449 results about "Methanesulfinic acid" patented technology

Provided is a process for preparing crystalline imatinib mesylate in substantially pure α-form, which preferably includes crystallizing imatinib mesylate from an organic solvent containing imatinib and methanesulfonic acid, and seed crystals of imatinib mesylate α-form, wherein the seed crystals are added before imatinib mesylate begins to precipitate from the mixture. Also provided are stable, free-flowing imatinib mesylate crystals in substantially pure α-form, and a pharmaceutical composition containing the stable, free-flowing imatinib mesylate crystals.

In one embodiment, a method for activating a metal layer prior to depositing a cobalt-containing capping layer is provided which includes exposing the metal layer to an electroless activation solution to deposit a palladium layer on the metal layer and depositing the cobalt-containing capping layer on the palladium layer. The electroless activation solution contains palladium nitrate at a concentration in a range from about 0.01 mM to about 1.0 mM, nitric acid at a concentration in a range from about 0.01 mM to about 3.0 mM and water. In another embodiment, the electroless activation solution contains palladium nitrate at a concentration in a range from about 0.01 mM to about 1.0 mM, methanesulfonic acid at a concentration in a range from about 0.01 mM to about 3.0 mM and water.

Disclosed is a method for producing graphene functionalized at its edge positions of graphite. Organic material having one or more functional groups is reacted with graphite in reaction medium comprising methanesulfonic acid and phosphorus pentoxide, or in reaction medium comprising trifluoromethanesulfonic acid, to produce graphene having organic material fuctionalized at edges. And then, high purity and large scaled graphene and film can be obtained by dispersing, centrifugal separating the functionalized graphene in a solvent and reducing, in particular heat treating the graphene. According to the present invention graphene can be produced inexpensively in a large amount with a minimum loss of graphite.

The invention relates to an environment-response intelligent weave fabric and relative preparation. Wherein, adding the fabric which is induced by argon microwave low-temperature plasma to generate free group on surface, into the dual monomer solution of 2-acrylamide-2-methanesulfonic acid and N-isopropyl acrylamide that contains N and N'-methylene dual acrylamide cross linker to process graft polymerization reaction, while the bath ratio is 1:40, to graft the dual intelligent gel on the fiber macromolecule of fabric, to attain said inventive product. When the invention is dry, it has no difference from general fabric, but when it is wet, the gel will adsorb water to expand and block the slits between fibers, to reduce the water and gas permeability of fabric, and avoid outer penetrating into the inner layer of fabric to stop heat emission. The invention can be used to produce army waterproof clothes, heat-accumulation temperature adjustable special clothes, etc.

The invention relates to the technical field of macromolecule fiber surface modification and in particular provides a method for modifying the ultrasonic chemical surface of PBO fiber. The method of the invention is characterized in that the method comprises: dipping the PBO fiber into chemical solution which is well arranged and evenly dispersed, vibrating for 1-10min with ultrasonic wave under the condition that the ultrasonic power is 30-100W, the ultrasonic frequency is 20-60 kHz, and the water bath temperature is 20-60DEG C, taking out the PBO fiber after modification, using deionized water or distilled water to wash repeatedly, taking out the PBO fiber which is modified after washing, and drying in 50-150DEG C, wherein chemical solution is at least one of mixed solution of polyphosphoric acid and anhydrous alcohol, polyphosphoric acid, methanesulfonic acid, nitric acid, formic acid and silane coupling agent. The investment cost for equipment which is used in the invention is low, the operation is convenient, the technical process is short, the modifying process is stable, the modified effect of the PBO fiber surface is increased, the fiber property loss is small, and the quality is reliable.

A method and cleaning solution that removes contaminants from a dielectric material and polished surfaces of copper interconnect structures prior to an electroless deposition of a capping layer without substantially adversely affecting the interconnect formed therefrom are disclosed. The cleaning solution includes combinations of a core mixture and sulfuric acid or sulfonic compounds such as sulfonic acids that include methanesulfonic acid. In one embodiment, the core mixture includes a citric acid solution and a pH adjuster such as tetra-methyl ammonium hydroxide or ammonia. One embodiment of the method includes providing a planarized substrate, applying the cleaning solution to the substrate to simultaneously clean at least one metal feature and a dielectric material of the substrate, and depositing the metal capping layer selectively on the at least one metal feature using electroless deposition.

the invention discloses a acrylamide crosslinking copolymer emulsion with 35-44% acrylamide crosslinking copolymer and water and preparing method in the reversed phase emulsion-typed macromolecular thickener of cosmetic, drug and ink industry, which comprises the following steps: blending acrylamide and 2-acrylamide-2-methanesulfonic acid; adding adjuvant to mix with oil phase; adding emulsifier of water-in-oil type and adjuvant emulsion; adding emulsifier of the oil-in-water type to obtain the product.

