68results about How to "Facilitate industrial scale-up production" patented technology

The invention discloses a carbon composite material. The carbon composite material comprises 0.1-35wt% of a carbon nanomaterial and 99.9-65wt% of amorphous carbon with a high surface area; the carbon nanometer is one or a mixture of more of carbon nanotubes, carbon fibers, graphene oxide and graphene; and the specific surface area, the pore volume and the conductivity of the composite material are not lower than 800m<2> / g, not lower than 0.3cm<3> and not lower than 4S / cm respectively, and the aperture of the composite material is 0.5-10nm. The carbon composite material has the respective characteristics of the carbon nanomaterial and the amorphous carbon, realizes the organic combination of the carbon nanomaterial and the amorphous carbon in functions, has high surface area and high conductivity, and can provide superior capacity and rate performance as an excellent electrode and conductive material of super capacitors, lithium ion capacitors, fuel batteries and lead carbon battery electrodes. The carbon composite material can remove impurities in water as an electrode material in water treatment devices.

The invention discloses a preparing method of anatase type titanium dioxide nanometer powder, which comprises the following steps: dripping titanic acid tetrabutyrate resin in the deionized water solution of alcohol to form even titanium solution; adding 0.1-1mol / L composite dispersing liquid of amide polyacrylate, polyvinyl alcohol and carbowax in the titanium solution evenly; adding ammonia or sodium hydroxide in the even solution with titanium to do ultrasonic reaction; disposing reacted product through heat to obtain even grain size anatase type titanium dioxide nanometer powder.

The invention provides a method for separating and purifying reduced glutathione (GSH) from a reduced GSH contained fermentation leaching liquid. The method comprises the following steps of: (1) treating the fermentation leaching liquid sequentially through anion exchange resin and a non-polar absorbent to obtain a reduced GSH contained solution; and (2) concentrating the reduced GSH contained solution, and then, crystallizing and drying. The reduced GSH separated and purified by using the method provided by the invention has the advantages that the purity of the reduced GSH can be up to over 98.5% (titration, drying), and relevant impurities conform to the requirement of European pharmacopoeia.

The invention discloses a method for preparing 6-cyano-(3R, 5R)-dihydroxyl tert-butyl caproate by using genetically engineered bacteria as a whole-cell biocatalyst. The method specifically comprises the following steps of designing and optimizing a tandem co-expression policy of a carbonyl reductase and a glucose dehydrogenase according to the expression characteristics of the carbonyl reductase and the glucose dehydrogenase, establishing a brand-new biological catalysis system in which cyclic regeneration of coenzymes is matched with the reduction of the 6-cyano-(3R, 5R)-dihydroxyl tert-butyl caproate, thus realizing in-situ biological synthesis of the 6-cyano-(3R, 5R)-dihydroxyl tert-butyl caproate, namely a chiral side chain synthesis precursor of atorvastatin. By optimizing expression conditions and reaction conditions and under the conditions that a cosolvent is 5% dimethyl sulfoxide, a reaction solution pH is 7.0, the temperature is 20 DEG C, and a ratio of glucose to a substrate is 1.2: 1, the concentration of the substrate for the in-situ biological synthesis of the 6-cyano-(3R, 5R)-dihydroxyl tert-butyl caproate can be 35g / L, and meanwhile, the addition of an exogenous coenzyme is completely avoided, and therefore, the method has wide application prospect.

The invention discloses a preparing method of alumina nanometer powder, which comprises the following steps: adding organic dispersant solution in the initial reacting solution; forming even aluminium dispersing reacting solution and alkaline dispersing reacting solution; adding aluminium dispersing reacting solution in the alkaline dispersing reacting solution; proceeding ultrasonic chemical reaction; obtaining slurry suspension; washing slurry suspension through ultrasound; drying; proceeding heat disposal to obtain the alumina nanometer powder.

