Thermo-sensitive fluorocarbon surfactant, preparation method and application thereof

A fluorocarbon surface and active agent technology, applied in chemical instruments and methods, gel preparation, colloid chemistry, etc., can solve the problems of increasing cleaning channels, toxicity, etc.

Active Publication Date: 2021-09-07
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires additional cleaning channels and is potentially toxic

Method used

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  • Thermo-sensitive fluorocarbon surfactant, preparation method and application thereof
  • Thermo-sensitive fluorocarbon surfactant, preparation method and application thereof
  • Thermo-sensitive fluorocarbon surfactant, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A thermosensitive fluorocarbon surfactant prepared by the following synthetic route:

[0068]

[0069] The preparation method of described thermosensitive fluorocarbon surfactant mainly comprises the steps:

[0070] (1) Acylation: first weigh 22.5g of perfluoropolyether (PFPE-COOH) with carboxyl groups (DuPont, Krytoxl57FSH, average molecular weight is 6500) and dissolve it in 60ml of solvent fluorine oil (3M, Novec7100), then add 2.5ml of ethyl alcohol Diacyl chloride, under the protection of nitrogen, heated at reflux at 65°C for 48h; when the reaction mixture was cooled to room temperature, it was concentrated by distillation with a rotary evaporator to obtain acylated perfluoropolyether (PFPE-COC1), and the solvent and excess Oxalyl chloride;

[0071] (2) Reaction: Dissolve the PFPE-COCl obtained in step (1) in 30ml of Novec7100 and dichloromethane mixed solvent (Novec7100:dichloromethane volume ratio=1:2), under nitrogen protection, add 2.4g ammonia Blocked po...

Embodiment 2

[0074] The thermosensitive fluorocarbon surfactant prepared by the present invention is added in the oil phase, by such as image 3 The microfluidic device shown prepares microgels, and the microfluidic device includes: ① first input channel, input alginic acid prepolymer solution, ② second input channel, input oil phase containing acid and surfactant, ③ for the output channel. The surface of the inner wall of the microchannel is treated with hydrophobicity.

[0075]Dissolve fluorescein-labeled sodium alginate in cell culture medium containing phenol red to prepare a sodium alginate content of 1% (w / v), as the water phase of the water-in-oil emulsion, and enter ① the first input channel. The mixed solution obtained by adding the temperature-sensitive fluorocarbon surfactant and acetic acid into the fluorinated oil Novec HFE7100, as the oil phase of the water-in-oil emulsion system, enters the second input channel of ②. The temperature-sensitive fluorocarbon surfactant in the...

Embodiment 3

[0077] The temperature-sensitive fluorocarbon surfactant prepared by the present invention is added into the oil phase, and a microgel is prepared through a microfluidic device, such as Figure 7 As shown, including ① first input channel, input alginic acid prepolymer solution, ② second input channel, input oil phase containing acid and surfactant, ③ third input channel, input pure water or buffer solution; ④ is output channel. The surface of the inner wall of the microchannel is treated with hydrophobicity.

[0078] Dissolve fluorescein-labeled sodium alginate in deionized water to obtain a sodium alginate content of 1% (w / v), then add a final concentration of 50 mM calcium ethylenediaminetetraacetic acid (Ca-EDTA) chelate aqueous solution ; Use the gel prepolymer solution configured above as the water phase of the water-in-oil emulsion, and enter ① the first input channel. The mixed solution obtained by adding the temperature-sensitive fluorocarbon surfactant and acetic ac...

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Abstract

The invention discloses a fluorocarbon surfactant, a preparation method and application thereof, and belongs to the technical field of macromolecular surfactants. The fluorocarbon surfactant comprises a fluorine-loving component A and a temperature-sensitive component B, wherein the fluorine-loving component A comprises a fluorine-loving chain with a carbon chain length of at least C8, the temperature-sensitive component B comprises thermosensitive components such as poly N-alkyl acrylamide, a nonlinear polyethylene glycol based thermosensitive polymer and the like, and the fluorine-loving component A and the temperature-sensitive component B are connected through covalent bonds or non-covalent bonds. The fluorocarbon surfactant disclosed by the invention can be used for preparing micro-droplets, can keep the micro-droplets to be relatively good in stability under a relatively low temperature condition, and can be demulsified under a relatively high temperature condition. The fluorocarbon surfactant disclosed by the invention has the advantages of temperature-controllable surface activity capability, contribution to external control of emulsion droplet fusion and the like.

Description

technical field [0001] The invention belongs to the technical field of polymer surfactants, in particular to temperature-sensitive fluorocarbon surfactants and their preparation methods and applications. Background technique [0002] Microdroplets have promising applications in biomedicine, from the therapeutic delivery of cells and drugs to the production of microgels. Generally, micro-droplets can be prepared by emulsion method or microfluidic technology, however, after the preparation of micro-droplets, the emulsion droplets need to be broken on demand, and traditional methods often require a large number of cleaning processes, which are not only time-consuming and labor-intensive, but also may cause The active substances are deactivated in the microgel. Surfactants can prevent the fusion of micro-droplets by reducing the interfacial tension of oil and water, and can even maintain the stability of the droplet system under heating and pressure conditions. Such overly sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F17/22B01F17/42B01J13/00C08G81/02C09K23/22C09K23/42
CPCB01J13/0065C08G81/025
Inventor 王华楠安传锋张玉洁李瀚庭
Owner DALIAN UNIV OF TECH
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