Abamectin transdermal solution and preparation method thereof
A technology of abamectin and solution, applied in the field of abamectin transdermal solution and its preparation, can solve the problem of strong skin irritation, large first-pass effect, inability to satisfy parasitic diseases and secondary infection of bacteria and fungi at the same time To meet the needs of treatment of sexual skin diseases and other issues, to achieve good stability, improve drug efficacy, reduce drug residues and side effects
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Embodiment 1
[0023] An avermectin transdermal solution, in parts by weight, comprising 5 parts of avermectin, 20 parts of azone, 10 parts of sec-butyl acetate, 20 parts of ethyl acetate, N,N-dimethylethyl acetate 5 parts of amide, 5 parts of glycerol methylal, 5 parts of methylpyrrolidone.
[0024] The preparation method of described Abamectin transdermal solution, comprises the steps:
[0025] 1) After mixing ethyl acetate, sec-butyl acetate, and methylpyrrolidone, heat to 40-50° C. for 30 minutes, and add abamectin to dissolve;
[0026] 2) Add glycerol methylal and N,N-dimethylacetamide to the solution described in step 1) in turn, and after mixing uniformly into a clear solution, add azone ultrasonic stirring and mixing; wherein the ultrasonic treatment frequency is 50 kHz, Vacuum sterilized packaging.
Embodiment 2
[0028] An avermectin transdermal solution, in parts by weight, comprising 1 part of avermectin, 5 parts of azone, 5 parts of sec-butyl acetate, 5 parts of ethyl acetate, N,N-dimethylethyl acetate 15 parts of amides, 15 parts of glycerol methylal, and 15 parts of methylpyrrolidone.
[0029] The preparation method of described Abamectin transdermal solution, comprises the steps:
[0030] 1) After mixing ethyl acetate, sec-butyl acetate, and methylpyrrolidone, heat to 40-50° C. for 10 minutes, and add abamectin to dissolve;
[0031] 2) adding glycerol methylal and N,N-dimethylacetamide to the solution described in step 1) in turn, and after mixing uniformly into a clear solution, adding azone ultrasonic stirring and mixing, wherein the ultrasonic treatment frequency is 50kHz; Vacuum sterilized packaging.
Embodiment 3
[0033] An avermectin transdermal solution, in parts by weight, comprising 3 parts of avermectin, 10 parts of azone, 8 parts of sec-butyl acetate, 10 parts of ethyl acetate, N,N-dimethylethyl acetate 15 parts of amides, 9 parts of glycerol methylal, 7 parts of methylpyrrolidone, 3 parts of sucrose acetate isobutyrate, and 10 parts of benzyl alcohol.
[0034] The preparation method of described Abamectin transdermal solution, comprises the steps:
[0035] 1) After mixing ethyl acetate, sec-butyl acetate, and methylpyrrolidone, heat to 40-50° C. for 20 minutes, add benzyl alcohol to mix, and add abamectin to dissolve;
[0036] 2) Add glycerol methylal and N,N-dimethylacetamide to the solution described in step 1) in turn, and after mixing uniformly into a clear solution, add azone, ultrasonically stir and mix well, add sucrose acetate isobutyrate Mix well; the ultrasonic treatment frequency is 60 kHz, and it is obtained by vacuum sterilization and packaging.
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