116results about How to "Does not involve the use of" patented technology

The invention discloses a preparation method of a polyimide / graphene composite material. The preparation method comprises the following steps: firstly, mixing polyimide with graphite and stirring at a high speed to obtain polyimide / graphene composite particles; and then carrying out hot press molding on polyimide / graphene composite particles to prepare the composite material. According to the preparation method of the polyimide / graphene composite material disclosed by the invention, under the condition that any reagent is not added, the modification of grapheme on polyimide is achieved so as to obtain the composite material with excellent electrical conductivity and the preparation method is simple and environmentally friendly and is suitable for industrial production.

The invention discloses a preparation method of a glycidyl methacrylate melt-grafted polyolefin material. The preparation method comprises the following steps: directly adding glycidyl methacrylate and graphene oxide onto polyolefin pellets or powder, uniformly mixing at normal temperature, and adding the physical mixture into reaction equipment; and uniformly mixing an initiator and a styrene liquid, adding the mixture into the above reaction equipment, and melt-blending at a certain temperature. The prepared glycidyl methacrylate grafted polyolefin has high grafting rate and high molecular weight or high grafting rate and low crosslinking degree.

The invention discloses a preparation method of a manganese dioxide / carbon-based flexible electrode material. The method comprises steps of (1) cleaning and drying a flexible carbon substrate; (2) carrying out dipping acidification treatment of the treated carbon substrate by using mixed acid; wherein the mixed acid is formed by mixing concentrated nitric acid and concentrated sulfuric acid according to the volume ratio of 1:1-1:6; (3) preparing 10-1000mM metal salt aqueous solution, wherein the metal salt is at least one of potassium permanganate, sodium permanganate, lithium permanganate, barium permanganate and zinc permanganate; (4) putting the carbon substrate treated in the (2) into metal salt solution, and carrying out ultrasonic treatment for 20-60 minutes; (5) heating the mixturesubjected to ultrasonic treatment in the (4); and (6) naturally cooling the product subjected to heating treatment to room temperature, washing, and carrying out vacuum drying to obtain the manganesedioxide / carbon-based flexible electrode material. The preparation method is advantaged in that manganese dioxide is firmly attached to a surface of the flexible carbon substrate, can be used for a flexible supercapacitor, and has relatively high specific capacity and good cycling stability.

The invention discloses a preparation method of special alumina for high-purity lithium battery separation membranes. The preparation method comprises: preparing boehmite by using aluminum hydroxide as a raw material, using ultrafine aluminum hydroxide as a seed crystal, using ammonia water as an additive and using soft water as a reaction medium through a hydrothermal reaction; carrying out hightemperature calcination on the boehmite to obtain alpha-Al2O3 raw powder; and grinding the alpha-Al2O3 raw powder by a horizontal sander, and carrying out spray drying, or grinding by a jet mill to obtain the alumina for lithium battery separation membranes. According to the present invention, sodium oxide impurities can be removed through the hydrothermal reaction; and the obtained alumina has characteristics of high chemical purity, controllable crystal micro-morphology and relatively narrow particle size distribution, has the Al2O3 content of more than or equal to 99.95%, has the Na2O content of less than or equal to 0.02%, has the contents of impurities such as Fe2O3 and the like of less than or equal to 70 ppm, mainly has spherical and cubic structure, has a specific surface area of 3.5-6.0 m<2> / g, and can meet the requirements of electrochemical performance and safety performance of lithium battery separation membrane materials.

The invention discloses a polylactic acid-lignin-starch composite material and a preparation method therefor. The preparation method comprises the following steps: (1) firstly, proportionally weighing100 parts of PLA, 20-50 parts of lignin and 20-50 parts of starch, carrying out uniform mixing at normal temperature, and adding the physical mixture into reaction equipment; and (2) uniformly mixing0.01-5 parts (by weight) of initiator, 0.01-15 parts (by weight) of reaction monomer and 0.1-1 part (by weight) of antioxidant, adding the mixture into a reaction vessel, and carrying out blending ata certain temperature, thereby obtaining the polylactic acid-lignin-starch composite material. According to the polylactic acid-lignin-starch composite material and the preparation method therefor, through modifying the PLA resin with the lignin and the starch, the mechanical properties of the PLA can be effectively improved on the basis of not affecting the complete biodegradability of the material, meanwhile, the production cost is reduced greatly, and the marketing is better facilitated.