The invention belongs to the field of tin chemical engineering and in particular relates to a method for preparing a stable tin methanesulfonate solution. The method comprises the steps of preparing anode and cathode sheets from refined tin, adding stabilizers into methanesulfonic acid to prepare an anolyte, adding electroplating additives into methanesulfonic acid to prepare the catholyte, shade, separating the anolyte from the catholyte by an anion separator, preparing a crude tin methanesulfonate solution by a direct current electric melting method, and concentrating the crude tin methanesulfonate solution in vacuum under the protection of inert gas to obtain the stable tin methanesulfonate solution, wherein the stabilizers are phenol, ascorbic acid or tartaric acid and the electroplating additives are phenol sulphonic acid, latex, gelatin, cresol, aloin, cresylic acid or beta-naphthol. The stable tin methanesulfonate solution prepared by the method disclosed by the invention has the characteristics of stable quality and no precipitation, is difficult to oxidize and discolor, and has the advantages of simple preparation process, low cost, environment friendliness and the like, and good popularization and application value are achieved.

The invention discloses a titanium and titanium alloy surface anodic oxidation coloring method and belongs to the technical field of metal surface treatment. The method includes the following steps that a cleaned commercial pure titanium sample is put in a solution with a proportion of HF: HNO3: H2O for electrolytic polishing; the cleaned and dried sample is put in a mixed solution of concentrated sulfuric acid and methanesulfonic acid for anodic oxidation treatment; and the sample obtained after being subjected to the anodic oxidation treatment is rapidly cleaned through ethyl alcohol and deionized water and then dried under the vacuum condition so that the colored sample can be obtained. Anodic oxide films in different colors are obtained through control over anodic oxidation voltage and treatment time, and the anodic oxide films are bright and uniform in color and luster and good in corrosion resistance.

Belonging to the field of modified silica gel adsorbents, the invention particularly relates to a di-amidoxime group containing modified silica gel adsorbent specific to heavy metal copper ions in an adsorption solution and a preparation method thereof. The preparation method includes: taking silica gel as a starting raw material, conducting activation by a methanesulfonic acid solution, performing impregnation in a toluene solution of KH550, carrying out drying, then adding the obtained dry particles into an N, N-dimethylformamide solution of acrylonitrile to undergo first modification, and carrying out a treatment, then adding the dried first modified particles into a mixed solution of a hydroxylamine hydrochloride solution and a sodium carbonate solution to perform second modification, and conducting a treatment, thus obtaining dried second modified particles, i.e. a di-amidoxime group containing modified silica gel adsorbent finished product. The di-amidoxime group involved in the invention can be chelated with a heavy metal, thus having a strong adsorption effect on heavy metal copper ions. And compared with single-oxime group adsorbents, the di-amidoxime group containing modified silica gel adsorbent disclosed in the invention has substantially improved adsorption performance on copper ions, and the adsorption capacity is increased to 30mg / g.

The invention discloses a preparation method and medical application of 4-tert-butyl-6-phenyl-2-amino-6H-1,3-thiazine salt. The preparation method of the 4-tert-butyl-6-phenyl-2-amino-6H-1,3-thiazine salt comprises the steps of: stirring 0.010 mol of 1-phenyl-4,4-dimethyl pentene-3-ketone, 0.012 mol of thiourea and 0.011 mol of acid in an organic solvent at a temperature of between 30 and 80 DEG C, performing TLC detection on reaction process, completing reaction, filtering, washing and drying the obtained product and obtaining the 4-tert-butyl-6-phenyl-2-amino-6H-1,3-thiazine salt (I). The 4-tert-butyl-6-phenyl-2-amino-6H-1,3-thiazine salt (I) can be medically used for preparing influenza virus neuraminidase inhibitors. In a formula, HX is hydrochloric acid, phosphoric acid, hydrobromic acid, sulphuric acid, trifluoroacetic acid or methanesulfonic acid, and Y is Cl, Br, CH3, Et, CF3, OCH3 or OEt.

