67results about How to "Suitable for industrial preparation" patented technology

The invention discloses a halogen-free and heavy-atom-free room-temperature phosphorescent material as well as a preparation method and application thereof. A room-temperature phosphorescent reactionmaterial is compounded with a polymer to obtain a pure organic polymer material with a long-life room-temperature phosphorescent light-emitting characteristic; wherein the room-temperature phosphorescent reaction material is selected from one or more of acridine and derivatives thereof, acridinium salt and derivatives thereof, or acridone and derivatives thereof. The halogen-free and heavy-atom-free room-temperature phosphorescent material has a very strong luminescence property, a long luminescence service life and a wide color adjustable range at a room temperature; the raw materials are simple and easily available, and the preparation method is simple, quick, low in cost and suitable for industrial preparation and has a high actual application and popularization value. No metal elementor toxic halogen element exists, only water is used as a solvent in the whole processing process, no organic solvent is used, and the method has obvious advantages in the aspect of environmental protection.

The invention relates to a preparation method of an alveolate multilayer pore structure activated carbon film. The technical scheme comprises the following steps of: taking cellulose acetate as film material, and taking low-boiling point organic solvent as solvent, so that film casting liquid can be prepared; preparing an alveolate multilayer pore structure cellulose acetate film by a water vapor assisting method, hydrolyzing in 0.1mol / L NaOH / ethanol solution for 10-24 hours, soaking in 1-5% of inorganic salt solution to be activated, stabilizing, carbonizing, washing, and drying, so that the alveolate multilayer pore structure activated carbon film can be prepared. The preparation method combines the water vapor assisting method with the carbonization, and is simple in technology, and suitable for the large-scale industrial preparation. The prepared alveolate multilayer pore structure activated carbon film has the characteristics of being multilayer in alveolate pore structure, large in specific surface area, and high in porosity. The prepared alveolate multilayer pore structure activated carbon film has a very high absorption function to organic dyestuff, and is easy to recycle.

The invention relates to a method for preparing a silicon carbide nanofiber. The method comprises the following steps: S1, dissolving polysilane into a ternary mixed solvent of N,N-dimethyl formamide / 1,4-dioxane / tetrahydrofuran so as to obtain a polysilane solution; S2, quenching the polysilane solution for 60-120 minutes at minus 50 DEG C to minus 10 DEG C, performing extraction for four times with ethanol, and performing freezing drying for 24 hours so as to obtain a first precursor; S3, in the presence of helium, performing radiation cross-linking on the first precursor with an electronic beam with a radiation dosage of 200-800KGy, retaining in helium, and performing annealing treatment for one hour at 120 Deg C so as to obtain a second precursor; S4, performing stabilization treatmentand high-temperature sintering on the second precursor, thereby obtaining the silicon carbide nanofiber. According to the method, a polycarbosilane precursor nanofiber is prepared by using a thermallyinduced phase separation method in a ternary solvent, the silicon carbide nanofiber is prepared through radiation cross-linking, stabilization and high-temperature sintering, and the method is simplein process and applicable to large-scale industrial preparation.

The invention discloses a drug composition containing baricitinib and a preparation method and application of the drug composition. The drug composition comprises the baricitinib and an auxiliary material which can be received pharmaceutically, wherein the auxiliary material comprises a filling agent and a disintegrating agent. The preparation method of the drug composition comprises the steps that the filling agent and the disintegrating agent are evenly mixed, so that the mixed auxiliary material is obtained; and then a baricitinib crude drug and the mixed auxiliary material are evenly mixed or pelletizing liquor containing the baricitinib crude drug is evenly mixed with the mixed auxiliary material, and drug-carrying pellets of the solid drug composition containing the baricitinib are obtained through pelletizing. According to the drug composition containing the baricitinib and the preparation method and application of the drug composition, the solid drug composition which can be dissolved out rapidly in vitro and contains the baricitinib is prepared by controlling the particle size of the baricitinib, using microcrystalline cellulose, mannitol and the like in the hydrophilic auxiliary material as the filling agent, and using croscarmellose sodium and the like as the disintegrating agent; and the preparation technique is simple and suitable for industrialization.

