The invention provides a new detection index for
drug sensitivity under the state of an
inflammatory bowel disease and application of the new detection index in the design of a
drug therapy scheme, relates to multiple fields of pharmaceutical
pharmacokinetics,
pharmacology, cytobiology and
molecular biology, creatively reveals natural
drug-resistant phenomena of the
inflammatory bowel disease and expounds related mechanisms. According to the new detection index, the
phosphorylation of STAT3 is promoted by virtue of
cell factors TNF-a, IL17 and LPS, which are excessively secreted in mice with the
inflammatory bowel disease, in a way of STAT3 / Nf-kb, then the
phosphorylation and the
nuclear translocation of P65 are induced, the expression of
peripheral blood monouclear cells P-gp is promoted, and the
drug concentration of an immune inhibitor in the cells is reduced, the
treatment effect of the immune inhibitor is inhibited, and the natural
drug resistance is generated; by administering a P-gp specific inhibitor, the
drug resistance phenomenon can be reverted. The new detection index prompts that P-gp expression quantity of
peripheral blood lymphocyte can serve as an evaluation index of the natural
drug resistance of patients with IBD (inflammatory bowel
disease), and by virtue of the combination of the P-gp inhibitor, the decrease of the pharmaceutical effect caused by the natural drug resistance can be reverted, so that a new thought is provided for the treatment scheme of IBD.