but also can prevent the drug from being released in advance in blood circulation.
Owner:XIAMEN UNIV
Liposome-nanoparticle hybrids for treating chronic glomerulonephritis
PendingCN112076158AEasy to packFacilitated releaseOrganic active ingredientsInorganic non-active ingredientsAntiendomysial antibodiesAnti fibrotic
The invention provides antibody-modified liposome-nanoparticle hybrids (Liposome-nanoparticle hybrids, LNHy) with a lipid shell and a nanoparticle core, which take charged nanoparticles as an inner core, and a liposome phospholipid bilayer with opposite charges is coated onto the surface to form a cell-like structure with a core-shell. The hybrids have targeting ability and can encapsulate an anti-inflammatory drug and an anti-fibrosis drug which have prevention and / or treatment effects on chronic glomerulonephritis, so that the effective treatment effect of double regulation and control on chronic glomerulonephritis is realized.
Owner:SOUTHWEST UNIVERSITY FOR NATIONALITIES
Front-end rear release mechanism of interventional stent conveyor, conveyor and using method
PendingCN113599040ARelease function after implementing the front endAvoid early releaseStentsEngineeringMechanical engineering
The invention provides a front-end rear release mechanism of an interventional stent conveyor, a conveyor and a using method. The front-end rear release function of an interventional stent is achieved by arranging a moving claw capable of moving on a first limiting piece in the axial direction on a front-end assembly and connecting the moving claw with a metal block of a rear-end assembly of the conveyor through a drawing wire. The rear end assembly realizes positioning locking and axial movement of a release sleeve and a screw rod through a guide locking mechanism arranged on the release sleeve and the screw rod, so that positioning locking and axial movement of the moving claw on the first limiting piece are realized, and the problem that the interventional stent is released in advance due to the fact that the moving claw is unlocked in advance can be solved; and meanwhile, the problem that the interventional stent cannot be released due to the fact that the moving claw cannot be unlocked can be solved. The guide locking mechanism is designed to be a guide column and an L-shaped guide groove formed in the outer surface of the screw rod, it is guaranteed that the front-end rear release mechanism is safe in self-locking and rapid in unlocking, and the safety, reliability and positioning accuracy of the conveyor are further improved.
Owner:北京有卓正联医疗科技有限公司
Cross-linkable mitochondrial targeting pegylated phospholipid medicinal material and preparation method and application thereof
ActiveCN105031657AProlong circulation time in the bodyGood long cycle functionOrganic active ingredientsMacromolecular non-active ingredientsSide effectOrganic base
The invention discloses a cross-linkable mitochondrial targeting pegylated phospholipid medicinal material. Please see the structural formula of the cross-linkable mitochondrial targeting pegylated phospholipid medicinal material in the specification, wherein n is equal to 10, 12, 14 and 16. The preparation method includes the steps that fatty acid acyl phosphatidylethanolamine-polyethylene glycol(peg)-maleimide, polypeptide D- (KLAKLAK)2-C5 and organic base serve as raw materials, and the molecular ratio of the polypeptide to the organic base to the fatty acid acyl phosphatidylethanolamine-polyethylene glycol(peg)-maleimide is (1-3): (1-3):1; under protection of nitrogen, the fatty acid acyl phosphatidylethanolamine-polyethylene glycol(peg)-maleimide, the organic base and a first solvent are mixed so that a first solution can be obtained, the polypeptide is dissolves in a second solvent so that a second solution can be obtained, the first solution and the second solution are mixed, and a mixed solution is stirred to react for 12-8 h at the temperature of 20-40 DEG C. Medicine carrying liposome prepared from the medicinal material can further improve the tumor treatment effect, the toxic and side effects are reduced, and long-time preservation is facilitated.
