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Preparation method of antibacterial functional gradient porous HA-Ag bone filling scaffold with active interlayer

A functional gradient and interlayer technology, applied in medical science, tissue regeneration, prostheses, etc., can solve the problem that high-porosity structure and high-mechanical properties cannot coexist, and achieve the effect of controllable pore parameters, high porosity, and simple process

Active Publication Date: 2017-01-11
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems existing in the current HA bone repair scaffold materials, the present invention provides a preparation method of a functionally gradient porous HA-Ag bone-filling scaffold with an antibacterial active interlayer; the purpose is to further improve the biological activity and osteogenic activity of the bone-filling scaffold and antibacterial properties, and at the same time solve the problem that the high porosity structure and high mechanical properties of the scaffold material cannot coexist, and effectively improve the long-term stability of the bone filling scaffold implanted in the bone defect

Method used

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  • Preparation method of antibacterial functional gradient porous HA-Ag bone filling scaffold with active interlayer
  • Preparation method of antibacterial functional gradient porous HA-Ag bone filling scaffold with active interlayer
  • Preparation method of antibacterial functional gradient porous HA-Ag bone filling scaffold with active interlayer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) According to the mass percentage of hydroxyapatite (HA) 97% and Ag 3%, respectively weigh 100 nm hydroxyapatite (HA) powder and Ag powder, and put the above two powders into an agate ball mill jar Carry out ball milling, seal with alcohol, vacuumize to 20Pa, and then ball mill for 50 h, the obtained HA-Ag mixed powder is still placed in alcohol, and set aside;

[0025] (2) Mix the HA-Ag powder obtained in step (1) with NH 4 HCO 3 The powder was mixed in the mixer for 120min to obtain mixed powder A; the mass percentage of HA-Ag powder in mixed powder A was 95%, NH 4 HCO 3 The mass percentage of the powder is 5%, and the average particle size of the sieve is 100 μm.

[0026] (3) According to Sr powder 95%, NH 4 HCO 3 5% mass percentage of powder, respectively weigh Sr powder and NH 4 HCO 3 The powders were mixed in a mixer for 30 minutes to obtain mixed powder B.

[0027] (4) Weigh 10 g of hydroxyapatite HA powder with a purity of more than 99.7% and a partic...

Embodiment 2

[0032] (1) According to the mass percentage of hydroxyapatite HA 80% and Ag 20%, weigh 100 nm hydroxyapatite HA powder and Ag powder respectively, put the two powders into an agate ball mill jar for ball milling, and use alcohol After sealing, evacuate to 30Pa, then ball mill for 100 h, and the obtained HA-Ag mixed powder is still placed in alcohol, and set aside;

[0033] (2) Mix the HA-Ag mixed powder obtained in step (1) with NH 4 HCO 3 The powder was mixed in the mixer for 240min to obtain mixed powder A; the mass percentage of HA-Ag powder in the mixed powder was 75%, NH 4 HCO 3 The mass percentage of the powder is 25%, and the average particle size of the sieve is 700 μm.

[0034] (3) According to Sr powder 90%, NH 4 HCO 3 10% by mass of powder, weigh Sr powder and NH respectively 4 HCO 3 The powders were mixed in a mixer for 60 minutes to obtain mixed powder B.

[0035] (4) Weigh 20g of HA powder with a purity of more than 99.7% and a particle size of 100nm, rec...

Embodiment 3

[0040] (1) According to the mass percentage of hydroxyapatite HA 85% and Ag 15%, weigh 100 nm hydroxyapatite HA powder and Ag powder respectively, put the above two powders into an agate ball mill jar for ball milling, and use After sealing with alcohol, vacuumize to 25Pa, then ball mill for 80 h, the obtained HA-Ag mixed powder is still placed in alcohol, and set aside;

[0041] (2) Mix the HA-Ag powder obtained in step (1) with NH 4 HCO 3 The powder was mixed in the mixer for 200min to obtain mixed powder A; the mass percentage of HA-Ag powder in mixed powder A was 80%, NH 4 HCO 3 The mass percentage of the powder is 20%, and the mixed powder A is sieved with an average particle size of 500 μm.

[0042] (3) According to Sr powder 90%, NH 4 HCO 3 10% by mass of powder, weigh Sr powder and NH respectively 4 HCO 3 The powders were mixed in a mixer for 55 minutes to obtain mixed powder B.

[0043] (4) Weigh 15g of hydroxyapatite HA powder with a purity of more than 99.7%...

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Abstract

The invention discloses an antibacterial functional gradient porous HA-Ag bone filling scaffold with an active interlayer and belongs to the technical field of biomedical material preparation. The functional gradient porous HA-Ag bone filling scaffold material with the active interlayer is prepared by weighing and ball-milling hydroxyapatite HA and Ag powder according to an ingredient proportion, weighing and mixing mixed powder and an ammonium bicarbonate pore former according to a porosity proportion, preparing three kinds of powder, then laying the powder in a gradient manner, mechanically pressing into a block pressed blank, putting the pressed blank into a discharge plasma sintering furnace, performing sintering after vacuuming a system to 2-6Pa, heating at a rate of 50-100min / DEG C, keeping at 800-1000 DEG C for 5-10min, and cooling to room temperature in the furnace. The material can induce adhesion and proliferation of bone cells on the surface of the material actively, has good osteogenesis activity and antibacterial property, high porosity and mechanical stability at the same time, and can serve as a good artificial bone filling material.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial functional gradient porous HA-Ag bone-filling scaffold with an active interlayer, and belongs to the technical field of preparation of biomedical materials. Background technique [0002] Hydroxyapatite (HA) is considered to be the preferred scaffold or filling material in the field of bone repair because of its chemical structure similar to human bone and excellent biological activity. Silver (Ag) is widely used as an alloying element in biomaterials due to its good antimicrobial properties (Staphylococcus and Escherichia coli) and biological activity. Strontium (Sr) can effectively promote bone healing and new bone growth due to its unique therapeutic effect in osteoporosis, increase bone formation and reduce bone resorption. Cell experiments have proved that the fusion of Sr can effectively promote the proliferation and differentiation of osteoblasts. In addition, pre-clinical experi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/00B22F3/02B22F3/105B22F7/02A61L27/42A61L27/04A61L27/56A61L27/54
CPCA61L27/425A61L27/54A61L27/56A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2430/02B22F1/0003B22F3/02B22F3/1007B22F3/105B22F7/002B22F2998/10B22F2999/00B22F2201/20
Inventor 潘学坤谢辉陆玉姬
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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