The invention provides a structural color super-hydrophobic coating and a preparation method thereof. The preparation method comprises the following steps: subjecting submicron microspheres to surfaceroughening modification so as to obtain roughened microspheres, then uniformly mixing the roughened microspheres with carbon powder, then adding an obtained mixture into a dimethyl siloxane resin solution, and carrying out full dispersion so as to obtain the structural color super-hydrophobic coating. The coating provided by the invention is simple in preparation process, low in cost and friendlyto the environment; the coating can be used as a self-cleaning and heavy-metal-free colored environmentally-friendly waterborne coating, is easy to be smeared, and has high adhesive force, corrosionresistance and wide applicability; a coating layer prepared from the coating provided by the invention can be rapidly repaired and reduced after being damaged; and the super-hydrophobic coating has high strength and has important application value and wide application prospects in the polymer coating industry.

The invention discloses a method for synthesizing a 2,4,5-trimethoxyethylphenylketone intermediate of alpha-asarin, which is characterized by comprising the following steps of: directly reacting 2,4,5-trimethoxybenzene, which servers as a raw material, with propanoic acid or propionic anhydride under the action of polyphosphoric acid, or a mixture of phosphoric acid and phosphoric anhydride, or a mixture of the polyphosphoric acid, the phosphoric acid and the phosphoric anhydride; and performing hydrolysis to obtain the 2,4,5-trimethoxyethylphenylketone. The product can be used as the raw material or the intermediate of the alpha-asarin or the raw material for synthesizing other medicaments, and also can be used as spices. The method of the invention has the advantages of simple process, low cost, high product quality, high yield and the like and is safe and reliable in operation and suitable for industrial production. The method can effectively solve the problems of complicated operation and the like of the synthesis of the 2,4,5-trimethoxyethylphenylketone intermediate of the alpha-asarin.

The invention relates to a preparation method of a multi-layer hole active carbon membrane coating solid phase micro-extraction head. According to the technical scheme of the invention, the surface ofa stainless steel wire is covered with a polycarboxymethyl silane precursor of a multi-layer hole structure with a vapor assistance method, and stabilization, carbonization and chlorination reactionis performed to obtain the multi-layer hole active carbon membrane coating solid phase micro-extraction head. The preparation method provided by the invention is simple in process, does not cause environmental pollution and is suitable for large-scale industrial preparation. A multi-layer hole active carbon membrane coating has the characteristics of large specific surface area, high porosity andthe like, so that the extraction head is strong in enrichment capacity, large in extraction quantity, good in thermal stability, rapid in parsing speed and long in service life, has higher precision and accuracy and can rapidly determine the content of volatile organic compounds in air.

The invention relates to a Chinese medicinal preparation for treating diabetes and a preparation method thereof. The Chinese medicinal preparation is prepared from the following raw material medicaments in part by weight: 3 to 60 parts of astragalus, 1 to 15 parts of ginseng, 1 to 20 parts of radix rehmanniae preparata, 2 to 20 parts of dwarf lilyturf turber, 1 to 30 parts of medlar, 2 to 20 parts of white mulberry root-bark and 1 to 10 parts of Chinese magnoliavine fruit. The preparation method comprises the following steps of: mixing the medicaments; adding water into the mixture to decoct twice, wherein the water, of which the amount is eight times that of the total weight of the raw materials is added every time and the mixture is decocted for 2 hours every time; filtering the obtained product, merging filtrate and concentrating the merged filtrate to form an extract; taking ginseng according to the weight part, drying the ginseng, grinding the dried ginseng into fine powder, uniformly mixing the fine powder with the extract, drying the mixture and grinding the dried mixture into fine powder serving as active ingredients; and preparing the active ingredients and a vector or an excipient which is acceptable pharmaceutically into various formulations. The Chinese medicinal preparation has scientific and reasonable formula design, takes effects of replenishing qi and nourishing Yin, promoting the production of body fluid to quench thirst and clearing away heat and activating blood together by combining seven traditional Chinese medicines and has effects of reducing blood sugar, regulating lipid and reducing blood viscosity.

