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Magnetic particle-modified hollow gold nanoparticles as well as preparation method and application thereof

A gold nanoparticle and magnetic particle technology, applied in the field of magnetic particle modified hollow gold nanoparticle and its preparation, can solve the problems of lack of anticancer drug delivery and drug controlled release, etc.

Pending Publication Date: 2020-11-06
XINXIANG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, the nanoparticles produced by these existing technologies can only be used as single-modal imaging contrast agents, and lack the design of anti-cancer drug delivery and drug controlled release, such as; enhanced lingering time in the human body, sufficient drug loading, reasonable controlled release of drugs, etc.

Method used

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  • Magnetic particle-modified hollow gold nanoparticles as well as preparation method and application thereof
  • Magnetic particle-modified hollow gold nanoparticles as well as preparation method and application thereof
  • Magnetic particle-modified hollow gold nanoparticles as well as preparation method and application thereof

Examples

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Embodiment

[0038] This example prepares hollow gold nanoparticles modified with superparamagnetic particles loaded with drugs, and the process flow chart is as follows figure 1 Shown, the specific preparation method is:

[0039] 1) Preparation of superparamagnetic particles (SPIO)

[0040] Hydrophilic superparamagnetic magnetite (SPIO) was synthesized by chemical co-precipitation method. 10 mmol of iron(III) chloride and 5 mmol of iron(II) chloride were dissolved in 24 ml of aqueous hydrochloric acid (HCl 1M). Then, under the protection of dry nitrogen, the solution was added dropwise into a 1M NaOH aqueous solution, and mechanically stirred for 60 minutes at room temperature. Subsequently, 5 g of citric acid (Citric acid; CA) was added, and mechanically stirred at 80° C. for 30 minutes. The black precipitate was subjected to magnetic separation, washed three times with absolute ethanol, and then dispersed in 20 ml of dichloromethane. The solution was shaken ultrasonically for 10 min...

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Abstract

The invention relates to the technical field of medical nano materials, in particular to magnetic particle-modified hollow gold nano particles and a preparation method and application thereof. According to the magnetic particle-modified hollow gold nanoparticles, magnetic particles wrap the outer layers of the hollow gold nanoparticles, and pores of the hollow gold nanoparticles are filled. Underthe condition that drugs are loaded in the hollow gold nanoparticles, the magnetic particles can play a gating role and can prevent premature drug release. After a drug carrier reaches a diseased region, the magnetic particles are separated from the hollow gold nanoparticles due to the electric ion vibration and the heat effect of the gold nanoparticles under the irradiation of near-infrared light, and the loaded drugs can be rapidly released to diseased tissues from the pores of the hollow gold nanoparticles, so that the treatment effect is improved, and the damage to normal cells is reduced.

Description

technical field [0001] The invention relates to the technical field of medical nanomaterials, in particular to a hollow gold nanoparticle modified by magnetic particles and a preparation method and application thereof. Background technique [0002] Cancer is the most important health problem in the world, and chemotherapy is one of the most commonly used methods in anti-cancer treatment. However, traditional chemotherapy has side effects such as killing normal cells, damaging the human immune system and prone to recurrence. To reduce these side effects and improve therapeutic efficacy, researchers have focused on the development of drug-loaded nanoparticles and targeted nanoparticle-based anticancer drug delivery systems. [0003] In the targeted drug delivery system based on nanoparticles, it is a key technology to design a reasonable and effective drug carrier. The ideal drug carrier should have good space, time and dose control functions, such as when the drug carrier is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/52A61K31/704A61K49/04A61K49/08A61K49/18A61P35/00B22F1/02B22F1/00B22F9/24
CPCA61K41/0052A61K47/52A61K31/704A61K49/04A61K49/08A61K49/1824A61P35/00B22F9/24B22F1/07B22F1/145B22F1/16
Inventor 金珍范晓峰常金龙赵俊强于毅李忠伟顿雁兵申杰奋
Owner XINXIANG MEDICAL UNIV
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