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Fat emulsion of oil of zedoary turmeric and preparation method

A fat emulsion and curcuma oil technology, applied in the field of medicine, can solve the problems of unsafe, not involving the preparation method of curcuma oil fat emulsion, restricting the application of curcuma oil, etc.

Inactive Publication Date: 2006-07-05
董英杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The currently marketed Zedoary Oil Injection and Zedoary Oil Glucose Injection contain a large amount of co-solvent Tween-80, which produces many side effects in clinical practice, such as hemolysis, allergies, etc., and brings many unsafe factors to clinical application.
Greatly limit the application of zedoary oil
Chinese patent No. 03146102.6 discloses zedoary oil injection and its preparation method. In this patent, the technical solution adopted is still to use surfactant Tween-80. In order to use Tween-80, but it must be made into powder injection
Above literature and patent all do not relate to the preparation method of zedoary oil fat emulsion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Zedoary oil fat emulsion of the present invention is to be made up of following raw material by weight ratio:

[0031] Zedoary oil: soybean oil: lecithin: glycerin: oleic acid: water for injection = 1:10:1.25:2.5:0.2:85.05;

[0032] Weigh 10 g of zedoary oil according to the above weight ratio, add it to 100 g of injection-grade soybean oil (Beiya Pharmaceutical Oil Company, Tieling City), add 12.5 g of refined egg yolk lecithin (German Lipoid Company), and 2 g of oleic acid at high speed Homogenize for 5 minutes at 15000rpm in a homogenizer (Zhejiang Jintan Instrument Factory), add 500g of water for injection at about 60°C, 25g of glycerin, and homogenize for 3 minutes at 20,000rpm, add the remaining 351g of water for injection at 15000rpm Homogenize for 5 minutes to form colostrum, and add colostrum to a high-pressure milk homogenizer (ATS company in Italy), pass N 2 Protection, the initial pressure is 20-30MPa, circulate for 2 minutes, then increase to 80-100Mpa, ci...

Embodiment 2

[0034] Zedoary oil fat emulsion of the present invention is to be made up of following raw material by weight ratio:

[0035] Zedoary oil: soybean oil: lecithin: glycerin: oleic acid: water for injection = 1:5:0.5:2:0:91.5;

[0036] Take 10g of zedoary oil according to the above weight ratio, add it to 50g of injection-grade soybean oil, add 5g of refined egg yolk lecithin at the same time, homogenize in a high-speed homogenizer at 15,000rpm for 2 minutes, add 500g of water for injection at 60°C, and 20g of glycerin , at 20,000rpm, homogenize for 3 minutes, add the remaining 60°C water for injection 415g, and homogenize at 15,000rpm for 3 minutes to form colostrum. 2 Protected, after 2 cycles, a uniform emulsion is formed. All the other are with embodiment 1. As determined by gas chromatography, it contains 16mg / 10ml of curcumol and 8mg / 10ml of gemmasone, and the emulsion particles with a particle size of 50-3000nm are greater than 95%.

Embodiment 3

[0038] Zedoary oil fat emulsion of the present invention is to be made up of following raw material by weight ratio:

[0039] Zedoary oil: soybean oil: lecithin: glycerin: oleic acid: water for injection = 5:30:5:2.5:1:66.5;

[0040] Weigh 50g of turmeric oil according to the above weight ratio, add it to 300g of injection-grade soybean oil, add 50g of lecithin, 10g of oleic acid at the same time, homogenize for 5 minutes at 15000rpm in a high-speed homogenizer, add 500g of water for injection at 60°C, 25g of glycerin, homogenized at 20000rpm for 3 minutes, added the remaining 165g of water for injection at 60°C, homogenized at 20000rpm for 4 minutes to form colostrum, and then, using a high-pressure homogenizer, under a pressure of 60MP, pass N 2 Protected, after 5 cycles, a uniform emulsion was formed. All the other are with embodiment 1. As determined by gas chromatography, it contains 86mg / 10ml of curcumol and 39mg / 10ml of gemma, and the emulsion particles with a particl...

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Abstract

An oil-in-water zedoary oil-fat emulsion for treating viral disease and cancer by injecting or oral taking is proportionally prepared from zedoary oil, soybean oil, lecithin, glycerin, oleic acid and the water for injection through high-speed stirring or ultrasonic oscillating, and high-pressure homogenizing. Its advantages are low by-effect and high curative effect.

Description

Technical field [0001] The invention relates to a zedoary oil fat emulsion and a preparation method. The emulsion has antiviral and anticancer effects, can be used for injection or oral administration, and belongs to the technical field of medicines. Background technique [0002] Zedoary oil is the plant volatile oil extracted from Curcuma phaeocaulis Valeton. or Curcuma kwangsiensis S.G.Lee et C.F. or Curcuma Wenyujin Y.H.chen et C.Ling from Zingiberaceae. Its quality standard should meet the requirements of Chinese Pharmacopoeia. Cancer, anti-virus, pain relief, antipruritic and other effects, injections, suppositories, and ointments made from zedoary oil have been widely used clinically. [0003] The currently marketed Zedoary Oil Injection and Zedoary Oil Glucose Injection contain a large amount of Tween-80 as a co-solvent, which produces many side effects in clinical practice, such as hemolysis, allergies, etc., and brings many unsafe factors to clinical application. G...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/10
Inventor 董英杰
Owner 董英杰
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