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Preparation and application method of near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks

A technology of metal-organic frameworks and nanoparticles, which can be used in medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of no way to stimulate the nano drug-loaded system and poor UV penetration ability , uncontrollability and other problems, to achieve the effect of simple and easy preparation method, stable repeatability, and prevention of early release

Inactive Publication Date: 2020-06-05
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although some very good progress has been made in the construction of supramolecular nano-valve-gated NMOFs and the targeted release of drugs, there are still many problems to be solved. The most prominent problem is the use of The weak acidity of the tumor microenvironment or the various ions in the human body can control the drug release of nanosystems, which is uncontrollable; secondly, if ultraviolet light is used to induce drug release, due to the poor tissue penetration ability of ultraviolet light, there is no way to stimulate the drug release. to the nano-drug loading system, resulting in slow drug failure

Method used

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  • Preparation and application method of near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks
  • Preparation and application method of near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks
  • Preparation and application method of near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Weigh 210.83mg of YCl 3 ·6H 2 O, 116.25 mg YbCl 3 ·6H 2 O, 1.92 mg TmCl 3 ·6H 2 O was placed in a three-necked flask, added 6ml of oleic acid and 15ml of 1-octadecene, heated to 120°C to remove water for 30min, then heated to 160°C, reacted for 1h, and cooled to room temperature. Add 10ml of methanol solution containing 148.15mg of ammonium fluoride and 100mg of sodium hydroxide into it, and stir at room temperature for 30min, then raise the temperature to 70°C to remove the methanol in the system, and finally raise the temperature to 300°C for 1.5h, and cool to At room temperature, first add 10ml of ethanol to precipitate the generated upconverting nanoparticles, and centrifuge at 9000rpm for 5min, remove the supernatant, and the obtained precipitate is NaYF 4 : Yb, Tm. The precipitate was first washed with 5ml of ethanol and 5ml of water and centrifuged, repeated 3 times, then dispersed with cyclohexane, ethanol precipitated and centrifuged, repeated 3 times...

Embodiment 2

[0042] (1) Weigh 259.24mg of GdCl 3 ·6H 2 O, 116.25 mg YbCl 3 ·6H 2 O, 1.92 mg TmCl 3 ·6H 2 O was placed in a three-necked flask, added 6ml of oleic acid and 15ml of 1-octadecene, heated to 120°C to remove water for 30min, then heated to 160°C, reacted for 1h, and cooled to room temperature. Add 10ml of methanol solution containing 148.15mg of ammonium fluoride and 100mg of sodium hydroxide into it, and stir at room temperature for 30min, then raise the temperature to 70°C to remove the methanol in the system, and finally raise the temperature to 300°C for 1.5h, and cool to At room temperature, first add 10ml of ethanol to precipitate the generated upconversion nanoparticles, and centrifuge at 9000rpm for 5min, remove the supernatant, and the obtained precipitate is NaGdF 4 : Yb, Tm. The precipitate was first washed with 5ml of ethanol and 5ml of water and centrifuged, repeated 3 times, then dispersed with cyclohexane, ethanol precipitated and centrifuged, repeated 3 tim...

Embodiment 3

[0048] (1) Weigh 281.88mg of LuCl 3 ·6H 2 O, 116.25 mg YbCl 3 ·6H 2 O, 1.92 mg TmCl 3 ·6H 2 O was placed in a three-necked flask, added 6ml of oleic acid and 15ml of 1-octadecene, heated to 100°C to remove water for 60min, then heated to 160°C, reacted for 1h, and cooled to room temperature. Add 10ml of methanol solution containing 148.15mg of ammonium fluoride and 100mg of sodium hydroxide into it, and stir at room temperature for 60min, then raise the temperature to 80°C to remove the methanol in the system, and finally raise the temperature to 300°C for 1.5h, and cool to At room temperature, first add 10ml of ethanol to precipitate the generated upconverting nanoparticles, and centrifuge at 9000rpm for 5min, remove the supernatant, and the obtained precipitate is NaYF 4 : Yb, Tm. The precipitate was first washed with 5ml of ethanol and 5ml of water and centrifuged, repeated 3 times, then dispersed with cyclohexane, ethanol precipitated and centrifuged, repeated 3 time...

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Abstract

The invention relates to a preparation method of a near-infrared response drug sustained release system based on up-conversion nanoparticle @ metal-organic frameworks. The preparation method comprisesthe steps of preparing up-conversion nanoparticles having a core / shell structure by a coprecipitation method, and through a polymer modification method, enabling the up-conversion nanoparticles to have water-solubility; by a hydrothermal method, enabling the metal-organic frameworks to grow on the surfaces of the up-conversion nanoparticles to obtain the core / shell structure of the up-conversionnanoparticle @ metal-organic frameworks; and modifying azobenzene to the surfaces of the metal-organic frameworks, loading cancer treatment medicines to the metal-organic frameworks, and through subject and object action between azobenzene and cyclodextrin, enabling the cyclodextrin to be located on the surfaces of the metal-organic frameworks, so that medicines loaded in the metal-organic frameworks can achieve the enclosing effects, and release is realized through illumination with near infrared light. The method is simple to prepare, good in repeatability and good in biocompatibility. The near infrared light which has deep penetrating depth to biologic tissue can achieve the effect of controlled release of the medicines.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and relates to a method for preparing and using a near-infrared responsive drug sustained-release system based on upconversion nanoparticles@metal-organic framework. Background technique [0002] Nano metal-organic frameworks (Nano Metal-Organic Frameworks, NMOFs) are easy to prepare, with adjustable structure and pores, multifunctionality, and controllable particle size. Its large pores and large specific surface area enable it to load a large number of drug molecules. The skeleton structure formed by coordination makes it biodegradable. Therefore, NMOFs have broad application prospects in biomedicine. The novel molecular machine supramolecular nanovalve functionalized NMOFs has both the robustness of the traditional NMOFs drug delivery system and the accuracy and precision of the molecular machine; The problem of large pre-release volume faced by the delivery system can be i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/32A61K47/18A61K47/69A61K31/513A61P35/00
CPCA61K47/02A61K47/32A61K47/183A61K47/6951A61K31/513A61P35/00
Inventor 谭丽丽郭文锋尚利
Owner NORTHWESTERN POLYTECHNICAL UNIV
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