Method for preparing polymer microsphere

Abstract

The invention discloses a preparation method of polymer microballoon sphere with uniform size, which can dissolve biodegradable polymer material in at least one organic solvent to form an O phase, and then adds the optional aqueous solution W1 containing medicine or medicine granule S into a fat phase O for emulsification to prepare colostrum; the obtained colostrum is added into an outer water phase W containing stabilizing agent to form pre-compound emulsion; then, the pre-compound emulsion is pressed through a microporous film by pressure to obtain compound latex; at last, after being solidified, the compound latex is centrifugated, washed, frozen and dried, so as to obtain the polymer microballoon sphere. The method of the invention is simple in technique, uniform in the grain diameter of the obtained product, good in repetitiveness of each batch product and easy in commercial process.

Description

technical field [0001] The invention relates to a preparation method of polymer microspheres in the fields of medicine, biochemical industry, etc., more specifically, relates to a preparation method of rapidly preparing polymer microspheres with uniform size. Background technique [0002] Drug-loaded polymers play an important role in the controlled release system of drugs. The solvent evaporation / extraction method has been used to prepare drug microspheres for a long time, but most of them are still in the stage of laboratory research, and there are still many problems. This restricts the clinical application of microsphere preparations. Traditional preparation methods use mechanical stirring, homogenization, and other methods to prepare emulsions. Although the process conditions are simple, the preparation repeatability is very poor, and there are large differences in performance between different batches of products, which is not easy for industrial scale-up production. ...

AI Technical Summary

Problems solved by technology

Traditional preparation methods use mechanical stirring, homogenization, and other methods to prepare emulsions. Although the process conditions are simple, the preparation repeatability is very poor, and there are large differences in performance between different batches of products, which is not easy for industrial scale-up production. The particle size uniformity is very poor, and the particle size is difficult to control

[0003] Chinese patent (publication number CN1605359) discloses a preparation method of polymer microspheres with uniform size for embedding hydrophilic drugs. , has high requirements on the stability of colostrum, and the preparation efficiency is low. In addition, organic solvents and hydrophobic polymer materials with a solubility in water of less than 2% must be used in the preparation process to prepare uniform and controllable particle sizes. drug microspheres

However, all three methods use a large amount of organic solvents, which can easily denature the drug.

Although the particle size of the microspheres formed by the emulsification diffusion method is small, about 0.1 μm, it cannot effectively entrap hemoglobin

Generally speaking, when preparing nanospheres and nano drug-loaded microspheres, the nanoparticles prepared by the existing technology have uneven particle size, poor repeatability, and high energy consumption, which is not easy for industrial production.

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