The invention belongs to the technical field of egg product processing and particularly relates to a desalination method of salted egg white. The desalination method is characterized by adopting an electrodialysis method; and according to the desalination method, the salted egg white is used as a liquid in a thinned compartment of an electrodialyzer, running water is used as a liquid in a concentrated compartment of the electrodialyzer, a sodium chloride solution is used as a liquid in an electrode compartment of the thinned compartment, and the electrodialysis desalination operation is carried out with a certain flow rate and a certain temperature under a certain membrane pair voltage. According to the desalination method, in main operation parameters, the salted egg white in the thinned compartment serves a stock solution to be diluted by 2-50 times, the pH of the salted egg white is regulated to 3-11, and the concentration of the sodium chloride solution in the electrode compartment is 20-40g / L; the flow rate of the salted egg white in the thinned chamber is regulated to 30-80L / h, the flow rate of the running water in the concentrated compartment is regulated to 30-80L / h, and the flow rate of the sodium chloride solution in the electrode compartment is regulated to 30-50L / h; the membrane pair voltage of the electrodialyzer is regulated to 0.5-1.5V; and the working environment temperature of the electrodialyzer is regulated to 10-40 DEG C. Under preferable conditions, the desalination rate can reach more than 95%, and the loss ratio of egg-white proteins is below 10%. According to the desalination method, the salinity in the salted egg white can be effectively removed.

The invention discloses a heterogenous photocatalyst with a multichannel carrier separation function and a preparation method and application of the heterogenous photocatalyst with the multichannel carrier separation function.The heterogenous photocatalyst 100% in total, comprises, by weight, 0.1-10% of ZnO and the balance mixed-phase titanium dioxide P25.The ZnO serving as a compound-phase component is dispersed in the catalyst uniformly, two phases are sufficiently mixed together, electron-hole produced by ultraviolet excitation of the P25 can be separated effectively, and the ZnO / P25 heterogenous photocatalyst demonstrates more excellent photocatalytic performance than the P25.When the heterogenous photocatalyst is applied to ultraviolet light catalytic reaction of low-concentration methylbenzene organic gas, methylbenzene in a system can be completely oxidized into carbon dioxide and water at room temperature.The preparation method is simple, mild in preparation conditions, convenient to operate and convenient for enlarged industrialized production.

The invention discloses a titanium carbide-titanium tetrasulfide (Ti<3>S<4>) composite material with an accordion-shaped microstructure and a preparation method therefor. Ti<3>SiC<2>, Ti<3>AlC<2> or Ti<2>AlC ceramic powder material is etched by hydrofluoric acid; the prepared accordion-shaped titanium carbide material, used as the raw material, is reacted with titanium carbide through elementary sulfur in a high temperature condition to prepare the titanium carbide-titanium tetrasulfide (Ti<3>S<4>) composite nanomaterial with the accordion-shaped microstructure. The titanium carbide-titanium tetrasulfide (Ti<3>S<4>) composite nanomaterial is used as the negative electrode material of a lithium ion battery; and the composite material shows relatively high specific capacity and high rate capability and charging-discharging cycling performance.

The invention discloses a method for preparing ginkgolide K. The method includes the following steps: 1, ginkgolide B is dissolved into organic solvents to obtain a solution; 2, fluorinating agents are added into the solution obtained in the step 1 for conducting a dehydration reaction, and the ginkgolide K is obtained through separation and purification. The method for preparing the ginkgolide K is easy to operate; meanwhile, the high yield and the high purity are achieved, and convenience is brought to industrialization large-scale production. (please see the specification for the formula).

The invention discloses a method for synthesizing titanium dioxide nanometer powder at low temperature, and belongs to the technical field of material powder preparation. In this method, titanyl sulfate is first dissolved in an appropriate amount of deionized water containing organic additives, stirred evenly, and then the solvent is evaporated and concentrated to obtain a uniform solid mixture containing titanium and organic additives; the solid mixture is gradually added to an appropriate excess of hydroxide Stir, grind and mix in sodium. The mixing material is washed with deionized water and left to stand to obtain a precipitate, which is then filtered, washed with water, dried and calcined to obtain a high-purity titanium dioxide nano-powder with good dispersibility. The method of the invention has the advantages of simple and easy controllable process parameters, uniform particle size, adjustable particle size, resource saving, little pollution and the like.

