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A surgical coupling device detachably connects a tool holder to a surgical instrument, wherein the tool holder is provided with a recess into which a coupling portion of the instrument can be inserted detachably, wherein a locking recess is provided in an inner wall of the recess, with which a locking member can be engaged detachably, the locking member being supported at the instrument, wherein the locking member is selectively movable into a locking position and a release position by a servo drive.

A medical device is provided, comprising a first unit and a releasably attachable second unit. The first unit comprises a mounting surface adapted for application to the skin of a subject, and a transcutaneous device comprising a distal pointed end adapted to penetrate the skin of the subject, wherein the transcutaneous device has a first position in which the distal end is retracted relative to the mounting surface, and a second position in which the distal end projects relative to the mounting surface. The second unit comprises actuatable driving means adapted to move the transcutaneous device from the first position to the second position when the driving means is actuated with the second unit attached to the first unit. By this arrangement the first unit can be applied to the skin of the subject using the second unit as a gripping and handling means, whereafter the driving means can be actuated for insertion of the transcutaneous device.

The present invention relates to medical devices which are adapted for application to a skin surface of a user and comprise a transcutaneous device which is supplied in a sterile condition. Thus, a medical device is provided, comprising a mounting surface adapted for application to the skin of a subject, a first portion having a first end adapted to penetrate the skin of the subject, and a second portion in fluid communication with the first portion and having a second end. The device further comprises enclosure means being transformable from an initial configuration encapsulating the first and second portions in an initial aseptic state, to a second configuration in which the ends of the first and second portions are allowed to communicate with the exterior through the enclosure means, wherein the enclosure means does not enclose the mounting surface.

A gettered polycrystalline group III metal nitride is formed by heating a group III metal with an added getter in a nitrogen-containing gas. Most of the residual oxygen in the gettered polycrystalline nitride is chemically bound by the getter. The gettered polycrystalline group III metal nitride is useful as a raw material for ammonothermal growth of bulk group III nitride crystals.

The present invention generally relates to skin-mountable devices. A device in accordance with the invention comprises a first skin-mountable unit having a mounting surface comprising adhesive means for adhering the unit to the skin of a subject, and a second handling unit releasably attached to the skin-mountable unit. The handling unit comprises an interior space at least partially accommodating the skin-mountable unit and has an opening through which the skin-mountable member can be moved when detached from the handling unit, the handling unit having a portion surrounding the opening. The device further comprises a seal member releasably attached to the circumferential portion, thereby providing a closed space for the skin-mountable unit. In this way a device is provided allowing for easy handling as a user can use the handling unit to grip and handle the combined device during operation thereof, just as the second unit can be designed and optimized for ease of use during manipulation of the skin-mountable unit.

Lancet device having an adjustable penetration depth. The lancet device includes a housing, a cap for covering the housing and for positioning the lancet device relative to a skin surface, a needle holding member for holding a lancet which needle holding member is at least partially contained within the housing, a biasing element for biasing the needle holding member toward an extended position, and a trigger for releasing the needle holding member from a retracted position. The lancet device further includes a mechanism for adjusting a penetration depth of a lancet. The penetration depth adjustment mechanism may involve adjusting a travel distance of the needle holding member, wherein the mechanism is positioned within at least one of the housing and the cap during at least a portion of length of travel of the needle holding member. The penetration depth adjustment mechanism may involve adjusting a travel distance of the needle holding member by adjusting a length of the needle holding member. The penetration depth adjustment mechanism may involve aligning at least one stop of the housing with at least one protrusion of the needle holding member. The penetration depth adjustment mechanism may involve a cavity in the needle holding member for holding a lancet, wherein the cavity depth of the needle holding member is adjusted.

