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Shape memory hydrogel with calcium ion complexing and oxidation reduction dual response and preparation method of shape memory hydrogel

A dual-response, calcium ion technology, applied in the field of modified carboxyl-containing polysaccharide, hydrophilic thermoplastic polymer hydrogel and its preparation, acrylate field, can solve problems such as biological tissue damage, achieve mild response conditions, good dual Shape memory function, good biocompatibility

Active Publication Date: 2018-06-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in practical applications, excessive temperature will cause irreversible damage to biological tissues, so it is necessary to develop new triggering methods for shape memory to meet the needs of different fields

Method used

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  • Shape memory hydrogel with calcium ion complexing and oxidation reduction dual response and preparation method of shape memory hydrogel
  • Shape memory hydrogel with calcium ion complexing and oxidation reduction dual response and preparation method of shape memory hydrogel
  • Shape memory hydrogel with calcium ion complexing and oxidation reduction dual response and preparation method of shape memory hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 1g of sodium alginate and 4ml of water into a round-bottomed flask, stir and dissolve at room temperature for 4 hours, then add 1.13g of mercaptoethylamine hydrochloride, exhaust the air in the flask with nitrogen, and stir for 24 hours in the dark, and the reaction is modified. sodium alginate. figure 1 The proton nuclear magnetic resonance spectrum of the modified sodium alginate measured by nuclear magnetic resonance instrument (IBC Bruker Avance 400, Germany). The corresponding position of the solvent peak is 4.79ppm, and the absorption peak with a chemical shift of about 4ppm is the absorption peak of hydrogen on sodium alginate. There are two absorption peaks at the chemical shift of 2.82ppm and 2.90ppm, and the integral ratio is 1:1. The absorption peak of hydrogen on the methylene in mercaptoethylamine shows that mercaptoethylamine is successfully grafted onto sodium alginate.

[0038] Dissolve 0.5g of modified sodium alginate, 1g of polyvinyl alcohol, and ...

Embodiment 2

[0047] Add 2g of sodium carboxymethylcellulose and 12ml of water into a round bottom flask, stir and dissolve at room temperature for 4 hours, then add 1.25g of 3-mercapto-1-propylamine, exhaust the air in the flask with nitrogen, and stir for 36 hours under dark conditions. Modified sodium carboxymethylcellulose was obtained.

[0048] Dissolve 0.5g of modified sodium carboxymethylcellulose, 0.5g of agar, and 0.01g of ethylene glycol diacrylate in a serum bottle of 7ml of distilled water, add 140μL of Sudan red dye, stir until there are no bubbles, add 0.5mg of supernatant Ammonium sulfate, as an initiator, initiates the polymerization of ethylene glycol diacrylate. The mixture was stirred at 65 °C for 30 min and cooled to room temperature. Use a syringe to inject the hydrogel into a silicone tube with a diameter of 1 mm and a length of 8 cm to obtain a hydrogel with a diameter of 1 mm, which is water-swellable and insoluble in water, and has certain elasticity. Curves of st...

Embodiment 3

[0053] Add 4g of sodium alginate and 15ml of water into a round-bottomed flask, stir and dissolve at room temperature for 4 hours, then add 1.65g of 2-aminothiophenol, exhaust the air in the flask with nitrogen, and stir for 36 hours in the dark, and the reaction is modified. sodium alginate.

[0054] Dissolve 1g of modified sodium alginate, 1.5g of polyvinyl alcohol, and 0.02g of ethylene glycol dimethacrylate in a serum bottle of 10ml of distilled water, add 200μL of Sudan red dye, stir until there are no bubbles, add 1.5mg of supernatant Ammonium sulfate, as an initiator, initiates the polymerization of ethylene glycol dimethacrylate. The mixture was stirred at 85 °C for 30 min and cooled to room temperature. Use a syringe to inject the hydrogel into a silicone tube with a diameter of 1 mm and a length of 8 cm, freeze it in a -18°C refrigerator for 6 hours, take out the hydrogel and thaw it at 30°C for 6 hours. This freezing-thawing cycle was repeated five times to obtain...

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Abstract

The invention discloses shape memory hydrogel with calcium ion complexing and oxidation reduction dual response and a preparation method of the shape memory hydrogel. The preparation method comprisesthe following steps that 6-30 weight parts of polysaccharide containing sulfydryl, 12-30 weight parts of hydrophilic thermoplastic macromolecules, 0.12-5 weight parts of acrylic ester, and 0.01-0.08 weight part of an initiator are dissolved in 50-80 parts of water, the initiator causes unsaturated bonds on the acrylic ester to have polymerization reaction, change-temperature treatment is carried on the polymerization product at the temperature range of -18 DEG C to 60 DEG C, and thus the shape memory hydrogel is obtained. The hydrogel has the calcium ion response shape memory performance, theoxidation reduction response shape memory performance, and the procedural dual response shape memory performance of the two, has good shape memory performance, is mild in response condition, is good in biocompatibility, and has wide application prospect in the aspects of bioengineering and the like.

Description

technical field [0001] The present invention relates to a hydrogel and a preparation method thereof, more specifically, to a modified carboxyl-containing polysaccharide, acrylate, and a hydrophilic thermoplastic polymer hydrogel and a preparation method thereof, which have calcium ion-responsive shape memory Performance, redox response shape memory performance, and can achieve the above dual program response and shape memory function. Background technique [0002] Hydrogel is a polymer material with cross-linked structure that is hydrophilic but water-insoluble and capable of absorbing a large amount of water (usually water content greater than 50% of the total mass) with water as the dispersion medium. As a new type of shape-memory polymer, shape-memory hydrogel changes its initial condition under certain conditions and fixes it, and then it can restore its initial condition by external conditions (such as heat, electricity, light, chemical induction, etc.) shape, has good...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/32A61L27/52A61L27/26C08F122/14
CPCA61K9/06A61K47/32A61K47/36A61L27/26A61L27/52C08F122/1006C08L33/02
Inventor 文秀芳唐林雅皮丕辉徐守萍程江
Owner SOUTH CHINA UNIV OF TECH
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