The invention discloses a synthesis method for pharmaceutically acceptable salt of alkylhydrazine. According to the method, with hydrazine hydrate and BOC anhydride as starting raw materials, BOC hydrazine is synthesized firstly, then alkyl compounds are added in, BOC alkylhydrazine is obtained, finally BOC is removed, and the pharmaceutically acceptable salt of the corresponding alkylhydrazine is obtained in a conversion manner. According to the synthesis method, the raw materials for use are low in price and cost and easy to obtain. The synthesis method is short in synthesis route and high in yield, the obtained product is high in chemical purity, special production equipment is not needed for all reactions, and obtained intermediates and the final product do not need column chromatography and crystallization and purification.

The invention discloses oil-soluble nano-magnesium silicate hydroxide and a preparation method thereof. The preparation method of the oil-soluble nano-magnesium silicate hydroxide includes the steps: dissolving magnesium nitrate, sodium silicate and sodium hydroxide in water to obtain first solution; heating and holding the first solution to obtain second solution; centrifuging the second solution to obtain an intermediate; coupling the intermediate and a coupling agent to obtain oil-soluble magnesium silicate hydroxide. The magnesium silicate hydroxide prepared by the method is nano-particles with uniform dimensions, the nano-particles can be stably dispersed in base oil, and the method solves the problem that natural serpentine powder cannot be stably dispersed in base oil.

The invention discloses a gadolinium chromate / silver / silver phosphate compound photocatalyst and an application thereof in purification of volatile organic compounds (VOCs). The expression of the compound is GdCrO3 / Ag / Ag3PO4. the preparation method comprises the following steps: 1) placing a gadolinium source and a chromium source into a mortar according to a ratio of 1:1, adding a proper amount of urea, uniformly carrying out grinding, and then carrying out roasting in a specific atmosphere at a high temperature to obtain gadolinium chromate; 2) loading silver particles on the gadolinium chromate to obtain a gadolinium chromate / silver compound; and 3) loading silver phosphate on the gadolinium chromate / silver compound to obtain the gadolinium chromate / silver / silver phosphate compound. Elemental Ag in the GdCrO3 / Ag / Ag3PO4 prepared by the preparation method is subjected to plasma resonance under excitation of visible light to generate hot electron-hole pairs. The hot electron-hole pairs are connected with a semiconductor GdCrO3 and Ag3PO4 with energy gap separation without sacrificing oxidation or reduction potentials of the semiconductor GdCrO3 and Ag3PO4, so that the photocatalytic oxidation reduction capability of the compound is enhanced. The GdCrO3 / Ag / Ag3PO4 is used for photocatalytic degradation of organic pollutants, and can completely catalyze purification of typical organic gas pollutants such as toluene, xylene, benzene and the like under visible light irradiation and mild reaction conditions such as 90 DEG C.

The invention provides a preparation method of a nano-filtration membrane. The preparation method comprises an interfacial polymerization reaction step and a post-processing step, wherein the interfacial polymerization reaction step is as follows: preparing an aqueous phase solution and an oil phase solution, pouring the aqueous phase solution and the oil phase solution into the membrane surface of the nano-filtration membrane in sequence and pouring away; the post-processing step is as follows: evaporating for 0.2-2 minutes in a baking oven with a temperature of 80-100 DEG C, then immediately soaking in an aqueous solution containing 30-100 weight percent of modifying agent for 30-120 seconds after evaporation and preparing a reverse osmosis membrane. As the membrane obtained after the completion of interfacial polymerization reaction is soaked in the aqueous solution containing the modifying agent in the preparation process, the high-performance nano-filtration membrane of which the throughout and the organic small molecular interception rate are obviously improved is obtained.