The invention belongs to the field of traditional Chinese medicine preparation, and relates to a method for enriching daphnane type total diterpenoid ingredients from a grassland poisonous weed-stellera chamaejasme L. and application of the daphnane type total diterpenoid ingredients in preparation of anti-HIV medicine. According to the method, the total diterpenoid ingredients are enriched from the thymelaeaceae plant-stellera chamaejasme L., anti-HIV activity testing and main active ingredient content determining are conducted on all components, and results show that the anti-HIV activity is in an obvious rising trend along with increasing of the content of the daphnane type total diterpenoid ingredients in the components; when the total diterpenoid content of the enriched components is higher than 27%, the extremely high anti-HIV activity is displayed, the EC50 value can reach 0.005 microgram or below, the selection index SI is larger than 2,000, and high efficiency and low toxicity are achieved. The method for quickly enriching the daphnane type total diterpenoids from the stellera chamaejasme L. is established, and the enriched total diterpenoids can be used for preparing the anti-HIV medicine.

The invention relates to a preparation method of lavender essential oil oil-in-water emulsion, the preparation method comprises the following steps: deionized water, gelatin, glycerol and an emulsifier into xanthan gum are sequentially added, and mixed to obtain a continuous phase; lavender essential oil is used as a dispersion phase; the essential oil emulsifying film is used as an emulsifying medium, a compressed gas tank is used for providing pressure, the dispersion phase is pressed into a film tube of the essential oil emulsifying film to form jet flow under the transmembrane pressure difference, and the dispersion phase leaves the surface of the film tube and enters the continuous phase under the shearing force action of the continuous phase, so that the lavender essential oil oil-in-water emulsion is formed. The nanoscale lavender essential oil emulsion is prepared with low energy consumption and high flux, the stability and physiological absorbance of the emulsion are effectively improved, the storage period of the essential oil is prolonged, and the method has the advantages of being simple in process, convenient to operate, small in emulsion particle size, good in dispersity and the like, and is an efficient method for preparing the lavender essential oil emulsion. The method is suitable for large-scale industrial preparation of the lavender essential oil emulsion.

The invention provides a special anti-blocking agent for ammonium sulfate as well as a preparation method and application thereof. The anti-blocking agent is a water-soluble liquid anti-blocking agent, and is concretely prepared from 20 to 50 percent of water, 10 to 30 percent of volatile solvents, 20 to 40 percent of film-forming agents, at most 10 percent of habit modifiers, at most 10 percent of surfactants, at most 10 percent of crystal control agents and at most 3 percent of antifoaming agents. The special anti-blocking agent effectively overcomes the use defect of the oil and tablet anti-blocking agent; the anti-blocking effect is improved; meanwhile, the surface whitening, powdering and mildewing phenomenon of ammonium sulfate fertilizers can be effectively reduced; the preparationprocess is simple; the efficiency is high; the use is convenient; the special anti-blocking agent is suitable for industrialized preparation and is favorable for popularization and application.

The invention provides an anti-tumor angiogenesis immune composite peptide. The anti-tumor angiogenesis immune composite peptide includes an immunogenicity epitope of a vascular endothelial growth factor (VEGF), an immunogenicity epitope of platelet-derived growth factor (PDGF) and an immunogenicity epitope of erythropoietin EPO. The anti-tumor angiogenesis immune composite peptide has the capability of targeting three target sites, VEGF, PDGF and EPO, thus effectively inhibiting tumor growth; in addition, the anti-tumor angiogenesis immune composite peptide can be used as an active immunization vaccine, and effectively reduce the antibody drug immunogenic response. The invention also provides a preparation method and application of the anti-tumor angiogenesis immune composite peptide.

The invention discloses a synthetic method of PHBA, and belongs to the technical field of pharmaceutical synthesis. According to the method, L-glutamic acid is taken as the raw material, and is subjected to diazotization, hydrolysis, aminolysis and Hoffman degradation to obtain (S)-4-amino-2-hydroxybutyrate which is not purified and used directly for synthesizing (S)-alpha-hydroxyl-gamma-N-phthaloylaminobutyric acid. The synthetic method solves the problems that the conventional method is cumbersome in operation, high in energy consumption and serious in environmental pollution due to the fact that ion exchange resin is required to be used repeatedly for separation and purification of a product, steps of reactions are organically combined, the whole process is considered, and numerous distillation and purification processes are omitted, so that the whole process is greatly simplified, the total yield of the product is larger than 60%, the content of the product is larger than 99.0%, the optical purity is higher than 99.0%, the quality is stable, reaction conditions are mild, pollution of the three wastes is little, the preparation cost is low, and the method is suitable for industrial preparation of (S)-alpha-hydroxyl-gamma-N-phthaloylaminobutyric acid.