The invention discloses an NiFeMo ternary electrolytic water electrode and a preparation method thereof. Firstly, iron salt, nickel salt, urea and NH4F are used as raw materials under a low-temperature hydrothermal condition to prepare NiFe-LDH / NF, then NiFe-LDH / NF and a compound containing molybdenum are subjected to a low-temperature hydrothermal reaction to obtain Ni-Fetrace@NFM / NF, then Ni-Fetrace@NFM / NF is placed in a flowing reducing atmosphere for heat treatment for a certain time, and a final material of Ni / NiFeMoOx / NF is obtained; and in the process, an LDH substrate is reduced to Ninanoparticles, and mutually cross-linked with NiFe-MoOx generated by reduced molybdate to form a composite material with a hierarchical porous nanosheet structure. The hierarchical porous nanosheet structure facilitates bubble diffusion, a formed alloy is cross-linked with MoOx and combined with a conductive substrate to have excellent electrical conductivity, and in the way, the material has excellent reaction kinetics; and NiFe-MoOx with the high hydrogen evolution activity and the Ni nanoparticles with the high hydrogen evolution activity both endows the material with excellent hydrogen andoxygen evolution properties, and then catalytic performance of all electrolytic water with application prospects is obtained.

The invention discloses a synthetic method of 4-chloro-7H-pyrrolo[2,3-d] pyrimidine. The compound is an important intermediate for synthesizing rheumatoid arthritis JAK inhibitors: ruxolitinib and tofacitinib. The synthetic method comprises the following steps: by taking a compound I (4,6-dichloro-5-allyl pyrimidine) as an initial raw material, performing a nucleophilic substitution reaction with ammonia water to generate a compound II; then performing a reaction on the compound II and ozone and performing a reduction reaction to generate a compound III; and finally, performing self ring-closing reaction in an acidic environment to generate a compound IV, that is, the 4-chloro-7H-pyrrolo[2,3-d] pyrimidine. The synthetic route is as shown in the formula in the description. According to the synthetic process provided by the invention, the raw material is cheap and easily available, the synthetic route is simple, the cost is low, the yield is high, and the synthetic method is easy for industrial production.

The invention relates to a double-perovskite catalyst as well as a preparation method and application thereof, and belongs to the technical field of catalysts. The double-perovskite catalyst providedby the invention has a chemical formula of A2BB'O6, wherein A is a rare-earth metal element La, Ce, Nd or Gd; B is Co, Fe, Ni, Cu, Mn, Zn, Al or Ga; B' is Co, Fe, Ni, Cu, Mn, Zn, Al or Ga; and B is not equal to B'. According to the invention, the double-perovskite catalyst A2BB'O6 with nano-regular morphology is prepared in an NaNO3 and KNO3 molten salt system by a molten salt method. The double-perovskite catalyst can effectively and catalytically oxidize nitric oxide into nitrogen dioxide at a relatively low temperature and in a relatively wide temperature range; and the preparation method provided by the invention has advantages of simple process, easy operation, relatively low cost and easy industrial production.

The invention relates to a preparation method of 4, 4'-dia(4-aminophenoxy)-3, 3', 5, 5'-tetramethylbenzene, which comprises that 3, 3', 5, 5'- tetramethyl-4', 4'-biphenyl diphenol, and 4- halogenated nitrobenzene, in salt forming agents, strongly polar protonic or water insoluble organic solvent system, are heated, refluxed and divided, concentrated , cooled, and added with water, while the product is precipitated, filtered, washed, and dried to obtain 4, 4'-dia(4-aminophenoxy)-3, 3', 5, 5'-tetramethylbenzene, and the 4, 4'-dia(4-aminophenoxy)-3, 3', 5, 5'-tetramethylbenzene in the reduction system of ferric chloride / 20-85% hydrazine hydrate, the cooperation of alcohol solvent and active carbon, is reacted to obtain final product. The invention has simple and environment-friend operation, which can be used for industrialization production, while the product can reach more than 99% of purity, and the solvent can be reclaimed.

