Diaryl neptanone compound and its preparing method

A technology for diarylheptanone and compound, which is applied in the field of new diarylheptanone compound and its preparation, and can solve problems such as undiscovered new type compound.

Inactive Publication Date: 2005-12-21
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The diaryl heptanone compounds found so far are all 3-keto-1,7-diaryl heptanone structures, and no new type of this type of compound has been found

Method used

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  • Diaryl neptanone compound and its preparing method
  • Diaryl neptanone compound and its preparing method
  • Diaryl neptanone compound and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1.1, the separation and preparation of 7-bis(4'-hydroxyphenyl)-5-hydroxyl-(2,3) epoxy-1-heptanone

[0052]Plant material: Dried stems and branches of mistletoe (Viscus coloratum (Kom.) Nakai) of the genus Mistletoe of the Morusaceae family.

[0053] Separation and preparation method: 2.0kg of stems and branches of mistletoe with leaves, reflux extraction twice with 20L of 95% ethanol, each time for 2 hours, combine the extracts, recover the ethanol and concentrate until it has no alcohol smell, add water to adjust to 4.0L, and filter with suction , the clarified liquid passes through D 101 The macroporous resin column (1.0Kg) was eluted with 4-5L of water, 20%, 40%, 75% and 95% ethanol in sequence, and 40% of the eluted fraction was collected and concentrated to dryness. The fraction eluted with 40% ethanol was repeatedly separated with Sephadex LH 20 to obtain 1,7-bis(4'-hydroxyphenyl)-5-hydroxy-(2,3)epoxy-1-heptanone. The extraction and separation flow ch...

Embodiment 2

[0053] Separation and preparation method: 2.0kg of stems and branches of mistletoe with leaves, reflux extraction twice with 20L of 95% ethanol, each time for 2 hours, combine the extracts, recover the ethanol and concentrate until it has no alcohol smell, add water to adjust to 4.0L, and filter with suction , the clarified liquid passes through D 101 The macroporous resin column (1.0Kg) was eluted with 4-5L of water, 20%, 40%, 75% and 95% ethanol in sequence, and 40% of the eluted fraction was collected and concentrated to dryness. The fraction eluted with 40% ethanol was repeatedly separated with Sephadex LH 20 to obtain 1,7-bis(4'-hydroxyphenyl)-5-hydroxy-(2,3)epoxy-1-heptanone. The extraction and separation flow chart is attached Figure 4 . Embodiment 2.1, the scavenging effect of 7-two (4'-hydroxyphenyl)-5-hydroxyl-(2,3) epoxy-1-heptanone to hydroxyl radical and superoxide anion radical

[0054] 1. Instruments and materials

[0055] 1.1 Instruments:

[0056] UV-260 ...

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Abstract

This invention involves a synthetic method to a new diarylheptanone compounds separated from high-grade plant. This kind of diarylheptanone compounds has general structure formula shown as follows, it is 1-ketonyl-1,7-diarylheptanone compounds. In general structure formulaó±, R1 should be H, H2, OH, ú¢O, -(CH2)m-, OR' ; n=1 to 5; m=1 to 40. Compounds above-mentioned are distilled from altitude plant such as seed plant, passing a series of steps, get diarylheptanone compounds ,it has good function of medical treatment and health care.

Description

technical field [0001] The invention belongs to the field of medicine and natural product chemistry, and specifically relates to a novel diaryl heptanone compound and a preparation method thereof. Background technique [0002] Diarylheptanones are rarely found in the plant kingdom. The diarylheptanone compounds found in Zingiberaceae plants have a strong spicy taste and are one of the main spicy components of Zingiberaceae plants; while the compounds found in Betulaceae plants have strong antioxidant activity. These diaryl heptanone compounds discovered so far are all of 3-keto-1,7-diaryl heptanone structure, and no new type of this type of compound has been found yet. Contents of the invention [0003] The object of the present invention is to provide a kind of new diaryl heptanone compound. [0004] Another object of the present invention is to provide a preparation method of the above-mentioned diaryl heptanone compound. [0005] Another object of the present inventi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D303/32
Inventor 周铜水姚辉陈道峰陈家宽
Owner FUDAN UNIV
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