The invention discloses 7-azaspiro-[3,5]-nonane-2-ol and a hydrochloride compound thereof. Concretely, N-Boc-4-piperidone is used as a raw material, a wittig reaction is carried out in order to prepare N-Boc-4-methylenepiperidine, zinc / copper is used for catalysis of trichloroacetyl chloride in order to carry out [2+2] cyclisation for preparing N-Boc-7-azaspiro ketone; the azaspiro ketone intermediate is reduced into N-Boc-7-azaspiro-ol by sodium borohydride at a room temperature, and finally 2mol / L hydrochloric acid-ethyl acetate is used for removing Boc in order to prepare a target product hydrochloride whose purity reaches 98%. The product has the advantages of economical and easily available reagents and raw materials which are needed, simple operation, and high product purity; and the product is suitable for batch production.

The invention discloses a method for preparing pure enantio-methylpropane-2-sulfinamide. The method comprises the following steps: carrying out selective oxidation on di-tert-butyl disulfide and hydrogen peroxide, reacting with an acylation reagent so as to obtain tert-butylsulfinyl chloride and tertiary butyl sulfonyl bromide, further reacting with hydrazine hydrate so as to obtain tertiary butylhydrazide, further carrying out resolution and separation with a DBTA resolving agent, and carrying out cracking with zinc acetate, thereby obtaining the pure enantio-methylpropane-2-sulfinamide. Themethod is simple, convenient and stable in process operation, high in yield and good in environment protection, and compared with a conventional process, the method is cheap and easy in raw materialobtaining, low in production cost of pure enantio-methylpropane-2-sulfinamide, and beneficial to industrial on-scale production.

The invention provides a method for enhancing catalytic performance of a cerium-base denitrification catalyst and application thereof. The method comprises the following steps: 1) impregnating CeO2 in an acidic solution, uniformly mixing, and evaporating by heating; and 2) drying the evaporated product in the step 1), and roasting to obtain the cerium-base denitrification catalyst finished product. The catalyst has the advantages of excellent denitrification property, high anti-poisoning capacity, low cost, abundant required raw material resources and cheap and accessible raw materials. The preparation process is simple and convenient, is low in energy consumption, can implement large-scale production, and has wide industrial application prospects.

The invention relates to a preparation method of a PIM kinase inhibitor and an intermediate of PIM kinase inhibitor. The invention provides a preparation method of a compound as shown in a formula I or pharmaceutical salt thereof, or a compound as shown in a formula V. The preparation method comprises the following steps. The method has the characteristics of simplicity and convenience in production, low production cost, high production efficiency, excellent product quality, stable quality, low pollution, high safety and the like, can effectively solve the problems of reaction impurity uncontrollability and yield reduction caused by raw material instability, and is convenient for industrialized enlargement production.

The invention discloses a fluorocarbon surfactant, a preparation method and application thereof, and belongs to the technical field of macromolecular surfactants. The fluorocarbon surfactant comprises a fluorine-loving component A and a temperature-sensitive component B, wherein the fluorine-loving component A comprises a fluorine-loving chain with a carbon chain length of at least C8, the temperature-sensitive component B comprises thermosensitive components such as poly N-alkyl acrylamide, a nonlinear polyethylene glycol based thermosensitive polymer and the like, and the fluorine-loving component A and the temperature-sensitive component B are connected through covalent bonds or non-covalent bonds. The fluorocarbon surfactant disclosed by the invention can be used for preparing micro-droplets, can keep the micro-droplets to be relatively good in stability under a relatively low temperature condition, and can be demulsified under a relatively high temperature condition. The fluorocarbon surfactant disclosed by the invention has the advantages of temperature-controllable surface activity capability, contribution to external control of emulsion droplet fusion and the like.

