Preparation method of chitin composite bio-glass tissue repair material

A bioglass, tissue repair technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as poor mechanical properties and poor drug adhesion, and achieve the effects of improving mechanical properties, good porosity, and improving medical properties.

Inactive Publication Date: 2017-09-15
HEFEI CHUANGWO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in view of the existence of its amorphous silicon skeleton, bioglass still presents an amorphous form, poor mechanical properties, and poor drug adhesion, and its application in biomedical materials remains to be further developed

Method used

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Examples

Experimental program
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Embodiment 1

[0019] A preparation method of chitin composite biological glass tissue repair material, comprising the following steps:

[0020] Step 1: Weigh 10g of chitin and place it in a three-necked flask, and add 3mol / L hydrochloric acid solution, wherein the feeding ratio of chitin and hydrochloric acid solution is 1 / 30g·mL -1 , boil the mixed solution to reflux, stirring continuously during the process, after the reaction lasts for 6 hours, centrifuge the mixed solution and remove the upper liquid, take the lower precipitate and put it back into the three-necked flask and press 1 / 30g·mL -1 Add the feed ratio to 3mol / L hydrochloric acid solution, continue to heat and reflux for 6 hours, centrifuge the mixed solution and remove the upper liquid, take the lower sediment and wash it repeatedly with deionized water until the pH value reaches between 3-4. Add 100mL deionized water to the mixture for ultrasonic dispersion, then transfer the evenly dispersed dispersion to a dialysis bag with...

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PUM

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Abstract

The invention discloses a preparation method of a chitin composite bio-glass tissue repair material and belongs to the field of biological medicine materials. The method comprises the steps of preparation of a chitin solution, preparation of a bioglass solution and electrostatic spinning to prepare a repair material. The chitin is capable of improving the mechanical property of the material and has antibacterial property; and the bioglass is capable of improving the medical property of the material. The prepared tissue repair material has good mechanical property, tissue repair performance and drug adhesiveness.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a chitin composite biological glass tissue repair material. Background technique [0002] Since the discovery of bioglass, people have paid more attention to the influence of bioglass components on biological activity. The rise of nanotechnology has made people realize that structure also has an important impact on biological activity, and more attention has been paid to the effect of size effect and microscopic fine structure on the structure and performance of materials. The nano-bioglass and mesoporous bioglass developed and designed from the nano-scale have attracted the attention of scholars at home and abroad. Bioglass can activate cell genes, help to enhance cell proliferation and differentiation, and has osteoinductive and osteoconductive effects. However, in view of the existence of its amorphous silicon skeleton, bioglass still p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/54A61L27/56A61L27/58A61L27/50
CPCA61L27/46A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/112A61L2300/236A61L2300/404A61L2300/412A61L2300/604A61L2430/02C08L5/08
Inventor 王吉鹏
Owner HEFEI CHUANGWO TECH CO LTD
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