Lancet device including a first housing. A first guide wall is disposed within the first housing. The first guide wall includes an opening. A cap removably mounted to the first housing. A needle holding member for holding a lancet. At least a portion of the needle holding member being able to move within the opening. A first spring for biasing the needle holding member toward an extended position. The first spring surrounding a portion of the needle holding member and being disposed between the first guide wall and a shoulder of the needle holding member. A movable trigger having a first position and a second position. A movable second housing including a proximal end, a distal end and a second guide wall arranged at the proximal end. The second guide wall including an opening. A portion of the needle holding member being able to move within the opening of the second guide wall. The second housing being configured to move the needle holding member to the retracted position when the second housing is moved away from the first housing. The proximal end of the second housing being configured to move axially within the distal end of the first housing. A second spring for biasing the second housing towards the first housing. The second spring surrounding a portion of the needle holding member and being disposed between the second guide wall and another shoulder of the needle holding member. At least a portion of the needle holding member is always retained within the first housing.

The present invention provides an assembly comprising a skin-mountable device with a mounting surface, the device being arranged in a packaging releasably attached to the device and having an opening through which the device can be moved when detached from the packaging. The device and the packaging comprises cooperating attachment means, whereby the attachment means allows the packaging to be moved in parallel with a skin surface for a predetermined distance when a force in parallel with the skin is applied to the packaging in the first direction, yet prevents movement of the packaging away from the general plane. The attachment means between the packaging and the skin-mountable device, allows the packaging to be used as a handling tool to place the device on a skin surface, the attachment means preventing that the device inadvertently falls out during handling, yet allows for easy and safe removal.

The invention provides a transcutaneous medical device (502, 250, 150, 600) comprising a lower surface adapted for application towards the skin of a subject, attaching means (571, 272, 161) for securing the lower surface relative to the skin, and a transcutaneous device (530, 182, 213, 651) adapted to penetrate the skin of the subject. The transcutaneous device is mounted for movement between an extended position in which the transcutaneous device projects relative to the lower surface and a retracted position in which the transcutaneous device is retracted relative to the lower surface. The medical device further comprises release means (550, 275, 162) which can be operated from a first state through an intermediate state to a second state, whereby operation of the release means from the first to the intermediate state causes the transcutaneous device to be moved from the extended position to the retracted position, and operation of the release means from the intermediate to the second state causes release of the attaching means.

The present invention relates to medical devices which are adapted for application to a skin surface of a user and comprise a transcutaneous device which is supplied in a sterile condition. Thus, a medical device is provided, comprising a mounting surface adapted for application to the skin of a subject, a first portion having a first end adapted to penetrate the skin of the subject, and a second portion in fluid communication with the first portion and having a second end. The device further comprises enclosure means being transformable from an initial configuration encapsulating the first and second portions in an initial aseptic state, to a second configuration in which the ends of the first and second portions are allowed to communicate with the exterior through the enclosure means, wherein the enclosure means does not enclose the mounting surface.

A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.

A method for manufacturing panels including a substrate on the basis of a pressed material mass, whereby it is started from a material mass to be densified, wherein the density of this material mass, in one or more densifying steps, is at least doubled. Prior to one or more of these densifying steps, a colorant is added to the material mass.

The present invention relates to a universal wiper adapter for connecting a wiper blade assembly to a wiper arm including a pair of sidewalls having an aperture and a land extending between the sidewalls cooperating to define a channel. The present invention further includes a cantilevered beam, between the sidewalls, having a super-surface and a subsurface each cooperating with the sidewalls to define an elongate passage and an elongate track, respectively. The channel and the elongate passage cooperate to receive two sizes of hook-type wiper arms, while the channel and the elongate track cooperate to receive three sizes of hook-type wiper arms. The present invention also includes a substrate between the sidewalls cooperating with the land and the apertures to receive two sizes of pin-type wiper arms. The substrate further cooperates with the sidewalls and the land to define an elongate cavity to receive a bayonet-type wiper arm.

A yaw-rate sensor having a substrate and a plurality of movable substructures that are mounted over a surface of the substrate, the movable substructures being coupled to a shared, in particular, central spring element, means being provided for exciting the movable substructures into a coupled oscillation in a plane that extends parallel to the surface of the substrate, the movable substructures having Coriolis elements, means being provided for detecting deflections of the Coriolis elements induced by a Coriolis force, a first Coriolis element being provided for detecting a yaw rate about a first axis, a second Coriolis element being provided for detecting a yaw rate about a second axis, the second axis being oriented perpendicularly to the first axis.