The present invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a preparation process of a bortezomib synthesis intermediate (R) 1-amino-3-methylbutyl boronic acid pinacol ester hydrochloride. The preparation process comprises that in an ether and / or benzene solvent, (R)-1-N-(tert-butyl sulfinyl)-3-methylbutyl imine and bis borate are subjected to nucleophilic addition at a temperature of 0-30 DEG C in a reactor filled with argon gas or nitrogen gas under co-catalysis of an azacyclo carbene copper tert-butoxide coordination compound (NHC) CuOt-Bu and a proton donor to obtain the (R)-1-N-(tert-butyl sulfinyl)-3-methylbutylamine-1-boronic acid pinacol ester.

The invention belongs to the technical field of material preparation and particularly provides a method for preparing aluminum-based composite materials at low temperature in the presence of catalysts. In the method, catalysts added to the salts used in the reaction for preparing the composite materials can enable the salts used in the reaction and aluminum melt to conduct the in-situ reaction under the condition that the reaction temperature is lower than the conventional synthesis temperature, increase the reaction rate, shorten the reaction time and ensure that the microstructure characteristics of the composite materials, including the type, dimensions and distribution of particles are unchanged. Therefore, the method of the invention is suitable for the preparation of aluminum-based composite materials on an industrial scale.

The invention belongs to the technical field of semiconductor devices, and particularly relates to a novel electron transport layer perovskite solar cell and a preparation method thereof. The method comprises the steps of (1) cleaning conductive glass, and processing the cleaned conductive glass through a plasma cleaning machine to obtain a pretreated conductive glass substrate; (2) preparing a GaN nano material by adopting a high-energy ball milling method, then spin-coating GaN dispersion liquid on the conductive glass substrate, and transferring to a heating table to prepare a GaN electrontransport layer; (3) spin-coating a perovskite precursor solution on the GaN electron transport layer, and rapidly transferring the GaN electron transport layer to a preheated heating table after spin-coating is finished to prepare a perovskite layer; (4) spin-coating a hole transport layer on a perovskite light absorption layer; and (5) evaporating an electrode on the prepared hole transport layer to complete the preparation of the perovskite solar cell. The GaN nano material is used as the electron transport layer, the electron transport efficiency of the solar cell can be improved, and therecombination rate is reduced, so that the photoelectric conversion efficiency and stability of the device are remarkably improved.

The invention provides a preparation method for a phosphorus-series flame-retardant polyester material, which belongs to the field of material preparation. The preparation method is characterized by comprising the following steps: preparing an aqueous solution from NaOH, gradually adding CEPP under stirring and carrying out a reaction for 5 h; carrying out reduced pressure distillation, crushing and drying so as to obtain white powdery solid CEPP-Na; fully drying PET and CEPP-Na in a dryer and carrying out melt blending in an internal mixer for 6 min; and subjecting the melt blend to hot pressing with an electric tablet press so as to prepare the plate-shaped material. A phosphorus flame retardant is prepared through process improvement and has good compatibility with PET; the synthesized material has good flame retardation effect and stable performance; and the preparation method saves cost, is simple in process and suitable for industrial preparation, and has great market value.

The invention discloses a derivative abiraterone, namely abiraterone single succinic acid ester, and a preparation method thereof. The structural formula of abiraterone single succinic acid ester is as shown in Formula I: (as shown in the Specification). The preparation method comprises the following step: carrying out an esterification reaction on succinic anhydride and abiraterone as shown in Formula III to obtain abiraterone single succinic acid ester. According to the preparation method, an appropriate synthesis method is adopted to efficiently and rapidly synthesize abiraterone single succinic acid ester; the preparation method is moderate in reaction conditions, simple in follow-up processing and suitable for industrial preparation, and provides a chemical entity source for follow-up medicinal chemical and clinical researches.