The invention discloses a jatropha curcas alkane type diterpenoid compound, a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: firstly extracting euphorbia helioscopia by using an ethanol aqueous solution to obtain a crude extract, and then sequentially carrying out extraction, ODS chromatographic column and HPLC chromatographic multi-stage separation to obtain the jatropha curcas alkane type diterpenoid compound. According to the invention, the preparation method of the jatropha curcas alkane type diterpenoid compound is simple, easy to operate, convenient for industrial large-scale production, and suitable for industrial large-scale production of the jatropha curcas alkane type diterpenoid compound; and the jatropha curcas alkane type diterpenoid compound prepared by the invention has obvious cytotoxicity to a drug-resistant cell line A549 / Taxol, and is expected to be used as a potential drug for treating drug-resistant lung cancer.

The invention discloses a preparation method of chiral optical pure p-toluene sulfamide. The preparation method comprises the following steps: performing acylating chlorination by using sodium p-tolylsulfinate and an acylating chlorination reagent to obtain p-toluene sulfonyl chloride, then mixing the p-toluene sulfonyl chloride with hydrazine hydrate to obtain p-toluene sulfonyl hydrazine, performing separation and dissociation with a tartaric acid resolving agent, and performing splitting decomposition with zinc acetate to obtain the pure p-toluene sulfamide. The process disclosed by the invention is easy and convenient to operate, stable, high in yield and environmentally friendly. Compared with the conventional process, the preparation method has the advantages that the raw materials are easy to obtain, the production cost of the existing chiral optical pure p-toluene sulfamide is substantially reduced, and the industrial large-scale production is facilitated.

The invention relates to the field of chemistry, particularly a preparation method of a key intermediate (S)-3-hydroxypyrrolidine hydrochloride of darifenacin for treating overactive bladder syndrome and an antihypertensive drug barnidipine. The preparation method comprises the following steps: carrying out Mitsunobu reaction on (R)-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine so as to be condensed with acid to obtain an upturned-structure ester, hydrolyzing ester bond under alkaline conditions to obtain (S)-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine, and removing Boc protecting groups under acidic conditions, thereby finally obtaining the key intermediate. The method is simple and easy to implement, has the advantages of cheap and accessible raw materials, lower cost and high yield, and has potential production value.

The invention relates to the technical field of polyester preparation, and discloses a preparation method of degradable PET-based copolyester, the degradable PET-based copolyester is terephthalic acid-ethylene glycol-glycollic acid copolyester, and the preparation method comprises the following steps: adding dimethyl terephthalate, ethylene glycol, glycollic acid, a catalyst and a stabilizer into a reactor; heating is performed twice in an inert atmosphere, the temperature is firstly increased to 150-190 DEG C, then the temperature is increased to 200-230 DEG C, and transesterification / esterification reaction is performed; and discharging water or methanol, heating twice in vacuum, firstly heating to 230-250 DEG C, then heating to 250-265 DEG C, and carrying out melt polycondensation reaction to obtain the terephthalic acid-ethylene glycol-glycolic acid copolyester. The heat stability and the intrinsic viscosity are improved by introducing the rapidly degradable PGA and adopting one-step melt polycondensation, and the intrinsic viscosity can be greater than 1.20 dL / g by further combining a solid phase polycondensation process.

The invention discloses a preparation method of a chiral optical pure p-toluenesulfinamide. The method includes: subjecting sodium p-tolylsulfinate and an acyl chlorination reagent to acyl chlorination to obtain p-toluene sulfinyl chloride, then reacting the p-toluene sulfinyl chloride with hydrazine hydrate to obtain p-toluene sulfinyl hydrazine, then subjecting the p-toluene sulfinyl hydrazine and a DBTA resolving agent to resolution dissociation, and then performing zinc / acetic acid cracking to obtain enantiomerically pure p-toluenesulfinamide. The process provided by the invention has thecharacteristics of simple and stable operation, high yield, and environmental friendliness, and compared with the prior art, the raw materials are cheap and easily available, and the production cost of the existing chiral optical pure p-toluenesulfinamide is greatly reduced, therefore the method is beneficial to industrial mass production.

