39results about How to "Adjustable particle size" patented technology

The invention discloses a method for preparing therapeutic substance-loaded microcapsules. The method applies the high-voltage electrostatic spray principle and comprises the steps of leading therapeutic substance-loaded charged polymer solution to instantaneously form ultrafine gel particles under the high-voltage electrostatic action, leading a mist of the particles to be received by polymer solution charged with opposite charges, leading a surface layer of the gel particles to be wrapped by a polymer gel shell layer of the opposite charges, forming structures of capsule cores and capsule walls, further filtering by a microporous membrane, and obtaining the therapeutic substance-loaded microcapsules. Microstructures and scale of the capsule cores and the capsule walls can be precisely controlled through voltage, solution concentration and distance from a jet orifice to receiving solution, and therapeutic substances are bound by the capsule cores and the capsule walls, thereby forming controlled release and improving therapeutic efficacy. The method has the advantages of simple and feasible process and good repeatability, the whole process of the preparation process is clean and pollution-free, the provided in-situ therapeutic substance-loaded microcapsules do not need the complex post-processing, the particle size is controllable, and the release rate of the therapeutic substances is convenient to control, thereby having good application prospect.

The invention relates to a silicon dioxide-based anti-adhesion agent used for a polyolefin thin film and a preparation method thereof. The silicon dioxide-based anti-adhesion agent is suitable for plastic thin film production enterprises. The preparation method includes the following steps of: 1) preparing silicon dioxide sol from tetraethyl orthosilicate under alkaline conditions; 2) adding a surfactant and a proper oil phase organic substance, and stirring the mixture to prepare a micelle with silicon dioxide as a shell layer; 3) adding trimethoxy silane containing an R group and a catalyst to the micelle with the silicon dioxide as the shell layer, and stirring the mixture to prepare silicon dioxide-based microspheres at a certain temperature, wherein the surfaces of silicon dioxide are modified by silane; and 4) drying the microspheres to remove the oil phase to obtain silicon dioxide hollow microspheres. The silicon dioxide-based anti-adhesion agent is a compound having definite structural and molecular formulas and molecular weight, but is a hollow microsphere which has a hierarchical pore structure and is based on silicon dioxide. The anti-adhesion agent can reinforce a plastic thin film and improves creep resistance, wherein a large quantity of micro projections and gaps are formed on the surface of the thin film, thereby increasing roughness of the thin film, reducing friction coefficient and preventing adhesion of the thin films.

The disclosed method to prehydrolyzed prepare shell-shaped inorganic nano crystal of silicon dioxide composite particle comprises: adding the n-ethyl silicate into the mixed liquid with ammonia, water and ethanol for prehydrolysis; then, adding finished metal oxide, noble metal or semi-conductor nano crystal with known method. This invention needs not any surface finish to obtain the product with regular shape and well chemical property fit to different requests.

The invention relates to a preparation method of an antislip ceramic aggregate. The technical scheme includes that the preparation method includes steps of (1), taking raw materials including, by weight, 50-60% of kaolin with the particle size smaller than or equal to 250 micrometers, 20-30% of feldspar powder with the particle size smaller than or equal to 58 micrometers, 10-15% of ground glass with the particle size smaller than or equal to 80 micrometers and 1.5-8% of chromophore with the particle size smaller than or equal to 45 micrometers, according to a formula; (2), feeding the raw materials into a ball mill to carry out ball milling after adding water into the raw materials, pouring slurry into a tank after ball milling, drying the slurry into blocks, grinding and granulating the blocks to obtain particle materials; (3), filling the particle materials formed in the step (2) into a saggar and then putting the saggar into a liquefied gas drawer kiln, and finally firing to obtain colored antislip ceramic aggregate. The preparation method is simple in procedure; the prepared colored antislip ceramic aggregate has stable chemical and physical performance, is corrosion-resistant, high-temperature resistant, aging resistant and colorful; signing construction coatings are thin, and thus, production cost is reduced greatly.