The invention discloses a magnetic graphene oxide-chitosan / glucan compound preparation method, which belongs to the technical field of material synthesis and biological medicine. The method comprisesthe following steps: taking magnetic graphene oxide as a negatively charged substrate material, a layer upon layer self assembly technology is used, positively charged chitosan and negative electricity glucan are wrapped layer by layer in a water system, so that a chitosan / glucan modified magnetic graphene oxide-chitosan / glucan compound is constructed. The chitosan / glucan modified magnetic graphene oxide-chitosan / glucan compound has good stability, has superparamagnetism and high drug loading rate, presents certain slow release and pH dependence drug-release behavior, and can be taken as an excellent anticancer drug carrier, the compound used for loading the drug is capable of increasing the stability and efficacy of the drug, and the chitosan / glucan modified magnetic graphene oxide-chitosan / glucan compound has great potential for treating solid tumor.

The invention discloses zeolite imidazole metal-organic frameworks ZIF-F, which is prepared by the following method: 1) dissolving zinc acetate dehydrate in water to obtain a zinc-source solution; 2)dissolving 2-methylimidazole in water to obtain a 2-methylimidazole solution; 3) adding the2-methylimidazole solution into the zinc-source solution while stirring, and continuously stirring at room temperature for 20-30 h; centrifuging at 8,000-15,000 rpm for 8-12 min, abandoning a supernatant, washing, and drying at 70-80 DEG C for 10-15 h to obtain the zeolite imidazole metal-organic frameworksZIF-F. In the preparation process, water is used as a solvent, and the use of an acid-base solution is not involved. The raw materials are cheap and easily available; the synthesis process is simple;the reaction condition is mild; the yield is high; and repeatability is good. The product is butterfly-shaped and is uniformly dispersed; the average pore diameter is 4 nm; and heat stability and solvent stability are good.

The invention relates to formoterol, a pharmaceutically acceptable salt thereof and a preparation method of an intermediate. The method for purifying the formoterol intermediate (a compound shown as aformula V) comprises the following steps of: I) performing a salt forming reaction of the crude compound shown as the formula V and fumaric acid in an organic solvent A to obtain fumarate of the compound shown as the formula V; II) performing a neutralization reaction of the fumarate of the compound of the formula V obtained in the step I) with the base in the organic solvent B to obtain a purified compound of the formula V; and III) crystallizing the purified compound shown as the formula V obtained in the step II) in an organic solvent C to obtain the formoterol intermediate.

The invention provides a new method for synthesizing paricalcitol, comprising the following steps of: a. reacting a compound II with alkali, then adding a compound I, carrying out a Julia reaction to generate a compound III; b. reacting the compound III with a fluorine-containing reagent to remove the protecting group so as to obtain a compound IV; c. removing the protecting group of the compound IV under acidic condition to obtain the product of paricalcitol. The method for synthesizing paricalcitol disclosed the invention has the advantages of low cost and high yield, and is simple in operation and easy in industrial production.

The invention relates to a preparation method of metal nanoparticle wrapped nitrogen-containing carbon nanotubes. The method concretely comprises the following steps: mixing a proper amount of melamine with a formaldehyde solution at room temperature, adding a certain amount, and adjusting the pH value of the obtained solution to 8-10 by using an alkali; heating the above obtained suspension in a specific temperature range for a period of time, cooling the heated suspension, and adding acetic acid in a dropwise manner while stirring for a long time; separating the above obtained white solid for later use; taking a quantified amount of a metal iron salt, dissolving the metal iron salt in ethanol, and adding an inert solid oxide carrier in proportion; removing ethanol to obtain a metal iron salt supported catalyst; and mixing the obtained white solid with the iron salt catalyst, grinding the obtained mixture, and processing the ground mixture in inert gas atmosphere at 900-1000DEG C for a prescribed time to obtain the target product. The method has the advantages of simple process, low device requirements, less energy consumption, and simple and easily controlled reaction process; and the obtained product has uniform morphology and a high specific surface area, and can be used as a good catalyst carrier and a gas molecule adsorbent.

