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Magnetic graphene oxide-chitosan/glucan compound preparation method and application thereof

A technology of oxidized stone and chitosan, which is applied in the field of material synthesis and biomedicine, can solve the problems of poor stability and easy agglomeration, and achieve the effects of high stability, excellent superparamagnetism and high loading rate

Active Publication Date: 2018-04-27
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The purpose of the present invention is to overcome the technical defects existing in the prior art, aiming at the disadvantages of poor stability of graphene oxide materials in physiological environment and prone to agglomeration, and simultaneously synthesizing magnetic materials with magneto-thermal-magnetic targeting properties to provide a magnetic A preparation method of graphene oxide-chitosan / dextran composite material, the carrier material has superparamagnetism and good magnetic properties, good stability in physiological environment, good dispersibility, and great antitumor drug The drug loading rate can greatly reduce the toxic and side effects of drugs, and has broad application prospects

Method used

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  • Magnetic graphene oxide-chitosan/glucan compound preparation method and application thereof
  • Magnetic graphene oxide-chitosan/glucan compound preparation method and application thereof
  • Magnetic graphene oxide-chitosan/glucan compound preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0046] Embodiment 1: the synthesis of magnetic graphene oxide

[0047] (1) An appropriate amount of graphene oxide was dispersed in a mixed solvent of ethylene glycol and diethylene glycol (1:19), and the concentration of graphene oxide was 2 mg / mL. The mixed suspension was crushed into a small-sized graphene oxide aqueous dispersion with a cell disruptor, the power was 250w, the ultrasonic time was 2h, and the ice-water bath was used; (2) Hexahydrate trichloride was added to the graphene oxide aqueous dispersion Iron (FeCl 3 •6H 2 O) (the mass ratio of graphene oxide to ferric chloride hexahydrate is 1:10), sodium acrylate (C 3 h 3 NaO 2 ) (the mass ratio of graphene oxide to sodium acrylic acid is 1:1) and sodium acetate (CH 3 COONa) (the mass ratio of graphene oxide to sodium acetate is 1:30), and incubated in a high-temperature reactor. The next day, the sample precipitate was washed alternately with water and ethanol, and the resulting precipitate was magnetic graph...

Embodiment 2

[0050] (1) Disperse an appropriate amount of graphene oxide in a mixed solvent of ethylene glycol and diethylene glycol (1:19), the concentration of graphene oxide is 1 mg / mL, and crush the mixed suspension into small Size graphene oxide aqueous dispersion, power 400w, ultrasonic time 0.5h, ice-water bath; (2) Add ferric chloride hexahydrate (FeCl 3 •6H 2 O) (the mass ratio of graphene oxide to ferric chloride hexahydrate is 1:15), sodium acrylate (C 3 h 3 NaO 2 ) (mass ratio of graphene oxide to sodium acrylate is 1:5) and sodium acetate (CH 3 COONa) (the mass ratio of graphene oxide to sodium acetate is 1:38), and incubated in a high-temperature reactor. The next day, the sample precipitate was washed alternately with water and ethanol, and the resulting precipitate was magnetic graphene oxide;

[0051] The synthesized magnetic graphene oxide has obvious magnetic properties and good superparamagnetism. The dynamic light scattering particle size analysis results show tha...

Embodiment 3

[0053] (1) An appropriate amount of graphene oxide was dispersed in a mixed solvent of ethylene glycol and diethylene glycol (1:19), and the concentration of graphene oxide was 4 mg / mL. The mixed suspension was broken into small-sized graphene oxide aqueous dispersion with a cell disruptor, the power was 300w, the ultrasonic time was 1h, and it was carried out in an ice-water bath; (2) Hexahydrate trichloride was added to the graphene oxide aqueous dispersion Iron (FeCl 3 •6H 2 O) (the mass ratio of graphene oxide to ferric chloride hexahydrate is 1:20), sodium acrylate (C 3 h 3 NaO 2 ) (the mass ratio of graphene oxide to sodium acrylate is 1:10) and sodium acetate (CH 3 COONa) (the mass ratio of graphene oxide to sodium acetate is 1:50), and incubated in a high-temperature reactor. The next day, the sample precipitate was washed alternately with water and ethanol, and the resulting precipitate was magnetic graphene oxide;

[0054] The synthesized magnetic graphene oxid...

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Abstract

The invention discloses a magnetic graphene oxide-chitosan / glucan compound preparation method, which belongs to the technical field of material synthesis and biological medicine. The method comprisesthe following steps: taking magnetic graphene oxide as a negatively charged substrate material, a layer upon layer self assembly technology is used, positively charged chitosan and negative electricity glucan are wrapped layer by layer in a water system, so that a chitosan / glucan modified magnetic graphene oxide-chitosan / glucan compound is constructed. The chitosan / glucan modified magnetic graphene oxide-chitosan / glucan compound has good stability, has superparamagnetism and high drug loading rate, presents certain slow release and pH dependence drug-release behavior, and can be taken as an excellent anticancer drug carrier, the compound used for loading the drug is capable of increasing the stability and efficacy of the drug, and the chitosan / glucan modified magnetic graphene oxide-chitosan / glucan compound has great potential for treating solid tumor.

Description

technical field [0001] The invention relates to a preparation method and application of a magnetic graphene oxide-chitosan / dextran composite, belonging to the technical fields of material synthesis and biomedicine. Background technique [0002] Cancer remains a challenging and devastating health problem worldwide. The current strategies to overcome this problem mainly include the synthesis of new anticancer drugs and the design of new drug delivery bodies. In order to deliver anti-tumor drugs to tumor tissues, various anti-tumor drug carriers have been studied, such as liposomes, polymer micelles, polymers, mesoporous silica, and calcium phosphate-based drug delivery systems. However, due to the unstable structure of organic materials currently used in the field of biomedicine, this makes the precise distribution and targeted release of carrier materials in the body difficult. At the same time, organic materials are prone to premature leakage after loading drugs, and The d...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/36A61K31/704A61P35/00
CPCA61K31/704A61K47/02A61K47/36
Inventor 谢萌张峰徐远国杨眉杨娜张雅楠
Owner JIANGSU UNIV
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