218results about How to "Easy to scale up industrial production" patented technology

The invention discloses a polypeptide medicament sustained release microsphere or a microcapsule preparation with uniform grain size, a preparation method thereof and application. The average grain size of the microsphere or the microcapsule preparation is between 50 nanometers and 100 microns, and the grain size distribution coefficient CV value is less than 20 percent. The polypeptide medicament has a definite structure, has functions of therapy or adjuvant therapy of type-2 diabetes, and is preferably one or more of GLP-1, Exenatide, Exendin-4 and derivatives and analogs thereof. The microsphere or the microcapsule preparation uses a microsphere or a microcapsule with uniform grain size as a substrate to prepare the polypeptide medicament into a sustained release preparation through an embedding mode, and by changing the grain size of the microsphere or the microcapsule, the sustained release cycle is adjustable between one week and one month, and the microsphere or the microcapsule preparation can be applied to the therapy or the adjuvant therapy of the type-2 diabetes and body weight control. Besides, the microsphere or the microcapsule preparation has the advantages of simple preparation process and mild preparation course, and can protect the biological activity of the embedded polypeptide medicament.

The invention discloses a method for preparing porous flaky nano aluminum oxide. The method is characterized by comprising the following steps: (1) dissolving soluble salt and an expanding agent into deionized water, and stirring till the soluble salt and the expanding agent are completely dissolved; (2) adding an aluminum precursor into the solution obtained in the step (1), and stirring till the aluminum precursor is completely dissolved; (3) performing hydrothermal crystallization on the solution obtained in the step (2) under a dynamic condition; (4) after hydrothermal treatment, cooling the solution to the room temperature, filtering, washing, drying, and roasting, thereby obtaining the porous flaky nano aluminum oxide. The porous flaky nano aluminum oxide prepared by using the method has the advantages of being large in specific surface area, adjustable in pore, controllable in thickness, good in dispersity, high in thermal stability, rich in pentacoordinate aluminum, and the like.

The invention provides an industrialized production method of high-purity pemetrexed disodium, comprising the following steps of: (1) adding crude pemetrexed disodium into a reactor, adding water and stirring to dissolve at a temperature of 10-30 DEG C; (2) adding tetrahydrofuran or acetonitrile serving as a dissolvent into the reaction solution of the step (1), dissolving out a part of solids, adding kieselguhr or silica gel and stirring for 5-30 minutes; and (3) filtering the reaction solution of the step (2), adding dissolvent same as the dissolvent added in the step (2) into filtrate, crystallizing for 0.5-10 hours at a temperature of 10-30 DEG C, isolating solids, and drying for 0.5-10 hours at a temperature of 20-40 DEG C to obtain the high-purity pemetrexed disodium. By means of the production method, the shortcomings that in the prior art column chromatography, purification and heating are needed, the product purity is low, the operation is cumbersome and the industrialized production is difficult to realize are overcome; the production method is simple and convenient for operation, is easy to realize the industrialized production and has the advantages of few consumption of dissolvent, energy saving, environmental protection and low labor intensity; and the products have the advantages of white color, high purity, less than 0.05% of impurities in a single product and good stability.

The invention discloses a preparation method of a nano iron fluoride-based composite material, which aims to solve the problems of high raw material cost, complex synthetic process, difficulty in uniform mixing of iron fluoride and carbon and oxygen elements, and inability for effective grain size control of the conventional preparation method. The preparation method of nanocrystalline iron fluoride comprises the following steps: (1) preparing a solution consisting of an iron source precursor, a polyalcohol solvent, and a complexing agent, and carrying out refluxing at a temperature of 30-80 DEG C; (2) adding a fluorinating reagent to a solution obtained through (1) for fluorination, and carrying out refluxing and stirring at a temperature of 140-200 DEG C to obtain a suspension; and (3) carrying out aging of the suspension at a temperature of 100-160 DEGC, carrying out washing and filtering of the aged suspension to obtain a solid, and finally calcinating the solid at a temperature of 200-350 DEG C to obtain the nano iron fluoride.

The invention relates to the field of medicine, and specifically, relates to a recombinant human growth hormone (rhGH) long-acting sustained-release microcapsule and a preparation method thereof. The preparation method of the rhGH long-acting sustained-release microcapsule comprises the following steps of 1, dissolving a diblock amphiphilic polymeric material in an organic solvent to obtain an oil phase O, 2, adding an rhGH-containing aqueous solution W1 or rhGH-containing particles S into the oil phase O obtained by the step 1, and carrying out emulsification preparation to obtain W1 / O or S / O primary emulsion, wherein the rhGH-containing aqueous solution W1 is utilized as an inner water phase, 3, adding the W1 / O or S / O primary emulsion into a stabilizer-containing outer water phase W2 to obtain W1 / O / W2 or S / O / W2 composite pre-emulsion, 4, carrying out a filter pressing process on the W1 / O / W2 or S / O / W2 composite pre-emulsion through a millipore membrane to obtain W1 / O / W2 or S / O / W2 composite emulsion, and 5, removing the organic solvent in the W1 / O / W2 or S / O / W2 composite pre-emulsion, carrying out solidification, centrifugal washing and freeze drying of the organic solvent-free W1 / O / W2 or S / O / W2 composite emulsion. The rhGH long-acting sustained-release microcapsule obtained by the preparation method has the advantages of even size, high encapsulation efficiency, high activity, low burst release quantity, good repeatability, simpleness of operation, and benefit to drug effect activity keeping and industrialized mass production.

