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Coating simultaneously having responsive medicine releasing and antibacterial functions, and preparation method of same

A responsive and coating technology, applied in the field of antibacterial surfaces and antibacterial coatings, can solve the problems of uncontrollable drug release and bacterial resistance, and achieve controllable coating preparation process, high drug loading efficiency, and simple equipment. Effect

Active Publication Date: 2018-02-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug release in the slow-release antibacterial coating is uncontrollable, and long-term use can easily lead to drug resistance of bacteria; at the same time, after bacterial infection of the patient's wound site, complications such as inflammation, fever, and pain will occur, and a certain amount of drugs need to be applied for treatment

Method used

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  • Coating simultaneously having responsive medicine releasing and antibacterial functions, and preparation method of same
  • Coating simultaneously having responsive medicine releasing and antibacterial functions, and preparation method of same
  • Coating simultaneously having responsive medicine releasing and antibacterial functions, and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of redox responsive random copolymer: Weigh 0.288g PDSA, 0.406g DMAC 12 and 0.0059g of 2,2-azobisisobutyrocyanide were added to the round bottom flask successively, and 15mL of N,N-dimethylformamide was added as a solvent, nitrogen gas was passed for 30min, and the reaction was carried out at 70°C for 20h. Redox-responsive random copolymers can be obtained by repeated precipitation three times in anhydrous ether and vacuum drying;

[0025] (2) Preparation of drug-loaded colloidal particles: Dissolve the random copolymer prepared in step (1) and the small molecule drug example paracetamol in N,N-dimethylformamide to form a 40 mg / mL solution, and the paracetamol concentration is 10 mg / mL mL, ultrapure water was added dropwise to the above solution at a volume ratio of 1:1, the random polymer self-assembled, and part of the paracetamol was coated in the random copolymer micelles to form redox-responsive drug-loaded micelles;

[0026] (3) Preparation of a c...

Embodiment 2

[0028] (1) Preparation of redox responsive random copolymer: Weigh 0.48g PDSA, 0.4872g DMAC 12 , 0.08gMMA and 0.0059g 2,2-azobisisobutylcyanide were added to the round-bottomed flask in turn, and 20mL N,N-dimethylformamide was added as a solvent, nitrogen gas was passed for 30min, and the reaction was carried out at 65°C for 24h. The reaction solution was repeatedly precipitated in anhydrous ether three times, and vacuum-dried to obtain a redox-responsive random copolymer;

[0029] (2) Preparation of drug-loaded colloidal particles: Dissolve the random copolymer prepared in step (1) and the small molecule drug example paracetamol in N,N-dimethylformamide to form a 40 mg / mL solution, and the paracetamol concentration is 10 mg / mL mL, ultrapure water was added dropwise to the above solution at a volume ratio of 1:1, the random polymer self-assembled, and part of the paracetamol was coated in the random copolymer micelles to form redox-responsive drug-loaded micelles;

[0030] (3...

Embodiment 3

[0032] (1) Preparation of redox-responsive random copolymer: Weigh 0.48g PDSA, 0.4872g DMAC12, 0.08gMMA and 0.0059g 2,2-azobisisobutyrocyanide, add them to a round bottom flask in turn, add 20mL N,N-dimethylformamide was used as a solvent, nitrogen gas was passed for 30 minutes, and the reaction was carried out at 65°C for 24 hours. The reaction solution was repeatedly precipitated in anhydrous ether three times, and vacuum-dried to obtain a redox-responsive random copolymer;

[0033] (2) Preparation of drug-loaded colloidal particles: Dissolve the random copolymer prepared in step (1) and the small molecule drug example paracetamol in N,N-dimethylformamide to form a 20 mg / mL solution, and the paracetamol concentration is 5 mg / mL mL, ultrapure water was added dropwise to the above solution at a volume ratio of 1:2, the random polymer self-assembled, and part of the paracetamol was coated in the random copolymer micelles to form redox-responsive drug-loaded micelles;

[0034] (3)...

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Abstract

The invention provides a preparation method of a quaternary ammonium salt-type antibacterial coating allowing stimulating responsive medicine releasing. The coating not only has excellent antibacterial effect but also achieves responsive releasing of a medicine for therapy. The preparation method of the coating includes the steps of: preparing a polymer, poly-1-bromododecyl dimethylaminoethyl methacrylate quaternary ammonium salt-co-N-[2-(pyridine-2-dithioalkyl)-ethyl]-acrylamide-co-methyl methacrylate (PPDM), which has redox-responsiveness, through free radical polymerization, and furthermoredissolving the polymer and a small-molecular medicine in an organic solvent to prepare redox-responsive drug-carrying colloid particles through a selective solvent method; and finally with a water dispersion liquid of the drug-carrying colloid particles as a deposition liquid, forming the coating on the surface of 316L stainless steel through electrophoretic deposition. The coating has excellentinhibition effect on escherichia coli and staphylococcus aureus and can achieve controllable releasing of a medicine by means of responsiveness to a reductive substance, e.g., glutathione. The preparation method has simple process and controllable conditions, is wide in adaptability on substrates, and is high in carrying rate of the medicine.

Description

technical field [0001] The invention relates to a coating with both responsive drug release and antibacterial functions and a preparation method thereof, belonging to the fields of antibacterial surfaces and antibacterial coatings. technical background [0002] The clinical application of biomedical metal materials is likely to cause bacterial adhesion and proliferation, further causing bacterial infection, causing a series of complications such as inflammation, pain, and fever. The preparation of antibacterial coatings on the surface of metal materials has become the main method to improve the above problems. At present, antibacterial coatings are mainly divided into two types: contact type and slow release type. The contact antibacterial coating mainly introduces quaternary ammonium salts into the coating, which can destroy the bacterial cell membrane, cause the loss of protein and nutrients in the bacterial cell, and cause bacterial death; (Shady Farah, Oren Aviv, Natalia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16C08F220/60C08F220/34C08F220/14
CPCA61L31/022A61L31/08A61L31/10A61L31/14A61L31/16A61L2300/208A61L2300/404A61L2300/602A61L2420/02C08F220/60C08F220/606C08L33/24C08F220/34C08F220/14
Inventor 刘晓亚李杨朱叶孟龙魏玮
Owner JIANGNAN UNIV
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