The present invention is directed to an irinotecan acid addition salt which is formed through addition of an acid selected from the group consisting of sulfuric acid, nitric acid phosphoric acid, methanesulfonic acid, citric acid maleic acid and succinic acid to Irinotecan, to a method for producing the salt, and to a pharmaceutical composition containing the salt. The addition salt requires no heating process during drug preparation and provides an aqueous drug product in which the salt is stably dissolved.

The invention discloses a high concentration zinc and vanadium redox cell. According to the invention, the novel zinc vanadium oxidation reduction cell is characterized in that a vanadium ion solution is taken as an anode active substance, zinc and a zinc ion solution are taken as an cathode active substance, wherein the equilibrium potential is 1.76 V under a standard state, the open-circuit voltage is 1.7 - 2.0 V under a charging state. The vanadium ions of the vanadium ion solution are existed as quintavalence and quadrivalence (V(I), V(IV)), and the total vanadium concentration can reach to 4.0 mol / L, a solvent is inorganic acid or organic acid. The zinc ion solution is a zinc ion electrolyte containing organic acid or inorganic acid. The organic acid is methanesulfonic acid or sulfamic acid. The inorganic acid is sulfuric acid or nitric acid. The high energy concentration redox cell can be exploited according to the invention.

The invention discloses ionic liquid capable of absorbing sulfur dioxide as well as a preparation method and application of the ionic liquid. Cations of the ionic liquid are nitrogen-containing organic matters and anions of the ionic liquid are organic acid groups. The nitrogen-containing organic matters are selected from one or ore of guanidine salts, alcamines, imidazoles, pyridines, tetrazoles, quaternary ammonium salts, thiazoles ad dicyandiamides matters; and the organic acid groups are selected from one or more of lactic acid, tartaric acid, citric acid, methanesulfonic acid, trifluoroacetic acid, malic acid, oxalic acid and acetic acid. The ionic liquid disclosed by the invention has a relatively good absorption effect on SO2 and relatively high selectivity. The preparation method is simple, reaction conditions are moderate, the raw materials are cheap and easily available, and the product has stable performances. An absorbent prepared from the ionic liquid has high absorption efficiency, can be cyclically utilized and has good stability, and can be used for absorbing the SO2 in flue gas at a high temperature; and the inactivation of the absorbent, caused by the fact that the ionic liquid is decomposed, is avoided.

The invention provides a derivative of macrolides, a method for preparing the same and application thereof. The derivative is a hydrate of erythrocin and salt, the molecular formula is C37H67NO13.A.nH2O, and n is between 1.0 and 11.0; and A is selected from an organic acid or inorganic acid, and one of lactobionic acid, thiocyanic acid, maleic acid, fumaric acid, thiocyanic acid, acetic acid, methanesulfonic acid, benzene sulfonic acid, nicotinic acid, lactic acid, citric acid, tartaric acid, aspartic acid, glutamic acid and phosphoric acid. The hydrate has better water solubility and storing stability, and is suitably used for preparing medicaments of treating and preventing infectious diseases of human or animals caused due to sensitive bacteria of Gram-positive or negative bacteria.

The present invention relates to a method for the electrochemical polishing of surfaces of metals and metal alloys, in particular surfaces of niobium, niobium alloys, tantalum and tantalum alloys. It uses an electrolyte that comprises methanesulfonic acid and ammonium bifluoride, and which is also an object of the present invention. Said electrolyte makes it possible to electropolish niobium-containing and / or tantalum-containing workpieces efficiently, with high quality and in a manner that is harmless both for the workpiece and for humans and the environment.

The invention relates to a new synthetic method of 1-(beta-D-pyran glucosyl)-4-methyl-3-[5-(4-fluorinated phenyl)-2-thienyl methyl] benzene (canagliflozin), and the method is characterized in that: coupling and etherification steps are separately operated, at the same time in the etherification process, usage amount of methanesulfonic acid is greatly reduced compared with the prior art, and the method can reduce the cost, is convenient in operation and improves the quality of products.

