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Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial

A composite nanomaterial and magnetic resonance imaging technology, which is applied in drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of reduced loading of anti-tumor drugs, cytotoxic side effects, and easy release and other issues, to achieve huge application transformation potential, high-efficiency chemotherapy effect, and slow-controlled release effect

Pending Publication Date: 2021-07-20
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at the same time, due to the existence of large cavities in HMON, most chemotherapeutic drugs cannot be stably loaded in HMON, and are easily eluted during the preparation process, resulting in a decrease in the loading of anti-tumor drugs, and are easily released during blood circulation. Normal tissues and cells produce unwanted toxic side effects

Method used

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  • Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial
  • Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial
  • Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] This implementation provides a hollow mesoporous organosilicon composite nanomaterial. FeGd-HN contrast agent is used to block HMON loaded with doxorubicin (DOX) to obtain HMON@DOX@FeGd-HN, and then RGD2 polypeptide is coupled.

[0108] The specific preparation method of the hollow mesoporous organosilicon composite nanomaterial comprises the following steps:

[0109] (1) Preparation of HMON

[0110] The HMON used in the present invention is based on the literature "Fan W, Lu N, Shen Z, et al. Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy [J]. Nature communications, 2019, 10(1):1-14." prepared by the method disclosed, the mesoporous template used is cetyltrimethylammonium chloride (CTAC), and the organosilicon source is bis-[3-(triethoxy silyl)propyl]-tetrasulfide (BTES).

[0111] Specifically, 2 g of CTAC and 0.1 g of triethanolamine were dissolved in 20 mL of water, stirred vi...

Embodiment 2

[0173] This implementation provides a hollow mesoporous organosilicon composite nanomaterial. FeGd-HN contrast agent is used to block paclitaxel (TAX)-loaded HMON to obtain HMON@TAX@FeGd-HN. The specific preparation method is as follows:

[0174]Mix 0.2 mL of the HMON2 solution (10.6 mg / mL) prepared in Example 1 with 0.4 mL of paclitaxel TAX solution (1.16 mg / mL) under ultrasonic conditions, and add water to keep the final total reaction solution volume at 1 mL, and stir in the dark TAX was loaded for 24 hours, centrifuged, washed 5 times with pure water, and HMON2@TAX was collected; then it was dispersed to 1mL C under ultrasonic conditions. Gd 5mM, C Fe = 10.2mM FeGd-HN solution, then magnetically stirred for 3 hours, and then the nanoparticles were centrifuged at 20000rpm for 20 minutes, and then washed 5 times with pure water, that is, the obtained FeGd-HN plugged hollow mesoporous silicon Drug controlled sustained release composite nanoparticles (HMON2@TAX@FeGd-HN3).

Embodiment 3

[0176] This implementation provides a hollow mesoporous organosilicon composite nanomaterial. FeGd-HN contrast agent is used to block HMON loaded with cisplatin (DDP) to obtain HMON@DDP@FeGd-HN. The specific preparation method is as follows:

[0177] 0.2 mL of the HMON2 solution (10.6 mg / mL) prepared in Example 1 was mixed with 0.4 mL of cisplatin DDP solution (1.16 mg / mL) under ultrasonic conditions, and water was added to keep the final total reaction solution volume at 1 mL, protected from light Stir for 24 hours to load DDP, centrifuge, wash with pure water 5 times, collect HMON2@TAX, and then disperse it to 1mL C under ultrasonic conditions. Gd 5mM, C Fe = 10.2mM FeGd-HN solution, then magnetically stirred for 3 hours, and then the nanoparticles were centrifuged at 20000rpm for 20 minutes, and then washed 5 times with pure water, that is, the obtained FeGd-HN plugged hollow mesoporous silicon Drug controlled sustained release composite nanoparticles (HMON2@DDP@FeGd-HN3)....

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Abstract

The invention discloses a hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and a preparation method thereof. The hollow mesoporous organic silicon composite nanomaterial comprises hollow mesoporous organic silicon nanoparticles (HMON) and a drug and a magnetic resonance imaging (MRI) contrast agent, the drug is carried in a cavity of the HMON, and the MRI contrast agent is blocked in a pore channel of the HMON. The hollow mesoporous organic silicon composite nanomaterial can well avoid early release of chemotherapeutic drugs and further improve the drug loading rate. The hollow mesoporous organic silicon composite nano material induces biodegradation to release the medicine loaded in the cavity through GSH response in a tumor microenvironment, so that slow release and controlled release of the chemotherapeutic medicine in the tumor microenvironment are realized, and the toxic and side effects on normal tissue cells are very small while an ideal anti-tumor effect is fully played.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hollow mesoporous organosilicon composite nanomaterial with functions of reverse contrast magnetic resonance imaging and drug controlled release and a preparation method thereof. Background technique [0002] Tumor is a disease with high morbidity and mortality. Although various anti-tumor methods have been developed, chemotherapy is still the most widely used treatment for tumors. Conventional cancer chemotherapy usually leads to severe systemic toxicity under the action of highly toxic drugs, and at the same time, the efficacy of tumor drugs is also greatly reduced. In fact, strong toxic side effects and low chemotherapy effect have become one of the main causes of death of cancer patients. Therefore, the construction of an ideal drug-loading system must satisfy the ability to deliver therapeutic drugs during the systemic circulation without premature leakage, a...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/64A61K45/00A61K51/08A61K51/12A61P35/00B82Y5/00B82Y25/00B82Y30/00B82Y40/00
CPCA61K47/6929A61K47/64A61K51/08A61K51/1251A61K45/00B82Y5/00B82Y25/00B82Y30/00B82Y40/00A61P35/00
Inventor 沈折玉黄林
Owner SOUTHERN MEDICAL UNIVERSITY
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