Owner:SICHUAN UNIV
Doxorubicin prodrug for combined use of tumor penetration enhanced photo-thermal and chemotherapy and preparation method of doxorubicin prodrug
ActiveCN114209824AGive full play to the effect of chemotherapyImprove drug utilizationOrganic active ingredientsDrug photocleavageChemo therapyTumor cells
The invention discloses an adriamycin prodrug for combined use of tumor penetration enhanced photothermal and chemotherapy and a preparation method of the adriamycin prodrug. The preparation method comprises the following steps: after DOX and NPC-PEG-SH react, connecting a sulfydryl end with a photothermal conversion material to synthesize DOX-photothermal conversion nanoparticles; further, a hydrazone bond is introduced into PEG and PCL to prepare pHPP; finally, the DOX-photothermal conversion nanoparticles are coated with the pHPP, and the DOX prodrug is prepared. The nano-drug prepared by the invention has the characteristic of combined use of photothermal and chemotherapy with enhanced in-tumor permeation, and can more effectively resist tumor cells. The nano-drug has an intelligent size regulation strategy, has a large size in blood to enhance long circulation, is disintegrated into small-size DOX-photothermal conversion nano-particles in a tumor to enhance permeation, and can generate heat under near-infrared illumination to release DOX after penetrating into the deep part of the tumor, so as to achieve the purpose of enhancing the penetration of the DOX-photothermal conversion nano-particles. Therefore, the aim of combining photo-thermal and chemotherapy is fulfilled.
Owner:HUAIYIN INSTITUTE OF TECHNOLOGY
Release assembly of implantation instrument, implantation instrument conveyor and implantation instrument conveying system
The invention relates to a release assembly of an implantation instrument, an implantation instrument conveyor and an implantation instrument conveying system. The release assembly of the implantationinstrument comprises a sheath core tube and an anchoring device arranged on the sheath core tube in a sleeving mode, wherein the sheath core tube and the anchoring device can be relatively separatedalong the axial direction, the release assembly of the implantation instrument further comprises a rear release assembly, the rear release assembly comprises a control member and a locking member, thecontrol member is connected with the near end of the sheath core tube, the axial displacement of the control member drives the sheath core tube to slide axially, the sheath core tube slides axially to enable the sheath core tube and the anchoring device to be separated relatively in the axial direction, and the locking member is connected with the control member and used for limiting rotation andaxial displacement of the control member. The release assembly of the implantation instrument can prevent the implantation instrument from being released in advance.
Owner:LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
Preparation method and application of gold-platinum composite nanometer diagnosis and treatment agent
ActiveCN110755640AEnables trimodal imagingRealize photothermal imagingEnergy modified materialsGeneral/multifunctional contrast agentsCancer cellPeroxidase
The invention provides a preparation method and application of a gold-platinum composite nanometer diagnosis and treatment agent, and relates to a method for obtaining Au2Pt-PEG-PS (PS: photosensitizer) through the steps of synthesizing Au2Pt nanometer particles by using L-proline as a chelating agent and L-ascorbic acid as a reducing agent and performing post modification, and an application of the Au2Pt-PEG-PS (PS: photosensitizer). The Au2Pt-PEG-PS nanometer particles have catalase activity and peroxidase activity, and can react with hydrogen peroxide (H2O2) overexpressed in tumors under the weak acid condition to produce oxygen (O2) and high-toxicity active oxygen hydroxyl radicals (.OH) in situ, so that the effects of overcoming anoxia, strengthening light power effects and killing cancer cells can be achieved. Au2Pt alloy further can realize multimode imaging of CT imaging, photoacoustic imaging, photothermal imaging and the like at the same time, and united treatment and diagnosis and treatment integration are realized.
Owner:ZHEJIANG NORMAL UNIVERSITY
Phototherapy nano preparation based on chemical cross-linking as well as preparation method and application thereof
ActiveCN106890341AAvoid early releaseInhibition of self-quenching effectPowder deliveryEnergy modified materialsCross-linkCancer cell
The invention discloses a preparation method and application of a novel phototherapy nano preparation based on polyhedral oligomeric silsesquioxane (POSS). The phototherapy nano preparation is prepared by forming nano particles by chemical cross-linking reaction between amino of the POSS and carboxyl of a photosensitizer and then performing surface pegylation. The nano preparation has the benefits that the photosensitizer is taken as one part by utilizing a chemical cross-linking method, so that the ultra-high drug loading capacity is realized; the advance drug leakage is avoided; a self-quenching effect of the photosensitizer is inhibited. Meanwhile, the drug has good water dispersibility, stability and biosafety. In addition, the phototherapy nano preparation can be endocytosed by cancer cells in large quantities and efficiently kill the cancer cells under light conditions. An in-vivo animal experiment proves that the phototherapy nano preparation can be enriched to a tumor area through passive targeting, so that tumor imaging and photodynamic therapy are realized.