High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.

The invention discloses a method for determining ammonia content in cigarette main stream smoke by ion chromatography, which comprises the following steps: trapping ammonia in main stream smoke by using a sulfuric acid solution as an extracting solution and absorption solution to prepare an ammonia sulfuric acid solution, filtering, and carrying out ion chromatography analysis. The ion chromatography analysis uses a CS19 chromatographic column. A 0.002 mol / L methanesulfonic acid solution is adopted for the 0th-11.0th minutes in the elution step, the concentration of the methanesulfonic acid for the 11.1th-22.0th minutes in the elution step is 0.050 mol / L, and the concentration of the methanesulfonic acid for the 22.1th-30.0th minutes in the elution step is restored to 0.002 mol / L. The cigarette sample obtained by the method has favorable NH4<+> chromatogram peak symmetry, thereby avoiding the influence of high-concentration Na<+> on the NH4<+> determination; the Na<+>, methylamine, ethylamine and NH4<+> in the sample solution have favorable separation degree; and thus, the method can satisfy the requirements for determination of ammonia content in cigarette main stream smoke.

A description is provided of a mixture which is preparable by allowing the reaction of a premixture of (av), methanesulfonic acid (bv), one or more esters of one or more phosphorous-oxygen acids and (cv) one or more silanes. The invention also concerns the use of said mixtures as additives for the polyisocyanate component of a two-component binding agent system for preparation of a polyurethane resin. The invention further concerns a solution containing polyisocyanate for use as a component of a molding material binding agent system, and the use of a solution containing polyisocyanate as the polyisocyanate component of a two-component binding agent system for preparation of a polyurethane resin and corresponding two-component binding agent systems for preparation of a polyurethane resin.

The invention relates to a graphene nanobelt graft modified PBO polymer and a preparation method thereof. The graphene nanobelt graft modified PBO polymer is mainly used for solving the technical problem that the existing PBO fiber is low in tensile strength. The graphene nanobelt graft modified PBO polymer has a structural formula (described in the specification), wherein A is graphene nanobelt, n is between 30 and 100, and s is between 30 and 100. The preparation method of the graphene nanobelt graft modified PBO polymer comprises the following steps: adding carboxylated graphene nanobelt into a polyphosphoric acid solution, and stirring to obtain a carboxylated graphene nanobelt dispersion solution; mixing PBO polymer with methanesulfonic acid and stirring, so as to obtain a PBO solution; mixing the carboxylated graphene nanobelt dispersion solution with the PBO solution, heating for reaction, and washing with water and drying, thus obtaining the graphene nanobelt graft modified PBO polymer. Tensile strength of a fiber prepared by utilizing the graphene nanobelt graft modified PBO polymer is 8-9GPa, so that the graphene nanobelt graft modified PBO polymer can be used for producing heat-resisting textiles or can be used as a fiber reinforcing material.

This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]benzamide with two molecules of methanesulfonic acid and to the polymorphic forms thereof, as well as to their pharmaceutical compositions.

The invention discloses a compound represented by a structural formula (1) which is described in the specification. The compound is prepared by subjecting 2-(2',4'-dihydroxyphenyl)benzothiazole and 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoic acid to a condensation reaction, wherein a condensation reaction medium is methanesulfonic acid and reaction temperature is 80 to 105 DEG C. The compound provided by the invention has high fluorescence quantum yield, long emission wavelength and good fluorescence labeling capability and is a xanthene hybrid with dual fluorescence emission performance, so the compound can be used as a ratio-dependent optical probe.

Provided are a residue removing liquid composition capable of completely removing a resist residue and a titanium (Ti)-derived residue that remains after dry etching and ashing in via hole formation in a production process for a semiconductor substrate having metal wiring of aluminium (Al) or an Al alloy, at a low temperature in a short time, not corroding parts of an interlayer insulating material, a wiring material and others, and a cleaning method for semiconductor devices using it.The residue removing liquid composition contains (A) ammonium fluoride, (B) methanesulfonic acid, (C) a carbon-carbon triple bond-having compound, (D) a water-soluble organic solvent, and (E) water, wherein the content of (A), (C), (D) and (E) in the residue removing liquid composition is from 0.005 to 2% by mass, from 0.1 to 10% by mass, from 60 to 75% by mass and from 5 to 38% by mass, respectively, and (B) is contained in an amount of from 0.9 to 1.5 times (by mol) the amount of (A).

