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Composition and process for production thereof

A composition and drug technology, applied in the direction of botanical equipment and methods, mixing methods, detergent compositions, etc., can solve the problems of unsatisfactory, air bubbles cannot exist stably for a long time, etc., achieve low manufacturing cost, safe and applicable , cost reduction effect

Inactive Publication Date: 2012-05-23
莱格瑞克株式会社 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is because the preferred diameter of the bubbles used in the invention described in the above-mentioned patents is 30 to 1000 microns, and it has been proved that the bubbles of 1000 microns (1 mm) cannot exist stably for a long time in the dispersion
In addition, the particle size of the air bubbles is very different from the ultrafine air bubbles used in the present invention, and its effect shows that, as shown in Examples, more than 10% of the dispersed oil has been separated within 48 hours. in no way satisfactory

Method used

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  • Composition and process for production thereof
  • Composition and process for production thereof
  • Composition and process for production thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] "BAVITAS" manufactured by Kyowa Co., Ltd. was used as an ultrafine bubble generating device utilizing a gas-liquid mixed shear method, and ultrafine bubbles were generated using pure water of 18.2 MΩ / cm. The particle size distribution at the time of generation and the change in the particle size distribution of bubbles after 3 months are shown in figure 1 middle. The measurement of the particle size distribution was performed using Multisizer 3 (manufactured by Beckman Coulter). No change in the number of bubbles in the portion having a particle diameter of 1 μm or less was observed.

[0065] At the same time, the particle size of the generated ultrafine bubbles was measured with a nanoparticle analysis system NanoSight Series (manufactured by NanoSight Corporation). The measurement results are shown in figure 2 and image 3 middle. The horizontal axis of the figure represents the particle size in nm, and the vertical axis represents the number of particles per 1m...

Embodiment 2-5

[0068] The mixture having the composition shown in Table 1 below was treated under the same conditions as in Example 1 using "BAVITAS" manufactured by Kyowa Machinery Co., Ltd. Here, the water used is not pure water but distilled water. The results are shown in Table 1.

[0069] [Table 1]

[0070]

[0071] ※1 Micro-bubble generating device: "BAVITAS" manufactured by Kyowa Machinery Co., Ltd.

[0072] In Examples 2-4, drugs exhibiting hydrophobicity were stably dispersed. Both the drug stored at room temperature (RT) and the drug stored at 40°C maintained a good emulsified state.

[0073] Figure 5-13 shows the results of measuring the particle size distribution of the dispersions obtained in Examples 2-4 immediately after preparation and after storage at room temperature and 40° C. using a particle size distribution measuring device LS 13 320 (manufactured by Beckman Coulter Co., Ltd.). The abscissa represents the particle diameter, and the volume % (upper graph) and n...

Embodiment 6-8

[0077] As the samples used in Examples 6-8, the components shown in the following Table 2 in parts by weight were sequentially blended and treated under the same conditions as in Example 1 using "BAVITAS" manufactured by Kyowa Corporation. However, the water used is not pure water but distilled water.

[0078] Surfactants were used in Comparative Examples 2 and 3, and volatile components were emulsified in the same manner as in Examples 6 and 7. In addition, in Comparative Example 4, the same drug as in Example 8 was dissolved in a homomixer.

[0079] [Table 2]

[0080]

[0081] 1: "BAVITAS" established by Concorde Co., Ltd.

[0082] 2: Thiabendazole

[0083] 3: Water-soluble plant extract

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Abstract

Disclosed are: a composition which enables the more effective development of the efficacy of a water-soluble medicinal agent in a solution containing the medicinal agent; and a dispersion in which a hydrophobic medicinal agent can be dispersed stably without requiring the use of any surfactant. Specifically disclosed are: a composition comprising ultra-fine air bubbles having a most frequent particle diameter of 500 nm or less, a medicinal agent and water; and a process for producing a composition comprising ultra-fine air bubbles having a most frequent particle diameter of 500 nm or less, a medicinal agent and water, which utilizes an ultra-fine air bubble generation apparatus.

Description

technical field [0001] The present invention relates to a composition containing a large number of ultrafine air bubbles and a drug, a dispersion capable of dispersing a hydrophobic drug in water without using a surfactant, a method for preparing the composition and the dispersion, and a detergent having a specific composition Composition and washing method using the detergent composition. Background technique [0002] In recent years, devices capable of generating ultrafine bubbles called nanobubbles are being developed. However, its utilization is limited to the use of water containing nanobubbles for washing, drainage treatment, etc., and research on systems containing drugs has not yet been conducted. [0003] Japanese Patent Application Laid-Open No. 2008-238165 is known as a method of using not nanobubbles but large-diameter bubbles in combination with chemical substances. The invention described in this patent application relates to a dispersion method capable of st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00A01M1/20A01N25/02A01N43/78A01P3/00A61K8/22A61L9/04A61Q13/00B01F3/04B01F3/08B01F17/00C11B9/00C11D7/24C11D17/00C11D17/08C09K23/00
CPCA01N25/34B01J13/0052A01N25/04A23L2/54A61P31/04A61P31/10A01N27/00A01N31/06A01N43/78A01N65/26A01N65/36A01N65/00
Inventor 辻秀泰辻康广冈彻杉茂鸟居真澄宫尾悠中山喜光鸟居智之森正仁
Owner 莱格瑞克株式会社
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