The invention provides a high-
magnesium microenvironment
bone marrow stem cell microsphere carrier as well as a preparation method and an application thereof,
magnesium ions are compounded into the
microsphere carrier to form a local high-
magnesium environment, the size of the
microsphere carrier is within 500 [mu]m, and the concentration of the magnesium ions is 2.5 mM to 10 mM. According to theconcept and the preparation method for constructing the
stem cell microsphere carrier of the local high-magnesium microenvironment, on one hand, when the
magnesium ion concentration is screened out tobe 2.5 mM to 5mM, the osteogenesis
induction effect is optimal; secondly, the
diameter of the prepared
stem cell microsphere carrier is within 500 microns, so that the
loading rate and survival rateof stem cells are effectively increased, osteogenic differentiation of the loaded stem cells is promoted by utilizing a local high-magnesium environment, and the defects of high cost, difficulty in slow release and the like caused by using
protein factors are reduced; finally, when the prepared high-magnesium microenvironment stem
cell microsphere carrier is used for
bone defect regeneration and repair, newly born bones in a defect area are obviously increased, and the repair effect is remarkably improved.