Owner:SOUTHEAST UNIV
Drug delivery and controlled release system with tumor initiation targeting capability and preparation method thereof
ActiveCN109260175AGood biocompatibilityIncrease the areaOrganic active ingredientsPharmaceutical non-active ingredientsSide effectTumor initiation
The invention relates to a drug delivery and controlled release system with tumor initiation targeting capability and a specific preparation method thereof, the controlled release system has a three-layer core-shell structure, wherein the inner layer is mesoporous silicon nanoparticles loaded with drugs, the pores of the mesoporous silicon nanoparticles loaded with drugs are sealed with activatednanodiamond, the middle layer is a polylysine layer, and the outer layer is a maleic anhydride polylysine layer. The preparation process comprises the following steps: preparing sulfhydryl-functionalized hollow mesoporous silicon HMSN-SH, S-(2-aminoethylmercapto) 2-acrylpyridine hydrochloride, functionalization of disulfide, drug-loaded nanoparticles, preparation of adamantane-terminated polylysine, preparation of maleic anhydride-terminated polylysine, self-decoration of polylysine layer by layer, self-decoration of maleic anhydride-terminated polylysine layer by layer; the drug delivery system has good passive targeting ability and stealth property. The drug system is enriched and released in cancer tissues. The drug utilization rate is high, and the toxicity and side effects are small.
Owner:HUBEI UNIV
Antileukemie GSH/pH responsive nanometer drug delivery system and preparation method thereof
InactiveCN109180835AAvoid early releaseAchieve stabilityPharmaceutical non-active ingredientsEmulsion deliveryTherapeutic effectBULK ACTIVE INGREDIENT
The invention relates to an antileukemie GSH / pH responsive nanometer drug delivery system and a preparation method thereof. A cross-linking compound of hydrophobic antineoplastic drug 6-thioguanine and biodegradable aldehyde sodium alginate is an active ingredient of the system. The system is prepared according to the following steps: oxidizing sodium alginate with sodium periodate, thereby acquiring aldehyde sodium alginate; grafting 6-thioguanine onto the molecular chain of aldehyde sodium alginate through schiff base reaction, thereby acquiring a pH responsive polymer prodrug; and acquiringdisulfide bond cross-linking polymer prodrug micelle in the manner of ultrasonically-assisted self-assembling in a buffer solution, thereby endowing particles with GSH and pH responsiveness. The preparation method provided by the invention is simple, is capable of promoting water solubility of 6-thioguanine and inhibition ratio of tumor cells, is capable of reducing toxic or side effect of normalcells and is expected to achieve the purpose of obviously promoting the therapeutic effect of chemotherapeutic drugs for leukemia.
Owner:WUHAN UNIV OF TECH
Filter chamber pressure-bearing open-and-close component for filtering element of flexible tube squeezer
InactiveCN102233202AImprove structural strengthReduce weightStationary filtering element filtersSlurryHigh pressure
The invention provides a filter chamber pressure-bearing open-and-close component for a filtering element of a flexible tube squeezer. In the invention, a flexible tube squeezer is high-pressure solid-liquid separation equipment for deep dehydration; and the filter chamber pressure-bearing open-and-close component for the filtering element of the flexible tube squeezer is a component combining a push-pull clamping force balance mechanism with a pressure-applying structure, and the component is related to maintenance of pressure in a filter chamber during the slurry squeezing process and discharge of a filter cake after squeezing. The push-pull clamping force balance mechanism comprises a front swing pressure-bearing plate, a rear swing pressure-bearing plate, an electric actuating mechanism, an upper push-pull cam plate, a lower push-pull cam plate, a traveling mechanism and a horizontal shaft; and by utilizing the component, the filtering element of the flexible tube squeezer can also replace the traditional plate-and-frame diaphragm of a plate-and-frame diaphragm squeezer. The filter chamber pressure-bearing open-and-close component has the advantages of simplified structure, easily controlled sealing pressure, greatly strengthened reliability, lowered manufacturing accuracy and prolonged service life; the component can assist in automatically completing the treatment process and is more beneficial to making big filtering element so as to realize ultra-large-scale treatment; and in addition, the equipment can be loaded on a transport vehicle to form mobile dewatering equipment.
Owner:张民良
Method and system for control conversation timer in conversation iniatial protocol network
InactiveCN1859428AReduce duplicate sendingImprove business qualityTransmissionTimerSession Initiation Protocol
The present invention discloses controlling session timer method in session initiation protocol (SIP) network, said method used in application service server (AS) and backward transaction user (TU) solid system, said backward TU solid configured having session timer. Said method includes A, said AS determining said session timer duration and transmitting to backward TU solid; B, step A mentioned backward TU solid according to received session timer duration to reconfigure own session timer. The present invention also discloses a system. The present invented method and system can reduce temporary responsive repeating transmission.
