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Zinc gluconate sugar tablet preparation and preparation method thereof

A technology of zinc gluconate and glucose syrup, applied in the field of medicine, can solve the problems of strong irritation of nasal mucosa, unsatisfactory effect of cold effect, limited clinical application, etc., and achieve the effects of avoiding metallic taste, being happy to take, and controllable quality.

Active Publication Date: 2011-02-02
莱阳司邦得制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In China, zinc gluconate preparations are used as zinc supplements in large quantities, and there are few products for treating colds. The zinc gluconate nasal spray produced by domestic enterprises has strong irritation to the nasal mucosa due to the nasal spray, and According to relevant data, the use of zinc gluconate nasal spray may cause permanent loss of smell, which is difficult for patients to accept clinically.
[0004] Chinese patent document CN1091638A (CN93101972.9) discloses a kind of anti-cold Zinc Kekang, main medicine is zinc gluconate, ibuprofen, chlorpheniramine, is processed into tablet capsule or electuary, relevant domestic and foreign reports zinc gluconate directly Gastrointestinal oral administration is unsatisfactory in the treatment of colds
Due to the above various deficiencies, existing zinc gluconate cold preparation products are greatly limited in clinical application

Method used

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  • Zinc gluconate sugar tablet preparation and preparation method thereof
  • Zinc gluconate sugar tablet preparation and preparation method thereof
  • Zinc gluconate sugar tablet preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1. Preparation of zinc gluconate sugar tablets

[0063] 1. The proportion of raw and auxiliary materials:

[0064] Zinc Gluconate: White Sugar: Maltose Syrup: Glycine: Fruit Flavoring Agent: Purified Water = 93.24: 1460: 2910 (in solids): 30: 30: 438 (mass ratio W / W)

[0065] 2. The preparation method, the steps are as follows:

[0066] (1) Weigh 1.865 kg of zinc gluconate, 0.6 kg of glycine, 29.2 kg of white sugar, 58.2 kg of maltose syrup (solids), 8.76 kg of purified water, and 0.6 kg of fruit flavoring agent according to the prescription.

[0067] (2) Add the weighed white sugar, maltose syrup and purified water into the dissolving tank, turn on the stirring, heat to 80-90°C to completely dissolve it; put in spare zinc gluconate and glycine, and continue stirring for 10 minutes. After completely dissolved. Turn on the vacuum pump, and pump the completely dissolved sugar liquid into the vacuum sugar evaporator (preheated at 90-100°C).

[0068] (3) Turn on the circulat...

Embodiment 2

[0073] Example 2. Preparation of zinc gluconate sugar tablets

[0074] 1. The proportion of raw and auxiliary materials:

[0075] Zinc Gluconate: White Sugar: Maltose Syrup: Glycine: Fruit Flavoring Agent: Purified Water = 93.24:1880:3750 (solid matter): 39:39:565 (mass ratio W / W)

[0076] 2. The preparation method, the steps are as follows:

[0077] 1) Weigh 1.865 kg of zinc gluconate, 0.78 kg of glycine, 37.6 kg of white sugar, 75 kg of maltose syrup (solids), 11.3 kg of purified water and 0.78 kg of fruit flavoring agent according to the prescription amount.

[0078] 2) Add the weighed white sugar, maltose syrup and purified water into the dissolving tank, turn on the stirring, heat to 80~90℃, and dissolve completely; put in spare zinc gluconate and glycine, continue to stir for 10 minutes, complete After dissolving; add flavoring fruit flavoring agent. Turn on the vacuum pump, and pump the completely dissolved sugar liquid into the vacuum sugar evaporator (preheated at 90-100°C). ...

Embodiment 3

[0083] Example 3. Preparation of zinc gluconate sugar tablets

[0084] 1. The proportion of raw and auxiliary materials:

[0085] Zinc Gluconate: White Sugar: Glucose Syrup: Glycine: Fruit Flavoring Agent: Purified Water = 93.24:1670:3330 (solid matter): 35:35:502 (mass ratio W / W)

[0086] 2. The preparation method, the steps are as follows:

[0087] (1) Weigh 1.865 kg of zinc gluconate, 0.7 kg of glycine, 33.4 kg of sugar, 66.6 kg of glucose syrup (solids), 10 kg of purified water and 0.7 kg of fruit flavoring agent according to the prescription amount.

[0088] The operations of (2) to (4) are the same as the corresponding steps (2) to (4) of Example 1.

[0089] (5) Control the temperature of the kneaded and uniform massecuite at 70-80℃, and send it to the heat-preserving rolling machine to roll into strips, and then enter the homogenizer to draw uniform and suitable sugar bars and enter the punching machine. Adjust the pressure of the punching machine and the tablet weight to 5.2 g / t...

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Abstract

The invention relates to a zinc gluconate sugar tablet preparation and a preparation method thereof. The sugar tablet comprises the following components by mass: 93.24-160 parts of zinc gluconate and pharmaceutic excipients such as 1460-2500 parts of white sugar, 2910-5000 parts of maltose syrup or glucose syrup, 30-52 parts of glycine, 438-750 parts of purified water and 30-52 parts of fruit flavoring agents. The preparation is prepared by dissolving sugar at high temperature, boiling sugar under vacuum, etc. The form of the preparation is semi-transparent hard sugar tablet and the preparation is the buccal tablet. The sugar tablet is dissolved in the mouth, so that the zinc ions can permeate the nose, throat and susceptible tissues in the nasal sinus to be combined with the influenza virus receptor to prevent the influenza virus from further spreading among the cells so as to achieve the aims of treating cold and alleviating cold symptoms.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation of zinc gluconate sugar tablets for treating colds and alleviating cold symptoms and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The cold is one of the most common diseases in the world and one of the main public health problems facing human beings. According to statistics, the annual incidence of cold is 10%-30%, and thousands of people are infected every year around the world. Almost no one in life has ever had a cold. The symptoms are: nasal congestion, runny nose, sneezing, cough, fever, body aches, etc. If not treated in time, it can induce pharyngitis, otitis media, bronchitis, pneumonia, and other diseases. [0003] A large number of zinc gluconate preparations are used as zinc supplements in China, and there are few products used for the treatment of colds. The zinc gluconate nasal spray produced by the existing domestic pediatric comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/191A61P31/00A61K9/20A61J3/10A61K47/26
Inventor 滕学厚乔敏
Owner 莱阳司邦得制药有限公司
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