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Preparation method of medicinal controlled-release coating having pH response on surface of titanium implant

A technology of controlled drug release and titanium implants, applied in surface reaction electrolytic coatings, coatings, prostheses, etc., can solve the problem of inability to respond to local tissue inflammation, failure to achieve antibacterial effects, antibiotic-resistant strains, etc. question

Active Publication Date: 2018-01-12
温州医科大学附属口腔医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above drug release systems are only aimed at regulating the drug release rate or reducing the early drug burst release, and cannot respond to whether there is inflammation in the local tissue. Regardless of whether there is infection in the peri-implant tissue, the antibacterial drugs are released according to the established program
Due to the limited amount of drug loading, in order to ensure long-term antibacterial performance, it will inevitably cause long-term low-dose release of antibacterial drugs, which may cause the generation of antibiotic-resistant strains; The amount of antibiotics can not reach the antibacterial effect

Method used

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  • Preparation method of medicinal controlled-release coating having pH response on surface of titanium implant
  • Preparation method of medicinal controlled-release coating having pH response on surface of titanium implant
  • Preparation method of medicinal controlled-release coating having pH response on surface of titanium implant

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Experimental program
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Effect test

Embodiment 1

[0028] Step 1. Preparation of TiO on the surface of titanium material 2 nanotube:

[0029]a. Pretreatment of pure titanium sheet: firstly polish a 10mm×10mm×1mm pure titanium sheet with SiC sandpaper, and then ultrasonically clean it in acetone, ethanol, and deionized water for 2 minutes respectively. Processing 2min, described polishing fluid is made of HF, H 3 PO 4 and H 2 O is composed according to the volume ratio of 1:2:7. After polishing, it is washed with deionized water and dried naturally.

[0030] b. Preparation of organic electrolyte: NH 4 F and deionized water were added to 50 mL of glycerol to give NH 4 F mass concentration is 0.50wt%, and deionized water mass concentration is the glycerin solution of 10wt%;

[0031] c. A two-electrode system is adopted, with pure titanium sheet as the anode and platinum sheet as the cathode, and the distance between the electrodes is 1cm. Under magnetic stirring and 30°C, the DH1715A~5 DC stabilized voltage supply provides ...

Embodiment 2

[0037] Step 1. Preparation of TiO on the surface of titanium material 2 nanotube:

[0038] a. Pretreatment of pure titanium sheet: firstly polish a 10mm×10mm×1mm pure titanium sheet with SiC sandpaper, and then ultrasonically clean it in acetone, ethanol, and deionized water for 2 minutes respectively. Processing 2min, described polishing fluid is made of HF, H 3 PO 4 and H 2 O is composed according to the volume ratio of 1:2:7. After polishing, it is washed with deionized water and dried naturally.

[0039] b. Preparation of organic electrolyte: NH 4 F and deionized water were added to 60 mL of glycerol to give NH 4 F mass concentration is 0.60wt%, and deionized water mass concentration is the glycerin solution of 12wt%;

[0040] c. A two-electrode system is adopted, with pure titanium sheet as the anode and platinum sheet as the cathode, and the distance between the electrodes is 1cm. Under magnetic stirring and 30°C, the DH1715A~5 DC stabilized voltage supply provides...

Embodiment 3

[0046] Step 1. Preparation of TiO on the surface of titanium material 2 nanotube:

[0047] a. Pretreatment of pure titanium sheet: firstly polish a 10mm×10mm×1mm pure titanium sheet with SiC sandpaper, and then ultrasonically clean it in acetone, ethanol, and deionized water for 3 minutes respectively. Processing 3min, described polishing fluid is made of HF, H 3 PO 4 and H 2 O is composed according to the volume ratio of 1:2:7. After polishing, it is washed with deionized water and dried naturally.

[0048] b. Preparation of water-based electrolyte: dilute sulfamic acid with 50mL deionized water to prepare a solution with a mass percentage of 2%, then add hydrofluoric acid to the above solution to prepare a solution containing hydrofluoric acid with a mass percentage of 0.5% water-based electrolyte.

[0049] c. Preparation of organic electrolyte: NH 4 F and deionized water were added to 50 mL of glycerol to give NH 4 F mass concentration is 0.80wt%, and deionized water...

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Abstract

The invention discloses a preparation method of a medicinal controlled-release coating having pH response on the surface of a titanium implant. The preparation method comprises the following steps: first, preparing a TiO2 nanotube array on the surface of the titanium implant by adopting an anodic oxidation method, wherein the TiO2 nanotube array serves as a nanometer loading device of medicines, then, grafting poly-L-glutamic acid to orifices of the TiO2 nanotubes, and preparing a medicine controlled-release system with an 'opening / closing' function by utilizing the property that the secondarystructure of PLGA has reversible change along with the change of the pH value, wherein the pH response range of PLGA on the TiO2 nanotubes is 5.5-7.0, the thickness has reversible change along with the change of the pH value, and the change of thickness of the polymer causes great change of the passing ability of liquid in nanopores. With the novel intelligent nanotube medicinal controlled-release system having pH response, the defect that the existing anti-microbial slow-release system on the surface of the titanium implant can not make corresponding response to the local tissue micro-environment of the implant is well overcome, the effective anti-microbial effect is really realized, and a novel method is provided for treating relevant infection of the implant.

Description

technical field [0001] The invention belongs to the technical field of titanium implant surface treatment, and more specifically relates to a preparation method of a pH-responsive drug release coating on the surface of a titanium implant. Background technique [0002] Titanium and titanium alloy implantation has become an important repair method for various human organ diseases or defects. However, the problem of implant-related infection caused by this has gradually become prominent. Infection can also lead to various adverse consequences. Currently, clinical Antimicrobial drugs are used to treat implant-related infections in the world, mainly by systemic administration. However, systemic administration has many disadvantages such as low concentration of target drugs and systemic side effects. The topical application of antibacterial drugs has the advantages of small drug dose required, releasing drugs from the device itself to act on local lesions, avoiding drug effects on...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/54A61L27/02A61L27/18C25D11/26
Inventor 刘劲松徐丽华董伊雯胡晓慧
Owner 温州医科大学附属口腔医院
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