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Glucan hydrogel and preparation method thereof

A technology of dextran and type dextran, which is applied in the fields of dextran hydrogel and its preparation, pH/redox dual-responsive dextran hydrogel and its preparation, and can solve problems such as complex reaction process and conditions , to achieve the effect of simple reaction conditions

Inactive Publication Date: 2019-01-08
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the multi-step method is mainly used to prepare pH / redox dual responsive hydrogels, and the reaction process and conditions are relatively complicated.

Method used

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  • Glucan hydrogel and preparation method thereof
  • Glucan hydrogel and preparation method thereof
  • Glucan hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of aldylated dextran:

[0029] Dissolve 5g of dextran (molecular weight: 10000g / mol) in 50mL of deionized water at room temperature, heat in an oil bath for 20 minutes until clear and transparent, and obtain an aqueous solution of dextran, add sodium periodate after cooling to room temperature to obtain a mixed solution, and mix the solution Medium sugar unit and sodium periodate medium IO 4 - The molar ratio of the solution was 1:2, stirred at room temperature and protected from light for 2 hours, dialyzed the resulting solution for 3 days, changed the water every 3 hours during the dialysis, and freeze-dried after the dialysis was completed, so that the degree of formylation was about 50% (that is, every 50 out of 100 sugar units are oxidized) aldehylated dextran solid; its infrared spectrum is as follows figure 1 As shown, 1729.84cm in the picture -1 is the stretching vibration absorption peak of C=O in the aldehyde group;

[0030] (2) Preparation...

Embodiment 2

[0034] (1) Preparation of aldylated dextran:

[0035] Dissolve 5g of dextran (molecular weight: 20,000g / mol) in 50mL of deionized water at room temperature, heat for 20min until it becomes clear and transparent, and obtain an aqueous solution of dextran. After cooling to room temperature, add sodium periodate to obtain a mixed solution. The sugar in the mixed solution unit with sodium periodate in IO 4 - The molar ratio is 1:1, stirred at room temperature and protected from light for 4 hours, dialyzed the resulting solution for 4 days, changed the water every 4 hours during the dialysis, freeze-dried after the dialysis, and obtained the aldehyde group with a degree of aldehydesylation of about 60%. Dextran solid;

[0036] (2) Preparation of pH / redox dual responsive dextran hydrogel:

[0037] Dissolve 0.075 g of the solid formylated dextran obtained in step (1) in 1.0 mL of deionized water to prepare a solution of formylated dextran with a concentration of 75 mg / mL. At room...

Embodiment 3

[0039] (1) Preparation of aldylated dextran:

[0040] Dissolve 5g of dextran (molecular weight: 40,000g / mol) in 50mL of deionized water at room temperature, heat for 20min until clear and transparent to obtain an aqueous solution of dextran, add sodium periodate after cooling to room temperature to obtain a mixed solution, and mix sugar in the solution unit with sodium periodate in IO 4 - The molar ratio of the solution is 1.5:1, stirred at room temperature and protected from light for 6 hours, dialyzed the resulting solution for 5 days, changed the water every 5 hours during dialysis, freeze-dried after the dialysis, and obtained an aldehyde group with a degree of aldehydesylation of about 70%. Dextran solid;

[0041] (2) Preparation of pH / redox dual responsive dextran hydrogel:

[0042] Dissolve 0.1 g of the solid formylated dextran obtained in step (1) in 1.0 mL of deionized water to prepare a solution of formylated dextran with a concentration of 100 mg / mL. At room tem...

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Abstract

The invention discloses a pH / redox double responsive glucan hydrogel and a preparation method thereof and belongs to the technical field of biomedical functional high molecular materials. The preparation method comprises the following steps: preparing formylated glucan by oxidizing sodium periodate with sodium periodate; dissolving glucan in deionized water to prepare an aqueous solution of certain concentration; adding a crosslinking agent containing amino and disulfide bonds into the aqueous solution at the same time; and adjusting the pH value of the solution to be alkaline and carrying outa crosslinking reaction to obtain the glucan hydrogel. The degrading behavior of the glucan hydrogel prepared by the method has certain pH and redox responsiveness. The preparation method is simple and mild in implementing condition. The obtained glucan hydrogel structure contains Schiff base bonds and disulfide bonds, has pH / redox double responsiveness, and can be applied to the field of biomaterials as an environment responsive drug carrier.

Description

technical field [0001] The invention relates to a dextran hydrogel and a preparation method thereof, in particular to a pH / redox dual response type dextran hydrogel and a preparation method thereof, belonging to the technical field of biomedical functional polymer materials. Background technique [0002] Hydrogel is a polymer with a three-dimensional network structure formed by physical or chemical crosslinking, which can swell and retain a large amount of water in aqueous solution without dissolving. Hydrogels have a strong ability to absorb water and are widely used in many technical fields, such as protein separation technology, preparation of contact lenses, drug delivery systems, etc. Among them, hydrogel, as a commonly used drug carrier, has become an effective auxiliary material for combined chemotherapy. It can control the drug release rate and deliver the drug to the target organ by changing the way the drug enters the body and the distribution in the body. . Ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/02C08K5/36C08B37/02
CPCC08B37/0009C08J3/075C08K5/36C08J2305/02
Inventor 苏红莹于坤韩晓东贾庆明陕绍云
Owner KUNMING UNIV OF SCI & TECH
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