The invention provides an anti-blocking agent for phosphogypsum as well as a preparation method and a use method of the anti-blocking agent. The anti-blocking agent comprises the following raw materials in percentage by mass: 3-7% of a surfactant, 2-6% of a volatile solvent, 1-10% of a film-forming agent and the balance of water, wherein the film-forming agent is high-hydrogen-content silicone oil; the volatile solvent is ethanol and / or methanol. When the anti-blocking agent provided by the invention is used for preventing ardealite from blocking, the adding amount of the anti-blocking agent is 1-10% of that of ardealite, the anti-blocking agent is added in a spraying manner and then uniformly mixed, and the anti-blocking agent can effectively prevent ardealite from blocking, is added in a spraying manner, and is convenient to use and good in anti-blocking effect.

The invention provides a preparation method of chiral 1-amino-2-propanol, which comprises the following steps: carrying out ring-opening reaction on trifluoroacetamide and chiral epoxypropane to generate an intermediate product I; and carrying out hydrolysis reaction on the intermediate product I to obtain the chiral 1-amino-2-propanol. According to the preparation method, the target product can be obtained through a two-step reaction, so that the preparation process of chiral 1-amino-2-propanol is greatly simplified; and the raw materials trifluoroacetamide and chiral epoxypropane are cheap and easily available, the reaction process is simple, the operation is convenient, harsh reaction conditions such as high temperature and high pressure are not needed, complex purification, post-treatment and chiral resolution operations are also not needed, and the obtained target product has high purity, high yield and high optical activity, and is suitable for large-scale industrial preparation.

The invention provides a waterborne polyurethane structure color waterproof coating material, a preparation method and application thereof. The waterborne polyurethane structure color waterproof coating material comprises the following components: monodisperse submicron microspheres, carbon black and waterborne polyurethane emulsion, wherein the monodisperse submicron microspheres and the waterborne polyurethane emulsion are compounded, and carbon black is added to inhibit white background scattering so as to obtain the high-strength waterborne polyurethane coating material with the angle-dependent-free structural color. The coating material disclosed by the invention is simple in preparation process, low in cost and environment-friendly, can be used as a waterproof and heavy-metal-free colored environment-friendly water-based coating material, is easy to smear, high in adhesive force, high in strength, resistant to corrosion and wide in applicability, and has important application value and wide application prospects in the water-based polyurethane industry.

The invention relates to a preparation method of a drug intermediate 2-aminonorbornane, and belongs to the field of fine chemical engineering. In the method, norbornene is used as an initial raw material, and the method comprises the following steps: firstly enabling an organic solvent to react with a borane-tetrahydrofuran adduct at low temperature to prepare norborneol borane; then putting the norborneol borane into ammonia, and uniformly stirring and cooling; slowly dropwise adding a sodium hypochlorite solution, reacting for 6 to 10 hours at a temperature of 15-25 DEG C, and adding inorganic acid into the reaction system; and separating, alkalizing, cleaning, drying and concentrating to obtain the 2-aminonorbornane. The preparation method has the advantages of high reaction speed, high product yield, low production cost, industrial preparation applicability and the like.

The invention relates to a phellinus linteus catharsis formula for prevention and cure of type II diabetes and a preparation process thereof and belongs to the technical field of traditional Chinese medicine for prevention and cure of type II diabetes. According to the technical scheme, the formula is prepared from, by weight, 20-30% of root bark of white mulberry, 20-30% of coptis chinensis, 10-20% of mangnolia officinalis, 5-10% of radix puerariae, 5-10% of astragalus membranaceus, 5-10% of fruits of fructus corni, 5-10% of radish seeds, 5-10% of rhizoma anemarrhenae, 5-10% of radix polygonati officinalis and 5-10% of atractylodes lancea. All herbs are matched to take the advantages of one another and achieve a synergistic effect, and through combined use of all the herbs, both manifestations and root causes can be treated, and the curative effect is enhanced; the hypoglycemic effect of the formula is equivalent to that of DMBG, and the formula does not have toxic and side effects compared with western medicine; the formula enables fasting blood-glucose and 2-hour post-meal blood glucose of a patient with the type II diabetes to be lowered for a long time and also enables cholesterol and triglyceride of a patient with hyperlipidemia to be lowered, and the curative effect is remarkable; the product is high in active ingredient content, stable, not prone to deterioration and beneficial to long-stem storage.