Owner:HUAWEI TECH CO LTD
Endoscope double-arm closing clamp for closing digestive tract perforation
The invention discloses an endoscope double-arm closing clamp for closing a digestive tract perforation. The closing clamp comprises a releasable clamping head assembly, a connecting block and a releasing assembly. Through the handheld part of an sliding operating handle, a side tong head can be independently controlled, and the clamping head assembly can be released. The closing clamp can processlarge perforation, the tong head can be repeatedly opened and closed, the tong head can be independently controlled, and meanwhile misoperation is prevented.
Owner:苏军凯
Preparation and application method of near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks
InactiveCN111228506APlay a closed roleAvoid early releaseOrganic active ingredientsInorganic non-active ingredientsCyclodextrinBiocompatibility
The invention relates to a preparation method of a near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks. The preparation method comprisesthe steps of preparing up-conversion nanoparticles having a core / shell structure by a coprecipitation method, and through a polymer modification method, enabling the up-conversion nanoparticles to have water-solubility; by a hydrothermal method, enabling the metal-organic frameworks to grow on the surfaces of the up-conversion nanoparticles to obtain the core / shell structure of the up-conversionnanoparticle @ metal-organic frameworks; and modifying azobenzene to the surfaces of the metal-organic frameworks, loading cancer treatment medicines to the metal-organic frameworks, and through subject and object action between azobenzene and cyclodextrin, enabling the cyclodextrin to be located on the surfaces of the metal-organic frameworks, so that medicines loaded in the metal-organic frameworks can achieve the enclosing effects, and release is realized through illumination with near infrared light. The method is simple to prepare, good in repeatability and good in biocompatibility. The near infrared light which has deep penetrating depth to biologic tissue can achieve the effect of controlled release of the medicines.
Owner:NORTHWESTERN POLYTECHNICAL UNIV
Magnetic field control spiral nano robot for targeted drug delivery
InactiveCN112791064ALow costEasy to operateOrganic active ingredientsEnergy modified materialsPolyethylene glycolPharmaceutical drug
The invention provides a magnetic field control spiral nano-robot for targeted drug delivery. The nano-robot comprises a spiral carbon nanotube matrix, a polyethylene glycol modification layer, magnetic nano drug-loaded particles and a target cell ligand. The spiral nano robot can achieve multiple functions of magnetic field driving, drug carrying, targeted cell recognition, controllable drug release, fluorescence feedback and the like, lays a foundation for scientific research and clinical treatment of drug delivery, and has potential application prospects in the field of biomedicine.
Owner:TSINGHUA UNIV
Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial
PendingCN113134096AAvoid early releaseHigh drug loading rateMaterial nanotechnologyPowder deliveryChemotherapeutic drugsOrganosilicon
The invention discloses a hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and a preparation method thereof. The hollow mesoporous organic silicon composite nanomaterial comprises hollow mesoporous organic silicon nanoparticles (HMON) and a drug and a magnetic resonance imaging (MRI) contrast agent, the drug is carried in a cavity of the HMON, and the MRI contrast agent is blocked in a pore channel of the HMON. The hollow mesoporous organic silicon composite nanomaterial can well avoid early release of chemotherapeutic drugs and further improve the drug loading rate. The hollow mesoporous organic silicon composite nano material induces biodegradation to release the medicine loaded in the cavity through GSH response in a tumor microenvironment, so that slow release and controlled release of the chemotherapeutic medicine in the tumor microenvironment are realized, and the toxic and side effects on normal tissue cells are very small while an ideal anti-tumor effect is fully played.
Owner:SOUTHERN MEDICAL UNIVERSITY
Oral nano-vaccine of large yellow croaker and immune type large yellow croaker feed prepared by the same
ActiveCN110935016ALow costSimple preparation processAntibacterial agentsPharmaceutical non-active ingredientsCelluloseMesoporous silica
The invention relates to an oral nano-vaccine of large yellow croaker and an immune type large yellow croaker feed prepared by the same. The oral nano-vaccine comprises MSN-DLDH nano-particles and enteric coatings coating the surfaces of the MSN-DLDH nano-particles. The MSN-DLDH nano particles are nano particles formed by assembling DLDH protein and a mesoporous silica micro-nano carrying system;and the enteric coatings are hydroxypropyl methylcellulose phthalate. The nano-vaccine disclosed by the invention has the advantages of low cost, simple preparation process, good capability of tolerating a strongly acidic stomach environment of fishes and the like. Besides, the vaccine has no toxicity to kidney cells of the large yellow croaker and is good in biocompatibility; and thus a technicalsupport is provided for research and development of oral nano-vaccines and clinical application in the future.