The invention provides a preparation method of an integrated high-performance electrode for a solid-state battery, which comprises the following steps: dispersing a positive electrode material and a binder in a solid-state electrolyte solution to form a mixed positive electrode suspension, spraying the mixed positive electrode suspension onto a current collector to form a positive electrode composite electrode by adopting a spraying method, and after the solvent is completely volatilized, directly spraying lithium powder on the opposite side of the current collector to obtain the integrated high-performance electrode for the solid-state battery. Compared with a traditional three-layer lamination method of the positive electrode, the negative electrode and the solid electrolyte layer, the method has the advantages that the positive electrode and the solid electrolyte are fused and molded, the negative electrode is directly sprayed with the lithium powder, and the structure can reduce the interface resistance and the impedance of the electrode plate to the greatest extent and improve the performance of the solid-state battery.

The invention provides a vegetable fermenting agent. The vegetable fermenting agent consists of lactobacillus plantarum powder, lactococcus lactis powder and excipients. The invention further relates to a vegetable fermenting method, and in the vegetable fermenting method, the vegetable fermenting agent according to the claims of 1-6 is used for fermenting vegetables. Dominant species are adopted, fermentation liquor can be used for enabling the vegetables to be in rapid fermentation so as to generate acids, about 24 hours after inoculating, the pH of the fermentation liquor can be rapidly reduced to 3.6-3.8, and the acid generating capacity is high; dominant environment can be guaranteed under low-salt environment, and living contaminants can be completely and effectively controlled. The method is high in fermentation speed, product quality is stable, the salt content is low, nitrite is not contained, the process flow is simple, the maneuverability is high, the success rate is high, and the vegetable fermenting agent and the fermenting method are convenient for industrial scaled production.

The invention provides a method for preparing nonoxynol without ethylene oxide. The method comprises the following steps that a, nonyl phenol and alkali which are taken as raw materials are added intoa reaction still, and air is replaced with nitrogen; b, the temperature rises, and ethylene oxide is introduced; c, after introducing is finished, a sample is taken for detecting cloud points, afterthe cloud points are qualified, alkali is supplemented, and the reaction continues for some time; d, the reaction stops, and the temperature is reduced; e, a sodium chloride aqueous solution is adopted for washing; f, vacuum drying is conducted; the nonoxynol is shown in the formula I. According to the method, after finishing of the reaction, sodium hydroxide is supplemented, ethylene oxide remaining in reaction liquid can be completely consumed, finally, the obtained nonoxynol crude drug does not contain the ethylene oxide, and the quality of the nonoxynol crude drug is improved. In the reaction process, the content of the ethylene oxide is reduced, the frequency of washing in the after-treatment process can be reduced, discharged waste water is reduced, and the method is green and environmentally friendly. The method is short in reaction steps and simple in operation, industrial scale-up production is convenient, and the nonoxynol without ethylene oxide can be obtained.

The invention discloses a method of synthesizing enantiomerically pure tert-butanesulfinamide. The method comprises the following steps of using tert-butyl disulfide and hydrogen peroxide for selective oxidation, then performing reaction on a product and an acylation reagent to obtain tert-butylsulfinyl chloride or tert-butylsulfinyl bromide, then performing reaction on the tert-butylsulfinyl chloride or the tert-butylsulfinyl bromide and hydrazine hydrate to obtain tert-butylsulfinyl hydrazine, then performing reaction on the tert-butylsulfinyl hydrazine and a DTTA resolving agent for resolution and dissociation, and performing zinc / acetic acid pyrolysis to obtain the enantiomerically pure tert-butanesulfinamide. The method provided by the invention is simple, convenient and stable in technological operation and high in yield, is environmentally friendly, is cheap and available in raw materials compared with the prior art, lowers the production cost of the existing enantiomerically pure tert-butanesulfinamide and is beneficial to industrialized mass production.