The invention belongs to the field of natural medicinal chemistry and discloses a method for purifying withaferin A. The method is: take the Indian ginseng raw material and grind it, add 6-10 times the amount of 80-90% methanol for ultrasonic extraction 2-3 times, extract the solution under reduced pressure to recover the reagent, add the concentrated solution to the macroporous resin for adsorption, first use 4-5 times the volume 40-60% methanol solution to elute impurities, and then use 3-5 times the amount of 90-99% methanol solution to elute. The eluent recovers methanol to obtain extract, and then separates by high-speed countercurrent chromatography, collects the target components according to the map, and concentrates Refrigerate and crystallize to a small volume, and dry to obtain high-purity withaferin A. Purifying withaferin A by adopting the present invention has simple and easy-to-operate process, short cycle, product purity above 98%, and is suitable for industrialized preparation.

The invention discloses application of polyvinyl benzene sulfonic acid or salt thereof as a room-temperature phosphorescent material. The structure of the polyvinyl benzene sulfonic acid or the salt thereof is represented by formula (I) shown in the description, and in the formula (I), R<+> is a hydrogen ion, a metal cation or an organic cation. The halogen-free and water-based printable room-temperature phosphorescent material disclosed by the invention has a very strong luminescent property at room temperature, the phosphorescent external quantum efficiency can reach 7-20%, the luminescent life is relatively long and is generally 1-3 seconds, and the luminescent range from blue to green can be covered; and the raw materials are simple and easy to obtain, the preparation method is simpleand rapid, the cost is low, no toxic halogen element exists, water can be used as a solvent in the whole processing process, and no organic solvent is used, so the method has obvious advantages in environmental protection, is suitable for industrial preparation and has good practical application and popularization value. .

The invention belongs to the field of energy material research, and particularly relates to a method for improving oxygen desorption performance of double perovskite oxide. The method comprises the following steps: preparing a metal nitrate aqueous solution of double perovskite oxides; adding citric acid and EDTA into the metal nitrate aqueous solution according to a ratio of the citric acid to the EDTA of 1:1.2 to 1.5:1 by the total mole number of metal ions, adding deionized water, and performing stirring and dissolving to form a precursor solution; adjusting the pH value of the precursor solution to 6.0-7.0, carrying out water bath evaporation drying at 75-85 DEG C with stirring until a gel is formed, and then performing drying; and calcining the dried gel at 350-450 DEG C for 30 minutes, heating the gel to 800-850 DEG C, and performing calcining for 7-8 hours. The invention proposes that the pH value has important influence on the oxygen desorption performance of the double perovskite oxide for the first time, and by adjusting the preparation process and performing pH adjustment in specific steps, the finally prepared double perovskite oxide has excellent oxygen desorption performance.

The invention aims to provide a novel organic chemical total synthetic method of a natural product, petrosiol E. D-xylose is adopted as the raw material, and the total synthesis of petrosiol E is enantio-selectively completed. The route has the following advantages: (1) the raw material is low in price and easy to get, and the used reagents and solvents are common industrial reagents; (2) the operation is easy and convenient, the reaction condition is mild, the yield is high, and the method is applicable to large-scale preparation; (3) the obtained petrosiol E is the same as the natural product in spectroscopic data and optical rotation data. The invention has the characteristic that the method comprises the steps as follows (referring to the description).

The present invention relates to the field of herbicides, and discloses a preparation method of refined dimethenamid, the method comprising: 1) in the presence of an acid, making a compound of the structure shown in formula (1) and (2S)-1-hydroxy Propyl-2-amine carries out the first contact reaction, obtains the compound of structure shown in formula (2); 2) in the presence of the first base, make the compound of structure shown in formula (2) and methyl etherification reagent carry out the second Contact reaction to obtain the compound of the structure shown in formula (3); 3) in the presence of the second base, make the compound of the structure shown in the formula (3) and chloroacetyl chloride carry out the third contact reaction to obtain refined dimethenamid . According to the method of the invention, the reaction conditions are mild, the yield is high, the operation is simple and convenient, and it is very suitable for industrial preparation.