Owner:FUJIAN NORMAL UNIV
Water-soluble dropping pill prepared from porous material and preparation method thereof
PendingCN113088389AWill not overflowStable aroma releaseTobacco smoke filtersEssential-oils/perfumesEmulsionLatex rubber
The invention discloses a water-soluble dropping pill prepared from a porous material and a preparation method thereof. According to the water-soluble dropping pill prepared from the porous material, the water-soluble dropping pill comprises an inner layer, a middle layer and an outer layer; the inner layer is formed by loading water-soluble essence on the porous material, the middle layer is a gel layer formed by cross-linking reaction of sodium alginate and calcium salt, and the outer layer is a latex water locking layer formed by curing emulsion. According to the water-soluble dropping pill prepared from the porous material, the inner layer is formed by loading the water-soluble essence on the porous material, and compared with a traditional dropping pill with the inner layer only formed by the water-soluble essence, after the dropping pill is pinched broken, the water-soluble essence cannot directly and rapidly overflow out, the essence component is slowly released under the adsorption effect of the porous material so that the aroma release amount can be maintained in the stable state during the whole cigarette smoking process, and the requirements of consumers on the stable, slow and long-time stable release of the cigarette aroma during the cigarette smoking process can be met.
Owner:WUHAN HUANGHELOU FLAVOR & SPICES
Multifunctional drug carrier material based on gold nanocage and preparation method thereof
ActiveCN114042155AWith photothermalWith photoacoustic propertiesOrganic active ingredientsSugar derivativesArginineTumor targeting
The invention discloses a multifunctional drug carrier material based on a gold nanocage and a preparation method thereof. The preparation method comprises the following steps: preparing the gold nanocage through an electrochemical replacement reaction between silver nanocubes and chloroauric acid, modifying sulfydryl-polyethylene glycol-amino to the surface of the gold cage by utilizing relatively strong interaction between the gold nanocage and a thiol group, modifying a gemcitabine prodrug responded by glutathione modified by p-nitrophenyl through a chemical reaction, and loading positively charged L-arginine through electrostatic interaction, and finally, wrapping by a tumor cell membrane through a liposome squeezer, so as to obtain the cell membrane-wrapped drug-loaded gold nanocage. The drug carrier disclosed by the invention has multifunctionality, namely multidrug delivery capacity, glutathione-responsive drug release performance, photo-thermal performance, tumor deep penetration effect and tumor targeting, and can be used for combined treatment of pancreatic malignant tumors.
Owner:ZHEJIANG UNIV
Full-automatic raisin-adding bread baking machine
Owner:GUANGDONG XINBAO ELECTRICAL APPLIANCES HLDG CO LTD
Lumen stent
PendingCN114681117AImprove accuracyAvoid early releaseStentsBlood vesselsBiomedical engineeringGeneral surgery
The invention provides a lumen stent which comprises a tubular main body with a plurality of axial planes and a semi-release device connected to the tubular main body, the semi-release device comprises a limiting rod and a plurality of binding lines arranged on the tubular main body, the binding lines are all detachably connected with the limiting rod, and when the binding lines are connected with the limiting rod, the binding lines are separated from the limiting rod. A plurality of binding lines are arranged on the tubular main body, the limiting rods extend along a curve between every two adjacent binding lines, and the limiting rods are located in at least two axial planes on rod bodies of every two adjacent binding lines. The binding lines in the lumen stent circumferentially restrain the lumen stent, so that the lumen stent can be in a semi-release state; therefore, the lumen stent can be adjusted and positioned, and the accuracy of axial and circumferential positioning of the lumen stent is improved.
Owner:LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
Magnetic particle-modified hollow gold nanoparticles as well as preparation method and application thereof
PendingCN111888472AControl releaseAvoid early releaseOrganic active ingredientsEnergy modified materialsDrug carrierPharmaceutical drug
The invention relates to the technical field of medical nano materials, in particular to magnetic particle-modified hollow gold nano particles and a preparation method and application thereof. According to the magnetic particle-modified hollow gold nanoparticles, magnetic particles wrap the outer layers of the hollow gold nanoparticles, and pores of the hollow gold nanoparticles are filled. Underthe condition that drugs are loaded in the hollow gold nanoparticles, the magnetic particles can play a gating role and can prevent premature drug release. After a drug carrier reaches a diseased region, the magnetic particles are separated from the hollow gold nanoparticles due to the electric ion vibration and the heat effect of the gold nanoparticles under the irradiation of near-infrared light, and the loaded drugs can be rapidly released to diseased tissues from the pores of the hollow gold nanoparticles, so that the treatment effect is improved, and the damage to normal cells is reduced.
