The invention provides a high-frequency low-loss MnZn ferrite material, which comprises main components and auxiliary components, wherein the main components are 53-56 mol percent of ferric oxide, 34-41 mol percent of manganese oxide and 6-10 mol percent of zinc oxide, the content of manganese oxide is measured by Mn; the auxiliary components are at least three selected from CaCO3, SiO2, Nb2O5, CoO, V2O5, SnO2 and TiO2, and based on the total weight of the main components, the auxiliary components comprise: 0.02-0.08 weight percent of CaCO3, 0.002-0.01 weight percent of SiO2, 0.02-0.06 weightpercent of Nb2O5, 0.03-0.20 weight percent of CoO, 0.01-0.05 weight percent of V2O5, 0-0.20 weight percent of SnO2 and 0-0.10 weight percent of TiO2. The invention also provides a manufacturing method of the high-frequency low-loss MnZn ferrite material.