The invention provides an improved allisartan isoproxil solid dispersion. A hot-melting extrusion preparation process is achieved on the basis of formulation design, and technical advantages of the hot-melting extrusion process which is simple and convenient for preparation, relatively short in consumed time and the like are realized, so that dissolution performance of the solid dispersion is guarantee; and furthermore, an allisartan isoproxil preparation is developed based on the solid dispersion.

The invention relates to a novel self-repairing and self-lubricating difunctional microcapsule as well as a preparation method and application thereof. Specifically, the invention provides a method for preparing a difunctional microcapsule, which comprises the following steps: impregnating hollow porous microspheres with a self-repairing agent to obtain a self-repairing agent impregnated microsphere capsule; uniformly mixing a self-lubricating agent in a molten state with the self-repairing agent impregnated microbead capsule to obtain a difunctional mixture; spraying the difunctional mixture on a collecting plate, and then collecting the cooled difunctional mixture from the collecting plate to obtain the difunctional microcapsule. The invention also provides the microcapsule prepared by the method, a method for preparing the self-repairing and self-lubricating difunctional composite material by using the microcapsule and the self-repairing and self-lubricating difunctional composite material prepared by the method. The preparation method has the advantages of being green and environmentally friendly, and the microcapsule with excellent self-repairing and self-lubricating functions or a composite material based on the microcapsule can be prepared.

The invention discloses organic silicon foam with an in-situ demulsification and adsorption function and application of the organic silicon foam in oil-water separation. The organic silicon foam is prepared by the steps of at room temperature, soaking 1-10 parts by mass of foam in a dopamine aqueous solution, taking out after soaking, cleaning and drying; dipping the foam dipped by dopamine into a 2-bromo isobutyryl bromide dichloromethane solution for graft modification for 4-20 hours, taking out, cleaning and drying; uniformly mixing 100-200 parts by mass of a solvent, 10-100 parts by mass of a single-ended unsaturated polyether monomer and 1-5 parts by mass of a catalyst, adding foam impregnated with the 2-bromo isobutyryl bromide dichloromethane solution, reacting for 5-10 hours at the temperature of 60-100 DEG C in an N2 atmosphere, adding 25-90 parts by mass of single-ended unsaturated organic silicon, and continuously reacting for 5-10 hours to prepare the foam with the in-situ demulsification and adsorption function. The organic silicon foam with the in-situ demulsification and adsorption function has broad-spectrum demulsifying property and can form demulsification and adsorption on anionic, cationic and non-ionic emulsions.

The invention relates to an N(2)-L-alanyl-L-glutamine synthesis method. The method comprises the following steps: reacting an initial raw material L-glutamine with pyruvoyl chloride to obtain alanyl-L-glutamine, reacting alanyl-L-glutamine with hydroxylamine hydrochloride or O-alkylhydroxylamine to obtain N(2)-2'-hydroximino-propionyl-glutamine or N(2)-2'-alkoxyimino-propionyl-glutamine, and hydrogenating to obtain N(2)-L-alanyl-L-glutamine. The method has the advantages of simple operation, mild reaction conditions, stable raw material sources, low cost, safe operation, environmental protection, and wide industrialized application prospect when the method is used for synthesizing N(2)-L-alanyl-L-glutamine.

The invention discloses an internet e-commerce information release and popularization-based control system and method. The control system comprises a user-oriented foreground display module, a user-oriented foreground control module, a background control module and a communication module. According to the internet e-commerce information release and popularization-based control system provided by the invention, display contents are updated and upgraded by utilizing a network technology, so that the information release timeliness is greatly improved; a function can be expanded as needed, so that a public information release service function and a security monitoring function are added; through statistics of interaction and feedback information of a foreground and a visitor, the display effect can be timely known; the display form of the foreground is generous, and the information richness greatly exceeds that of a conventional display method; and foreground and background systems do not relate to the use of a large amount of printed matters, so that wastes are not produced.