Owner:XINXIANG MEDICAL UNIV
A power control cabinet with a self-closing structure after a fire
ActiveCN114552410BPrevent escapeImprove securityBus-bar/wiring layoutsDispersed particle filtrationStructural engineeringMechanical engineering
Owner:南通华研自动化科技有限公司
Medicament for killing Solenopsis invicta, and preparation method thereof
The invention relates to a medicament for killing Solenopsis invicta, and a preparation method thereof. The medicament comprises, by weight, 0.13-0.24 part of fipronil, 2.5-5.5 parts of an indoxacarb / chitosan sustained-release microsphere, 0.3-0.8 part of a preservative, 1.5-3.5 parts of an adhesive, 30-40 parts of an attractant and 65-85 parts of a carrier; the surface of the indoxacarb / chitosansustained-release microsphere is coated with a layer of degradable film; and the carrier is one or a composition of two or more of wheat flour, sesame powder and corn flour. The preparation method ofthe medicament specifically comprises the following steps: S1, mixing and stirring the carrier and water to form an emulsion, adding active ingredients into the carrier emulsion, performing stirring until uniformity, adding the indoxacarb / chitosan sustained-release microsphere, and performing stirring until uniformity to prepare a mixed emulsion; S2, sequentially adding the adhesive, the attractant and the preservative into the mixed emulsion, and performing stirring until uniformity to prepare a primary medicament product; and S3, carrying out extrusion granulation, cooling and screening treatment on the primary medicament product to prepare the finished medicament finished product. The Solenopsis invicta killing durability of the medicament is improved.
Owner:深圳市威必达有害生物防治有限公司
Power control cabinet with self-sealing structure after fire
ActiveCN114552410APrevent escapeImprove securityBus-bar/wiring layoutsDispersed particle filtrationStructural engineeringMechanical engineering
The invention discloses an electric power control cabinet with a post-fire self-sealing structure, and belongs to the field of electric power control cabinets, and the electric power control cabinet with the post-fire self-sealing structure is characterized in that a plurality of ventilation slots are uniformly formed in a side cabinet plate, so that the interior of a cabinet body can be ventilated under daily conditions; the blocking plates are slidably connected into the cavities formed in the side cabinet plates, the conduction grooves corresponding to the ventilation grooves are evenly formed in the blocking plates, and the blocking plates are matched with supporting of the glass columns, so that the ventilation grooves can be automatically blocked in a staggered mode when fire breaks out in the cabinet body, flames in the cabinet body are effectively prevented from escaping outwards, and the service life of the cabinet body is prolonged. And the safety after the device is on fire is improved to a certain extent.
Owner:南通华研自动化科技有限公司
Cross-linkable mitochondria-targeted PEGylated phospholipid medicinal material and its preparation method and application
ActiveCN105031657BProlong circulation time in the bodyGood long cycle functionOrganic active ingredientsMacromolecular non-active ingredientsSide effectOrganic base
The cross-linkable mitochondria-targeting pegylated phospholipid pharmaceutical material of the present invention has the following structural formula: n=10, 12, 14, 16. Preparation method: using fatty acid acylphosphatidylethanolamine-polyethylene glycol-maleimide, polypeptide D-(KLAKLAK)2-C5 and organic base as raw materials, polypeptide, organic base, fatty acid acylphosphatidylethanolamine-polyethylene glycol The mol ratio of alcohol-maleimide is (1~3):(1~3):1; under nitrogen protection, fatty acid acylphosphatidylethanolamine-polyethylene glycol-maleimide, organic base Mixing with the first solvent to obtain a first solution, dissolving the polypeptide in a second solvent to obtain a second solution, mixing the first solution and the second solution, and stirring and reacting for 12 to 48 hours at 20 to 40° C. in the dark. The drug-loaded liposome prepared by using the medicinal material can further improve the tumor treatment effect, reduce toxic and side effects and facilitate long-term storage.
Owner:SICHUAN UNIV
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