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Preparation method of bracket with drug temperature-sensitive controlled-release function

A temperature-sensitive, drug-based technology, applied in stents, medical science, surgery, etc., to achieve the effects of good temperature sensitivity, controlled drug release function, strong operability, and simple preparation method

Inactive Publication Date: 2010-10-20
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the method for preparing a coating with drug temperature-sensitive controlled release.

Method used

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  • Preparation method of bracket with drug temperature-sensitive controlled-release function
  • Preparation method of bracket with drug temperature-sensitive controlled-release function
  • Preparation method of bracket with drug temperature-sensitive controlled-release function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Preparation of amphiphilic block copolymer of thermosensitive polymer and degradable hydrophobic polymer

[0037] (1) Mix NIPAm and NHMAAm at a ratio of 7mmol: 1mmol, dissolve them in 10ml of tetrahydrofuran (THF), then add 0.04mmol of benzoyl peroxide (BPO) to the solution as an initiator, and 0.08mmol of mercaptoethanol as a chain transfer agent. agent, solution through N 2 Gas 20min;

[0038] (2) Then in N 2 Placed in a constant temperature water bath at 70°C under the protection of , and reacted with electromagnetic stirring for 7 hours;

[0039] (3) After the reaction solution is cooled, remove impurities by suction filtration;

[0040] (4) 8-10 times the volume of diethyl ether is used as a precipitating agent, after several times of dissolution, precipitation, and vacuum drying to obtain a white powder.

[0041] (5) Copolymerize the prepared methylolacrylamide and N-isopropylacrylamide with polycaprolactone (PCL) according to the ratio of 1:4 (molar ratio)...

Embodiment 2

[0051] For the description of the advantages of the coating and stent with drug temperature-sensitive controlled release effect prepared by the method of the present invention, please refer to figure 2 , figure 2 It is a schematic diagram of the drug release principle of the stent with drug temperature-sensitive controlled release. 1 in the figure: small particles represent the drug; 2: uniform coating represents the PCL coating; 3: represents the temperature-sensitive part; 4: represents the PCL part in the amphiphilic copolymer. It should be noted that most of the current drug-eluting stents are directly coated with hydrophobic polymers such as polylactic acid and polycaprolactone to load drugs, and the drug release cannot be controlled by this coating. The present invention utilizes the synthesized temperature-sensitive copolymer and polycaprolactone as the mixed drug coating carrier. Under the action of water, the hydrophilic temperature-sensitive segment will migrate t...

Embodiment 3

[0053] 1. Preparation of amphiphilic block copolymer of thermosensitive polymer and degradable hydrophobic polymer

[0054] (1) Mix NIPAm and NHMAAm at a ratio of 5mmol: 1mmol, dissolve them in 10ml of tetrahydrofuran (THF), then add 0.04mmol of benzoyl peroxide (BPO) to the solution as an initiator, and 0.10mmol of mercaptoethanol as a chain transfer agent. agent, solution through N 2 Gas 20min;

[0055] (2) Then in N 2 Placed in a constant temperature water bath at 70°C under the protection of , and reacted with electromagnetic stirring for 7 hours;

[0056] (3) After the reaction solution is cooled, remove impurities by suction filtration;

[0057] (4) 8-10 times the volume of diethyl ether is used as a precipitating agent, after several times of dissolution, precipitation, and vacuum drying to obtain a white powder.

[0058] (5) Prepare the copolymer and polycaprolactone (PCL) according to the ratio of 1:6 (molar ratio), and react at 180°C for 24 hours to obtain the de...

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Abstract

The invention relates to a preparation method of a bracket with a drug temperature-sensitive controlled-release function. By the preparation method of the bracket, the coating with the drug temperature-sensitive controlled-release function is applied on the surface of the bracket in the modes of spin coating, dip coating or spray coating. The invention also provides a preparation method of the coating with the drug temperature-sensitive controlled-release function. The preparation method of the invention is simple and has strong operability. The coating with the drug temperature-sensitive controlled-release function prepared by the method of the invention has good temperature sensibility and drug controlled release function. The bracket with the drug temperature-sensitive controlled-release function prepared by the method can make histocyte drugs around the bracket have high concentration, and the drugs in blood have low concentration. With the existing drug eluting bracket, the histocyte drugs around the bracket have low concentration, and the drugs in the blood have high concentration. Compared with the existing drug eluting bracket, the bracket with the drug temperature-sensitive controlled-release function prepared by the method of the invention has significant advantages.

Description

【Technical field】 [0001] The invention relates to a preparation method of a stent, in particular to a preparation method of a stent with temperature-sensitive drug release control. 【Background technique】 [0002] In the field of interventional therapy, for the stenosis of blood vessels, trachea, esophagus, urethra, biliary tract and other organs, stents are usually implanted to expand the stenosis and effectively maintain the lumen. The stent is introduced into the lumen in the unexpanded state, positioned at the stenosis, expanded and placed there. Then people carry some drugs on the polymer to the surface of the stent by spin-coating, dip-coating or spray-coating to prepare the drug-eluting stent. Drug-eluting stents are also called drug-releasing stents. Drugs are carried by polymers coated on the surface of metal stents. When the stent is placed in the lesion in the lumen, the drugs are released from the polymer coating by elution. The stent prepared by the above metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/10A61L31/06A61F2/82
Inventor 李松岗全志伟谭庆刚
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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