The invention provides a Ni-Co-Fe three-component composite nanometer metal oxide. The phase of the metal oxide is in the form of a composite oxide containing three metal components, namely Ni, Co and Fe, and the three metal components are uniformly compounded to form a spheroidic nano metal oxide. The feeding molar ratio of Ni, Co and Fe is 0.5-2:0.5-2:1-4. The invention also discloses a method for preparing the Ni-Co-Fe three-component composite nanometer metal oxide. The Ni-Co-Fe three-component composite nanometer metal oxide can efficiently degrade chlorine-substituted aromatic hydrocarbons and is excellent in anti-chlorine toxicosis.

The invention belongs to the technical field of medicinal chemistry detection, and particularly relates to a method for detecting alanyl glutamine impurities in a compound amino acid injection. The detection method provided by the invention comprises the following steps: preparing an L-pyroglutamic acid reference substance solution; preparing a compound amino acid injection (containing alanyl glutamine) test solution by adopting cation exchange resin; determining high performance liquid chromatography conditions, detecting the L-pyroglutamic acid reference substance solution and the compound amino acid injection test solution by adopting high performance liquid chromatography, and calculating the content of alanyl glutamine impurities in the test solution by using a correction factor method. The method can accurately detect the content of the alanyl glutamine impurities in the complex sample, does not involve the use of an organic solvent in the experiment process, only uses the pyroglutamic acid with low price as a reference substance, and greatly saves the daily detection cost.

The invention discloses a preparation method of a formaldehyde-free washing-resistant flame-retardant fabric. The preparation method comprises the following steps: (1) soaking and cooking a fabric ina natural polyphenol compound solution, and drying the fabric to obtain a fabric deposited with a natural polyphenol compound; (2) soaking and cooking the fabric deposited with the natural polyphenolcompound in a fixing agent solution, washing the fabric with water and drying the fabric to obtain the fabric immobilized by the natural polyphenol compound; and (3) soaking and cooking the fabric immobilized by the natural polyphenol compound in a metal salt solution, washing the fabric with water, and drying the fabric to obtain the formaldehyde-free washing-resistant flame-retardant fabric. Theflame-retardant fabric provided by the invention has excellent washing-resistant flame-retardant performance, and still shows good flame-retardant performance after the fabric is subjected to 100 times of simulated washing and 100 times of friction tests, the oxygen index of the flame-retardant fabric can reach 30%, the flame-retardant fabric can be self-extinguished in horizontal combustion andvertical combustion experiments, and properties such as the original mechanical property and the hydrophilic property of the fabric can be well maintained.

The invention relates to a method for removing impurity iron in gasification slag. The method sequentially comprises a high-temperature carbon thermal reduction process and a magnetic separation ironremoval process. According to the invention, the mineral phase structure and element composition characteristics of the gasification slag are utilized; carbon contained in the gasification slag is used as a reducing agent; the iron element in the gasification slag is efficiently dissociated and fully reduced through staged temperature rise control, so that the mineral phase is converted into a stable mullite-quartz mineral phase; the impurity iron is separated out through magnetic separation treatment; the method is rapid and efficient; in the whole process, no toxic or harmful components areused, and no waste liquid is discharged; and the economic and environmental benefits are remarkable.

The invention discloses application of lactobacillus fermentum and a product thereof in oxidation resistance and tumor resistance, and belongs to the technical field of application of natural products. In particular discloses application of lactobacillus fermentum and a product thereof in preparation of antioxidant drugs, food or health care products, and application of lactobacillus fermentum and a product thereof in preparation of antitumor drugs, food or health care products, the lactobacillus fermentum is lactobacillus fermentum CQPC04, and the preservation number is CGMCC NO.14493; the lactobacillus fermentum product is obtained by fermenting grape skin with lactobacillus fermentum CQPC04. Experimental verification shows that compared with chemical components fermented by other strains or directly extracted by chemical reagents, the obtained fermentation product of the grape skin fermented by the lactobacillus fermentum CQPC04 has the effects of remarkably improving oxidation resistance and inhibiting liver cancer cell proliferation.

