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A coating with both responsive drug release and antibacterial functions and its preparation method

A responsive and functional technology, applied in the field of antibacterial coatings and antibacterial surfaces, can solve the problems of bacterial drug resistance and uncontrollable drug release, and achieve high drug loading efficiency, controllable coating preparation process, and enhanced hydrophilicity Effect

Active Publication Date: 2021-10-15
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug release in the slow-release antibacterial coating is uncontrollable, and long-term use can easily lead to drug resistance of bacteria; at the same time, after bacterial infection of the patient's wound site, complications such as inflammation, fever, and pain will occur, and a certain amount of drugs need to be applied for treatment

Method used

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  • A coating with both responsive drug release and antibacterial functions and its preparation method
  • A coating with both responsive drug release and antibacterial functions and its preparation method
  • A coating with both responsive drug release and antibacterial functions and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of redox-responsive random copolymer: Weigh 0.288g PDSA, 0.406g DMAC12 and 0.0059g 2,2-azobisisobutyrocyanide into a round bottom flask in turn, add 15mL N,N -Dimethylformamide is used as a solvent, nitrogen gas is passed for 30 minutes, and the reaction is carried out at 70°C for 20 hours. The reaction solution is repeatedly precipitated in anhydrous ether three times, and vacuum-dried to obtain a redox-responsive random copolymer;

[0026] (2) Preparation of drug-loaded colloidal particles: Dissolve the random copolymer prepared in step (1) and the small molecule drug example paracetamol in N,N-dimethylformamide to form a 40 mg / mL solution, and the paracetamol concentration is 10 mg / mL mL, ultrapure water was added dropwise to the above solution at a volume ratio of 1:1, the random polymer self-assembled, and part of the paracetamol was coated in the random copolymer micelles to form redox-responsive drug-loaded micelles;

[0027] (3) Preparation of a ...

Embodiment 2

[0029] (1) Preparation of redox-responsive random copolymer: Weigh 0.48g PDSA, 0.4872g DMAC12, 0.08gMMA and 0.0059g 2,2-azobisisobutyrocyanide, add them to a round bottom flask in turn, add 20mL N,N-dimethylformamide was used as a solvent, nitrogen gas was passed for 30 minutes, and the reaction was carried out at 65°C for 24 hours. The reaction solution was repeatedly precipitated in anhydrous ether three times, and vacuum-dried to obtain a redox-responsive random copolymer;

[0030] (2) Preparation of drug-loaded colloidal particles: Dissolve the random copolymer prepared in step (1) and the small molecule drug example paracetamol in N,N-dimethylformamide to form a 40 mg / mL solution, and the paracetamol concentration is 10 mg / mL mL, ultrapure water was added dropwise to the above solution at a volume ratio of 1:1, the random polymer self-assembled, and part of the paracetamol was coated in the random copolymer micelles to form redox-responsive drug-loaded micelles;

[0031] ...

Embodiment 3

[0033] (1) Preparation of redox-responsive random copolymer: Weigh 0.48g PDSA, 0.4872g DMAC12, 0.08gMMA and 0.0059g 2,2-azobisisobutyrocyanide, add them to a round bottom flask in turn, add 20mL N,N-dimethylformamide was used as a solvent, nitrogen gas was passed for 30 minutes, and the reaction was carried out at 65°C for 24 hours. The reaction solution was repeatedly precipitated in anhydrous ether three times, and vacuum-dried to obtain a redox-responsive random copolymer;

[0034] (2) Preparation of drug-loaded colloidal particles: Dissolve the random copolymer prepared in step (1) and the small molecule drug example paracetamol in N,N-dimethylformamide to form a 20 mg / mL solution, and the paracetamol concentration is 5 mg / mL mL, ultrapure water was added dropwise to the above solution at a volume ratio of 1:2, the random polymer self-assembled, and part of the paracetamol was coated in the random copolymer micelles to form redox-responsive drug-loaded micelles;

[0035](3...

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Abstract

The invention provides a preparation method of a quaternary ammonium salt type antibacterial coating capable of stimuli-responsive drug release. The obtained coating can realize responsive release of therapeutic drugs while having good bactericidal effect. The preparation method of the coating material is: preparing a redox responsive polymer poly-1-bromododecyl dimethylaminoethyl methacrylate quaternary ammonium salt-co-N-[2-(pyridine) by free radical polymerization ‑2‑disulfanyl)‑ethyl]‑acrylamide‑co‑methyl methacrylate (PPDM), further dissolving the polymer and small molecule drug in an organic solvent, and preparing a redox response by a selective solvent method Drug-loaded colloidal particles, and finally, the above-mentioned aqueous dispersion of drug-loaded colloidal particles is used as a deposition solution, and a coating is prepared on the surface of 316L stainless steel by electrophoretic deposition technology. The coating not only has a good inhibitory effect on Escherichia coli and Staphylococcus aureus, but also can realize the controlled release of drugs by responding to reducing substances such as glutathione; at the same time, the coating preparation method of the present invention has the advantages of simple process , controllable conditions, wide application of substrates, high drug loading rate and other advantages.

Description

technical field [0001] The invention relates to a coating with both responsive drug release and antibacterial functions and a preparation method thereof, belonging to the fields of antibacterial surfaces and antibacterial coatings. [0002] technical background [0003] The clinical application of biomedical metal materials is likely to cause bacterial adhesion and proliferation, further causing bacterial infection, causing a series of complications such as inflammation, pain, and fever. The preparation of antibacterial coatings on the surface of metal materials has become the main method to improve the above problems. At present, antibacterial coatings are mainly divided into two types: contact type and slow release type. The contact antibacterial coating mainly introduces quaternary ammonium salts into the coating, which can destroy the bacterial cell membrane, cause the loss of protein and nutrients in the bacterial cell, and cause bacterial death; (Shady Farah, Oren Aviv,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16C08F220/60C08F220/34C08F220/14
CPCA61L31/022A61L31/08A61L31/10A61L31/14A61L31/16A61L2300/208A61L2300/404A61L2300/602A61L2420/02C08F220/60C08F220/606C08L33/24C08F220/34C08F220/14
Inventor 刘晓亚李杨朱叶孟龙魏玮
Owner JIANGNAN UNIV
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