The invention relates to Chinese herbal medicine dispensation for antibiosis of hands and skin, and belongs to the field of preventive medicine. The Chinese herbal medicine dispensation for the antibiosis of the hands and the skin comprises the components, by weight, 0.95 to 1.05 parts of gallnut, 7.6 to 8.4 parts of scutellaria baicalensis and 1.9 to 2.1 parts of rhubarb. Preferably, the Chinese herbal medicine dispensation for the antibiosis of the hands and the skin comprises the components, by weight, 1 part of the gallnut, 8 parts of the scutellaria baicalensis and 2 parts of the rhubarb. The concentrations of all the Chinese herbal medicine extractives in the compound Chinese herbal medicine mixture are obvious lower than the concentrations, generating useful effect on test index bacteria, of all the Chinese herbal medicine extractives used independently. The novel compound Chinese herbal medicine mixture can be applied to the antibiosis of the hands and the skin, is an antibiosis mixture made of pure plants, no chemical additive is contained, and the novel compound Chinese herbal medicine mixture has no irritation and reproduction toxicity on the skin and is safe and toxic free to human bodies.