The invention discloses a borophene nanosheet and a preparation method thereof, and mainly solves the problem of preparing a two-dimensional borophene nanosheet from boron powder at present. The borophene nanosheet has a typical two-dimensional layered structure, the thickness of the borophene nanosheet ranges from 0.3 nm to 10 [mu]m, the transverse size of the borophene nanosheet ranges from 100 nm to 100 [mu]m, and the mass content of boron is larger than 90%. The preparation method comprises the following steps: providing boron powder, adding the boron powder into a solvent, carrying out ultrasonic treatment in a water bath, then adding the obtained product into concentrated acid, carrying out ultrasonic treatment, and carrying out centrifugal drying to obtain an intercalation product; performing high-temperature expansion on the intercalation product to obtain expanded boron powder; and finally, performing liquid-phase stripping on the expanded boron powder to obtain the borophene nanosheet. The invention provides a simple, green, efficient and low-cost method for preparing the borophene nanosheet, and large-scale production can also be realized.

The invention provides three high-activity iron-based catalysts for coal direct liquefaction and preparation methods for the three high-activity iron-based catalysts. The three catalysts are iron oleate, iron naphthenate and Fe3O4 hollow nanospheres respectively. The series of catalysts are oil-soluble, can contact with coal samples well and can react completely. A solvent tetrahydronaphthalene used in the process of preparing the Fe3O4 hollow nanospheres is the solvent used in coal direct liquefaction reaction; by adoption of the 'in-situ' synthesis technology, the catalysts can be directly used in the coal direct liquefaction reaction without aftertreatment; and the catalysts have high contact surface area and high activity in a reaction system. The catalysts are low in preparation cost and simple in preparation and are not required to be recycled. A small quantity of the catalyst is used in the coal direct liquefaction process, but the catalysts have high activity, so temperature and pressure required during the coal direct liquefaction are reduced, conversion ratio of the coal and the yield of oil are obviously increased, and industrial amplified application is realized.

The invention aims to provide a preparation method of a Cu-Im-Ga-Se quaternary semiconductor alloy. The preparation method comprises the concrete steps: placing a quartz crucible with Cu-Im-Ga raw materials in a vacuum induction furnace, vacuumizing, introducing argon, controlling the vacuum degree of the induction furnace at 20-30mmHg, gradually heating to 500-700 DEG C, then, heating to 900-1100 DEG C, melting for 10-30min, and cooling in the furnace to obtain a Cu-Im-Ga ternary alloy; respectively filling the prepared Cu-Im-Ga ternary alloy and Se powder at two ends of a quartz tube, vacuumizing, and sealing the quartz tube; heating the Cu-Im-Ga-Se filling end of the quartz tube to 850-950 DEG C by using a tube furnace; heating the Se powder filling end of the quartz tube to 300-330 DEG C by using the tube furnace, and preserving the temperature for 0-20min; preserving the temperature of 300-500 DEG C for 1-20h; heating from 500 DEG C to 750 DEG C; cooling the Cu-Im-Ga-Se filling end to 750 DEG C when the temperature at the Se powder filling end is up to 750 DEG C, and reacting Im with Se at the temperature of 750 DEG C for 5-60h; and shutting off the tube furnace to stop heating, and cooling to the room temperature to obtain a solid Cu-Im-Ga-Se sample.

A preparation method of a 2-methylimidazole and zinc complex with a hierarchical porous structure comprises the following steps: 1, mixing arranged soluble polystyrene microspheres adopted as a template with methanol and 2-methylimidazole, and stirring to obtain a solution a; and 2, dissolving zinc nitrate hydrate in methanol to obtain a solution b, adding the solution b to the solution a in a dropwise manner 5min later, stirring the solution a and the solution b at room temperature for 24h, centrifuging the obtained solution mixture, washing the obtained material to obtain a white solid, and removing the arranged soluble polystyrene microsphere template at 80DEG C by using N,N-dimethyl formamide or toluene to obtain the 2-methylimidazole and zinc complex with a hierarchical porous structure. The preparation method has the advantages of simplicity, wide sources of raw materials, low cost and easy industrial amplified production; and the above material finally prepared through the method has the advantages of high specific surface area, facilitation of enhancement of the hydrophobicity and diffusion of organic solvents due to macro-pores, meso-pores and micro-pores, large adsorption quantity of the organic solvents, and certain hydrophobicity.