The invention discloses a preparation method and application of a graphene oxide-protamine / sodium alginate compound and belongs to the technical field of material synthesis and biological medicines. According to the preparation method disclosed by the invention, small-size graphene oxide (GO) capable of loading a drug is used as an inner core and a shell layer is formed by protamine sulfate and sodium alginate in sequence by adopting a layer-by-layer self-assembly technology through non-covalent adsorption. Layer-by-layer self-assembled nano-carrier water has good dispersion performance and stability. The natural protamine sulfate and the sodium alginate are used as polyelectrolyte and the small-size graphene oxide is used as a core; all the materials have good biocompatibility; an anti-tumor drug is loaded in the core and has a great drug loading amount and good stability; the drug has long-period release performance and the toxic side effect of pure utilization of the drug is reduced.

The invention discloses a method for synthesizing 1,3,4,6-tetraacetyl-L-gulose. According to the method, a compound, namely, 1,3,4,6-tetraacetatyl-L-gulose is prepared from glucuronolactone serving as a raw material by performing the steps of acetonide protection, benzyl protection, lactone reduction, hemiacetal hydroxyl protection, acetonide de-protection, lactone reduction, hemiacetal hydroxyl de-protection, acetyl protection and benzyl deprotection. In the method, experience reagents are not used, so that the cost is reduced; involved operation is simple and convenient, conditions are easy to control, and industrial production is easy; the total yield is high, and can be magnified to gram grade and over.

The invention relates to preparation of a catalyst with carbon nanotubes as a carrier supported with an iron-nitrogen-carbon ternary active component. The preparation comprises the following specific steps: under a condition of room temperature, dissolving a proper amount of a soluble iron salt and 1,10-phenanthroline in a solvent, then stirring until the two components are completely coordinated; adding a proper amount of the carbon nanotube carrier to the solution, and carrying out ultrasonic treatment for a long time to make the suspension achieve uniform; and removing an ethanol solvent through natural drying or rotary evaporation and other methods, to obtain a catalyst precursor, and treating the precursor for a specified time at the temperature of 600-1000 DEG C in an inert gas atmosphere to obtain the product.

The invention discloses a composite catalyst for synthesizing p-dimethoxybenzen and a preparation method and industrial application thereof, and belongs to the technical field of chemical catalysts. The composite catalyst for synthesizing p-dimethoxybenzen comprises a main catalyst and an antioxidant, the main catalyst comprises an active component and an auxiliary agent; the active component is alkali metal or alkaline earth metal halide, and the auxiliary agent is metal nitrate, wherein the main catalyst comprises the following components in percentage by mole: 30%-90% of the active component and 10%-70% of the auxiliary agent. The composite catalyst for synthesizing the p-dimethoxybenzen is simple in preparation process and low in cost. The catalyst for synthesizing p-dimethoxybenzen can be used for producing p-dimethoxybenzen by using hydroquinone as a raw material and dimethyl carbonate as a methylation reagent, has high catalytic activity and high product yield, and can be in large-scale industrial application.

The invention discloses flame-retardant polyurethane foam with an electromagnetic shielding function and a preparation method of the flame-retardant polyurethane foam.The preparation method comprisesthe following steps that 1, placing polyurethane foam in a mixed solution A to be soaked, wherein the mixed solution A is obtained by mixing a phosphoric acid-containing solution and an aniline solution, and the substance amount ratio of phosphoric acid to aniline in the mixed solution A is 1: 10-1.5: 1; 2, adding ammonium persulfate into the mixed solution A in the step 1 for in-situ polymerization, and fully reacting to obtain polyurethane foam coated with phosphoric acid doped polyaniline, wherein the mass ratio of the ammonium persulfate to the aniline is 1: 1-1.5: 1; and 3, dip-coating the polyurethane foam coated with the phosphoric acid doped polyaniline in a conductive solution for N times, and drying to obtain the required flame-retardant polyurethane foam with the electromagneticshielding function. The obtained polyurethane foam is good in electromagnetic shielding effect and good in flame retardant property and can pass a vertical combustion test, and the oxygen index can reach 34.2%; and the preparation method is simple and environment-friendly.