155 results about "Glycal" patented technology

The invention mainly relates to a synthesis method of alvimopan. A preparation method of the related alvimopan comprises the following steps of: condensing phenylpropionic acid and substituted oxazolidone; undergoing reaction with chloromethyl benzyl ether under the action of a catalyst to obtain a single configuration; hydrolyzing, and recycling oxazolidone to obtain carboxylic acid; condensing with glycinate; performing deprotection and undergoing reaction with a leaving group donor; butting with (+)-(3R,4R)-4-(3-hydroxy phenyl)-3,4-dimethyl piperidine to obtain alvimopan ester; and hydrolyzing to obtain the alvimopan. The invention also relates to a novel intermediate of the alvimopan and preparation methods of the alvimopan and the novel intermediate of the alvimopan. The technical scheme of the invention has the advantages of simple process, low cost and high product purity, and is suitable for industrial production.

This invention relates to methods for preparing new menthol derivatives, i.e., N, N-dimethyl menthol glycinate, N, N-diethyl menthol glycinate and N, N-dihydroxyethyl menthol glycinate. This invention comprises three different methods for synthesizing menthol derivatives. Method 1 comprises: reacting chloroacetyl chloride and menthol at room temperature for 1-3 h, and reacting with amine at room temperature for 1-3 h to obtain the target products. Method 2 comprises: refluxing chloroacetic acid and menthol in cyclohexane in the presence of a Lewis acid catalyst for 1-3 h, and reacting with amine at room temperature for 1-3 h to obtain the target products. Method 3 comprises: refluxing N,N-disubstituted glycine and menthol in cyclohexane in the presence of a Lewis acid catalyst for 1-3 h to obtain the target products. The new menthol derivatives can be used as transdermal agents.

A surfactant composition comprising a sugar-based surfactant comprising a C8-C16 alkyl glucoside, a C8-C16 alkyl polyglucoside, or a combination of a C8-C16 alkyl glucoside and a C8-C16 alkyl polyglucoside; a C8-C18 amphodiacetate; a C8-C16 acyl sarcosinate, a C8-C16 acyl glutamate, a C8-C16 acyl glycinate, or a combination thereof; and optionally a C8-C14 acyl lactylate, wherein the composition is free of sulfated anionic surfactants.

The invention provides a preparation of a water soluble saccharide fluorescent molecular probe as well as a direct and rapid detection for iron ions in water and a biological tissue. The fluorescent molecular probe obtains very high selectivity and sensitivity for iron ions in water and serum; after the fluorescent molecular probe is selectively combined with the iron ions, the color change of the solution from yellow to red brown can be observed by naked eyes; and the lower detection limit can reach 10-6 M. Without need of instruments, the field real-time direct and rapid detection can be carried out. The fluorescent molecular probe can be prepared to obtain an iron ion detecting test paper and a detecting kit and can be also coated with films to obtain a portable solid detector by using viscosity of saccharide compounds. The specific structure of the saccharide fluorescent molecular probe (taking a glucosamine ligand for example): except for glucosamine, the saccharide ligand can be also other saccharide compounds and derivatives thereof.

Disclosed are glycopeptide derivatives substituted at the C-terminus and / or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

The invention discloses a preparation method of Ag / ZnFe2O4 / Fe3O4 heterogeneous magnetic microsphere with controllable morphology. The preparation method includes the steps of: (1) taking crystalline ferric chloride or crystalline ferric nitrate and crystalline zinc acetate as the raw materials, adopting glycine or L-aspartic acid as the complexing agent and taking ethylene glycol as the solvent, mixing the substances, then putting the mixture on a magnetic stirrer, adding the stirred solution into a hydrothermal reaction kettle, then flushing a beaker with ethylene glycol, and conducting pouring into the reaction kettle; (2) putting the reaction kettle into a constant-temperature blast oven, centrifuging the powder generated in the reaction kettle by a centrifugal machine at the end of thereaction, then respectively using anhydrous ethanol and deionized water for alternate washing repeatedly, and then putting the washed powder into a vacuum drying oven for drying; and (3) pouring silver nitrate, glucose and ZnFe2O4 / Fe3O4 composite powder into the beaker, adding deionized water for dissolving, stirring the substances uniformly, then putting the beaker on an ultrasonic cleaner for cleaning, then utilizing deionized water and anhydrous ethanol for mixed centrifugal washing, and then performing drying, thus obtaining Ag / ZnFe2O4 / Fe3O4 multi-component nano-powder.

This invention involves a synthetic method to a new diarylheptanone compounds separated from high-grade plant. This kind of diarylheptanone compounds has general structure formula shown as follows, it is 1-ketonyl-1,7-diarylheptanone compounds. In general structure formulaó±, R1 should be H, H2, OH, ú¢O, -(CH2)m-, OR' ; n=1 to 5; m=1 to 40. Compounds above-mentioned are distilled from altitude plant such as seed plant, passing a series of steps, get diarylheptanone compounds ,it has good function of medical treatment and health care.

The invention relates to the technical field of glycal, in particular to a postprocessing method for a glycal reaction solution. The glycal reaction solution is washed with acid within one hour until the aqueous phase PH is acidic or neutral, then the glycal reaction solution is washed until the aqueous phase PH is neutral or alkaline, organic phases are separated, and the purified glycal is obtained after drying. According to the postprocessing method for the glycal reaction solution disclosed by the invention, time, labor and cost are saved, waste eluent which can not be processed can not be largely produced, the yield and the purity of the obtained glycal are high, and the method can be used for production on a large scale.

Provided is a glyphosate synthesis technology. The glyphosate synthesis technology is characterized in that a metal alkoxide organic compound is adopted as a catalyst for glyphosate synthesis and particularly for depolymerization and addition during glyphosate synthesis. The glyphosate synthesis technology includes the following steps: an alcohol and paraformaldehyde are mixed and stirred to be uniform, the catalyst is added into a mixture solution or directly added into an alcohol solution of formaldehyde, and a transparent mixture solution is generated; triethylamine and glycine are added into the transparent mixture solution, stirring is conducted to carry out an addition reaction, and after the addition reaction is finished, dimethyl phosphite is added into the mixture solution to carry out a condensation reaction; and after the condensation reaction is finished, hydrochloric acid is added into the mixture solution to carry out hydrolysis, and then through crystallization, washingand drying, glyphosate is obtained. According to the technical scheme of the glyphosate synthesis technology, the specific catalyst is adopted, therefore, glyphosate synthesis reaction speed and selectivity are improved, reaction speeds of depolymerization and addition are high, the reactions are conducted completely, the final yield of a glyphosate product obtained through the glyphosate synthesis technology is increased by 3% or above compared with the final yield of a glyphosate product obtained through traditional technologies, and thus the glyphosate synthesis technology has a reaction advantage, an energy-saving advantage, a coat advantage and an environment-friendly advantage.