An acrylate functional monomer with anti-inflammatory effect and a preparation method thereof, comprising dissolving methylprednisolone in an organic solvent, adding an acid-binding agent, adding dropwise a dilute solution replacing acryloyl chloride, cooling the mixture in an ice-water bath and at room temperature. Continue the reaction, after the reaction is over, filter the reaction solution, add deionized water to the filtrate, precipitate solid precipitation, filter, wash the filter cake with deionized water, and dry to obtain the acrylate functional monomer, the prepared acrylate functional monomer Free radical copolymerization with other olefinic monomers can prepare polymers with anti-inflammatory functions, and construct polymer nanomicelles with a cell membrane-like structure. The polymer micelles are not suitable for diffusion of the anti-inflammatory drug methylprednisolone in practical applications. At the same time, its imitation cell membrane structure is conducive to the uptake of cells, and it can evenly release methylprednisolone through the hydrolysis of ester bonds, so that it can be used efficiently to reduce the dosage and avoid complications in long-term use. occurrence of the disease.