The invention relates to a bionic magnetosome loaded with siRNA and a preparation method of the magnetosome, and belongs to the field of chemistry and biomedicine. According to the bionic magnetosome, water-soluble MNC serves as the kernel and is wrapped by a white cell membrane, and siRNA is loaded between the MNC and the white cell membrane; antibodies or peptides with modifying groups can be coupled outside the white cell membrane of the bionic magnetosome in a covalence mode. By preparing MNC, M and MNC:siRNA and mixing an MNC:siRNA solution, an M solution and a buffer solution, the bionic magnetosome is obtained; the white cell membrane of the bionic magnetosome is modified by the peptides or antibodies through the modifying groups, and the bionic magnetosome coupled with the antibodies or peptides is obtained. The MNC in the bionic magnetosome has positive charges, can adsorb siRNA and is wrapped by M for bionics, a focus is reached efficiently and rapidly, and meanwhile immune elimination of organisms is avoided.

The invention relates to a preparation method of ferroferric oxide nanoparticles, relating to the field of preparation of inorganic non-metallic nano materials. The preparation method comprises the steps of: firstly, preparing a mixed dispersion solution of a ferric source and a ferrous source and a dispersion solution of an alkali source, adding the prepared mixed dispersion solution of the ferric source and the ferrous source into the dispersion solution of the alkali source, stirring for reaction for 50-70min to generate black precipitates in a reaction process, delivering reactants to a centrifuger, washing the separated precipitates sequentially with distilled water, a water-alcohol solution and absolute ethyl alcohol, centrifuging, separating and drying to obtain ferroferric oxide nanoparticles. In the invention, a used reaction solvent has the advantages of low cost and no toxicity and harmfulness, can be recycled and has no environment pollution problem; and used equipment is simple, operation conditions are easy to master, and thus, large-scale production is convenient.

The invention discloses a method for preparing a dual-structure flocky ZnO-base transparent conductive thin film. The method comprises the following steps of: 1) obtaining a solution A with large particles; 2) obtaining a solution B with small particles; 3) mixing and stirring the solution A and the solution B to obtain a mixed solution C; 4) coating the mixed solution C on one side of a photovoltaic glass substrate, coating the solution B on the other side of the photovoltaic glass substrate, and drying the glass substrate; and 5) sputtering and depositing on one side of the photovoltaic glass substrate to form the ZnO-base transparent conductive thin film, wherein in the step 1) and the step 2), a particle source is a silicon oxide or metal oxide precursor; and a particle size difference between each large particle and each small particle is 250 to 350 nm. By the method for preparing the dual-structure flocky ZnO-base transparent conductive thin film, the dual-structure flocky ZnO-base transparent conductive thin film can be obtained on one side of the photovoltaic glass substrate without execution of wet method etching, and an anti-reflection thin film can be obtained on the other side of the photovoltaic glass substrate; and the method is easy to operate and is suitable for industrial large-scale application.

The invention discloses a preparation method of an amphiphilic surfactant and a controllable preparation method of zwitterionic nano hollow capsules, wherein 2-(dodecyltrithiocarbonate)-2-methylpropionic acid is dissolved in In the dioxane solvent, dissolve the hydrophilic monomer, lipophilic monomer and azobisisobutyronitrile in benzyl alcohol, mix the above two solutions evenly, after the polymerization reaction, remove the solvent by ice methanol precipitation and vacuum drying Amphiphilic surfactants are produced. Based on this reagent, zwitterionic nano-hollow capsules are prepared by reverse-phase RAFT mini-emulsion interfacial polymerization. The amount of this reagent can be used to adjust the particle size of the prepared nano-hollow capsules, and further by adjusting the amount of cross-linking agent and core-shell By changing the ratio, the shell structure of zwitterionic hollow nanocapsules can be adjusted, which solves the problem that the structure and particle size of traditional nanocapsules are difficult to controllably prepare.