Autolysable high-strength quick-adhesion hydrogel, preparation method and applications thereof

Abstract

The invention discloses an autolysable high-strength quick-adhesion hydrogel, a preparation method and applications thereof, wherein the vinyl monomer N-acryloylglycine of a glycine derivative with good biocompatibility and nanometer active inorganic nanoparticles are used as reactants and are subjected to one-step free radical copolymerization under ultraviolet irradiation by using a photoinitiator to prepare the autolysable high-strength quick-adhesion hydrogel. According to the invention, through a large number of hydrogen bonds formed between the PACG molecular side chains in the formed hydrogel, the ion complexing of the carboxyl at the tail end of the molecular chain and the inorganic ions, and the physical adsorption effect between the polymer chain and the nanoparticles, the hydrogel is endowed with excellent mechanical properties, has extremely good adhesion strength to various matrixes, and shows good biocompatibility.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to the preparation, performance and application research of a self-dissolving high-strength and fast-adhesive hydrogel band-aid. [0002] technical background [0003] Hydrogel is a three-dimensional network polymer with high water content. Hydrogels have good biocompatibility and other excellent properties, such as: environmental responsiveness, antibacterial, self-healing, superabsorbent, etc. These characteristics make hydrogels have broad application prospects in biomedicine, sensors, self-healing materials, and water retention and drought resistance. Adhesive hydrogels are very important in daily life, work, and medical fields, especially wet adhesion is essential for hemostasis, wound healing, and medical conduction devices. Medical sealants and adhesives made of soft materials similar to biological soft tissues are beneficial for promoting wound healing. ...

AI Technical Summary

Problems solved by technology

However, traditional hydrogels are difficult to achieve the combination of adhesion and mechanical properties, especially hydrogels with good mechanical properties, because of their relatively hard polymer chains, they cannot achieve adhesion to soft tissues

Although the adhesion hydrogel induced by mussels has recently achieved wet adhesion, its adhesion effect is very related to the pH value in the environment and the adhesion time, and it will lose its adhesion after being placed for a long time. ability

Images