The invention provides a method for preparing polyether glycol by liquefying starch. The method is a new process for preparing the polyether glycol by taking the starch as a raw material, mixed polyhydric alcohol as a liquefying agent and methanesulfonic acid as a catalyst. According to the invention, the environment-friendly catalyst methanesulfonic acid is firstly adopted; the liquefaction ratio achieves 98.2%, the hydroxyl value is 360.0 mgKOH / g and the viscosity is 725 mpa.s at the liquefaction temperature of 150-170 DEG C; and the prepared polyether glycol is suitable for preparing a foaming polyurethane material. The method provided by the invention has the characteristics of simple preparation process, low cost and available raw material, moderate reaction condition, low cost and the like and is a clean process for preparing the polyether glycol through the recyclable raw material starch.

The invention provides a tin plating solution and an efficient tin plating process based on the tin plating solution. The tin plating solution includes the following raw materials in parts by mass: 23-27 parts of methanesulfonic acid, 24-29 parts of tin methanesulfonate, Matte tin additive 1-3 parts, pure water 44-48 parts, the raw material composition of described matte tin additive comprises stannous sulfate and sulfuric acid, the efficient tin plating process based on this tin plating solution comprises steps: ultrasonic dust removal, pickling, micro etched, tinned, sealed and dried. The invention can thoroughly clean the bare copper, has high tinning efficiency, and the formed tin layer has uniform thickness, no cracking, and is not easy to oxidize.

The invention provides a method for preparing tin methane sulfonate through hydrogen-free electrolysis, and relates to the field of manufacturing the tin methane sulfonate through industrial electrolytic synthesis and can be used for directly preparing a tin methane sulfonate solution through using an electrolytic process. According to the method provided by the invention, electrolyte is a methanesulfonic acid solution; a cathode of an electrode is a gas diffusion electrode, and an anode of the electrode is solid tin; the cathode and the anode are separated through a membrane; the electrolyte temperature is controlled within a range of 0-60 DEG C; a current density is set within a range of 10-800 A / m<2>; the electrolyte is stopped until a content of free methyl sulfuric acid in the anode electrolyte is up to 0.1-10 g / L; and the anode electrolyte is filtered and concentrated, so as to prepare the tin methane sulfonate solution with different concentrations. The method provided by the invention is suitable for being carried out at the constant temperature and the constant pressure, so that the tin methane sulfonate solution with high purity can be directly obtained. The method provided by the invention has the characteristics of being simple in process, free from separation, high in product purity, low in energy consumption and low in cost.

The invention discloses a method for preparing 4,6-diaminoresorcinol dihydrochloride through one-pot synthesis. The method mainly comprises the steps of: by taking Bronsted acid such as polyphosphoric acid, concentrated sulfuric acid or methanesulfonic acid as the catalyst and the solvent, realizing oximation, Beckmann rearrangement, hydrolysis and hydrocchlorination of 4,6-diacetylresorcinol, and thus obtaining the 4,6-diaminoresorcinol dihydrochloride (DAR.2HCl), wherein the mol ratio of hydroxylamine hydrochloride, the Bronsted acid catalyst and the 4,6-diacetylresorcinol is (2.0-2.5) / (1-10) / 1, and the reaction temperature ranges from 65 to 125 DEG C. The method provided by the invention is simple in process steps and efficient in preparation; therefore, the industrialization of the 4,6-diaminoresorcinol dihydrochloride is greatly promoted.

The invention discloses an application of NaF as an additive in a lead methanesulfonate flow battery electrolyte. The electrolyte is a mixture liquid of lead methanesulfonate and methanesulfonic acid, wherein the concentration of the (CH3SO3)2Pb is 0.1-2 M, the concentration of the CH3SO3H is 0-1 M and the concentration of the NaF is 0.005-0.02 M. The NaF, as the additive, prolongs the service life and improves Coulomb efficiency of a battery, wherein the service life of the battery can reach more than 1000 times, the Coulomb efficiency is basically more than 90%, and energy efficiency is higher than 78%.